The EEG burst suppression threshold test for the determination of CNS sensitivity to intravenous anesthetics in rats

Brain Research Protocols

Volumn 1, Issue 4, 1997, Pages 378-384

  Korkmaz, Seher ^a   Wahlström, Göran ^a  

^a UMEÅ UNIVERSITY   (Sweden)

Author keywords

Anesthesia induction; EEG burst suppression; Intravenous anesthetics; Intravenous infusion; Rat

Indexed keywords

CENTRAL DEPRESSANT AGENT; HEXOBARBITAL; INTRAVENOUS ANESTHETIC AGENT; PROPOFOL;

ANIMAL EXPERIMENT; ARTICLE; CENTRAL NERVOUS SYSTEM; CONTINUOUS INFUSION; CONTROLLED STUDY; DRUG POTENCY; DRUG SENSITIVITY; ELECTROENCEPHALOGRAM; EXCITABILITY; INTRAVENOUS ANESTHESIA; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANESTHETICS; ANIMALS; BRAIN; DIFFERENTIAL THRESHOLD; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROENCEPHALOGRAPHY; INFUSION PUMPS; INJECTIONS, INTRAVENOUS; MALE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0031251745     PISSN: 1385299X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1385-299X(97)00014-7     Document Type: Article

References (22)

1. [1] H. Bolander, G. Wahlström, Age-related changes in CNS-sensitivity to hexobarbital and thiopental in the rat, Arch. Int. Pharmacodyn. Ther. 267 (1984) 213-223.
2. [2] H. Bolander, G. Wahlström, Interaction between probenecid and two lipid-soluble barbiturates in the rat, Neuropharmacology 23 (1984) 977-981.
3. [3] H.G. Bolander, G. Wahlström, Acute tolerance to and distribution of hexobarbital in relation to depth and duration of anaesthesia in rats, Pharmacol. Toxicol. 63 (1988) 199-204.
4. [4] H.G. Bolander, G. Wahlström, L. Norberg, Reevaluation of potency and pharmacokinetic properties of some lipid-soluble barbiturates with an EEG-threshold method, Acta Pharmacol. Toxicol. 54 (1984) 33-40.
5. [5] S. Korkmaz, S. Carlsson, G. Wahlström, Maturation-related changes in tolerance development to hexobarbital after short term treatment with diazepam in the rat, Brain Res. 600 (1993) 345-348.
6. [6] S. Korkmaz, E. Ljungblad, G. Wahlström, Interaction between flumazenil and the anesthetic effects of hexobarbital in the rat, Brain Res. 676 (1995) 371-377.
7. [7] T. Koskela, G. Wahlström, Comparison of anaesthetic and kinetic properties of thiobutabarbital, butabarbital and hexobarbital after intravenous threshold doses in the male rat, Pharmacol. Toxicol. 64 (1989) 308-313.
8. [8] J.-E. Larsson, G. Wahlström, Optimum rate of administration of propofol for induction of anesthesia in rats, Br. J. Anaesth. 73 (1994) 692-694.
9. [9] J.-E. Larsson, G. Wahlström, Age-dependent development of acute tolerance to propofol and its distribution in a pharmacokinetic compartment-independent rat model, Acta Anesthesiol. Scand. 40 (1996) 734-740.
10. [10] C. Larsson-Backström, L.L. Lustig, A. Eklund, M. Thorstensson, Anaesthetic properties of pregnanolone in mice in an emulsion preparation for intravenous administration: a comparison with thiopentone, Pharmacol. Toxicol. 63 (1988) 143-149.
11. [11] L. Norberg, G. Wahlström, Interactions between hexobarbital and thiopental in male rats evaluated with an anesthesia threshold, Acta Pharmacol. Toxicol. 58 (1986) 96-104.
12. [12] L. Norberg, G. Wahlström, Anaesthetic effects of flurazepam alone and in combination with thiopental or hexobarbital evaluated with an EEG-threshold method in male rats, Arch. Int. Pharmacodyn. Ther. 292 (1988) 45-57.
13. [13] L. Norberg, G. Wahlström, T. Bäckström, The anaesthetic potency of 3 α-hydroxy-5α-pregnan-20-one and 3α-hydroxy-5β-pregnan-20-one determined with an intravenous EEG-threshold method in male rats, Pharmacol. Toxicol. 61 (1987) 42-47.
14. [14] A. Nordberg, G. Wahlström, Cholinergic mechanisms in physical dependence on barbiturates, ethanol and benzodiazepines, J. Neural Transm. (Gen. Sect.) 88 (1992) 199-221.
15. [15] S. Schliamser, K. Karlsson, J.-E. Larsson, S. Marklund, G. Wahlström, Interaction between benzylpenicilline and thiopental in the central nervous system of the rat, Pharmacol. Toxicol. 64 (1989) 222-227.
16. [16] G. Wahlström, Estimation of brain sensitivity to hexobarbitone (enhexymal NFN) in rats by an EEG threshold, Acta Pharmacol. Toxicol. 24 (1966) 404-418.
17. [17] G. Wahlström, Hexobarbitone sleeping times in rats following doses with similar EEG changes, Acta Pharmacol. Toxicol. 24 (1966) 419-434.
18. [18] G. Wahlström, Hexobarbital (enhexymalum NFN) sleeping times and EEG threshold doses as measurements of tolerance to barbiturates in the rat, Acta Pharmacol. Toxicol. 26 (1968) 64-80.
19. [19] G. Wahlström, Estimation of brain sensitivity to the convulsive effects of choline and changes induced by chronic barbital treatments in the rat, Eur. J. Pharmacol. 51 (1978) 219-227.
20. [20] G. Wahlström, L. Norberg, A comparative investigation in the rat of the anesthetic effects of the isomers of two barbiturates, Brain Res. 310 (1984) 261-267.
21. [21] M. Wang, G. Wahlström, K. Gee, T. Bäckström, Potency of lipid and protein formulation of 5 α-pregnanolone at induction of anaesthesia and the corresponding regional brain distribution, Br. J. Anaesth. 74 (1995) 553-557.
22. [22] A. Österlind, Å. Åkesson, G. Wahlström, Interactions between 1,2-propanediol (propylene glycol) and hexobarbital, Acta Pharmacol. Toxicol. 45 (1979) 245-248.