CD44 isoform expression in periodontal tissues: Cell-type specific regulation of alternative splicing

Journal of Periodontal Research

Volumn 32, Issue 8, 1997, Pages 634-645

  Hirano, F ^a   Hirano, H ^a   Hino, E ^a   Takayama, S ^a   Saito, K ^a   Kusumoto, Y ^a   Shimabukuro, Y ^a   Murakami, S ^a   Okada, H ^a  

^a OSAKA UNIVERSITY   (Japan)

Author keywords

Alternative splicing; CD44; Isoform expression; Periodontium

Indexed keywords

HERMES ANTIGEN; INTERLEUKIN 1; MESSENGER RNA; PHORBOL 13 ACETATE 12 MYRISTATE; PRIMER DNA; TUMOR NECROSIS FACTOR ALPHA;

ALTERNATIVE RNA SPLICING; ARTICLE; CELL COMMUNICATION; CELL COUNT; CELL CULTURE; CELL CYCLE; CLASSIFICATION; CYTOLOGY; EPITHELIUM CELL; EXON; EXTRACELLULAR MATRIX; FIBROBLAST; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; GINGIVA; HUMAN; IMMUNOLOGY; NORTHERN BLOTTING; PERIODONTAL LIGAMENT; POLYMERASE CHAIN REACTION; SERODIAGNOSIS;

ALTERNATIVE SPLICING; ANTIGENS, CD44; BLOTTING, NORTHERN; CELL COMMUNICATION; CELL COUNT; CELL CYCLE; CELLS, CULTURED; DNA PRIMERS; EPITHELIAL CELLS; EXONS; EXTRACELLULAR MATRIX; FIBROBLASTS; GENE EXPRESSION REGULATION; GINGIVA; HUMANS; INTERLEUKIN-1; PERIODONTAL LIGAMENT; POLYMERASE CHAIN REACTION; PRECIPITIN TESTS; RNA, MESSENGER; TETRADECANOYLPHORBOL ACETATE; TRANSCRIPTION, GENETIC; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0031266380     PISSN: 00223484     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0765.1997.tb00573.x     Document Type: Article

References (55)

