The role of androgens in female vertebrates

General and Comparative Endocrinology

Volumn 108, Issue 1, 1997, Pages 1-24

  Staub, Nancy L ^a   De Beer, Madeleine ^a  

^a GONZAGA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN;

ADIPOSE TISSUE; AGGRESSION; ANDROGEN METABOLISM; ANIMAL BEHAVIOR; BLOOD; CELL SURVIVAL; CENTRAL NERVOUS SYSTEM; COGNITION; EPIDERMIS; EVOLUTION; FEMALE; ION TRANSPORT; MUSCLE REGENERATION; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; REVIEW; SATELLITE CELL; SEXUAL BEHAVIOR; SOMATOSTATIN RELEASE;

EID: 0031260439     PISSN: 00166480     EISSN: 10956840     Source Type: Journal    
DOI: 10.1006/gcen.1997.6962     Document Type: Review

References (248)

1. Adkins-Regan E. Hormones and sexual differentiation. Hormones and Reproduction in Fishes, Amphibians, and Reptiles. 1987;Plenum, New York. p. 1-29.
2. Albert C., Callard I. P. Sex hormone binding globulin levels and free progesterone, testosterone and estradiol-17β during the annual cycle of the female turtle,Chrysemys picta. Steroids. 42:1988;355-356.
3. Albert D. J., Jonik R. H., Walsh M. L. Hormone-dependent aggression in male and female rats: Experimental, hormonal, and neural foundations. Neurosci. Biobehav. Rev. 16:1992a;177-192.
4. Albert D. J., Jonik R. H., Walsh M. L. Interaction of estradiol, testosterone, and progesterone in the modulation of hormone-dependent aggression in the female rat. Physiol. Behav. 52:1992b;773-779.
5. Albert D. J., Jonik R. H., Walsh M. L., Petrovic D. M. Testosterone supports hormone-dependent aggression in female rats. Physiol. Behav. 46:1989;185-189.
6. Alexander G. M., Sherwin B. B. Sex steroids, sexual behavior, and selection attention for erotic stimuli in women using oral contraceptives. Psychoneuroendocrinology. 18:1993;91-102.
7. Al-Shamma H. A., Arnold A. P. Importance of target innervation in recovery from axotomy-induced loss of androgen receptor in rat perineal motoneurons. J. Neurobiol. 28:1995;341-353.
8. Argente J., Chowen-Breed J. A., Steiner R. A., Clifton D. K. Somatostatin messenger RNA in hypothalamic neurons is increased by testosterone through activation of androgen receptors and not by aromatization to estradiol. Neuroendocrinology. 52:1990;342-349.
9. Attardi B., Geller L. N., Ohno S. Androgen and estrogen receptors in brain cytosol from male, female, and testicular feminized mice. Endocrinology. 98:1976;864-874.
10. Balthazart J. Aromatization of testosterone in the preoptic area and control of male sexual behavior in the Japanese quail. Wada M., Ishii S., Scanes C. G. Endocrinology of Birds: Molecular to Behavioral. 1990;297-311 Japan Sci. Soc. Press, Springer-Verlag, Tokyo, Berlin.
11. Bancroft J., Sherwin B. B., Alexander G. M., Davidson D. W., Walker A. Oral contraceptives, androgens, and the sexuality of young women. II. The role of androgens. Arch. Sex. Behav. 20:1991;121-135.
12. Bardin C. W., Catterall J. F. Testosterone: A major determinant of extragenital sexual dimorphism. Science. 211:1981;1285-1293.
13. Bass A. H., Hopkins C. D. Hormonal control of sexual differentiation: Changes in electric organ discharge waveform. Science. 220:1983;971-974.
14. Bass A. H., Hopkins C. D. Hormonal control of sex differences in the electric organ discharge (EOD) of mormyrid fishes. J. Comp. Physiol. A. 156:1985;587-604.
15. Bass A. H., Segil N., Kelley D. B. Androgen binding in the brain and electric organ of a mormyrid fish. J. Comp. Physiol. A. 159:1986;535-544.
16. Bass A. H., Volman S. F. From behavior to membranes: Testosterone-induced changes in action potential duration in electric organs. Proc. Natl. Acad. Sci. USA. 84:1987;9295-9298.
17. Bass A. H., Baker R. Sexual dimorphisms in the vocal control system of a teleost fish: Morphology of physiologically identified neurons. J. Neurobiol. 21:1990;1155-1168.
18. Beers W. H., Strickland S., Reich E. Ovarian plasminogen activator: Relationship to ovulation and hormonal regulation. Cell. 6:1975;387-394.
19. Bentvelsen F. M., McPhaul M. J., Wilson J. D., George F. W. The androgen receptor of the urogenital tract of the fetal rat is regulated by androgen. Mol. Cell. Endocrinol. 105:1994;21-26.
20. Beyer C., Green S. J., Hutchison J. B. Androgens influence sexual differentiation of embryonic mouse hypothalamic aromatase neuronsin vitro. Endocrinology. 135:1994;1220-1226.
21. 21. J. Steroid Biochem. Mol. Biol. 43:1992;721-724.
22. Binkley S. A. Endocrinology. 1995;Harper Collins, New York.
23. Bluthé R. M., Dantzer R. Social recognition does not involve vasopressinergic neurotransmission in female rats. Brain Res. 535:1990;301-304.
24. Bluthé R. M., Gheusi G., Dantzer R. Gonadal steroids influence the involvement of arginine vasopressin in social recognition in mice. Psychoneuroendocrinology. 18:1993;323-335.
25. Brantley R. K., Bass A. H. Secondary sex characters in a vocalizing fish: Intra- and intersexual dimorphism and role of androgens. Scott A. P., Sumpter J. P., Kime D. E., Rolfe M. S. Proceedings of the Fourth International Symposium on the Reproductive Physiology of Fish. 1991;197-199 FishSymp 91, Sheffield.
26. Brantley R. K., Marchaterre M. A., Bass A. H. Androgen effects on vocal muscle structure in a teleost fish with inter- and intra-sexual dimorphism. J. Morphol. 216:1993a;305-318.
27. Brantley R. K., Tseng J., Bass A. H. The ontogeny of inter- and intrasexual vocal muscle dimorphisms in a sound-producing fish. Brain Behav. Evol. 42:1993b;336-349.
