Involvement of fibrinogen in protamine-induced pulmonary hypertension

Journal of Surgical Research

Volumn 73, Issue 1, 1997, Pages 80-84

  Sogawa, Masakazu ^a,b   Mohammad, Syed F ^a  

^a UNIVERSITY OF UTAH   (United States)

^b NIIGATA UNIVERSITY   (Japan)

Author keywords

Fibrinogen; Heparin; Isolated rat lung model; Protamine; Pulmonary hypertension

Indexed keywords

FIBRINOGEN; HEPARIN; IODINE 125; PROTAMINE;

ANIMAL TISSUE; ARTICLE; FIBRINOGEN SYNTHESIS; LUNG PERFUSION; MEDIATOR RELEASE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PULMONARY HYPERTENSION; RAT; THROMBOCYTE AGGREGATION; THROMBOGENESIS; VASOCONSTRICTION;

EID: 0031278058     PISSN: 00224804     EISSN: None     Source Type: Journal    
DOI: 10.1006/jsre.1997.5208     Document Type: Article

References (26)

1. 1. Lowenstein, E., Johnston, W. E., Lappas, D. G., D'Ambra, M. N., Schneider, R. C., Daggett, W. M., Akins, C. W., and Philbin, D. M. Catastrophic pulmonary vasoconstriction associated with protamine reversal of heparin. Anesthesiology 59: 470, 1983.
2. 2. Just-Viera, J. O., Fischer, C. R., Gago, O., and Morris, J. D. Acute reaction to protamine: Its importance to surgeons. Am. Surg. 50: 52, 1984.
3. 3. Morel, D. R., Zapol, W. M., Thomas, S. J., Kitain, E. M., Robinson, D. R., Moss, J., Chenoweth, D. E., and Lowenstein, E. C5a and thromboxane generation associated with pulmonary vaso-and broncho-constriction during protamine reversal of heparin. Anesthesiology 66: 597, 1987.
4. 4. Holland, C. L., Singh, A. K., McMaster, P. R. B., and Fang, W. Adverse reactions to protamine sulfate following cardiac surgery. Clin. Cardiol. 7: 157, 1984.
5. 5. Weiss, M. E., Nyhan, D., Peng, Z. K., Horrow, J. C., Lowenstein, E., Hirshman, C., and Adkinson, N. F., Jr. Association of protamine IgE and IgG antibodies with life threatening reactions to intravenous protamine. N. Engl. J. Med. 320: 886, 1989.
6. 6. Sharath, M. D., Metzger, W. J., Richerson, H. B., Scupham, R. K., Meng, R. L., Ginsberg, B. H., and Weiler, J. M. Protamine-induced fatal anaphylaxis: Prevalence of antiprotamine immunoglobulin E antibody. J. Thorac. Cardiovasc. Surg. 90: 86, 1985.
7. 7. Katz, N. M., Kim, Y. D., Siegelman, R., Ved, S.A., Ahmed, S. W., and Wallance, R. B. Hemodynamics of protamine administration: Comparison of right atrial, left atrial, and aortic injections. J. Thorac. Cardiovasc. Surg. 94: 881, 1987.
8. 8. Wakefield, T. W., Bouffard, J. A., Spaulding, S. A., Petry, N. A., Gross, M. D., Lindblad, B., and Stanley, J. C. Sequestration of platelets in the pulmonary circulation as a consequence of protamine reversal of the anticoagulant effects of heparin. J. Vasc. Surg. 5: 187, 1987.
9. 9. Wakefield, T. W., Whitehouse, W. M., and Stanley, J. C. Depressed cardiovascular function and altered platelet kinetics following protamine sulfate reversal of heparin activity. J. Vasc. Surg. 1: 346, 1984.
10. 10. Montalescot, G., Kreil, E., Lynch, K., Greene, E. M., Torres, A., Carvalho, A., Fitzgibbon, C., Robinson, D. R., Lowenstein, E., and Zapol, W. M. Effect of platelet depletion on lung vasoconstriction in heparin-protamine reactions. J. Appl. Physiol. 66: 2344, 1989.
11. 11. McDonald, J. W. D., Ali, M., Morgan, E., Townsend, E. R., and Cooper, J. D. Thromboxane synthesis by sources other than platelets in association with complement-induced pulmonary leukostasis and pulmonary hypertension in sheep. Circ. Res. 52: 1, 1983.
