Evaluation of the hepatic iron index as a diagnostic criterion for genetic hemochromatosis

Journal of Laboratory and Clinical Medicine

Volumn 130, Issue 5, 1997, Pages 509-514

  Adams, Paul C ^a,b   Bradley, Colin ^a   Ralph Henderson, A ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b LONDON HEALTH SCIENCES CENTRE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0031281776     PISSN: 00222143     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-2143(97)90127-X     Document Type: Article

References (29)

1. Adams PC, Valberg LS. Evolving expression of hereditary hemochromatosis. Semin Liver Dis 1996;16:47-54.
2. Niederau C, Fischer R, Purschel A, Stremmel W, Haussinger D, Strohmeyer G. Long-term survival in patients with hereditary hemochromatosis. Gastroenterology 1996;110:1107-19.
3. Bassett ML, Halliday JW, Powell LW. Value of hepatic iron measurements in early hemochromatosis and determination of the critical iron level associated with fibrosis. Hepatology 1986;6:24-9.
4. Summers KM, Halliday JW, Powell LW. Identification of homozygous hemochromatosis subjects by measurement of hepatic iron index. Hepatology 1990;12:20-5.
5. Adams PC. Hepatic iron in hemochromatosis. Dig Dis Sci 1990;35:690-2.
6. Feder JN, Gnirke A, Thomas W, Tsuchihashi Z, Ruddy DA, Basava A, et al. A novel MHC class I-like gene is mutated in patients with hereditary hemochromatosis. Nat Genet 1996;13:399-408.
7. Jazwinska EC, Cullen LM, Busfield F, Pyper WR, Webb SI, Powell LW, et al. Haemochromatosis and HLA-H. Nat Genet 1996;14:249-51.
8. Jouanolle A-M, Gandon G, Jezequel P, Blayau M, Campion ML, Mosser J, et al. Haemochromatosis and HLA-H. Nat Genet 1996;14:251-2.
9. Adams PC. HLA identical siblings without phenotypic expression of genetic hemochromatosis: evidence against genetic recombination [abstract]. Can J Gastroenterol 1996;10:23A.
10. Adams PC, Bradley C, Frei JV. Hepatic zinc in hemochromatosis. Clin Invest Med 1991;14:16-20.
11. Olynyk JK, O'Neill R, Britton RS, Bacon BR. Determination of hepatic iron concentration in fresh and paraffin-embedded tissue: diagnostic implications. Gastroenterology 1994;106:674-7.
12. Jaeschke R, Guyatt G, Sackett DL. User's guide to the medical literature. III. How to use an article about a diagnostic test. B. What are the results and will they help me in caring for my patients? JAMA 1994;271:703-7.
13. Pellar TG, Galbraith L, Leung F, Henderson AR. A computer program to determine diagnostic decision thresholds and likelihood ratios illustrated with aspartate aminotransferase activities after a myocardial infarction. Ann Clin Biochem 1989;26:533-7.
14. Henderson AR. Assessing test accuracy and its clinical consequences: a primer for receiver operating characteristic curve analysis. Ann Clin Biochem 1993;30:521-39.
15. Pellar TG, Leung FY, Henderson AR. A computer program for rapid generation of receiver operating characteristic curves and likelihood ratios in the evaluation of diagnostic tests. Ann Clin Biochem 1988;25:411-6.
16. Adams PC, Deugnier Y, Moirand R, Brissot P. The relationship between iron overload, clinical symptoms and age in 410 patients with genetic hemochromatosis. Hepatology 1997;25:162-6.
17. Adams PC, Campion ML, Gandon G, LeGall JY, David V, Jouanolle AM. Clinical and family studies in genetic hemochromatosis: microsatellite and HLA-H studies in five atypical families. Hepatology (in press).
18. Edwards CQ, Griffen LM, Goldgar D, Drummond C, Skolnick MH, Kushner JP. Prevalence of hemochromatosis among 11,065 presumably healthy blood donors. N Engl J Med 1988;318:1355-62.
19. Adams PC. Prevalence of abnormal iron studies in heterozygotes for hereditary hemochromatosis: an analysis of 255 heterozygotes. Am J Hematol 1994;45:146-9.
20. Vandeursen CT, Fickers MMF, Brombach PJ. Does the hepatic iron index differentiate hereditary hemochromatosis from secondary hemochromatosis? Hepatology 1990;12:180.
21. Oliver M, Scully L, Guiraudon C, Adams PC. Non-HLA linked hemochromatosis in a Chinese woman. Dig Dis Sci 1995;40:1589-91.
22. Villeneuve JP, Bilodeau M, Lepage R, Cote J, Lefebvre M. Variability in hepatic iron concentration measurement from needle-biopsy specimens. J Hepatology 1996;25:172-7.
23. Olynyk JK, Reddy KR, Di Bisceglie AM, Jeffers LJ, Parker TI, Radick JL, et al. Hepatic iron concentration as a predictor of response to interferon alfa therapy in chronic hepatitis C. Gastroenterology 1995;108:1104-9.
24. Eason RJ, Adams PC, Aston CE, Searle J. Familial iron overload with possible autosomal dominant inheritance. Aust NZ J Med 1990;20:226-30.
25. Cohen C, Berson SD, Shulman G, Budgeon LR. Liver iron stores and hepatitis B antigen status. Cancer 1985;56:2202-4.
26. Gandon Y, Guyader D, Heautot JF, Reda MI, Yaouanq J, Buhe T, et al. Hemochromatosis: diagnosis and quantification of liver iron with gradient-echo MR imaging. Radiology 1994;193:533-8.
27. Clayton C, Hall P, Mackinnon M. Family screening for genetic haemochromatosis. What is the most effective method of contact? Med J Aust 1993;159:614-5.
28. Adams PC, Kertesz AE. Human leukocyte antigen typing of siblings in hereditary hemochromatosis: a cost approach. Hepatology 1992;15:263-8.
29. Carella M, D'Ambrosio L, Totaro A, Grifa A, Valentino M, Piperno A, et al. Mutation analysis of the HLA-H gene in Italian hemochromatosis patients. Am J Hum Genet 1997;60:828-32.