28. Brantley R. K., Wingfield J. C., Bass A. H. Sex steroid levels inPorichthys notatus, Horm. Behav. 27:1993c;332-347.
29. Breedlove S. M. Sexual dimorphism in the vertebrate nervous system. J. Neurosci. 12:1992;4133-4142.
30. Breedlove S. M., Arnold A. P. Hormone accumulation in a sexually dimorphic motor nucleus of the rat spinal cord. Science. 210:1980;564-566.
31. Breedlove S. M., Arnold A. P. Hormonal control of a developing neuromuscular system. I. Complete demasculinization of the male rat spinal nucleus of the bulbocavernosus using the anti-androgen Flutamide. J. Neurosci. 3:1983a;417-423.
32. Breedlove S. M., Arnold A. P. Hormonal control of a developing neuromuscular system. II. Sensitive periods for the androgen-induced masculinization of the rat spinal nucleus of the bulbocavernosus. J. Neurosci. 3:1983b;424-432.
33. Burke M. G., Leatherland J. F., Sumpter J. P. Seasonal changes in serum testosterone, 11-ketotestosterone, and 17β-estradiol levels in the brown bullhead,Ictalurus nebulosus. Can. J. Zool. 62:1984;1195-1199.
34. Cabeza M., de Leon L. D. Evaluation of levonorgestrel action on the flank organ and the sebaceous gland lipogenesis of female hamsters. Bol. Estud. Med. Biol. Mex. 41:1993;20-27.
35. Callard G. V. Autocrine and paracrine role of steroids during spermatogenesis: Studies inSqualus acanthiasNecturus maculosus. J. Exp. Zool. 261:1992;132-142.
36. Callard I. P., Lance V., Salhanick A. R., Barad D. The annual ovarian cycle ofChrysemys picta: Gen. Comp. Endocrinol. 35:1978;245-257.
37. Campbell C. M., Fostier A., Jalabert B., Truscott B. Identification and quantification of steroids in the serum of rainbow trout during spermiation and oocyte maturation. J. Endocrinol. 85:1980;371-378.
38. Cardwell J. R., Liley N. R. Hormonal control of sex and color change in the stoplight parrotfish,Sparisoma viridae. Gen. Comp. Endocrinol. 81:1991;7-20.
39. Clergue M., Moatti J. P., Milhet P. Androgènes et 17β-estradiol plasmatiques de l'Urodèle pyréEuproctus asper. Gen. Comp. Endocrinol. 58:1985;337-341.
40. Cochran R. C., Grier H. J. Regulation of sexual succession in the protogynous black sea bass,Centropristis striatus. Gen. Comp. Endocrinol. 82:1991;69-77.
41. Collado P., Valencia A., Del Abril A., Rodríguez-Zafra M., Pérez-Laso C., Segovia S., Guillamon A. Effects of estradiol on the development of sexual dimorphism in the bed nucleus of the accessory olfactory tract in the rat. Dev. Brain Res. 75:1993;285-287.
42. Connaughton M. A., Taylor M. H. Effects of exogenous testosterone on sonic muscle mass in the weakfish,Cynoscion regalis. Gen. Comp. Endocrinol. 100:1995;238-245.
43. Connolly P. B., Choate J. V. A., Resko J. A. Effects of exogenous androgen on brain androgen receptors of the fetal rhesus monkey. Neuroendocrinology. 59:1994;271-276.
44. Corvol M., Blanchard O., Tsagris L. Bone and cartilage responsiveness to sex steroid hormones. J. Steroid Biochem. Mol. Biol. 43:1992;415-418.
45. Croze F., Etches R. J. The physiological significance of androgen-induced ovulation in the hen. J. Endocrinol. 84:1980;163-171.
46. Dantzer R., Bluthé R. M., Koob G. F., Le Moal M. Modulation of social memory in male rats by neurohypophyseal peptides. Psychopharmacology. 91:1987;363-368.
47. Darwin C. The Descent of Man and Selection in Relation to Sex. 1871;The Modern Library: Random House, New York.
48. Davidson J. M., Camargo C. A., Smith E. R. Effects of androgen on sexual behavior in hypogonadal men. Endocrinology. 48:1979;955-958.
49. Delrio G., d'Istria M., Iela L., Chieffi G. The possible significance of testosterone in the female green frogRana esculenta. Boll. Zool. 46:1979;1-9.
50. Deslypere J. P., Verdonck L., Vermeulen A. Fat tissue: A steroid reservoir and site of steroid metabolism. J. Clin. Endocrinol. Metab. 61:1985;564-570.
51. DeVries G. J., Buijs R. M., Van Leeuwen F. W., Caffé A. R., Swaab D. F. The vasopressinergic innervation of the brain in normal and castrated rats. J. Comp. Neurol. 233:1985;236-254.
52. DeVries G. J., Duetz W., Buijs R. M., Van Heerikhuize J., Vreeburg J. T. M. Effects of androgens and estrogens on the vasopressin and oxytocin innervation of the adult rat brain. Brain Res. 399:1986;296-302.
53. d'Istria M., Chieffi-Baccari G., Di Matteo L., Minucci S., Varriale B., Chieffi G. Androgen receptor in the Harderian gland ofRana esculenta. J. Endocrinol. 129:1991;227-232.
54. d'Istria M., Delrio G., Botte V., Chieffi G. Radioimmunoassay of testosterone, 17β-oestradiol and oestrone in the male and female plasma ofRana esculenta. Steroids Lipids Res. 5:1974;42-48.
55. d'Istria M., Picilli A., Basile C., Delrio G., Chieffi G. Morphological and biochemical variations in the skin ofRana esculenta. Gen. Comp. Endocrinol. 48:1982;20-24.
56. Domínguez P., Antolín I., Boga J. A., Uría H., Menéndez-Peláez A. Androgen regulation of gene expression in the Syrian hamster Harderian gland. Mol. Cell. Endocrinol. 106:1994;81-89.
57. Dorlöchter M., Astrow S. H., Herrera A. A. Effects of testosterone on a sexually dimorphic frog muscle: Repeatedin vivo. J. Neurobiol. 25:1994;897-916.
58. Dubé J. Y., Lesage R., Tremblay R. R. Androgen and estrogen binding in rat skeletal and perineal muscle. Can. J. Biochem. 45:1976;50-55.
