Abbreviated Junctional Sequences Impoverish Antibody Diversity in Urodele Amphibians

Journal of Immunology

Volumn 159, Issue 7, 1997, Pages 3391-3399

  Patel, Hemal M ^a   Hsu, Ellen ^a  

^a NEW YORK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN J CHAIN;

AGING; AMBYSTOMA MEXICANUM; AMINO ACID SEQUENCE; ANIMAL; ANTIBODY SPECIFICITY; ARTICLE; CHEMISTRY; GENE REARRANGEMENT; GENETICS; GERM CELL; IMMUNOGLOBULIN STRUCTURE; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOLOGY; ISOLATION AND PURIFICATION; MALE; MOLECULAR CLONING; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; SOUTHERN BLOTTING;

AGING; AMBYSTOMA MEXICANUM; AMINO ACID SEQUENCE; ANIMALS; ANTIBODY DIVERSITY; BASE SEQUENCE; BLOTTING, SOUTHERN; CLONING, MOLECULAR; DNA; GENE REARRANGEMENT; GERM CELLS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN J-CHAINS; IMMUNOGLOBULIN JOINING REGION; IMMUNOGLOBULIN VARIABLE REGION; MALE; MOLECULAR SEQUENCE DATA;

EID: 0031252288     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (57)

1. Reynaud, C.-A., V. Anquez, A. Dahan, and J.-C. Weill. 1985. A single rearrangement event generates most of the chicken immunoglobulin light chain diversity. Cell 40:283.
2. H allotypes: implications for the generation of diversity. Cell 60:963.
3. Reynaud, C.-A., C. R. Mackay, R. G. Mueller, and J.-C. Weill. 1991. Somatic generation of diversity in a mammalian primary lymphoid organ: the sheep ileal Peyer's patches. Cell 64:995.
4. Weill, J.-C., and C. A. Reynaud. 1996. Rearrangement/hypermutation/gene conversion: when, where and why? Immunol. Today 17:92.
5. Du Pasquier, L. 1993. Evolution of the immune system. In Fundamental Immunology, Ch. 7. W. E. Paul, ed. Raven Press, New York, pp. 199-233.
6. Cohen, N. 1968. Chronic skin graft rejection in the Urodela. I. A comparative study of first- and second-set allograft reactions. J. Exp. Zool. 167:378.
7. Cohen, N. 1969. Chronic skin graft rejection in the Urodela. Transplantation 7:332.
8. Kaufman, J., H. Volk, and H.-J. Wallny. 1995. A "minimal essential Mhc" and an "unrecognized Mhc": two extremes in selection for polymorphism. Immunol. Rev. 143:63.
9. Ching, Y.-C., and R. J. Wedgewood. 1967. Immunologic responses in the axolotl, Siredon Mexicanum. J. Immunol. 99:191.
10. Houdayer, M., and M. Fougereau. 1972. Phylogeny of immunoglobulins: immune reaction of the axolotl Ambystoma mexicanum: kinetics of the immune response and characterization of antibodies. Ann. Immunol. Inst. Pasteur 123:3.
11. Tournefier, A. 1975. Incomplete antibodies and immunoglobulin characterization in adult urodeles, Pleurodeles waltlii Michah, and Triturus alpestris Laur. Immunology 29:209.
12. Charlemagne, J., and A. Tournefier. 1977. Humoral response to Salmonella typhimurium antigens in normal and thymectomized urodele amphibian Pleurodeles waltlii Michah. Eur. J. Immunol. 7:500.
13. Charlemagne, J. 1987. Antibody diversity in amphibians: noninbred axolotls used the same unique heavy chain and a limited number of light chains for their anti-2,4-dinitrophenyl antibody responses. Eur. J. Immunol. 17:421.
14. Kaufman, J., S. Ferrone, M. Flajnik, M. Kilb, and H. Völk. 1990. MHC-like molecules in some nonmammalian vertebrates can be detected by some cross-reactive monoclonal antibodies. J. Immunol. 144:2273.
