The effects of monoamine reuptake inhibiting antidepressants in experimental allergic neuritis

Journal of the Peripheral Nervous System

Volumn 2, Issue 1, 1997, Pages 30-42

  Zhu, Jie ^a   Mix, Eilhard ^b   Bengtsson, Bengt Olof ^c   Link, Hans ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b UNIVERSITY OF ROSTOCK   (Germany)

^c LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Autoimmunity; Cytokines; Experimental allergic neuritis; Guillain Barr syndrome; Monoamine reuptake inhibiting antidepressants

Indexed keywords

ANTIDEPRESSANT AGENT; NEUROTRANSMITTER UPTAKE INHIBITOR;

ANIMAL; HUMAN; IMMUNOLOGY; NEURITIS; PATHOLOGY; RAT; REVIEW;

ANIMALS; ANTIDEPRESSIVE AGENTS; HUMANS; NEURITIS, AUTOIMMUNE, EXPERIMENTAL; NEUROTRANSMITTER UPTAKE INHIBITORS; RATS;

EID: 0031290577     PISSN: 10859489     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (89)

1. Waksman BH, Adams RD: Allergic neuritis: an experimental disease of rabbits induced by the injection of peripheral nervous tissue and adjuvant. J. Exp. Med. 1955; 102:213-225.
2. Kadlubowski M, Hughes RA: Identification of the neuritogen for experimental allergic neuritis. Nature 1979; 277:140-141.
3. Milner P, Lovelidge CA, Taylor WA, Hughes RAC: P0 myelin protein produces experimental allergic neurilis in Lewis rats. J. Neurol. Sci. 1987; 79:275-285.
4. Shin HC, McFarlane EF, Pollard JD, Watson EG: Induction of experimental allergic neuritis with synthetic peptides from myelin P2 protein. Neurosci. Lett. 1989; 102:309-312.
5. Olee T, Powell HC, Brostoff SW: New minimum length requirement for a T cell epitope for experimental allergic neuritis. J. Neuroimmnnol. 1990; 27:187-190.
6. Saida T, Saida K, Dorfman SH, Silberberg DH, Sumner AJ, Manning MC, Lisak RP, Brown MJ: Experimental allergic neuritis induced by sensitization with galactocerebroside. Science 1979; 204:1103-1106.
7. Åström KE, Waksman BH: The possible transfer of experimental allergic encephalomyelitis and neuritis with living lymphoid cells. J. Pathol Bacteriol. 1962; 83:89-100.
8. Linington C, Izumo S, Suzuki M, Uyemura K, Meyermann R, Wekerle H: A permanent rat cell line that mediates experimental allergic neuritis in the Lewis rat in vivo. J. Immunol. 1984; 133:1946-1950.
9. Linington C, Lassmann H, Ozawa K, Kosin S, Mongan L: Cell adhesion molecules of the immunoglobulin supergene family as tissue-specific autoantigens: induction of experimental allergic neuritis (EAN) by P0 protein-specific T cell lines. Eur J. Immunol. 1992; 22:1813-1817.
10. Pollard JD, Westland KW, Harvey GK, Jung S, Bonner J, Spies JM, Toyka KV, Hartung HP: Activated T cells of noneural specificity open the blood-nerve barrier to circulating antibody. Ann. Neurol. 1995; 37:467-475.
11. Arnason BGW, Soliven B: Acute inflammatory demyelinating polyradiculoneuropathy. In: Peripheral neuropathy, 3rd edn. (Dyck PJ, Thomas PK, Griffin JW, Loe P, Poduslo JF, eds.). Philadephia: Saunders, 1993; pp 1437-1497.
12. Fujimoto S, Yuki N, Itoh T, Amako K: Specific serotype of Campylobacter jejuni associated with Guillain-Barré syndrome. J. Infect. Dis. 1992; 165:183.
13. Hartung HP: Pathogenesis of inflammatory demyelination: implications for therapy. Curr. Opin. Neurol. 1995; 8:191-199.
14. Koski CL, Gratz E, Sutherland J, Mayer RF: Clinical correlation with anti-peripheral-nerve myelin antibodies in Guillain-Barré syndrome. Ann. Neurol. 1986; 19:573-577.
15. Vrethem M, Skogh T, Berlin G, Holmgren H, Ernerudh J: Antibodies to peripheral nerve myelin may occur without clinical neuropathy in healthy persons. J. Neuroimmunol. 1991; 32:219-222.