59. Dubowsky S., Smalley K. N. Testosterone induced growth of the oviduct in the frog,Rana pipiens: Gen. Comp. Endocrinol. 89:1993;276-282.
60. Eckstein B., Ravid R. On the mechanism of the onset of puberty: Identification and pattern of 5α-androstane-3β-diol and its 3α epimer in peripheral blood of immature female rats. Endocrinology. 94:1974;224-229.
61. Eicheler W., Tuohimaa P., Vilja P., Adermann K., Forssmann W., Aumüller G. Immunocytochemical localization of human 5α-reductase 2 with polyclonal antibodies in androgen target and non-target human tissues. J. Histochem. Cytochem. 42:1994;667-675.
62. Erskine M. S. Serum 5α-androstane-3α,17β-diol increases in response to paced coital stimulation in cycling female rats. Biol. Reprod. 37:1987;1139-1148.
63. Erskine M. S., Hippensteil M., Kornberg E. Metabolism of dihydrotestosterone to 3α-androstanediol in brain and plasma: Effect on behavioural activity in female rats. J. Endocrinol. 134:1992;183-195.
64. Everitt B. J., Herbert J. The effects of dexamethasone and androgens on sexual receptivity of female rhesus monkeys. J. Endocrinol. 51:1971;575-588.
65. Ferrari M. B., McAnelly M. L., Zakon H. H. Individual variation in and androgen-modulation of the sodium current in electric organ. J. Neurosci. 15:1995;4023-4032.
66. Fischer L., Catz D., Kelley D. An androgen receptor mRNA isoform associated with hormone-induced cell proliferation. Proc. Natl. Acad. Sci. USA. 90:1993;8254-8258.
67. Fischer L. M., Catz D., Kelley D. B. Androgen-directed development of theXenopus laevis. Dev. Biol. 170:1995;115-126.
68. Fischer L. M., Kelley D. B. Androgen receptor expression and sexual differentiation of effectors for courtship song inXenopus laevis. Semin. Neurosci. 3:1991;469-480.
69. Fitzpatrick M. S., Gale W. L., Schreck C. B. Binding characteristics of an androgen receptor in the ovaries of coho salmon,Oncorhynchus kisutch. Gen. Comp. Endocrinol. 95:1994;399-408.
70. Fivizzani A. J., Oring L. W. Plasma steroid hormones in relation to behavioral sex role reversal in the spotted sandpiper,Actitis macularia. Biol. Reprod. 35:1986;1195-1201.
71. Fivizzani A. J., Oring L. W., El Halawani M. E., Schlinger B. A. Hormonal basis of male parental care and female intersexual competition in sex-role reversed birds. Wada M., Ishii S., Scanes C. G. Endocrinology of Birds: Molecular to Behavioral. 1990;273-286 Japan Sci. Soc. Press, Springer-Verlag, Tokyo, Berlin.
72. Forger N. G., Fishman R. B., Breedlove S. M. Differential effects of testosterone metabolites upon the size of sexually dimorphic motoneurons in adulthood. Horm. Behav. 26:1992;204-213.
73. Fortune J. E. Steroid production byXenopus. Dev. Biol. 99:1983;502-509.
74. Frank L. G. Social organization of the spotted hyaenaCrocuta crocuta. Anim. Behav. 34:1986;1510-1527.
75. Frank L. G., Glickman S. E., Licht P. Fatal sibling aggression, precocial development, and androgens in neonatal spotted hyenas. Science. 252:1991;702-704.
76. Fujimoto J., Nishigaki M., Hori M., Ichigo S., Itoh T., Tamaya T. The effect of estrogen and androgen on androgen receptors and mRNA levels in uterine leiomyoma, myometrium and endometrium of human subjects. J. Steroid Biochem. Mol. Biol. 50:1994;137-143.
77. Gao X., Phillips P., Oldfield B., Trinder D., Risvanis J., Stephenson J., Jonston C. Androgen manipulation and vasopressin binding in the rat brain and peripheral organs. Eur. J. Endocrinol. 130:1994;291-296.
78. Garnier D. H. Androgen and estrogen levels in the plasma ofPleurodeles waltl, Gen. Comp. Endocrinol. 63:1985;381-392.
79. Gay V. L., Tomacari R. L. Follicle-stimulating hormone secretion in the female rat: Cyclic release is dependent on circulating androgen. Science. 184:1974;75-77.
80. Gelinas D., Callard G. V. Immunolocalization of aromatase- and androgen receptor-positive neurons in the goldfish brain. Gen. Comp. Endocrinol. 106:1997;155-168.
81. Gerdes M. J., Dang T. D., Lu B., Larsen M., McBride L., Rowley D. R. Androgen-regulated proliferation and gene transcription in a prostate smooth muscle cell line (PS-1). Endocrinology. 137:1996;864-872.
82. Glickman S. E., Frank L. G., Davidson J. M., Smith E. R., Siiteri P. K. Androstenedione may organize or activate sex-reversed traits in female spotted hyenas. Proc. Natl. Acad. Sci. USA. 84:1987;3444-3447.
83. Godwin J. R., Thomas P. Sex change and steroid profiles in the protandrous anemonefishAmphiprion melanopus. Gen. Comp. Endocrinol. 91:1993;144-157.
84. Goldstein L. A., Senglaub D. R. Hormonal control of neuron number in sexually dimorphic spinal nuclei of the rat. IV. Masculinization of the spinal nucleus of the bulbocavernosus with testosterone metabolites. J. Neurobiol. 21:1990;719-730.
85. Gonzalez-Diddi M., Komisaruk B., Beyer C. Differential effects of testosterone and dihydrotestosterone on the diverse uterine tissues of the ovariectomized rat. Endocrinology. 91:1972;1129-1132.
86. Gore-Langton R. E., Armstrong D. T. Follicular steroidogenesis and its control. Knobil E., Neill J. The Physiology of Reproduction. 1988;331-383 Raven Press, New York.
87. Gorski R. A., Gordon J. H., Shryne J. E., Southam A. M. Evidence for a morphological sex difference within the medial preoptic area of the rat brain. Brain Res. 148:1978;333-346.