1. Haynes BF, Telen MJ, Hale LP, Denning SM. CD44-a molecule involved in leukocyte adherence and T-cell activation, Immunol Today 1989; 10: 423-428.
2. Webb DS, Shimizu Y, Van Seventer GA, Shaw S, Gerrard TL. LFA-3, CD44, and CD45: physiologic triggers of human monocyte TNF and IL-1 release. Science 1990; 249: 1295-1297.
3. Galandrini R, Galluzzo E, Albi N, Grossi CE, Velardi A. Hyaluronate is costimulatory for human T cell effector functions and binds to CD44 on activated T cells. J Immunol 1994; 153: 21-31.
4. Miyake K, Underhill CB, Lesley J, Kincade PW. Hyaluronate can function as a cell adhesion molecule and CD44 participates in hyaluronate recognition. J Exp Med 1990; 172: 69-75.
5. Lesley J, Hyman R, Kincade PW. CD44 and its interaction with extracellular matrix. Adv Immunol 1993; 54: 271-335.
6. Aruffo A, Stamenkovic I, Melnick M, Underhill CB, Seed B. CD44 is the principal cell surface receptor for hyaluronate. Cell 1990; 61: 1303-1313.
7. Carter WG, Wayner EA. Characterization of the class III collagen receptor, a phosphorylated, transmembrane glycoprotein expressed in nucleated human cells. J Biol Chem 1988; 263: 4193-4201.
8. Jalkanen S, Jalkanen M. Lymphocyte CD44 binds the COOH-terminal heparin-binding domain of fibronectin. J Cell Biol 1992; 116: 817-825.
9. Toyama Sorimachi N, Miyasaka M. A novel ligand for CD44 is sulfated proteoglycan. Int Immunol 1994; 6: 655-660.
10. Tölg C, Hofmann M, Herrlich P, Ponta H. Splicing choice from ten variant exons establishes CD44 variability. Nucleic Acids Res 1993; 21: 1225-1229.
11. Screaton GR, Bell MV, Jackson DG, Cornelis FB, Gerth U, Bell JI. Genomic structure of DNA encoding the lymphocyte homing receptor CD44 reveals at least 12 alternatively spliced exons. Proc Natl Acad Sci U S A 1992; 89: 12160-12164.
12. Stamenkovic I, Aruffo A, Amiot M, Seed B. The hematopoietic and epithelial forms of CD44 are distinct polypeptides with different adhesion potentials for hyaluronate-bearing cells, Embo J 1991; 10: 343-348.
13. Brown TA, Bouchard T, St. John T, Wayner E, Carter WG. Human keratinocytes express a new CD44 core protein (CD44E) as a heparan-sulfate intrinsic membrane proteoglycan with additional exons. J Cell Biol 1991; 113: 207-221.
14. Arch R, Wirth K, Hofmann M, et al. Participation in normal immune responses of a metastasis-inducing splice variant of CD44. Science 1992; 257: 682-685.
15. Hofmann M, Rudy W, Zöller M, et al. CD44 splice variants confer metastatic behavior in rats: homologous sequences are expressed in human tumor cell lines. Cancer Res 1991; 51: 5292-5297.
16. Günthert U, Hofmann M, Rudy W, et al. A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells. Cell 1991; 65: 13-24.
17. He Q, Lesley J, Hyman R, Ishihara K, Kincade PW. Molecular isoforms of murine CD44 and evidence that the membrane proximal domain is not critical for hyaluronate recognition. J Cell Biol 1992; 119: 1711-1719.
18. Sy MS, Guo YJ, Stamenkovic I. Distinct effects of two CD44 isoforms on tumor growth in vivo. J Exp Med 1991; 174: 859-866.
19. Bennett KL, Jackson DG, Simon JC, et al. CD44 isoforms containing exon V3 are responsible for the presentation of heparin-binding growth factor. J Cell Biol 1995; 128: 687-698.
20. Tanaka Y, Adams DH, Hubscher S, Hirano H, Siebenlist U, Shaw S. T-cell adhesion induced by proteoglycan-immobilized cytokine MIP-1 beta. Nature 1993; 361: 79-82.
21. Okada H, Kida T, Yamagami H. Identification and distribution of immunocompetent cells in inflamed gingiva of human chronic periodontitis. Infect Immun 1983; 41: 365-374.
22. Hamada S, Takada H, Ogawa T, Fujiwara T, Mihara J. Lipopolysaccharides of oral anaerobes associated with chronic inflammation: chemical and immunomodulating properties. Int Rev Immunol 1990; 6: 247-261.
23. Murakami S, Saho T, Shimabukuro Y, Isoda R, Miki Y, Okada H. Very late antigen integrins are involved in the adhesive interaction of lymphoid cells to human gingival flbroblasts. Immunology 1993; 79: 425-433.
24. Murakami S, Shimabukuro Y, Saho T, et al. Immunoregulatory roles of adhesive interactions between lymphocytes and gingival fibrobiasts. J Periodont Res 1997; 32: 110-114.
25. Murakami S, Saho T, Asari A, et al. CD44-hyaluronate interaction participates in the adherence of T-lymphocytes to gingival fibroblasts. J Dent Res 1996; 75: 1545-1552.
26. Somerman MJ, Foster RA, Imm GM, Sauk JJ, Archer SY. Periodontal ligament cells and gingival fibroblasts respond differently to attachment factors in vitro. J Periodontol 1989; 60: 73-77.
27. Oda D, Watson E. Human oral epithelial cell culture I. Improved conditions for reproducible culture in serum-free medium. In Vitro Cell Der Biol 1990; 26: 589-595.
28. Murakami S, Shimabukuro Y, Miki Y, et al. Inducible binding of human lymphocytes to hyaluronate via CD44 does not require cytoskeleton association but does require new protein synthesis. J Immunol 1994; 152: 467-477.
29. Rosenberg WM, Prince C, Kaklamanis L, et al. Increased expression of CD44v6 and CD44v3 in ulcerative colitis but not colonic Crohn's disease. Lancet 1995; 345: 1205-1209.