16. Khalili-Shirazi A, Hughes RAC, Brostoff SW, Linington C, Gregson N: T cell responses to myelin in Guillain-Barré syndrome. J. Neurol. Sci. 1992; 111:200-203.
17. Sharief MK, Thompson EJ: Elevated serum levels of tumor necrosis factor-α in Guillain Barré syndrome. Ann. Neurol. 1993; 33:591-596.
18. Hartung HP, Hughes RAC, Taylor WA, Heining K, Reiners K, Toyka KV: T cell activation in Guillain-Barré syndrome and in MS: elevated serum levels of soluble IL-2 receptors. Neurology 1990; 40:215-218.
19. Maimone D, Annuniziata P, Simone IL, Livrea P, Guazzi GC: Interleukin-6 levels in the cerebrospinal fluid and serum of patients with Guillain-Barré syndrome and chronic inflammatory demyelinating polyradiculoneuropathy. J. Neuroimmunol. 1993; 47:55-62.
20. Oka N, Akiguchi I, Kawasaki T, Ohnishi K, Kimura J: Elevated serum levels of endothelial leukocyte adhesion molecules in Guillain-Barré syndrome and chronic inflammatory demyelinating polyneuropathy. Ann. Neurol. 1994; 35:621-624.
21. Leonard BE: Stress and the immune system: Immunological aspects of depressive illness. In: Stress, the Immune System and Psychiatry. (Leonard BE, Miller K, eds), Chichester: John Wiley, 1995, 114-125.
22. Leonard BE: Effect of antidepressants on specific neurotransmitters: are such effects relevant to the therapeutic action? In: Handbook of Depression and Anxiety: A Biological Approach. (den Boer JA, Ad Sitsen JM, eds) New York: Marcel Dekker, 1994, 379-404.
23. Kronfol Z: Immune function in depression and anxiety. In: Handbook of Depression and Anxiety: A Biological Approach. (den Boer JA, Ad Sitsen JM, eds) New York: Marcel Dekker, 1994, 515-527.
24. Maes M, Meltzer H, Jacobs J, Suy E, Calabrese J, Minner B, Raus J: Autoimmunity in depression: increased antiphospholipid autoantibodies. Acta. Psychiatr. Scand. 1993; 87:160-166.
25. Surman OS: Possible immunological effects of psychotropic medication. Psychosomatics 1993; 34:139-143.
26. Agius MA, Arnason BGW: Autoimmune neurological diseases and their potential relevance to psychiatric diseases. In: Psychoimmunology Update, Progress in Psychiatry, (Gorman JM, Kertzner RM, eds) Washington DC: American Psychiatric Press, 1991, 9-29.
27. Miller AH, Lackner C: Tricyclic antidepressants and immunity. In: Depressive Disorders and Immunity. Progress in Psychiatry. (Miller AH, ed), Washington DC: American Psychiatric Press, 1989, 87-103.
28. Hoffmann PM, Powers JM, Weise MJ, Brostoff SW: Experimental allergic neuritis: I. Rat strain differences in the response to bovine myelin antigens. Brain Res. 1980; 195:355-362.
29. Linington C, Mann A, Izumo S, Uyemura K, Suzuki M, Meyermann R, Wekerle H: Induction of experimental allergic neuritis in the BN rat: P2 protein-aspecific T cells overcome resistance to actively induced disease. J. Immunol. 1986; 137:3826-3831.
30. Hamaguchi K, Ohno R, Tsuji T, Yamashita T, Negishi T, Nomura K, Hosokawa T: Activated T lymphocyte subsets in experimental allergic neuritis. J. Neuroimmunol. 1991; 34:191-196.
31. Zhu J, Link H, Mix E, Olsson T, Huang W-X: Th1-like cell responses to peripheral nerve myelin components over the course of experimental allergic neuritis in Lewis rats. Acta Neurol. Scand. 1994a; 90:19-25.
32. Zhu J, Mix E, Issazadeh S, Link H: Dynamics of mRNA expression of interferon-γ, interleukin-4 and transforming growth factor-β in sciatic nerves and lymphoid organs in experimental allergic neuritis. Eur. J. Neurol. 1996; 3:232-240.
33. Mosmann TR, Coffman RL: Two types of mouse helper T-cell clone. Immunol. Today 1987; 8:223-227.