88. Gratto-Trevor C. L., Fivizzani A. J., Oring L. W., Cooke F. Seasonal changes in gonadal steroids of a monogamous versus a polyandrous shorebird. Gen. Comp. Endocrinol. 80:1990;407-418.
89. Greenberg B. Some effects of testosterone on the sexual pigmentation and other sex characters of the cricket frog (Acris gryllus. J. Exp. Zool. 91:1942;435-440.
90. Greenblatt R. B., Oettinger M., Bohler C. S.-S. Estrogen-androgen levels in aging men and women: Therapeutic considerations. J. Am. Geriatr. Soc. 24:1976;173-178.
91. Grisham W., Arnold A. P. A direct comparison of the masculinizing effects of testosterone, androstenedione, estrogen, and progesterone on the development of the zebra finch song system. J. Neurobiol. 26:1995;163-170.
92. Grober M. S., Jackson I. M. D., Bass A. H. Gonadal steroids affect LHRH preoptic cell number in a sex/role changing fish. J. Neurobiol. 22:1991;734-741.
93. Gurney M. E., Konishi M. Hormone-induced sexual differentiation of brain and behavior in zebra finches. Science. 208:1980;1380-1383.
94. Handa R. J., Connolly P. B., Resko J. A. Ontogeny of cytosolic androgen receptors in the brain of the fetal rhesus monkey. Endocrinology. 122:1988;1890-1986.
95. Hanken J., Jennings D. H., Olsson L. Mechanistic basis of life-history evolution in anuran amphibians: Direct development. Am. Zool. 37:1997;160-171.
96. Hannigan P., Kelley D. B. Androgen-induced alterations in vocalizations of femaleXenopus laevis: J. Comp. Physiol. A. 158:1986;517-527.
97. Harvey L. A., Propper C. R., Woodley S. K., Moore M. C. Reproductive endocrinology of the explosively breeding desert spadefoot toad,Scaphiopus couchii. Gen. Comp. Endocrinol. 105:1997;102-113.
98. Hausberger M., Henry L., Richard M. A. Testosterone-induced singing in female European starlings (Sturnus vulgaris. Ethology. 99:1995;193-208.
99. Hauser K. F., Toran-Allerand C. D. Androgen increases the number of cells in fetal mouse spinal cord cultures: Implications for motoneuron survival. Brain Res. 485:1989;157-164.
100. Herbert J. Hormones and reproductive behaviour in rhesus and talapoin monkeys. J. Reprod. Fertil. Suppl. 11:1970;119-140.
101. Herbert J., Trimble M. R. Effect of oestradiol and testosterone on the sexual receptivity and attractiveness of the female rhesus monkey. Nature. 216:1967;165-166.
102. Herbst A. L., Mishell D. R. Jr., Stenchever M. A., Droegemueller W. Comprehensive Gynecology. 1992;Mosby, St. Louis.
103. Hermkes A., Probst B. Neural androgen receptors and scent marking of male gerbils: Modulation by females. Physiol. Behav. 51:1992;1179-1182.
104. Hews D. K., Moore M. C. Influence of androgens on differentiation of secondary sex characters in tree lizards,Urosaurus ornatus. Gen. Comp. Endocrinol. 97:1995;86-102.
105. Hild-Petito S., West N. B., Brenner R. M., Stouffer R. L. Localization of androgen receptor in the follicle and corpus luteum of the primate ovary during the menstrual cycle. Biol. Reprod. 44:1991;561-568.
106. Hillier S. G., Ross G. T. Effects of exogenous testosterone on ovarian weight, follicular morphology and intraovarian progesterone concentration in estrogen-primed hypophysectimized immature female rats. Biol. Reprod. 20:1979;261-268.
107. Höhn E. O., Cheng S. C. Gonadal hormones in Wilson's phalarope (Steganopus tricolor. Gen. Comp. Endocrinol. 8:1967;1-11.
108. Huang X., Harlan R. E. Androgen receptor immunoreactivity in somatostatin neurons of the periventricular nucleus but not in the bed nucleus of the stria terminalis in male rats. Brain Res. 652:1994;291-296.
109. Hutchison J. B., Beyer C., Hutchison R. E., Wozniak A. Sexual dimorphism in the developmental regulation of brain aromatase. J. Steroid Biochem. Mol. Biol. 53:1995;307-313.
110. Hutchison J. B., Wozniak A., Beyer C., Hutchison R. E. Regulation of sex-specific formation of oestrogen in brain development: Endogenous inhibitors of aromatase. J. Steroid Biochem. Mol. Biol. 56:1996;201-207.
111. Iela L., Rastogi R. K., Delrio G., Bagnara J. T. Reproduction in the Mexican leaf frog,Pachymedusa dacnicolor. Gen. Comp. Endocrinol. 63:1986;381-392.
112. Jacobs E. C., Grisham W., Arnold A. P. Lack of a synergistic effect between estradiol and dihydrotestosterone in the masculinization of the zebra finch song system. J. Neurobiol. 27:1995;513-519.
113. Jänne O., Bullock L. P., Bardin C. W., Jacob S. T. Early androgen action in kidney of normal and androgen-insensitive (tfm/y) mice: Changes in RNA polymerase and chromatin template activities. Biochim. Biophysic. Acta. 418:1976;330-343.
114. Jaubert A., Pecquery R., Dieudonne M., Giudicelli Y. Estrogen binding sites in hamster white adipose tissue: Sex- and site-related variations; modulation by testosterone. Gen. Comp. Endocrinol. 100:1995;179-187.
115. Johns J. Testosterone induced nuptial feathers in phalaropes. Condor. 66:1964;449-454.
116. Jones I. C., Bellamy D., Chan K. O., Follett B. K., Henderson I. W., Phillips J. G., Smart R. S. Biological actions of steroid hormones in nonmammalian vertebrates. Idler D. R. Steroids in Nonmammalian Vertebrates. 1972;414-480 Academic Press, New York.
117. Joubert Y., Tobin C., Lebart M. C. Testosterone-induced masculinization of the rat levator ani muscle during puberty. Dev. Biol. 162:1994;104-110.
118. Joubert Y., Tobin C. Testosterone treatment results in quiescent satellite cells being activated and recruited into cell cycle in rat levator ani muscle. Dev. Biol. 169:1995;286-294.
