Cushing's Syndrome due to Bilateral Adrenocortical Adenomas with Different Pathological Features

Internal Medicine

Volumn 36, Issue 11, 1997, Pages 804-809

  Tamura, Hideki ^a   Sugihara, Hitoshi ^a   Minami, Shiro ^a   Emoto, Naoya ^a   Shibasaki, Tamotsu ^a   Shuto, Yujin ^a   Shimizu, Kazuo ^a   Gomi, Yukari ^b   Sasano, Hironobu ^c   Wakabayashi, Ichiji ^a  

^a NIPPON MEDICAL SCHOOL   (Japan)

^b Itoh Hospital   (Japan)

^c TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

G protein gene mutation; Immunohistochemistry

Indexed keywords

CORTICOTROPIN; CYTOCHROME P450; DEXAMETHASONE; GLUCOCORTICOID; GUANINE NUCLEOTIDE BINDING PROTEIN; METYRAPONE;

ADRENAL CORTEX ADENOMA; ADRENAL CORTEX TUMOR; ADRENALECTOMY; ARTICLE; BLOOD; CASE REPORT; CODON; CUSHING SYNDROME; ENZYMOLOGY; FEMALE; GENETICS; HUMAN; IMMUNOHISTOCHEMISTRY; METABOLISM; MIDDLE AGED; MUTATION; PATHOLOGY;

ADRENAL CORTEX NEOPLASMS; ADRENALECTOMY; ADRENOCORTICAL ADENOMA; ADRENOCORTICOTROPIC HORMONE; CODON; CUSHING SYNDROME; CYTOCHROME P-450 ENZYME SYSTEM; DEXAMETHASONE; FEMALE; GLUCOCORTICOIDS; GTP-BINDING PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; METYRAPONE; MIDDLE AGED; MUTATION;

EID: 0031279113     PISSN: 09182918     EISSN: None     Source Type: Journal    
DOI: 10.2169/internalmedicine.36.804     Document Type: Article

References (20)

1. Sasano H, Miyazaki S, Sawai T, et al. Primary pigmented nodular adrenocortical disease (PPNAD): immunohistochemical and in situ hybridization analysis of steroidogenic enzymes in eight cases. Mod Pathol 5: 23, 1992.
2. Sasano H, Suzuki T, Nagura H. ACTH-independent macronodular adrenocortical hyperplasia: immunohistochemical and in situ hybridization studies of steroidogenic enzymes. Mod Pathol 7: 215, 1994.
3. Aiba M, Hirayama A, Iri H, et al. Adrenocorticotropic hormone-independent bilateral adrenocortical macronodular hyperplasia as a distinct subtype of Cushing's syndrome. Enzyme histochemical and ultrastructural study of four cases with a review of the literature. Am J Clin Pathol 96: 334, 1991.
4. Aiba M, Hirayama A, Iri H, et al. Primary adrenocortical micronodular dysplasia: enzyme histochemical and ultrastructural studies of two cases with a review of the literature. Hum Pathol 21: 503, 1990.
5. Young WF Jr, Carney JA, Musa BU, Wulffraat NM, Lens JW, Drexhage HA. Familial Cushing's syndrome due to primary pigmented nodular adrenocortical disease: reinvestigation 50 years later. N Engl J Med 321: 1659, 1989.
6. Kirschner MA, Powell RD, Lipsett MB. Cushing's syndrome: nodular cortical hyperplasia of adrenal glands with clinical and pathological features suggesting adrenocortical tumor. J Clin Endocr 24: 947, 1964.
7. Kato K, Horio S, Nonoyama M, et al. A case of Cushing's syndrome due to bilateral multiple adrenocortical adenomas. Horumon Rinsho 24: 145, 1976 (in Japanese).
8. Mimou N, Sakato S, Nakabayashi H, Saito Z, Takeda R, Matsubara F. Cushing's syndrome associated with bilateral adrenal adenomas. Acta Endocrinol (Copenh) 108: 245, 1985.
9. Okamoto S, Oosumi T, Fujimoto M, et al. Cushing's syndrome due to bilateral adrenal adenoma. Horumon Rinsho 33: 691, 1985 (in Japanese).
10. Nakata K, Hayakawa M, Yokono K, et al. A case of Cushing's syndrome due to bilateral adrenocortical adenomas. Jpn J Int Med 75: 528, 1986.
11. Satoh K, Miyagata S, Harata T, Nishizawa O, Tsutida S. A case report of Cushing's syndrome due to bilateral adrenal adenomas. Nippon Hinyokika Gakkai Zasshi 79: 1463, 1988.
12. Kato S, Masunaga R, Kawabe T, et al. Cushing's syndrome induced by hypersecretion of cortisol from only one of bilateral adrenocortical tumors. Metabolism 41: 260, 1992.
13. Aiba M, Kawakami M, Ito Y, Fujimoto Y, Suda T, Demura H. Bilateral adrenocortical adenomas causing Cushing's syndrome: report of two cases with enzyme histochemical and ultrastructural studies and a review of the literature. Arch Pathol Lab Med 116: 146, 1992.
14. Williamson EA, Johnson SJ, Foster S, Kendall-Taylor P, Harris PE. G protein gene mutations in patients with multiple endocrinopathies. J Clin Endocrinol Metab 80: 1702, 1995.
15. Koizumi S, Beniko M, Ikota A, et al. Adrenocorticotropic hormone-independent bilateral adrenocortical macronodular hyperplasia: a case report and immunohistochemical studies. Endocr J 41: 429, 1994.
16. Smals AGH, Pieters GF, Van Haelst UJ, Kloppenborg PW. Macronodular adrenocortical hyperplasia in long-standing Cushing's disease. J Clin Endocrinol Metab 58: 25, 1984.
17. Schteingart DE, Tsao MS. Coexistence of pituitary adrenocorticotropin-dependent Cushing's syndrome with a solitary adrenal adenoma. J Clin Endocrinol Metab 50: 961, 1980.
18. Lacroix A, Bolté E, Tremblay J, et al. Gastric inhibitory polypeptide-dependent cortisol hypersecretion: a new cause of Cushing's syndrome. N Engl J Med 327: 974, 1992.
19. Reznik Y, Allali-Zerah V, Chayvialle JA, et al. Food-dependent Cushing's syndrome mediated by aberrant adrenal sensitivity to gastric inhibitory polypeptide. N Engl J Med 327: 981, 1992.
20. Weinstein LS, Shenker A, Gejman PV, Merino MJ, Friedman E. Spiegel AM. Activating mutations of the stimulalory G protein in the McCune-Albright syndrome. N Engl J Med 325: 1688, 1991.