15. Fellah, J. S., F. Kerfourn, and J. Charlemagne. 1994. Evolution of T cell receptor genes: extensive diversity of Vβ families in the Mexican axolotl. J. Immunol. 153:4539.
16. Fellah, J. S., C. Jacques, and J. Charlemagne. 1994. Characterization of immunoglobulin heavy chain variable regions in the Mexican axolote. Immunogenetics 39:201.
17. Hsu, E., and L. Du Pasquier. 1984. Ontogeny of the immune system in Xenopus. II. Antibody repertoire differences between larvae and adults. Differentiation 28: 116.
18. Schwager J., N. Buerkert, M. Courtet, and L. Du Pasquier. 1991. The ontogeny of diversification at the immunoglobulin heavy chain locus in Xenopus. EMBO J. 10:2461.
19. Lee, A., and E. Hsu. 1994. Isolation and characterization of the Xenopus terminal deoxynucleotidyl transferase. J. Immunol. 152:4500.
20. Bachmann, K. 1970. Feulgen slope determinations of urodele nuclear DNA amounts. Histochemie 22:289.
21. Sparrow, A. H., H. J. Price, and A. G. Underbrink. 1972. Evolution of genetic systems. Brookhaven Svmp. Biol. 23:451.
22. Ducibella, T. 1974. The occurrence of biochemical metamorphic events without anatomical metamorphosis. Dev. Biol. 38:175.
23. Turchin, A., S. Desravines, and E. Hsu. 1996. Isolating any vertebrate immunoglobulin heavy chain variable region by polymerase chain reaction. In Immunological Methods IV, Ch. 33.2. I. Lefkovits and B. Pernis, eds. Academic Press, New York.
24. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular Cloning, 2nd Ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor.
25. Turchin, A., and E. Hsu. 1996. The generation of antibody diversity in the turtle. J. Immunol. 156:3797.
26. H CDR1 nucleotide sequences are conserved in all jawed vertebrates. Int. Immunol. 8:847.
27. Fellah, J. S., J. Schwager, J. Charlemagne, and M. V. Wiles. 1992. Evolution of vertebrate IgM: complete amino acid sequence of the constant region of Ambystoma mexicanum μ chain deduced from cDNA sequence. Eur. J. Immunol. 22: 2592.
28. Auffray, C., and F. Rougeon. 1980. Purilication of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA. 1980. Eur. J. Biochem. 107:303.
29. Lee, A., S. Desravines, and E. Hsu. 1993. IgH diversity in an individual with only one million B lymphocytes. Dev. Immunol. 3:211.
30. Desravines, S., and E. Hsu. 1993. Measuring CDR3 length variability in individuals during ontogeny. J. Immunol. Methods 168:219.
31. Alt, F. W., A. L. Bothwell, M. Knapp, E. Siden, E. Mather, M. Koshland, and D. Baltimore. 1980. Synthesis of secreted and membrane-bound immunoglobulin μ heavy chain is directed by mRNAs that differ at their 3′ ends. Cell 20:293.
32. Ware, V. C., B. W. Tague, C. G. Clark, R. L. Gourse, R. C. Brand, and S.A. Gerbi. 1983. Sequence analysis of 28S ribosomal DNA from the amphibian, Xenopus laevis. Nucleic Acids Res. 11:7795.
33. Salim, M., and B. E. H. Maden. 1981. Nucleotide sequence of Xenopus laevis 18S rihosomal RNA inferred from gene sequence. Nature 291:205.
34. Pearson, W. R., and D. J. Lipman. 1988. Improved tools for biological sequence comparison. Proc. Natl. Acad. Sci. USA 85:2444.
35. Altschul, S. F., W. Gish, W. Miller, E. W. Myers, and D. J. Lipman. 1990. Basic local alignment search tool. J. Mol. Biol. 215:403.
36. Yamawaki-Kataoka, Y., and T. Honjo. 1987. Nucleotide sequences of variable region segments of the immunoglobulin heavy chain of Xenopus laevis. Nucleic Acids Res. 15:5888.
