Schistosoma japonicum GSH S-transferase Sj26 is not the molecular target of praziquantel action

Experimental Parasitology

Volumn 87, Issue 3, 1997, Pages 268-274

  Milhon, Jon L ^a   Thiboldeaux, Robert L ^a   Glowac, Kim ^a   Tracy, James W ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTATHIONE TRANSFERASE; PRAZIQUANTEL;

ANIMAL EXPERIMENT; ARTICLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG TARGETING; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; SCHISTOSOMA JAPONICUM;

ANIMALIA; BOVINAE; SCHISTOSOMA JAPONICUM;

EID: 0031282319     PISSN: 00144894     EISSN: None     Source Type: Journal    
DOI: 10.1006/expr.1997.4231     Document Type: Article

References (27)

1. Ausubel, F. M., Brent, R., Kingston, D. E., Moore, D. D., Seidman, J. G., Smith, J. A., and Struhl, K. 1996. "Current Protocols in Molecular Biology." Wiley, New York.
2. Bradford, M. M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254.
3. Brindley, P. J., and Sher, A. 1987. The chemotherapeutic effect of praziquantel against Schistosoma mansoni in dependent on the host antibody response. J. Immunol. 136, 215-220.
4. Danielson, U. H., and Mannervik, B. 1985. Kinetic independence of the subunits of cytosolic glutathione transferase from the rat. Biochem. J. 231, 263-267.
5. Fallon, P. G., Tao, L.-F., Ismail, M. M., and Bennett, J. L. 1996. Schistosome resistance to praziquantel: Fact or artifact? Parasitol. Today 12, 316-320.
6. Goldstein, J., and Combes, B. 1966. Spectrophotometric assay of the liver enzyme that catalyzes sulfobromophthalein-glutathione conjugation. J. Lab. Clin. Med. 67, 863-872.
7. Habig, W. H., and Jakoby, W. B. 1981. Assays for differentiation of glutathione S-transferases. In "Methods in Enzymology" (W. B. Jakoby, Ed.), Vol. 77, pp. 398-405. Academic Press, New York.
8. Harnett, W., and Kusel, J. R. 1986. Increased exposure of parasite antigens at the surface of adult male Schistosoma mansoni exposed to praziquantel in vitro. Parasitology 93, 401-405.
9. Holy, J. M., O'Leary, K. A., Oaks, J. A., and Tracy, J. W. 1989. Immunocytochemical localization of the major GST in adult S. mansoni. J. Parasitol. 75, 181-190.
10. Ivanetich, K. M., Thumser, A. E., Phillips, S. E., and Sikakana, C. N. 1990. Reversible inhibition of rat hepatic glutatione S-transferase 1-2 by bilirubin. Biochem. Pharmacol. 40, 1563-1568.
11. Ji, X., von Rosenvinge, E. C., Johnson, W. W., Armstrong, R. N., and Gilliland, G. L. 1996. Location of potential transport binding site in a sigma class glutathione transferase by x-ray crystallography. Proc. Natl. Acad. Sci. USA 93, 8208-8213.
12. Kaminsaka, K., Gatmaitan, Z., Moore, C. L., and Arias, I. M. 1975. Ligandin reverses bilirubin inhibition of liver mitochondrion respiration in vitro. Pediatr. Res. 9, 903-905.
13. Kloetzel, K., and Lewert, R. M. 1966. Pigment formation in Schistosoma mansoni infections in the white mouse. Am. J. Trop. Med. Hyg. 5, 847-853.
14. 4. Nature 227, 680-685.
15. Mannervik, B., and Danielson, U. H. 1988. Glutathione transferases: Structure and catalytic activity. CRC Crit. Rev. Biochem. 23, 283-337.
16. McTigue, M. A., Williams, D. R., and Tainer, J. A. 1995. Crystal structures of a schistosomal drug and vaccine target: Glutathione S-transferase from Schistosoma japonica and its complex with the leading antischistosomal drug praziquantel. J. Mol. Biol. 246, 21-27.
17. Mehlhorn, H., Becker, B., Andrews, P., Thomas, H., and Frenkel, J. K. 1981. In vivo and in vitro experiments on the effects of praziquantel on Schistosoma mansoni. A light and electron microscopic study. Arzneimittelforschung 31(3a), 544-554.
18. O'Leary, K. A., Hathaway, K. M., and Tracy, J. W. 1992. Schistosoma mansoni: Single-step purification and characterization of glutathione S-transferase isoenzyme 4. Exp. Parasitol. 75, 47-55.
19. O'Leary, K. A., and Tracy, J. W. 1988. Purification of three cytosolic glutathione S-transferases from adult Schistosoma mansoni. Arch. Biochem. Biophys. 264, 1-12.
20. Porchet, E., McNair, A., Caron, A., Kusnierz, J. P., Zemzoumi, K., and Capron, A. 1994. Tissue expression of the Schistosoma mansoni 28 kDa glutathione S-transferase. Parasitology 109, 565-572.
21. Redman, C. A., Robertson, A., Fallon, P. G., Modha, J., Kusel, J. R., Doenhoff, M. J., and Martin, R. J. 1996. Praziquantel: An urgent and exciting challenge. Parasitol. Today 12, 14-20.
22. Sies, H. 1988. Oxidative stress: Quinone redox cycling. ISI Atlas Sci. Biochem. 109-114.
23. r protective antigen of Schistosoma mansoni. EMBO J. 7, 465-472.
24. Tracy, J. W., and Vande Waa, E. A. 1995. Xenobiotic metabolism,. In "Biochemical and Molecular Biology of Parasites" (J. J. Mair and M. Müller, Eds.), pp. 161-175. Academic Press, London.
25. Tracy, J. W., and Webster, L. T., Jr. 1996. Drugs used in the chemotherapy of helminthiasis. In "Goodman's and Gilman's The Pharmacological Basis of Therapeutics" (J. G. Hardman, L. E. Limbird, P. B. Molinoff, R. W. Rudden, and A. G. Gilman, Eds.), 9th ed., pp. 1009-1026. McGraw-Hill, New York.
26. Walker, J., Crowley, P., Moreman, A. D., and Barrett, J. 1993. Biochemical properties of cloned glutathione S-transferase from Schistosoma mansoni and Schistosoma japonicum. Mol. Biochem. Parasitol. 61, 255-264.
27. Zussman, R. A., Bauman, P. M., and Petruska, J. C. 1970. The role of ingested hemoglobin in the nutrition of Schistosoma mansoni. J. Parasitol. 56, 75-79.