119. Kasperk C., Fitzsimmons R., Strong D., Mohan S., Jennings J., Wergedal J., Baylink D. Studies of the mechanism by which androgens enhance mitogenesis and differentiation in bone cells. J. Clin. Endocrinol. Metab. 71:1990;1322-1329.
120. Keller C. H., Zakon H. H., Sanchez D. Y. Evidence for a direct effect of androgens upon electroreceptor tuning. J. Comp. Physiol. A. 158:1986;301-310.
121. 3. J. Comp. Neurol. 199:1981;221-231.
122. Kelley D. B. Sexual differentiation inXenopus laevis. Tinsley R. C., Kobel H. R. The Biology ofXenopus. 1996;143-176 Clarendon, Oxford.
123. Kelley D. B., Dennison J. The vocal motor neurons ofXenopus laevis: J. Neurobiol. 21:1990;869-882.
124. Kelley D. B., Morrell J. I., Pfaff D. W. Autoradiographic localization of hormone-concentrating cells in the brain of an amphibian,Xenopus laevis. J. Comp. Neurol. 164:1975;47-62.
125. Kelley D. B., Sassoon D., Segil N., Scudder M. Development and hormone regulation of androgen receptor levels in the sexually dimorphic larynx ofXenopus laevis. Dev. Biol. 131:1989;111-118.
126. Konishi M., Akutagawa E. Neuronal growth, atrophy, and death in a sexually dimorphic song nucleus in zebra finches. Nature. 315:1985;145-147.
127. Kosut S. S., Wood R. I., Herbosa-Encarnación C., Foster D. L. Prenatal androgens time neuroendocrine puberty in the sheep: Effect of testosterone dose. Endocrinology. 138:1997;1072-1077.
128. Kraulis I., Naish S. J., Gravenor D., Ruf K. B. 5α-androstane-3α,17β-diol: Inhibitor of sexual maturation in the female rat. Biol. Reprod. 24:1981;445-453.
129. Krieg M. Characterization of the androgen receptor in the skeletal muscle of the rat. Steroids. 28:1976;261-274.
130. Kruuk H. The Spotted Hyena. 1972;Univ. of Chicago Press, Chicago.
131. Kurz E. M., Bowers C. A., Sengelaub D. R. Morphology of rat spinal motoneurons with normal and hormonally altered specificity. J. Comp. Neurol. 292:1990;638-650.
132. Kurz E. M., Sengelaub D. R., Arnold A. P. Androgens regulate the dendritic length of mammalian motoneurons in adulthood. Science. 232:1986;395-398.
133. Kwon H. B., Ahn R. S. Relative roles of theca and granulosa cells in ovarian follicular steroidogenesis in the amphibian,Rana nigromaculata. Gen. Comp. Endocrinol. 94:1994;207-214.
134. Kwon H. B., Ahn R. S., Lee W. K., Im W., Lee C. C., Kim K. Changes in the activities of steroidogenic enzymes during the development of ovarian follicles inRana nigromaculata. Gen. Comp. Endocrinol. 92:1993;225-232.
135. Landsman R. E., Harding C. F., Moller P., Thomas P. The effects of androgens and estrogens on the external morphology and electric organ discharge waveform ofGnathonemus petersii. Horm. Behav. 24:1990;532-553.
136. Lapcík O., Hampl R., Hill M., Stárka L. Plasma levels of epitestosterone from prepuberty to adult life. J. Steroid Biochem. Mol. Biol. 55:1995;405-408.
137. Licht P., Frank L. G., Pavgi S., Yalcinkaya T. M., Siiteri P. K., Glickman S. E. Hormonal correlates of 'masculinization' in female spotted hyaenas (Crocuta crocuta. J. Reprod. Fertil. 95:1992;463-474.
138. Licht P., McCreery B. R., Barnes R., Pang R. Seasonal and stress related changes in plasma gonadotropins, sex steroids, and corticosterone in the bullfrog,Rana catesbeiana. Gen. Comp. Endocrinol. 50:1983;124-145.
139. Lieberherr M., Grosse B. Androgens increase intracellular calcium concentration and inositol 1,4,5-trisphosphate and diacylglycerol formation via a pertussis toxin-sensitive G-protein. J. Biol. Chem. 269:1994;7217-7223.
140. Lindeque M., Skinner J. D., Millar R. P. Adrenal and gonadal contribution to circulating androgens in spotted hyaenas (Crocuta crocuta. J. Reprod. Fertil. 8:1986;211-217.
141. Lindeque M., Skinner J. D. Fetal androgens and sexual mimicry in spotted hyaenas (Crocuta crocuta. J. Reprod. Fertil. 65:1982;405-410.
142. Logan C. A., Wingfield J. C. Autumnal territorial aggression is independent of plasma testosterone in mockingbirds. Horm. Behav. 24:1990;568-581.
143. Longcope C. Adrenal and gonadal androgen secretion in normal females. Clin. Endocrinol. Metab. 15:1986;213-228.
144. Mak P., Callard I. P., Callard G. V. Characterization of an estrogen receptor in the testis of the urodele amphibianNecturus maculosus. Biol. Reprod. 28:1983;261-270.
145. Mani S. K., Allen J. M. C., Clark J. H., Blaustein J. D., O'Malley B. W. Convergent pathways for steroid hormone- and neurotransmitter-induced rat sexual behavior. Science. 265:1994;1246-1249.
146. Marin M. L., Tobias M. L., Kelley D. B. Hormone-sensitive stages in the sexual differentiation of laryngeal muscle fiber number inXenopus laevis. Development. 110:1990;703-712.
147. Marugo M., Torre G., Bernasconi D., Fazzuoli L., Cassulo S., Giordano G. Androgen receptors in normal and pathological thyroids. J. Endocrinol. Invest. 14:1991;31-35.
148. Manolagas S. C., Bellido T., Jilka R. L. Sex steroids, cytokines and the bone marrow: New concepts on the pathogenesis of osteoporosis. Non-Reproductive Actions of Sex Steroids. 1995;Wiley, New York.
149. Matsumoto A., Micevych P. E., Arnold A. P. Androgen regulates synaptic input to motoneurons of the adult rat spinal cord. J. Neurosci. 8:1988;4168-4176.
150. Matthews L. H. Reproduction in the spotted hyaena,Crocuta crocuta. Philos. Trans. R. Soc. London B. 230:1939;1-78.
151. Mayer I., Schmitz M., Borg B., Schulz R. Seasonal endocrine changes in male and female Arctic charr (Salvelinus alpinus. Can. J. Zool. 70:1992;37-42.