12. 12. Hobbhahn, J., Conzen, P. F., Habazettl, H., Gutamann, R., Kellermann, W., and Peter, K. Heparin reversal by protamine in humans: Complement, prostaglandins, blood cells, and hemodynamics. J. Appl. Physiol. 71: 1415, 1991.
13. 13. Morel, D. R., Lowenstein, E., Nguyenduy, T., Robinson, D. R., Repine, J. E., Chenoweth, D. E., and Zapol, W. M. Acute pulmonary vasoconstriction and thromboxane release during protamine reversal of heparin anticoagulation in awake sheep: Evidence for the role of reactive oxygen metabolites following non-immunological complement activation. Circ. Res. 62: 905, 1988.
14. 14. Hakim, T. S., Picone, A., Oleary, C. E., and Camporesi, E. M. Protamine-induced pulmonary venoconstriction in heparinized pigs. Anesth. Analg. 81: 38, 1995.
15. 15. Mohammad, S. F., Chuang, H. Y. K., Crowther, P. E., and Mason, R. G. Interactions of poly(L-lysine) with human platelets: Correlation of binding with induction of platelet aggregation. Thromb. Res. 15: 781, 1979.
16. 16. Feingold, H. M., Pivacek, L. E., Melaragno, A. J., and Valeri, C. R. Coagulation assays and platelet aggregation patterns in human, baboon, and canine blood. Am. J. Vet. Res. 47: 2197, 1986.
17. 17. Shanberg, J. N., Murato, M., Quattrociocchi-Longe, T., and van Neste, L. Heparin-protamine complexes in the production of heparin rebound and other complications of extracorporeal bypass procedures. Am. J. Clin. Pathol. 87: 210, 1987.
18. 18. Demple, C. E., and Heene, D. L. Purification of human plasma fibrinogen by chromatography on protamine-agarose. Thromb. Res. 46: 19, 1987.
19. 19. Chenoweth, D. E., Cooper, S. W., Hugh, T. E., Stewart, R. W., Blackstone, E. H., and Kirklin, J. W. Complement activation during cardiopulmonary bypass: Evidence for generation of C3a and C5a anaphylatoxins. N. Engl. J. Med. 304: 497, 1981.
20. 20. Kirklin, J. K., Westaby, S., Blackstone, E. H., Kirklin, J. W., Chenoweth, D. E., and Pacifico, A. D. Complement and the damaging effects of cardiopulmonary bypass. J. Thorac. Cardiovasc. Surg. 86: 845, 1983.
21. 21. Rent, R., Ertel, N., Eisenstein, R., and Gewurz, H. Complement activation by interaction of polyanions and polycations. I. Heparin-protamine induced consumption of complement. J. Immunol. 114: 120, 1975.
22. 22. Hobbahn, J., Conzen, P. E., Zenker, B., Goetz, A. E., Peter, K., and Brendel, W. Beneficial effect of cyclooxygenase inhibition on adverse hemodynamic responses after protamine. Anesth. Analg. 67: 253, 1988.
23. 23. Garcia-Szabo, R. R., Peterson, M. B., Watkins, W. D., Bizios, R., Kong, D. L., and Malik, A. B. Thromboxane generation after thrombin: Protective effect of thromboxane synthetase inhibition on lung fluid balance. Circ. Res. 53: 214, 1983.
24. 24. Montalescot, G., Lowenstein, E., Ogletree, M. L., Greene, E. M., Robinson, D. R., Hartl, K., and Zapol, W. M. Thromboxane receptor blockade prevents pulmonary hypertension induced by heparin-protamine reactions in awake sheep. Circulation 82: 1765, 1990.
25. 111In-protamine. J. Appl. Physiol. 75: 963, 1993.
26. 26. De Paulis, R., Mohammad, S. F., Chiariello, L., Morea, M., and Olsen, D. B. The role of plasma proteins in formation of obstructive protamine complexes. J. Cardiothorac. Vasc. Anesth. 5:227, 1991.