Exacerbation of acetazolamide teratogenesis by amiloride and its analogs active against NA+/H+ exchangers and NA+ channels

Reproductive Toxicology

Volumn 11, Issue 6, 1997, Pages 823-831

  Bell, Sheila M ^a,b   Schreiner, Claire M ^a   Resnick, Elisabeth ^a   Vorhees, Charles ^a   Scott Jr , William J ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b CINCINNATI CHILDREN S HOSPITAL RESEARCH FOUNDATION   (United States)

Author keywords

Acetazolamide; Amiloride; Ectrodactyly; Intracellular pH; Mouse; Sodium hydrogen exchanger

Indexed keywords

ACETAZOLAMIDE; AMILORIDE; AMILORIDE DERIVATIVE; ANTIPORTER; BENZAMIL; CARBONATE DEHYDRATASE INHIBITOR; DIURETIC AGENT; TRIAMTERENE;

ANIMAL; ANIMAL MODEL; ARTICLE; CONGENITAL MALFORMATION; DOSE RESPONSE; DRUG POTENTIATION; FEMALE; FETUS; LIMB MALFORMATION; MOUSE; MOUSE STRAIN; NONHUMAN; PREGNANCY; SODIUM CHANNEL; SUBCUTANEOUS DRUG ADMINISTRATION; TERATOGENICITY; TOXICITY TESTING;

ABNORMALITIES, DRUG-INDUCED; ACETAZOLAMIDE; AMILORIDE; ANIMALS; CARBONIC ANHYDRASE INHIBITORS; DRUG SYNERGISM; FEMALE; MICE; MICE, INBRED C57BL; PREGNANCY; SODIUM CHANNEL BLOCKERS; SODIUM-HYDROGEN ANTIPORTER;

EID: 0031282718     PISSN: 08906238     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0890-6238(97)00066-X     Document Type: Article

References (57)