34. Mosmann TR, Sad S: The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol. Today 1996; 17:138-146.
35. Kuchroo VK, Das MP, Brown JA, Ranger AM, Zamvil SS, Sobel RA, Weiner HL, Nabavi N, Glimcher LH: B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy. Cell 1995; 80:707-718.
36. Olsson T: Critical influences of the cytokine orchestration on the outcome of myelin antigen-specific T-cell autoimmunity in experimental autoimmune encephalomyelitis and multiple sclerosis. Immunol. Rev. 1995; 144:245-268.
37. Zhu J, Mix E, Olsson T, Link H: Cellular mRNA expression of interferon-γ, interleukin 4 and transforming growth factor-β by rat mononuclear cells stimulated with peripheral nerve myelin antigens in experimental allergic neuritis. Clin. Exp. Immunol. 1994b; 98:306-312.
38. Collart MA, Belin D, Vassalli JD, de Kossodo S, Vassalli P: Gamma-interferon enhances macrophage transcription of the tumor necrosis factor/cachetin, interleukin-1, and urokinase genes, which are controlled by short-lived repressors. J. Exp. Med. 1986; 164: 2113-2118.
39. Hardy KJ, Sawada T: Human γ-interferon strongly upregulates its own gene expression in peripheral blood lymphocytes. J. Exp. Med. 1989; 170:1021-1026.
40. Bai XF, Zhu J, Zhang GX, Kaponides G, Bo Höjeberg, Link H: IL-10 suppresses experimental autoimmune neuritis, and down-regulates cytokine mRNA expression of Th1 macrophages source. (Submitted 1996.)
41. Kiefer R, Funa K, Schweitzer T, Jung S, Bourde O, Toyka KV, Hartung HP: Transforming growth factor β1 in experimental allergic neuritis. Am. J. Pathol. 1996; 148:211-223.
42. Gregorian SK, Lee WP, Beck LS, Rostami A, Amento EP: Regulation of experimental autoimmune neuritis by transforming growth factor-beta 1. Cell Immunol. 1994; 156:102-112.
43. Guénard V, Rosenbaum T, Gwynn LA, Doetschman T, Ratner N, Wood PM: Effect of transforming growth factor-beta 1 and -beta 2 on Schwann cell proliferation on neurites. Glia 1995; 13:309-318.
44. Toyka KV, Heininger K: Humoral factors in peripheral nerve disease. Muscle Nerve 1987; 10:222-232.
45. Raine C, Bornstein M: Experimental allergic neuritis-ultrastructure of serum induced myelin aberrations in peripheral nervous system cultures. Lab. Invest. 1979; 40:423-432.
46. Zhu J, Link H, Weerth S, Linington C, Mix E, Qiao J: The B cell repertoire in experimental allergic neuritis involves multiple myelin proteins and GM1. J. Neurol. Sci. 1994c; 125:132-137.
47. Osterman PO, Lundemo G, Pirskanen R, Fagius J, Pihlstedt P, Sidén Å: Beneficial effects of plasma exchange in acute inflammatory polyradiculoneuropathy. Lancet 1984; 2:1296-1298.
48. Hughes RAC, Powell HC, Braheny SL, Brostoff SW: Endoneurial injection of antisera to myelin antigens. Muscle and Nerve 1985; 8:516-522.
49. Hays AP, Latov N, Takatsu M, Sherman WH: Experimental demyelination of nerve induced by serum of patients with neuropathy and an anti-MAG IgM M-protein. Neurology 1987; 37:242-256.
50. Heidenreich F, Leifeld L, Jovin T: T cell-dependent activity of ganglioside GM1-specific B cells in Guillain-Barré syndrome and multifocal motor neuropathy in vitro. J. Neuroimmunol. 1994; 49:97-108.
51. Spies JM, Pollard JD, Bonner JG, Westland KW, McLeod JG: Synergy between antibody and P2-reactive T cells in experimental allergic neuritis. J. Neuroimmunol. 1995; 57:77-84.
52. Zielasek J, Jung S, Gold R, Liew FY, Toyka KV, Hartung HP: Administration of nitric oxide synthase inhibitors in experimental autoimmune neuritis and experimental autoimmune encephalomyelitis. J. Neuroimmunol. 1995; 58:81-88.