152. Meijs-Roelofs H. M. A., Kramer P., Gribling-Hegge L. Possible role of 5α-androstane-3α,17β-diol in the control of follicle-stimulating hormone secretion in the immature rat. J. Endocrinol. 92:1982;37-42.
153. Menendez-Pelaez A., Rodriguez C., Dominguez P. 5-Aminolevulinate synthase mRNA levels in the Harderian gland of Syrian hamsters: Correlation with porphyrin concentrations and regulation by androgens and melatonin. Mol. Cell. Endocrinol. 80:1991;177-182.
154. Meseguer A., Catterall J. F. Mouse kidney androgen-regulated protein messenger ribonucleic acid is expressed in the proximal convoluted tubules. Mol. Endocrinol. 1:1987;535-541.
155. Meyer J. H., Zakon H. H. Androgens alter the tuning of electroreceptors. Science. 217:1982;635-637.
156. Meyer J. J., Leong M., Keller C. H. Hormone-induced and ontogenetic changes in electric organ discharge and electroreceptor tuning in the weakly electric fish,Apteronotus. J. Comp. Physiol. A. 160:1987;385-394.
157. Miller M. A., Urban J. H., Dorsa D. M. Steroid dependency of vasopressin neurons in the bed nucleus of the stria terminalis byin situ. Endocrinology. 125:1989;2335-2340.
158. Mooradian A. D., Morley J. E., Korenman S. G. Biological actions of androgens. Endocr. Rev. 8:1987;1-28.
159. Moore F. L., Wood R. E., Boyd S. K. Sex steroids and vasotocin interact in a female amphibian (Taricha granulosa. Horm. Behav. 26:1992;156-166.
160. 333Anolis carolinensis: J. Comp. Neurol. 188:1979;201-224.
161. Mosconi G., Cei J. M., Ibañez N., Alvarez B. B., Carneval O., Battisti A., Polzonetti-Magni A. M. Changes in plasma sex steroids in females of two sympatricLeptodactylus. J. Herpetol. 30:1996;68-70.
162. Moutier R., Signore P., Nosten-Bertrand M. Mandible shape analysis in a testicular feminization (Tfm. J. Hered. 83:1992;235-237.
163. Naftolin F. Brain aromatization of androgens. J. Reprod. Med. 39:1994;257-261.
164. Nordeen E. J., Nordeen K. W., Sengelaub D. R., Arnold A. P. Androgens prevent normally occurring cell death in a sexually dimorphic spinal nucleus. Science. 229:1985;671-673.
165. Nottebohm F. Testosterone triggers growth of brain vocal control nuclei in adult female canaries. Brain Res. 189:1980;429-436.
166. Nottebohm F., Arnold A. P. Sexual dimorphism in vocal control areas of the songbird brain. Science. 194:1976;211-213.
167. Olcese J., Wesche A. The Harderian gland. Comp. Biochem. Physiol. 93A:1989;655-665.
168. Parker L. N. Adrenarche. Endocrinol. Metab. Clin. North. Am. 20:1991;71-83.
169. Patchev V. K., Hayashi S., Orikasa C., Almeida O. F. X. Implications of estrogen-dependent brain organization for gender differences in hypothalamo-pituitary-adrenal regulation. FASEB J. 9:1995;419-423.
170. Payne A. P., Swanson H. H. The effect of sex hormones on the aggressive behavior of the female golden hamster (Mesocricetus auratus. Anim. Behav. 20:1972;782-787.
171. Perel E., Danilescu D., Kindler S., Kharlip L., Killinger D. W. The formation of 5α-reduced androgens in stromal cells from human breast adipose tissue. J. Clin. Endocrinol. Metab. 62:1986;314-318.
172. Pérez J., Kelley D. B. Trophic effects of androgen: Receptor expression and the survival of laryngeal motor neurons after axotomy. J. Neurosci. 16:1996;6625-6633.
173. Pottinger T. G., Carrick T. R., Hughes S. E., Balm P. H. M. Testosterone, 11-ketotestosterone, and estradiol-17β modify baseline and stress-induced interrenal and corticotropic activity in trout. Gen. Comp. Endocrinol. 104:1996;284-295.
174. Prat F., Zanuy S., Carillo M., DeMones A., Foster A. Seasonal changes in plasma levels of gonadal steroids of sea bass,Dicentrarchus labrax. Gen. Comp. Endocrinol. 78:1990;361-373.
175. Prins G. S., Birch L. The developmental pattern of androgen receptor expression in rat prostate lobes is altered after neonatal exposure to estrogen. Endocrinology. 136:1995;1303-1314.
176. Rand M. S. Hormonal control of polymorphic and sexually dimorphic coloration in the lizardSceloporus undulatus erythrocheilus. Gen. Comp. Endocrinol. 88:1992;461-468.
177. Rissman E. F., Clendenon A. L., Krohmer R. W. Role of androgens in the regulation of sexual behavior in the female musk shrew. Neuroendocrinology. 51:1990;468-473.
178. Robins D. M., Samuelson L. C. Retrotransposons and the evolution of mammalian gene expression. Genetica. 86:1992;191-201.
179. Roselli C. E. Sex differences in androgen receptors and aromatase activity in microdissected regions of the rat brain. Endocrinology. 128:1991;1310-1316.
180. Rosenfield R. L., Lucky A. W. Acne, hirsutism, and alopecia in adolescent girls. Adolesc. Endocrinol. 22:1993;507-532.
181. Rosenkilde P., Ussing A. P. What mechanisms control neoteny and regulate induced metamorphosis in urodeles? Int. J. Dev. Biol. 40:1996;665-673.
182. Rossi R., Zatelli M. C., Franceschetti P., Maestri I., Magri E., Aguiari G., Cavazzini P., degli Uberti E. C., del Senno L. Inhibitory effect of dihydrotestosterone on human thyroid cell growth. J. Endocrinol. 151:1996;185-194.
183. Sakai T. The mammalian Harderian gland: Morphology, biochemistry, function, and phylogeny. Arch. Histol. Jpn. 44:1981;299-333.
