Transplantation of fetal neocortex ameliorates sensorimotor and locomotor deficits following neonatal ischemic-hypoxic brain injury in rats

Experimental Neurology

Volumn 147, Issue 2, 1997, Pages 487-497

  Jansen, Elizabeth M ^a   Solberg, Leah ^a   Underhill, Suzanne ^a   Wilson, Sarah ^a   Cozzari, Constantino ^b   Hartman, Boyd K ^a   Faris, Patricia L ^a   Low, Walter C ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b CNR   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN INJURY; BRAIN ISCHEMIA; CELL TRANSPLANTATION; CONTROLLED STUDY; LOCOMOTION; NEOCORTEX; NONHUMAN; PRIORITY JOURNAL; RAT; SENSORIMOTOR FUNCTION; TREATMENT OUTCOME;

EID: 0031258146     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.1997.6596     Document Type: Article

References (37)

1. Barth T. M., Jones T. A., Schallert T. Functional subdivisions of the rat somatic sensorimotor cortex. Behav. Brain Res. 39:1990;73-95.
2. Barth T. M., Stanfield B. B. Homotopic, but not heterotopic, fetal cortical transplants can result in functional sparing following neonatal damage to the frontal cortex in rats. Cerebral Cortex. 4:1994;271-278.
3. Castro A. J., Hogan T. P., Sorensen B. S., Klausen E. H., Danielsen E. H., Zimmer J., Neafsey E. J. Heterotopic neocortical transplants. An anatomical and electrophysiological analysis of host projections to occipital cortical grafts placed into sensorimotor cortical lesions made in newborn rats. Dev. Brain Res. 58:1991;231-236.
4. Chang F-L. F., Steedman J. G., Lund R. The lamination and connectivity of embryonic cerebral cortex transplanted into newborn rat cortex. J. Comp. Neurol. 244:1986;401-411.
5. Donatelle J. M. Growth of the corticospinal tract and the development of placing reactions in postnatal rats. J. Comp. Neurol. 175:1977;207-232.
6. Dunnett S. B. Is it possible to repair the damaged prefrontal cortex by neural tissue transplantation? Prog. Brain Res. 85:1990;285-297.
7. Elsayed M. H., Hogan T. P., Shaw P. L., Castro A. J. Use of fetal cortical grafts in hypoxic-ischemic brain injury in neonatal rats. Exp. Neurol. 137:1996;127-141.
8. Fricker R., Abrous D. N., Torres E. M., Svendsen C. N., Dunnett S. B. Developmental dependence of nigral dopaminergic neurons on their striatal targets: Loss following excitotoxic striatal lesions in neonatal rats. Soc. Neurosci. Abstr. 19:1993;669.
9. Gonzalez M. F., Sharp F. R. Fetal frontal cortex transplanted to injured motor/sensory cortex of adult rats. I. NADPH-diaphorase neurons. J. Neurosci. 7:1987;2991-3001.
10. Grabowski M., Brundin P., Johansson B. B. Fetal neocortical grafts implanted in adult hypertensive rats with cortical infarcts following a middle cerebral artery occlusion: Ingrowth of afferent fibers from the host brain. Exp. Neurol. 116:1992;105-121.
11. Grabowski M., Brundin P., Johansson B. B. Functional integration of cortical grafts placed in brain infarcts of rats. Ann. Neurol. 34:1993;362-368.
12. Hicks S. P., D'Amato C. J. Motor-sensory cortex-corticospinal system and developing locomotion and placing in rats. Am. J. Anat. 143:1975;1-42.
13. Jansen E. M., Low W. C. Long term effects of neonatal ischemic-hypoxic brain injury on sensorimotor and locomotor tasks in rats. Behav. Brain Res. 78:1996;189-194.
14. Jansen E. M., Low W. C. Quantitative analysis of contralateral hemisphere hypertrophy and sensorimotor performance in adult rats following unilateral neonatal ischemic-hypoxic brain injury. Brain Res. 708:1996;93-99.
15. Jansen E. M., Underhill S., Low W. C. Histochemistry of neocortical grafts in rats following neonatal ischemic-hypoxia. Exp. Neurol. 143:1996;329.
16. Jansen E. M., Solberg L., Wilson S., Low W. C. Transplantation of fetal neocortical tissue in a rodent model of ischemic-hypoxia: Behavioral analysis. Exp. Neurol. 135:1995;166.
17. Little W. J. On the influence of abnormal parturition, difficult labor, premature birth, and asphyxia neonatorum on the mental and physical conditions of the child, especially in relation to deformities. Trans. Obstet. Soc. London. 3:1862;293-344.
