An ATP-Sensitive potassium (KATP) channel opener, nicorandil, lowers the threshold for ischemic preconditioning in barbital-anesthetized dogs

Heart and Vessels

Volumn 12, Issue SUPPL. 12, 1997, Pages 175-177

  Mizumura, Tsuneo ^a   Saito, Satoshi ^a   Ozawa, Yukio ^a   Kanmatsuse, Katsuo ^a   Gross, Garrett J ^b  

^a NIHON UNIVERSITY   (Japan)

^b MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

ATP; Ischemic preconditioning; Nicorandil; Sensitive potassium channels; Threshold

Indexed keywords

BARBITAL; DRUG DERIVATIVE; NICORANDIL; NICOTINAMIDE; POTASSIUM CHANNEL; ADENOSINE TRIPHOSPHATE; MICROSPHERE; POTASSIUM CHANNEL STIMULATING AGENT; TRIPHENYLTETRAZOLIUM;

ANIMAL; ARTICLE; BLOOD FLOW; DOG; DRUG EFFECT; DRUG POTENTIATION; FEMALE; HEART; HEART INFARCTION PREVENTION; MALE; METHODOLOGY; TIME; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY OCCLUSION; CONFERENCE PAPER; CONTROLLED STUDY; CORONARY HEMODYNAMICS; GRAVIMETRY; INTRACORONARY INFUSION; LEFT ANTERIOR DESCENDING CORONARY ARTERY; NONHUMAN; PRIORITY JOURNAL; REPERFUSION;

ANIMALS; BARBITAL; DOGS; FEMALE; HEART; ISCHEMIC PRECONDITIONING, MYOCARDIAL; MALE; NIACINAMIDE; NICORANDIL; POTASSIUM CHANNELS; REGIONAL BLOOD FLOW; TIME FACTORS;

EID: 0031283361     PISSN: 09108327     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (6)

1. Murry CE, Jennings RB, Reimer KA (1986) Preconditioning with ischemia: A delay of lethal cell injury in ischemic myocardium. Circulation 74:1124-1136
2. Gross GJ, Auchampach JA (1992) Blockade of ATP-sensitive potassium channels prevents myocardial preconditioning in dogs. Circ Res 70:223-233
3. Yao Z, Gross GJ (1994) Activation of ATP-sensitive potassium channels lowers threshold for ischemic preconditioning in dogs. Am J Physiol 267(Heart Circ Physiol 36):H1888-H1894
4. Miura T, Ogawa T, Iwamoto T, Shimamoto K, Iimura O (1992) Dipyridamole potentiates the myocardial infarct size-limiting effect of ischemic preconditioning. Circulation 86:979-985
5. Mizumura T, Nithipatikom K, Gross GJ (1996) Infarct size-reducing effect of nicorandil is mediated by the KATP channel but not by its nitrate-like properties in dogs. Cardiovasc Res 32:274-285
6. Saito S, Mizumura T, Takayama T, Honye J, Fukui T, Kamata T, Moriuchi M, Hibiya K, Tamura Y, Ozawa Y, Kanmatsuse K, Osawa K, Ishihata F, Nakakimura H, Sakai K (1995) Antiischemic effects of nicorandil during coronary angioplasty in humans. Cardiovasc Drugs Ther 9:257-263