30. Hirano H, Screaton GR, Bell MV, Jackson DG, Bell JI, Hodes RJ. CD44 isoform expression mediated by alternative splicing: tissue-specific regulation in mice. Int Immunol 1994; 6: 49-59.
31. Belitsos PC, Hildreth JE, August JT. Homotypic cell aggregation induced by anti-CD44(Pgp-1) monoclonal antibodies and related to CD44(Pgp-1) expression. J Immunol 1990; 144: 1661-1670.
32. Auersperg N, Kruk PA, MacLaren IA, Watt FM, Mydral SE. Heterogeneous expression of keratin, involucrin, and extracellular matrix among subpopulations of a poorly differentiated human cervical carcinoma: possible relationships to patterns of invasion. Cancer Res 1989; 49: 3007-3014.
33. Ke Y, Gerwin BI, Ruskie SE, Pfeifer AM, Harris CC, Lechner JF. Cell density governs the ability of human bronchial epithelial cells to recognize serum and transforming growth factor beta-1 as squamous differentiation-inducing agents. Am J Pathol 1990; 137: 833-843.
34. Oda D, Dale BA, Bourekis G. Human oral epithelial cell culture. II. Keratin expression in fetal and adult gingival cells. In Vitro Cell Dev Biol 1990; 26: 596-603.
35. Collin C, Ouhayoun JP, Grund C, Franke WW. Suprabasal marker proteins distinguishing keratinizing squamous epithelia: cytokeratin 2 polypeptides of oral masticatory epithelium and epidermis are different. Differentiation 1992; 51: 137-148.
36. Yong K, Khwaja A. Leucocyte cellular adhesion molecules. Blood Rev 1990; 4: 211-225.
37. Shimizu Y, van Seventer GA, Horgan KJ, Shaw S. Roles of adhesion molecules in T-cell recognition: fundamental similarities between four integrins on resting human T cells (LFA-1, VLA-4, VLA-5, VLA-6) in expression, binding, and costimulation. Immunol Rev 1990; 114: 109-143.
38. Herman IM. Molecular mechanisms regulating the vascular endothelial cell motile response to injury. J Cardiovasc Pharmacol 1993; 22(suppl 4): S25-36.
39. Damsky C, Sutherland A, Fisher S. Extracellular matrix 5: adhesive interactions in early mammalian embryogenesis, implantation, and placentation. FASEB J 1993; 7: 1320-1329.
40. Takahashi K, Takigawa M, Takashiba S, et al. Role of cytokine in the induction of adhesion molecules on cultured human gingival fibroblasts. J Periodontol 1994; 65: 230-235.
41. Hormia M, Virtanen I, Quaranta V. Immunolocalization of integrin alpha 6 beta 4 in mouse junctional epithelium suggests an anchoring function to both the internal and the external basal lamina. J Dent Res 1992: 71: 1503-1508.
42. Tonetti MS, Gerber L, Lang NP. Vascular adhesion molecules and initial development of inflammation in clinically healthy human keratinized mucosa around teeth and ossco-integrated implants. J Periodont Res 1994; 29: 386-392.
43. Droll A, Dougherty ST, Chiu RK, et al. Adhesive interactions between alternatively spliced CD44 isoforms. J Biol Chem 1995; 270: 11567-11573.
44. Dougherty GJ, Landorp PM, Cooper DL, Humphries RK. Molecular cloning of CD44R1 and CD44R2, two novel isoforms of the human CD44 lymphocyte "homing" receptor expressed by hemopoietic cells. J Exp Med 1991; 174: 1-5.
45. Salmi M, Gron Virta K, Sointu P, Grenman R, Kalimo H, Jalkanen S. Regulated expression of exon v6 containing isoforms of CD44 in man: downregulation during malignant transformation of tumors of squamocellular origin. J Cell Biol 1993; 122: 431-442.
46. Matsuki Y, Yamamoto T, Hara K. Localization of interleukin-1 (IL-1) mRNA-expressing macrophages in human inflamed gingiva and IL-1 activity in gingival crevicular fluid. J Periodont Res 1993; 28: 35-42.
47. Takada H, Mihara J, Morisaki I, Hamada S. Induction of interleukin-1 and -6 in human gingival flbroblast cultures stimulated with Bacteroides lipopolysaccharides. Infect Immun 1991; 59: 295-301.
48. Geivelis M, Turner DW, Pederson ED, Lamberts BL. Measurements of interleukin-6 in gingival crevicular fluid from adults with destructive periodontal disease. J Periodontol 1993; 64: 980-983.
49. Reinhardt RA, Masada MP, Kaldahl WB, et al. Gingival fluid IL-1 and IL-6 levels in refractory periodontitis. J Clin Periodontol 1993; 20: 225-231.
50. Mackay CR, Terpe HJ, Stauder R, Marston WL, Stark H, Günthert U. Expression and modulation of CD44 variant isoforms in humans. J Cell Biol 1994; 124: 71-82.
51. Koopman G, Griffioen AW, Ponta H, et al. CD44 splice variants; expression on lymphocytes and in neoplasia. Res Immunol 1993; 144: 750-754.
52. Yamashita Y, Hirano H, Hodes RJ. Tissue-specific and growth-regulated expression of CD44 variable exon determinants in the mouse: analysis of protein expression using monoclonal antibodies. Cell Immunol 1997; 176: 22-33.
53. Jackson DG, Bell JI, Dickinson R, Timans J, Shields J, Whittle N. Proteoglycan forms of the lymphocyte homing receptor CD44 are alternatively spliced variants containing the v3 exon. J Cell Biol 1995; 128: 673-685.
54. Balzac F, Retta SF, Albini A, et al. Expression of beta 1B integrin isoform in CHO cells results in a dominant negative effect on cell adhesion and motility. J Cell Biol 1994; 127: 557-565.
55. Cai X, Foster CS, Liu JJ, et al. Alternatively spliced fibronectin molecules in the wounded cornea: analysis by PCR. Invest Ophthalmol Vis Sci 1993; 34: 3585-3592.