Insulinotropic action of 1,2,3-tri(methylsuccinyl)glycerol ester

Biochemical and Molecular Medicine

Volumn 62, Issue 1, 1997, Pages 76-84

  Malaisse, Willy J ^a   Ladrière, Laurence ^b   Laghmich, Aouatif ^b   Louchami, Karim ^b   Jijakli, Hassan ^b   Viñambres, Concepción ^b   Villanueva Peñacarrillo, Maria L ^b   Valverde, Isabel ^b   Björkling, Fredrik ^b  

^a FREE UNIVERSITY OF BRUSSELS   (Belgium)

^b NONE

Author keywords

1,2,3 tri(methylsuccinyl)glycerol ester; Diabetes mellitus; Insulin release; Pancreatic islets

Indexed keywords

ACYLGLYCEROL LIPASE; SUCCINIC ACID;

ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; DIABETES MELLITUS; GLUCONEOGENESIS; HORMONE ACTION; INSULIN LIKE ACTIVITY; INSULIN RELEASE; INSULIN RESPONSE; NONHUMAN; PANCREAS ISLET; PEPTIDE SYNTHESIS; RAT;

ANIMALIA;

EID: 0031259577     PISSN: 10773150     EISSN: None     Source Type: Journal    
DOI: 10.1006/bmme.1997.2621     Document Type: Article

References (21)

1. 1. Malaisse WJ. The esters of carboxylic nutrients as insulinotropic tools in non-insulin-dependent diabetes mellitus. Gen Pharmacol 26:1133-1141, 1995.
2. 2. Bosco D, Meda P, Thorens B, Malaisse WJ. Heterogeneous secretion of individual B cells in response to D-glucose and nonglucidic nutrient secretagogues. Am J Physiol 268: C611-C618, 1995.
3. 3. Malaisse WJ, Rasschaert J, Villanueva-Peñacarrillo ML, Valverde I. Respiratory, ionic and functional effects of succinate esters in pancreatic islets. Am J Physiol 264:E428-E433, 1993.
4. 4. Malaisse WJ, Zhang T-M, Leclercq-Meyer V, Sener A, Björkling F. Insulinotropic action of the D-glucosyl and 3-O-methyl-D-glucosyl monomethyl esters of succinic acid. Diabetes Res 25:93-105, 1994.
5. 5. Sener A, Conget I, Rasschaert J, Leclercq-Meyer V, Villanueva-Peñacarrillo ML, Valverde I, Malaisse WJ. Insulinotropic action of glutamic acid dimethyl ester. Am J Physiol 267:E573-E584, 1994.
6. 6. Vicent D, Garcia-Martinez JA, Villanueva-Peñacarrillo ML, Valverde I, Malaisse WJ. Insulinotropic action of the dimethyl ester of glutamic acid in anaesthetised rats. Med Sci Res 22:299-300, 1994.
7. 7. Vicent D, Villanueva-Peñacarrillo ML, Malaisse-Lagae F, Leclercq-Meyer V, Valverde I, Malaisse WJ. In vivo stimulation of insulin release by succinic acid methyl esters. Arch Int Pharmacodyn 327:246-250, 1994.
8. 8. Zhang T-M, Björkling F, Malaisse WJ. In vivo stimulation of insulin secretion by novel esters of succinic acid. Horm Metab Res 27:251-252, 1995.
9. 9. Zhang T-M, Sener A, Malaisse WJ. Metabolic effects and fate of succinic acid methyl esters in rat hepatocytes. Arch Biochem Biophys 314:186-192, 1994.
10. 10. Malaisse-Lagae F, Malaisse WJ. Insulin release by pancreatic islets. In Methods in Diabetes Research (Lamer J, Pohl SL, Eds.), New York: Wiley, 1984, Vol 1, pp 147-152.
11. 11. Herchuelz A, Malaisse WJ. Regulation of calcium fluxes in pancreatic islets. Dissociation between calcium and insulin release. J Physiol (London) 283:409-424, 1978.
12. 12. Delgado E, Villanueva-Peñacarrillo ML, Valverde I, Malaisse WJ. Stimulation of protein biosynthesis in pancreatic islets by quinine. Med Sci Res 19:439-440, 1991.
13. 86Rb outflow from pancreatic islets. I. Reciprocal changes in the response to glucose, tetraethylammonium and quinine. Mol Cell Endocrinol 17:103-110, 1980.
14. 14. Herchuelz A, Sener A, Malaisse WJ. Regulation of calcium fluxes in rat pancreatic islets. Calcium extrusion by sodium-calcium countertransport. J Membrane Biol 57:1-12, 1980.
15. 15. Jijakli H, Ulusoy S, Malaisse WJ. Dissociation between the potency and reversibility of the insulinotropic action of two meglitinide analogues. Pharmacol Res 34:105-108, 1996.
16. 16. Garcia-Martinez JA, Villanueva-Peñacarrillo ML, Valverde I, Björkling F, Malaisse WJ. Stimulation of insulin release and potentiation of the insulinotropic action of antidiabetic agents by 1,2,3-tri(methylsuccinyl)glycerol ester in anaesthetized rats. Submitted for publication.
17. 17. Jijakli H, Bakkali Nadi A, Cook L, Best L, Sener A, Malaisse WJ. Insulinotropic action of methyl pyruvate: Enzymatic and metabolic aspects. Arch Biochem Biophys 335:245-257, 1986.
18. 18. Ladrière L, Laghmich A, Malaisse-Lagae F, Björkling F, Malaisse WJ. Comparison between the insulinotropic potential of ten new esters of succinic acid. Submitted for publication.
19. 19. Hutton JC, Sener A, Herchuelz A, Valverde I, Boschero AC, Malaisse WJ. The stimulus-secretion coupling of glucose-induced insulin release. XLII. Effects of extracellular pH on insulin release: Their dependency on nutrient concentration. Horm Metab Res 12:294-299, 1980.
20. 20. Malaisse WJ. The beta cell in non-insulin-dependent diabetes: Giving light to the blind. Diabetologia 37:S36-S42, 1994.
21. 21. Malaisse WJ. Alteration of pancreatic B-cell D-glucose metabolism in type 2 diabetes: The G quintet. Endocrinologia 40:309-313, 1993.