18. Mampalam T. J., Gonzazlez M. F., Weinstein P., Sharp F. R. Neuronal changes in fetal cortex transplanted to ischemic adult rat cortex. J. Neurosurg. 69:1988;904-912.
19. Markus E. J., Petit T. L. Neocortical synaptogenesis, aging, and behavior: Lifespan development in the motor-sensory system of the rat. Exp. Neurol. 96:1987;262-278.
20. Oakman S. A., Faris P. L., Kerr P. E., Cozzari C., Hartman B. K. Distribution of pontomesencephalic neurons projecting to substantia nigra differs significantly from those projecting to ventral tegmental area. J. Neurosci. 15:1995;5859-5869.
21. Pan H. S., Engber T. M., Chase T. N., Walters J. R. The effects of striatal lesions on turning behavior and globus pallidus single unit response to dopamine agonist administration. Life Sci. 46:1990;73-80.
22. Paxinos G., Watson C. The Rat Brain in Stereotaxic Coordinates. 1986;Academic Press, San Diego.
23. Plumet J., Cadusseau J., Roger M. Fetal cortical transplants reduce motor deficits resulting from neonatal damage to the rat's frontal cortex. Neurosci. Lett. 109:1990;102-106.
24. Plumet J., Cadusseau J., Roger M. Skilled forelimb use in the rat: Amelioration of functional deficits resulting from neonatal damage to the frontal cortex by neonatal transplantation of fetal cortical tissue. Rest. Neurol. Neurosci. 3:1991;135-147.
25. Pundt L. L., Kondoh T., Low W. C. NADPH diaphorase histochemistry and functional analysis of human fetal striatal brain tissue transplanted into a rodent model of Huntington's disease. Transplant. Proc. 26:1994;3295.
26. Rice J. E. III, Vannucci R. C., Brierley J. B. The influence of immaturity on hypoxic-ischemic brain damage in the rat. Ann. Neurol. 9:1981;131-141.
27. Sandor R., Gonzalez M. F., Moseley M., Sharp F. R. Motor deficits are produced by removing some cortical transplants grafted into injured sensorimotor cortex of neonatal rats. J. Neural Transpl. Plast. 2:1991;221-233.
28. Schreyer D. J., Jones E. G. Growth and target finding by axons of the corticospinal tract in prenatal and postnatal rats. Neuroscience. 7:1982;1837-1853.
29. Schultz M. K., McNulty J. A., Handa R. J., Hogan T. P., Tillotson G. L., Shaw P. L., Zimmer J., Castro A. J. Fetal neocortical transplants grafted into neocortical lesion cavities made in newborn rats: An analysis of transplant integration with the host brain. Cell Transplant. 4:1995;123-132.
30. Slavin M. D., Held J. M., Basso D. M., Lesensky S., Curran E., Gentile A. M., Stein D. G. Fetal brain tissue transplants and recovery of locomotion following damage to the sensorimotor cortex in rats. Prog. Brain Res. 78:1988;33-38.
31. Sørensen J. C., Zimmer J., Castro A. J. Fetal cortical transplants reduce the thalamic atrophy induced by frontal cortical lesions in newborn rats. Neurosci. Lett. 98:1989;33-38.
32. Sørensen J. C., Castro A. J., Klausen B., Zimmer J. Projections from fetal neocortical transplant placed in the frontal neocortex of newborn rats. APhaseolus vulgaris. Exp. Brain Res. 92:1992;299-309.
33. Tomic D., Zobundzija M., Meaugorac M. Postnatal development of nicotinamide adenine dinucleotide phosphate diaphorase (NADPH-s) positive neurons in rat prefrontal cortex. Neurosci. Lett. 170:1994;217-220.
34. Ungerstedt U., Arbuthnott G. W. Quantitative recording of rotational behavior in rats after 6-hydroxydopamine lesions of the nigostriatal dopamine system. Brain Res. 24:1970;485-493.
35. Valtschanoff J. G., Weinberg R. J., Kharazia V. K., Schmidt H. H. H. W., Nakane M., Rustioni A. Neurons in rat cerebral cortex that synthesize nitric oxide: NADPH diaphorase histochemistry, NOS immunohistochemistry, and colocalization with GABA. Neurosci. Lett. 157:1993;157-161.
36. Vincent S. R., Hope B. T. Neurons that say NO. Trends Neurosci. 15:1992;108-113.
37. Yan X. X., Garey L. J., Jen L. S. Development of NADPH-diaphorase activity in the rat neocortex. Dev. Brain Res. 79:1994;29-38.