184. Sands R., Studd J. Exogenous androgens in postmenopausal women. Am. J. Med. 98:1995;76-79.
185. Sar M., Lubahn D. B., French F. S., Wilson E. M. Immunohistochemical localization of the androgen receptor in rat and human tissues. Endocrinology. 127:1990;3180-3186.
186. Sassoon D. A., Gray G. E., Kelley D. B. Androgen regulation of muscle fiber type in the sexually dimorphic larynx ofXenopus laevis. J. Neurosci. 7:1987;3198-3206.
187. Sassoon D., Kelley D. B. The sexually dimorphic larynx ofXenopus laevis: Am. J. Anat. 177:1986;457-472.
188. Sassoon D., Segil N., Kelley D. Androgen-induced myogenesis and chondrogenesis in the larynx ofXenopus laevis. Dev. Biol. 113:1986;135-140.
189. Sauerwein H., Meyer H. H. D. Androgen and estrogen receptors in bovine skeletal muscle: Relation to steroid-induced allometric muscle growth. J. An. Sci. 67:1989;206-212.
190. Sawaya M. E. Biochemical mechanisms regulating hair growth. Skin Pharmacol. 7:1994;5-7.
191. Schlinger B. A., Amur-Umarjee S., Shen P., Campagnoni A. T., Arnold A. P. Neuronal and non-neuronal aromatase in primary cultures of developing zebra finch telencephalon. J. Neurosci. 14:1994;7541-7552.
192. Schlinger B. A., Arnold A. P. Brain is the major site of estrogen synthesis in a male songbird. Proc. Natl. Acad. Sci. USA. 88:1991a;4191-4194.
193. Schlinger B. A., Arnold A. P. Androgen effects on the development of the zebra finch song system. Brain Res. 561:1991b;99-105.
194. Schlinger B. A., Callard G. V. Aromatization mediates aggressive behavior in quail. Gen. Comp. Endocrinol. 79:1990;39-53.
195. Schlinger B. A., Fivizzani A. J., Callard G. V. Aromatase, 5α- and 5β-reductase in brain, pituitary and skin of the sex-role reversed Wilson's phalarope. J. Endocrinol. 122:1989;573-581.
196. Schwabl H. Yolk is a source of maternal testosterone for developing birds. Proc. Natl. Acad. Sci. USA. 90:1993;11446-11450.
197. Schwabl H. Maternal testosterone in the avian egg enhances postnatal growth. Comp. Biochem. Physiol. A Comp. Physiol. 114:1996;271-276.
198. Schwartz Z., Nasatzky E., Ornoy A., Brooks B. P., Soskolne W. A., Boyan B. D. Gender-specific, maturation-dependent effects of testosterone on chondrocytes in culture. Endocrinology. 94:1994;1344-1640.
199. Scott A. P., Sumpter J. P., Hardiman P. A. Hormone changes during ovulation in the rainbow trout (Salmo gairdneri. Gen. Comp. Endocrinol. 49:1983;128-134.
200. Segil N., Silverman L., Kelley D. B. Androgen-binding levels in a sexually dimorphic muscle ofXenopus laevis. Gen. Comp. Endocrinol. 66:1987;95-101.
201. Shen P., Campagnoni C. W., Kampf K., Schlinger B. A., Arnold A. P., Campagnoni A. T. Isolation and characterization of a zebra finch aromatase cDNA:In situ. Mol. Brain Res. 24:1994;227-237.
202. Sheridan P. J., Hagino N., Weaker F. J. Androgen-concentrating cells in the periventricular brain of the female rhesus monkey. J. Comp. Neurol. 207:1982;93-98.
203. Sheridan P. J., McGill Jr. H. C., Lissitzky J. C., Martin P. M. The primate thyroid gland contains receptors for androgens. Endocrinology. 115:1984;2154-2159.
204. Sherwin B. B. A comparative analysis of the role of androgen in human male and female sexual behavior: Behavioral specificity, critical thresholds, and sensitivity. Psychobiology. 16:1988a;416-425.
205. Sherwin B. B. Estrogen and/or androgen replacement therapy and cognitive functioning in surgically menopausal women. Psychoneuroendocrinology. 13:1988b;345-357.
206. Sherwin B. B. Sex hormones and psychological functioning in postmenopausal women. Exp. Gerontol. 29:1994;423-430.
207. Sherwin B. B., Gelfand M. M. Sex steroids and affect in the surgical menopause: A double-blind, cross-over study. Psychoneuroendocrinology. 10:1985;325-335.
208. Slater C. H., Fitzpatrick M. S., Schreck C. B. Characterization of an androgen receptor in salmonid lymphocytes: Possible link to androgen-induced immunosuppression. Gen. Comp. Endocrinol. 100:1995;218-225.
209. Slater C. H., Schreck C. B. Testosterone alters the immune response of chinook salmon (Oncorhynchus tshawytscha. Gen. Comp. Endocrinol. 89:1993;291-298.
210. Slater C. H., Schreck C. B. Physiological levels of testosterone kill salmonid leukocytesin vitro. Gen. Comp. Endocrinol. 106:1997;113-119.
211. Smith S. J., Palmer B. D., Selcer K. W. Androgen receptor and aromatase activity in the turtle oviduct. Am. Zool. 35:1995;6A.
212. Stárka L. Epitestosterone - A hormone or not. Endocr. Regul. 27:1993;43-48.
213. N. L. Staub, 1989, The evolution of sexual dimorphism in the salamander genusAneides, University of California, Berkeley.
214. Staub N. L. The effect of testosterone on females of the sexually dimorphic plethodontid salamanderAneides hardii. Am. Zool. 31:1991;7A.
215. Staub N. L. The presence of modified-granular glands in male and femaleAneides lugubris. Herpetologica. 53:1997;339-344.
216. Takahashi L. K., Lisk R. D. Organization and expression of agonistic and socio-sexual behavior in golden hamsters over the estrous cycle and after ovariectomy. Physiol. Behav. 31:1983;477-482.
217. Takayasu S., Adachi K. Thein vivoin vitro. Endocrinology. 90:1972;73-80.
218. Takeda H., Nakamoto T., Kokontis J., Chodak G. W., Chang C. Autoregulation of androgen receptor expression in rodent prostate: Immunohistochemical andin situ. Biochem. Biophys. Res. Commun. 177:1991;488-496.