53. Jung S, Huitinga I, Schmidt B, Zielasek J, Dijkstra CD, Toyka KV, Hartung HP: Selective elimination of macrophages by dichlormethylene diphosphonate-containing liposomes suppresses experimental autoimmune neuritis. J. Neurol. Sci. 1993; 119:195-202.
54. Aune TM, Golder HW, McGrath KM: Inhibitors of secretion synthesis and antagonists of serotonin 1A receptors inhibit T lymphocyte function in vitro and cell-mediated immunity in vivo. J. Immunol. 1994; 153:489-498.
55. Josefsson E, Bergquist J, Ekman R, Tarkowski A: Catecholamines are synthesized by mouse lymphocytes and regulate function of these cells by induction of apoptosis. Scand. J. Immunol. 1995; 41:624.
56. Khan MM: Differential effects of histamine on T helper type 2 (TH2) lymphocytes. Proc. West. Pharmacol. Soc. 1995; 38:79-81.
57. Devoino L, Eliseeva L, Eremina O, Idova G, Cheido M: 5-Hydroxytryptophan effect on the development of the immune response: IgM and IgG antibodies and rosette formation in primary and secondary responses. Eur J. Immunol. 1975; 5:394-399.
58. Sternberg EM, Trial J, Parker CW: Effect of serotonin on murine macrophages: suppression of Ia expression by serotonin and its reversal by 5-HT2 serotonergic receptor antagonists. J. Immunol. 1986; 137:276-282.
59. Bonnet M, Lespinats G, Burtin C: Histamine and serotonin suppression of lymphocyte response to phytohemagglutinin and allogeneic antigen. Cell Immunol. 1984; 83:280-291.
60. Sternberg EM, Wedner HJ, Leung MK, Parker CW: Effect of serotonin (5-HT) and other monoamines on murine macrophages: Modulation of interferon gamma induced phagocytosis. J. Immunol. 1987; 138: 4360-4365.
61. Hellstrand K, Czerkinsky C, Ricksen A, Jansson B, Asea A, Kylefjord H, Hermodsson S: Role of seretonin in the regulation of interferon-γ production by human natural killer cells. J. Interferon Res. 1993; 13:33-38.
62. 1c receptor activation and independently by PKC. Am. J. Physiol. 1993; 265:C2571-C1578.
63. Mix E, Olsson T, Solders G, Link H: Effect of ion channel blockers on immune response and course of experimental allergic neuritis. Brain 1989, 112:1405-1418.
64. Cowen PJ, Anderson IM, Gartside SE: Endocrinological responses to 5-HT. In: Whitaker-Azmitia PM, Peroutka SJ, (eds.) The neuropharmacology of serotonin. Ann. N. Y. Acad. Sci. 1990; 600:250-259.
65. Nilsson BS: Adverse reactions in connection with zimeldine treatment: a review. Acta Psychiatr. Scand. 1983; 68: suppl 308, 115-119.
66. Bengtsson B-O: On the hypersensitivity syndrome induced by the selective serotonin reuptake inhibiting antidepressant zimeldine. A clinical and experimental study. Thesis. Linköping, Sweden, 1992.
67. 3H-thymidine incorporation in lymphocyte cultures from psychiatric patients with or without a hypersensitivity reaction during zimeldine therapy. Int. Clin. Psychopharmacol. 1994; 9:179-185.
68. Shimomura T, Tanaka H, Takahashi K: Plasma serotonergic activation in rats during the course of experimental allergic neuritis. Japanese J. Psychiatry Neurol. 1990; 44:637-640.
69. Zhu J, Liu DS, Yao ML, Lin SH: Disturbance of immunoregulation in experipheral allergic neuritis in rabbits: II. The relationship between the changes in CSF and serum serotonin concentrations and immune response. Clin. J. Nerv. Mental Dis. 1991; 24:101-103.
70. Harvey GK, Pollard JD: Peripheral nervous system demyelination from systemic transfer of experimental allergic neuritis serum. J. Neuroimmunol. 1992; 41:159-166.
71. Matsuyama H, Haymaker W: Distribution of lesion in the Landry-Guillain-Barré syndrome, with emphasis on involvement of the sympathetic nervous system. Acta Neuropathol. 1967; 8:230-241.
