Crystal and molecular structure of the antimalarial agent α-(dibutylaminomethyl)-2, 7-dichloro-9-(p-chlorobenzylidene)-4-fluorenemethanol(benflumetol)

Yaoxue Xuebao

Volumn 32, Issue 11, 1997, Pages 824-829

  Zhong, J X ^a   Deng, R X ^a   Wang, J ^a   Zheng, Q T ^b   Jiao, K F ^a  

^a BEIJING INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY   (China)

^b INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Antimalarial; Benflumetol; Cinchona alkaloids; X ray

Indexed keywords

ANTIMALARIAL AGENT; BENFLUMETOL; ETHANOLAMINE DERIVATIVE; FLUORENE DERIVATIVE; QUININE;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; CRYSTALLIZATION; X RAY CRYSTALLOGRAPHY;

ANTIMALARIALS; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; ETHANOLAMINES; FLUORENES; MOLECULAR STRUCTURE; QUININE;

EID: 0031261051     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Ginsbury H, Gearg TG. Current concepts and new ideas on the mechanism of action of quinoline-containing antimalarials. Biochem Pharmacol, 1987,36:1567
2. Howells RE. The antimalarial action of chloroquine and mechanims of resistance. Ann Trop Med Parasitol, 1987,81:629
3. Schlesinger PH, Krogstad DJ, Herwaldt BL. Antimalarial agents: mechanisms of action. Antimicrob Agents Chemother, 1988,32:793
4. Sweeney TR, Strube RE. Burher' s Medicinal Chemistry. 4th. New York: John Wiley and Sons, Inc, 1979:333-413
5. Phillips RE, Warrell DA, White NJ, et al. Intravenous quinidine for the treatment of severe falciparum malaria. N Eng I J Med, 1985,312:1273
6. White NJ, Looareesuwan S, Warrell DA, et al. Quinidine in falciparam malarial. Lancet, 1981,ii:1069
7. Oleksyn BJ. Molecular Structure and Biological Activity. Elsevier: Science Publishing Co, 1982:181-190
8. Saxena AK, Saxena M. Progress in Drug Research. Vol 30. Stuttgart: Birkhanser, 1986:222-230
9. 2O: implications for structure analysis. Proc Natl Acad Sci USA, 1981, 78:5938
10. 2. Acta Crystallogr Sect C, 1983,39:310
11. Oleskyn BJ, Lebioda L, Sliwinski J. Proceedings of the IIIrd Symposium on Organic Crystal Chemistry. Poznan: UAM, 1980:200-204
12. Oleksyn B, Stadnicka KM, Hodorowicz SA. The crystal structure and absolute configuration of cinchoninium tetrachlorocadmate(II) dihydrate. Acta Crystallogr Sect B Crystallogr Cryst Chem, 1978,34:811
13. 3, a new derivative of quinine. Acta Crystallogr Sect C, 1985,41:977
14. Cheklov AN, Kaluski Z, Struchkov YT, et al. Crystal structure and absolute configuation of ( + )-10-bromo-10, 11-dihydroepiquinidine. J Struct Chem (USSR), 1974,15:780
15. Karle JM, Karle IL. Crystal and molecular structrue of the antimalarial agent 4-(tert-butyl )-2-(-tert-butylaminomethyl )-6-(4-chlorophenyl) phenol dihydrogen phosphate (WR194, 695 phosphate). Antimicrob Agents Chemother, 1988,32:540