37. H gene organization in a relict species, the coelacanth Latimeria chalumnae: evolutionary implications. Proc. Natl. Acad. Sci. USA 90: 6661.
38. Brodeur, P., and R. Riblet. 1984. The immunoglobulin heavy chain variable region (IgH-V) locus in the mouse. I. One hundred IgH-V genes comprise seven families of homologous genes. Eur. J. Immunol. 14:922.
39. Kabat, E. A., T. T. Wu, H. M. Perry, K. S. Gottesman, and C. Foeller. 1991. Sequences of Proteins of Immunological Interest, 5th Ed. U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health, Bethesda, MD.
40. H fusions. Proc. Natl. Acad. Sci. USA 79:4118.
41. Lafaille, J., A. DeCloux, M. Bonneville, Y. Takagaki, and S. Tonegawa. 1989. Junctional sequences of T cell receptor genes: implications for αβ T cell lineages and for a novel intermediate of VDJ joining. Cell 59:859.
42. H gene utilization in VDJ joining: implications for the joining mechanism and the ontogenetic timing of Ly1 B cell and B-CLL progenitor generation. EMBO J. 9:2133.
43. Feeney, A. J. 1990. Lack of N region in fetal and neonatal mouse immunoglobulin VDJ junctional sequences. J. Exp. Med. 172:1377.
44. Casimir, C. M., P. B. Gates, P. B. Ross-Macdonald, J. F. Jackson, R. K. Patient, and J. P. Brockes. 1988. Structure and expression of a newt cardio-skeletal myosin gene: implications for the C value paradox. J. Mol. Biol. 202:287.
45. Fellah, J. S., and J. Charlemagne. 1988. Characterization of an IgY-like low molecular weight immunoglobulin class in the Mexican axolotl. Mol. Immunol. 25:1377.
46. Wu, T. T., G. Johnson, and E. A. Kabat. 1993. Length distribution of CDRH3 in antibodies. Proteins 16:1.
47. Nadel, B., and A. J. Feeney. 1995. Influence of coding-end sequence on coding-end processing in V(D)J recombination. J. Immunol. 155:4322.
48. Padlan, E. 1994. Anatomy of the antibody molecule. Mol. Immunol. 31:169.
49. H and junctional diversity in the fetal, adult, and aged B cell repertoires. J. Immunol. 146: 1996.
50. Bogue, M., S. Gilfillan, C. Benoist, and D. Mathis. 1992. Regulation of N-region diversity in antigen receptors through differentiation and thymus ontogeny. Proc. Natl. Acad. Sci. USA 89:11011.
51. Hsu, E., and L. Du Pasquier. 1992. Changes in the amphibian antibody repertoire are correlated with metamorphosis and not with age or size. Dev. Immunol. 2:1.
52. Du Pasquier, L., B. Blomberg, and C. C. A. Bernard. 1979. The ontogeny of immunity in amphibians. Eur. J. Immunol. 9:900.
53. Wilson, M., E. Hsu, A. Marcuz, M. Courtet, L. Du Pasquier, and C. Steinberg. 1992. What limits affinity maturation of antibodies in Xenopus - the rate of somatic mutation or the ability to select mutants? EMBO J. 11:4337.
54. L families and is related to mammalian lambda genes. J. Immunol. 157:1544.
55. Mußmann, R. 1996. B-cell development in the amphibian Xenopus. Doctoral dissertation, University of Basel, Basel, Switzerland.
56. Rock, E. P., P. R. Sibbald, M. M. Davis, and Y.-h. Chien. 1994. CDR3 length in antigen-specific immune receptors. J. Exp. Med. 179:323.
57. Koniski, A. D., and N. Cohen. 1992. Reproducible proliferative responses of salamander (Ambystoma mexicanum) lymphocytes cultured with mitogens in serum-free medium. Dev. Comp. Immunol. 16:441.