Intracellular Ca2+ inactivates L-type Ca2+ channels with a Hill coefficient of ~1 and an inhibition constant of ~4 μm by reducing channel's open probability

Biophysical Journal

Volumn 73, Issue 4, 1997, Pages 1857-1865

  Hofer G F ^a   Hohenthanner, K ^a   Baumgartner, W ^a   Groschner, K ^b   Klugbauer, N ^c   Hofmann, F ^c   Romanin, C ^a  

^a JOHANNES KEPLER UNIVERSITY LINZ   (Austria)

^b UNIVERSITY OF GRAZ   (Austria)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIHYDRO 2,6 DIMETHYL 5 NITRO 4 [2 (TRIFLUOROMETHYL)PHENYL] 3 PYRIDINECARBOXYLIC ACID METHYL ESTER; ADENOSINE TRIPHOSPHATE; BARIUM ION; CALCIUM CHANNEL; CALCIUM ION; CALPASTATIN; MEMBRANE PROTEIN; BARIUM; CALCIUM; RECOMBINANT PROTEIN;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CHANNEL GATING; CHO CELL; CONTROLLED STUDY; DEPOLARIZATION; GUINEA PIG; HEART MUSCLE CELL; INHIBITION KINETICS; NONHUMAN; PATCH CLAMP; PROBABILITY; SURFACE CHARGE; ANIMAL; BINDING SITE; BIOPHYSICS; CELL MEMBRANE POTENTIAL; CHEMISTRY; CYTOPLASM; DRUG EFFECT; GENETICS; HAMSTER; HEART MUSCLE; IN VITRO STUDY; KINETICS; METABOLISM; PROTEIN CONFORMATION; RABBIT;

ANIMALIA; CAVIA PORCELLUS; SUS SCROFA;

ANIMALS; BARIUM; BINDING SITES; BIOPHYSICS; CALCIUM; CALCIUM CHANNELS; CHO CELLS; CRICETINAE; CYTOPLASM; GUINEA PIGS; KINETICS; MEMBRANE POTENTIALS; MYOCARDIUM; PROTEIN CONFORMATION; RABBITS; RECOMBINANT PROTEINS;

EID: 0031252785     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3495(97)78216-X     Document Type: Article

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