72. Kalimo H, Molnar GK, Saska M, Riekkinen PJ: Involvement of autonomic nervous system in experimental allergic neuritis. J. Neuroimmunol. 1982; 2:9-19.
73. Abrass CK, O'Connor SW, Scarpace PJ, Abrass IB: Characterization of the β-adrenergic receptor of the rat peripheral macrophages. J. Immunol. 1985; 135:1338-1352.
74. Kim DH, Muthyala S, Soliven B, Wiegmann K, Wollmann R, Chelmicka-Schorr E: The β2-adrenergic agonist terbutaline suppresses experimental allergic neuritis in Lewis rats. J. Neuroimmunol. 1994; 51:177-183.
75. Chelmicka-Schorr E, Kwasniewski MN, Czlonkowska A: Sympathetic nervous system modulates macrophages function. Int. J. Immunopharmacol. 1992; 14: 841-846.
76. Lapchak PA, Araujo DM: Interleukin-2 regulates monoamine and opioid peptide release from the hypothalamus. Neuroreport 1993; 4:303-306.
77. Harvey GK, Toyka KV, Hartung HP: Effects of mast cell degranulation on blood-nerve barrier permeability and nerve conduction in vivo. J. Neurol. Sci. 1994; 125:102-109.
78. Bengtsson B-O, Zhu J, Thorell L-H, Olsson T, Link H: Effects of zimeldine and its metabolites, clomipramine, imipramine and maprotiline in experimental allergic neuritis in Lewis rats. J. Neuroimmunol. 1992; 39:109-122.
79. Zhu J, Bengtsson B-O, Mix E, Thorell L-H, Olsson T, Link H: Effect of monoamine reuptake inhibitory antidepressants on major histocompatibility complex on macrophages in normal rats and rats with experimental allergic neuritis (EAN). Immunopharmacology 1994d; 27:225-244.
80. Zhu J, Bengtsson B-O, Mix E, Thorell L-H, Olsson T, Link H: Peripheral nerve myelin (BPM) modulates the effect of antidepressants on major histocompatibility complex (MHC) expression on macrophages in experimental allergic neuritis (EAN). Int. J. Immunopathol. Pharmacol. 1995; 8:185-198.
81. Bengtsson B-O, Zhu J, Mix E, Ekerling L, Thorell L-H, Olsson T, Link H: Clomipramine and imipramine suppress clinical signs and T and B cell response to myelin proteins in experimental allergic neuritis in Lewis rats. Biol. Psychiat., accepted, 1996.
82. Sommer N, Löschmann P-A, Northoff GH, Weller M, Steinbrecher A, Steinbach JP, Lichtenfels R, Meyermann R, Riethmuller A, Fontana A, Dichgans J, Martin R: The antidepressant rolipram suppresses cytokine production and prevents autoimmune encephalomyelitis. Nature Medicine 1995; 1:244-248.
83. Crowson AN, Magro CM: Antidepressant therapy. A possible cause of atypical cutaneous lymphoid hyperplasia. Arch. Dermatol. 1995; 131:925-929.
84. Jemison LM, Wiliams SK, Lublin FD, Knobler RL, Korn gold R; Interferon-γ inducible endothelial cell class II major histocompatibility complex expression correlates with strain- and site-specific susceptibility to experimental allergic encephalomyelitis. J. Neuroimmunol. 1993; 47:15-22.
85. Finocchiaro LME, Arzt ES, Fernandez-Castelo S, Criscuolo M, Finkielman S, Nahmod VE: Serotonin and melatonin synthesis in peripheral blood mononuclear cells: stimulation by interferon-γ as part of an immunomodulatory pathway. J. Interferon Res. 1988; 8: 705-716.
86. Blakely RD, Berson HE, Fremeau Jr RT, Caron MG, Peek MM, Prince HK, Bradley CC: Cloning and expression of a functional serotonin transporter from rat brain. Nature 1991; 354:66-70.
87. Hoffmann BJ, Meray E, Brownstein MJ: Cloning of a serotonin transporter affected by antidepressants. Science 1991; 254:579-580.
88. Faraj BA, Olkowski ZL, Jackson RT: Expression of a high-affinity serotonin transporter in human lymphocytes. Int. J. Immunopharmacol. 1994; 16:561-567.
89. 3H]-dopamine to human lymphocytes: possible relationship to neutransmitter uptake sites. Pharmacology 1991; 42:135-141.