1. 1. Layton WM Jr, Hallesy DW. Deformity of forelimb in rats: association with high doses of acetazolamide. Science (Washington DC) 1965;149:306-8.
2. 2. Layton WM. Teratogenic action of acetazolamide in golden hamsters. Teratology. 1971;4:95-102.
3. 3. Maren TH. Carbonic anhydrase: chemistry, physiology, and inhibition. Physiol Rev. 1967;47:595-781.
4. 4. Roos A, Boron WF. Intracellular pH. Physiol Rev. 1981;61:297-421.
5. 5. Weaver TE, Scott WJ Jr. Acetazolamide teratogenesis: association of maternal respiratory acidosis and ectrodactyly in C57B1/6J mice. Teratology. 1984;30:187-202.
6. 6. Weaver TE, Scott WJ Jr. Acetazolamide teratogenesis: interaction of maternal metabloic acidosis in the induction of ectrodactyly in C57B1/6J mice. Teratology. 1984;30:195-202.
7. 7. Scott WJ, Duggan CA, Schreiner CM, Collins MD. Reduction of embryonic intracellular pH: a potential mechanism of acetazolamide-induced limb malformations. Toxicol Appl Pharmacol. 1990;103:238-54.
8. 8. Ellison AC, Maren TH. The effect of potassium metabolism on acetazolamide-induced teratogenesis. Hopkins Med J. 1972;103: 105-15.
9. 9. Schreiner C, Collins MD, Scott WJ, Vorhees CV, Colvin J, McCandless D. Estimating intracellular pH in developing rodent embryos using a computer imaging technique: changes in embryonic pH and proliferation rates following maternal treatment with acetazolamide. Teratology. 1995;52:160-8.
10. 10. Kleyman TR, Cragoe, EJ Jr. Amiloride and its analogs as tools in the study of ion transport. J Memb Biol. 1988;105:1-21.
11. 11. Kuczuk MH, Scott W. Potentiation of acetazolamide induced ectrodactyly in SWV and C57B1/6J mice by cadmium sulfate. Teratology. 1984;29:427-35.
12. 12. Wilson JG. Embryological considerations in teratology/methods for administering agents and detecting malformations in experimental animals. In: Wilson JG, Warkany J, eds. Teratology: principles and techniques. Chicago: University of Chicago Press; 1965:251-77.
13. 13. Kramer HJ, Rorig M, Volger KD. Effects of triamterene and its phase I and phase II metabolites on sodium transport of the isolated frog skin. Pharmacology. 1981;23:149-55.
14. 14. Hirsch KS, Scott WJ Jr. Searching for the mechanism of acetazolamide teratogenesis. In: Kalter H, ed. Issues and reviews in teratology. New York: Plenum Publishing Corporation; 1983:309-47.
15. 15. Miller TA, Scott WJ Jr. Abnormalities in ureter and kidney development in mice given acetazolamide-amiloride or dimethadione (DMO) during embryogenesis. Teratology. 1992;46:541-50.
16. + exchanger and growth factor-induced cytosolic pH change: role in cellular proliferation. Biochim Biophys Acta. 1989;988:73-91.
17. 17. Orlowski J, Kandasamy RA, Shull GE. Molecular cloning of putative members of the Na/H exchanger gene family. J Biol Chem. 1992;267:9331-9.
18. + exchanger (NHE5/SLC9A5) to chromosome 16q22.1. Genomics. 1995;25: 615-22.
19. + exchanger isoforms. Am J Physiol. 1995;C283-96.
20. + antiporter and its developmental expression pattern. Teratology. 1993;47:413.
21. 21. Yu FH, Shull GE, Orlowski J. Functional properties of the rat Na/H exchanger NHE-2 isoform expressed in Na/H exchanger-deficient chinese hamster ovary cells. J Biol Chem. 1993;268: 25536-41.
22. + exchange and cell proliferation in AR42J pancreatic cell line. Am J Physiol. 1990: G842-9.
23. + Exchange. Boca Raton FL: CRC Press; 1988.
24. + exchange system in various cell types. Biochem Biophys Res Commun. 1983;116:86-90.
25. + exchangers, NHE-1 in the maternal-facing (brush border) membrane and NHE-2 in the fetal-facing (basal) membrane. Biochem J. 1992;284:33-8.
26. + exchanger of the placental brush-border membrane is pharmacologically distinct from that of the renal brush-border membrane. J Biol Chem. 1990;265:1249-52.
27. + channel: biophysical properties, pharmacology, ontogenesis, and molecular cloning. Proc Natl Acad Sci USA 1994;91:247-51.
28. 28. Canessa CM, Horisberger J-D, Schild L, Rossier BC. Expression cloning of the epithelial sodium channel. Kidney Int. 1995;48: 950-5.
29. 29. Luo J, Tannock IF. Inhibition of the regulation of intracellular pH: potential of 5-(N,N-hexamethylene) amiloride in tumour-selective therapy. Br J Cancer. 1994;70:617-24.
30. 30. Flouvat B, Roux A, Leneveu A, Prinseau J, Alexndre JA. Combination of long-acting furosemide and instant-acting amiloride: pharmokinetics and pharmacodynamics in human subjects. Fundam Clin Pharmacol. 1991;5:741-52.
