Design of stapled DNA-minor-groove-binding molecules with a mutable atom simulated annealing method

Journal of Computer-Aided Molecular Design

Volumn 11, Issue 6, 1997, Pages 539-546

  Walker, Wynn L ^a   Kopka, Mary L ^a   Dickerson, Richard E ^a   Goodsell, David S ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

DNA minor groove binding molecules; Rational drug design

Indexed keywords

ATOMS; HYDROGEN BONDS; SIMULATED ANNEALING; SYNTHESIS (CHEMICAL);

BINDING MOLECULES; DISTAMYCIN; DNA-MINOR-GROOVE-BINDING MOLECULE; FREE ATOMS; GROOVE-BINDING; MINOR GROOVES; NETROPSIN; RATIONAL DRUG DESIGNS; SIDE BY SIDES; SIMULATED ANNEALING METHOD;

DNA;

CONGOCIDINE; DISTAMYCIN A; DNA; DRUG DERIVATIVE; HYDROXIDE; LEXITROPSIN;

ARTICLE; BINDING SITE; CHEMISTRY; ENTROPY; HYDROGEN BOND; NUCLEOTIDE SEQUENCE; STRUCTURE ACTIVITY RELATION; ULTRASTRUCTURE;

BASE SEQUENCE; BINDING SITES; DISTAMYCINS; DNA; ENTROPY; HYDROGEN BONDING; HYDROXIDES; NETROPSIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0031262126     PISSN: 0920654X     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1007985019866     Document Type: Article

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