A label-free affinity sensor with compensation of unspecific protein interaction by a highly sensitive integrated optical Mach-Zehnder interferometer on silicon

Sensors and Actuators, B: Chemical

Volumn 44, Issue 1-3, 1997, Pages 350-355

  Brosinger, Franz ^a   Freimuth, Herbert ^b,d,e   Lacher, Manfred ^b   Ehrfeld, Wolfgang ^b   Gedig, Erk ^c   Katerkamp, Andreas ^c   Spener, Friedrich ^c,f,g   Cammann, Karl ^c  

^a IBM   (Germany)

^b INSTITUT FÜR MIKROTECHNIK MAINZ GMBH   (Germany)

^c ICB Institut fur Chemo und Biosensorik GmbH   (Germany)

^d JOHANNES GUTENBERG UNIVERSITY   (Germany)

^e MAX PLANCK INSTITUTE FOR POLYMER RESEARCH   (Germany)

^f UNIVERSITY OF MINNESOTA   (United States)

^g Inst for Lipid Res of Federal Ctr   (Germany)

Author keywords

Integrated optical Mach Zehnder interferometer; Sensor; Silicon

Indexed keywords

ETHANOL; INTEGRATED OPTICS; INTERFEROMETERS; MIXTURES; PROTEINS; REFRACTIVE INDEX; SILICON; WATER;

AFFINITY SENSORS; INTEGRATED OPTICAL MACH-ZEHNDER INTERFEROMETERS (IO MZI);

IMMUNOSENSORS;

EID: 0031245062     PISSN: 09254005     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0925-4005(97)00226-8     Document Type: Article

References (7)

1. J. Ingenhoff, B. Drapp, G. Gauglitz, Biosensors using integrated optical devices, Fresenius J. Anal. Chem. 346 (1993) 580-583.
2. G. Gauglitz, J. Ingenhoff, Design of new integrated optical substrates for immuno analytical applications, Fresenius J. Anal. Chem. 349 (1994) 355-359.
3. H.P. Zappe, H.E.G. Arnot, R.E. Kunz, Technology and devices for hybrid and monolithically integrated optical sensors, Sensors and Actuators A 41-43 (1994) 141-144.
4. R.G. Heideman, R.P.H. Kooyman, J. Greve, Development of an optical waveguide interferometric immunosensor, Sensors and Actuators B 4 (1991) 297-299.
5. W. Lukosz, K. Tiefenthaler, Sensitivity of integrated optical grating and prism couplers as (bio)chemical sensors, Sensors and Actuators 15 (1988) 273-284.
6. M. Franek, V. Kolar, M. Granatova, Z. Nevorankova, Monoclonal ELISA for 2,4-dichlorophenoxyacetic acid. Characterization of antibodies and assay optimization, J. Agric. Food Chem. 42 (1994) 1369-1371.
7. R.C. Weast (Eds.), Handbook of Chemistry and Physics, 61st ed., CRC Press, Boca Raton, FL, 1980, pp. D-236.