31. 31. Spahn H, Reuter K, Mutschler E, Gerok W, Knauf H. Pharmokinetics of amiloride in renal and hepatic disease. Eur J Clin Pharmacol. 1987;33:493-8.
32. 32. Palmer LG. Ion selectivity of the apical membrane Na channel in the toad urinary bladder. J Membr Biol. 1982;67:91-8.
33. + Channel blockers inhibit voltage-dependent intracellular pH changes in principal cells of frog (Rana pipiens) skin. Comp Biochem Physiol. 1993;105A: 503-11.
34. 34. Lukacs GL, Kapus A, Nanda A, Romanek R, Grinstein S. Proton conductance of the plasma membrane: properties, regulation, and functional role. Am J Physiol. 1993;265:C3-14.
35. 35. Harvey BJ. Cross-talk between sodium and potassium channels in tight epithelia. Kidney Int. 1995;48:1191-9.
36. 36. Tang C-M, Presser F, Morad M. Amiloride selectively blocks the low threshold (T) calcium channel. Science (Washington DC) 1988;240:213-5.
37. 37. Davis RJ, Czech MP. Amiloride directly inhibits growth factor receptor tyrosine kinases activity. J Biol Chem. 1985;260:2543-51.
38. 38. Presek P, Reuter G. Amiloride inhibits the protein tyrosine kinases associated with the cellular and the transforming src-gene products. Biochem Pharmacol. 1987;36:2821-6.
39. 39. Besterman JM, Elwell LP, Blanchard SG, Cory M. Amiloride intercalates into DNA and inhibits DNA topoisomerase II. J Biol Chem. 1987;262:13352-8.
40. 40. Garritsen A, Beukers MW, Ijzerman AP, Cragoe EJ Jr, Soudijn W. The mode of interaction of amiloride and some of its analogues with the adenosine A1 receptor. Neurochem Int. 1992;20:207-13.
41. 41. Vassali JD, Belin D. Amiloride selectively inhibits the urokinase-type plasminogen activator. FEBS Lett. 1987;214:187-91.
42. 42. Bubien JK, Warnock DG. Amiloride-sensitive sodium conductance in human B lymphoid cells. Am J Physiol. 1993;C1175-82.
43. 43. Wanek N, Bryant SV. Temporal pattern of posterior positional identity in mouse limb buds. Dev Biol. 1991;147:480-4.
44. 44. Gutknecht DR, Koster CH, Tertoolen LGJ, de Laat SW, Duston AJ. Intracellular acidification of gastrula ectoderm is important for posterior axial development in Xenopus. Development (Cambridge, U.K.) 1995;121:1911-25.
45. 45. Sater AK, Alderton JM, Steinhardt RA. An increase in intracellular pH during neural induction in Xenopus. Development (Cambridge, U.K.) 1994;120:433-42.
46. 46. Saunders JW Jr, Gasseling MT. Ectodermal-mesenchymal interactions in the origin of limb symmetry. In: Fleischmajer R, Billingham RE, eds. Epithelial-mesenchymal interactions. Baltimore: Williams and Wilkins; 1968:78-97.
47. 47. Milaire J. Histological changes induced in developing limb buds of C57B1 mouse embryos submitted in utero to the combined influence of acetazolamide and cadmium sulphate. Teratology. 1985; 32:433-51.
48. 48. Laird DW, Yancey SB, Bugga L, Revel J-P. Connexin expression and gap junctional communication compartments in the developing mouse limb. Dev Dyn. 1992;195:153-61.
49. 49. Kelley RO, Fallon JF. A freeze-fracture and morphometric analysis of gap junctions of limb bud cells: initial studies on a possible mechanism for morphogenetic signalling during development. In: Fallon JF, Caplan AI, eds. Progress in clinical and biological research Vol 110A: Limb development and regeneration Part A. New York: Alan R. Liss Inc.; 1983:119-30.
50. 50. Spray DC, Bennett MLV. Physiology and pharmacology of gap junctions. Ann Rev Physiol. 1985;47:281-303.
51. 51. Doel MS. Genetical studies on the skeleton of the mouse. XXVIII. Tail short. Proc. R. Soc. London Ser B. 1961;155:78-95.
52. 52. Kocher W, Kocher-Becker U. Bilaterally symmetric and asymmetric realization of limb malformations. In: Merker HJ, Nau H, Neubert D, eds. Teratology of the limbs. Berlin: Walter de Gruyter; 1980:259-71.
53. 53. Searle AG. The genetics and morphology of two luxoid mutants in the house mouse. Genet Res. 1964;5:171-97.
54. 54. Maas R, Rauchman M. Genetic control of kidney morphogenesis. In: Kavlock RJ, Daston GP, eds. Handbook of experimental pharmacology vol. 124. I: drug toxicity in embryonic development I: advances in understanding mechanisms of birth defects: morphogenesis and processes at risk. Berlin: Springer Publishing; 1997:129-71.
55. 55. Tickle C, Eichele G. Vertebrate limb development. Annual Rev Cell Biol. 1994;10:121-52.
56. 56. Eaton DC, Becchetti A, Ma H, Ling BN. Renal sodium channels: regulation and single channel properties. Kidney Int. 1995;48: 941-9.
57. 57. Hummler E, Barker P, Gatzy J, et al. Early death due to defective neonatal lung liquid clearance in alpha ENaC-deficient mice. Nat Genet. 1996;12:325-8.