219. Tamaya T., Misao R., Nakagawa M., Itoh T., Wada K., Fujimoto J., Imai A. Estrogen and androgen receptors in aorta of the rabbit and regulation by estrogen and androgen. Res. Commun. Chem. Pathol. Pharmacol. 82:1993a;3-11.
220. Tamaya T., Wada E., Nakagawa M., Misao R., Itoh T., Imai A., Mori H. Sexual dimorphism of binding sites of testosterone and dihydrotestosterone in rabbit model. Comp. Biochem. Physiol. 105A:1993b;745-749.
221. Tanaka K., Inoue T. Role of steroid hormones and catecholamines in the process of ovulation in the domestic fowl. Wada M., Ishii S., Scanes C. G. Endocrinology of Birds: Molecular to Behavioral. 1990;59-68 Japan Sci. Soc. Press, Springer-Verlag, Tokyo, Berlin.
222. Tilly J. L., Johnson A. L. Presence and hormonal control of plasminogen activator in granulosa cells of the domestic hen. Biol. Reprod. 37:1987;1156-1164.
223. Tobias M. L., Marin M. L., Kelley D. B. Temporal constraints on androgen directed laryngeal masculinization inXenopus laevis. Dev. Biol. 147:1991;260-270.
224. Tobias M. L., Marin M. L., Kelley D. B. The roles of sex, innervation, and androgen in laryngeal muscle ofXenopus laevis. J. Neurosci. 13:1993;324-333.
225. Townsend D. S., Moger W. H. Plasma androgen levels during male parental care in a tropical frog (Eleutherodactylus. Horm. Behav. 21:1987;93-99.
226. Trimble M. R., Herbert J. The effect of testosterone or oestradiol upon the sexual and associated behaviour of the adult female rhesus monkey. J. Endocrinol. 42:1968;171-185.
227. Vermeulen A. The hormonal activity of the postmenopausal ovary. J. Clin. Endocrinol. Metab. 42:1976;247-253.
228. Vermeulen A., Verdonck L. Plasma androgen levels during the menstrual cycle. Am. J. Obspet. Gynecol. 125:1976;491-494.
229. Vilchis F., Pérez-Palacios G. Steroid hormone receptors and the sexual phenotype of the Harderian gland in hamsters. J. Endocrinol. 121:1989;149-156.
230. Vornberger W., Prins G., Musto N. A., Suarez-Quian C. A. Androgen receptor distribution in rat testis: New implications for androgen regulation of spermatogenesis. Endocrinology. 134:1994;2307-1316.
231. Wada M., Wingfield J. C., Gorbman A. Correlation between blood level of androgens and sexual behavior in male leopard frogs,Rana pipiens. Gen. Comp. Endocrinol. 29:1976;72-77.
232. Wade J., Arnold A. Functional testicular tissue does not masculinize development of the zebra finch song system. Proc. Natl. Acad. Sci. USA. 93:1996;5264-5268.
233. Wade J., Schlinger B. A., Arnold A. Aromatase and 5β-reductase activity in cultures of developing zebra finch brain: An investigation of sex and regional differences. J. Neurobiol. 27:1995;240-251.
234. Wallen K., Goy R. W. Effects of estradiol benzoate, estrone, and propionates of testosterone or dihydrotestosterone on sexual and related behaviors of ovariectomized rhesus monkeys. Horm. Behav. 9:1977;228-248.
235. Waxenberg S. E., Drellich M. G., Sutherland A. M. The role of hormones in human behavior. I. Changes in female sexuality after adrenalectomy. J. Clin. Metab. 19:1959;193-202.
236. Weisman Y., Cassorla F., Malozowski S., Kreig R. J. Jr., Goldray D., Kaye A. M., Somjen D. Sex-specific response of bone cells to gonadal steroids: Modulation in perinatally androgenized females and in testicular feminized male rats. Steroids. 58:1993;126-133.
237. Whittier J. M., Mason R. T., Crews D. Plasma steroid hormone levels of female red-sided garter snakes,Thamnophis sirtalis parietalis: Gen. Comp. Endocrinol. 67:1987;33-43.
238. Wilson C. M., McPhaul M. J. A and B forms of the androgen receptor are present in human genital skin fibroblasts. Proc. Natl. Acad. Sci. USA. 91:1994;1234-1238.
239. Wilson J. D., George F. W., Griffin J. E. The hormonal control of sexual dimorphism. Science. 211:1981;1278-1284.
240. Wingfield J. C. Control of territorial aggression in a changing environment. Psychoneuroendocrinology. 19:1994a;709-721.
241. Wingfield J. C. Regulation of territorial behavior in the sedentary song sparrow,Melospiza melodia morphna. Horm. Behav. 28:1994b;1-15.
242. Wingfield J. C., Grimm A. S. Seasonal changes in plasma cortisol, testosterone and oestradiol-17β in the plaice,Pleuronectes platessa. Gen. Comp. Endocrinol. 31:1977;1-11.
243. Yalcinkaya T. M., Siiteri P. K., Vigne J., Licht P., Pavgi S., Frank L. G., Glickman S. E. A mechanism for virilization of female spotted hyenas in utero. Science. 206:1993;1929-1931.
244. Yang J., Long D. W., Bacon W. L. Changes in plasma concentrations of luteinizing hormone, progesterone, and testosterone in turkey hens during the ovulatory cycle. Gen. Comp. Endocrinol. 106:1997;281-292.
245. Yeung W. S. B., Chan S. T. H. The plasma sex steroid profiles in the freshwater, sex-reversing teleost fish,Monopterus albus. Gen. Comp. Endocrinol. 65:1987;233-242.
246. Yoshimura Y., Chang C., Okamoto T., Tamura T. Immunolocalization of androgen receptor in the small, preovulatory, and postovulatory follicles of laying hens. Gen. Comp. Endocrinol. 91:1993;81-89.
247. Zakon H. H. Weakly electric fish as model systems for studying long-term steroid action on neural circuits. Brain Behav. Evol. 42:1993;242-251.
248. Zerani M., Vellano C., Amabili F., Carnevali O., Andreoletti G. E., Polzonetti-Magni A. Sex steroid profile and plasma vitellogenin during the annual reproductive cycle of the crested newt (Triturus carnifex. Gen. Comp. Endocrinol. 82:1991;337-344.