Developments in technology and applications of microsystems

Current Opinion in Chemical Biology

Volumn 1, Issue 3, 1997, Pages 410-419

  Kopp, Martin U ^a   Crabtree, H John ^a   Manz, Andreas ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMISTRY; ELECTRONICS; INSTRUMENTATION; METHODOLOGY; REVIEW; SEMICONDUCTOR;

CHEMISTRY, ANALYTICAL; MINIATURIZATION; SEMICONDUCTORS;

EID: 0031244526     PISSN: 13675931     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1367-5931(97)80081-6     Document Type: Article

References (47)

1. Lemmo AV, Fisher JT, Geysen HM, Rose DJ: Characterization of an inkjet chemical microdispenser for combinatorial library synthesis. Anal Chem 1997, 69:543-551.
2. Manz A, Widmer HM: Miniaturized total chemical analysis systems: a novel concept for chemical sensing. Sensors Actuators B 1990, 1:244-248.
3. Terry SC, Jerman JH, Angell JB: A gas Chromatographic air analyzer fabricated on a silicon wafer. IEEE Trans Electron Devices 1979, 26:1880-1886.
4. Van den Berg A, Bergveld P (Eds): Micro Total Analysis Systems. Boston: Kluwer Academic Publisher; 1995.
5. Manz A, Becker H (Eds): Microsystem Technology in Chemistry and life sciences. Heidelberg: Springer Verlag; 1997, in press. [Topics in Current Chemistry, Volume 194.]
6. Manz A, Becker H (Eds): Microsystem Technology in Chemistry and life sciences. Heidelberg: Springer Verlag; 1997, in press. [Topics in Current Chemistry, Volume 194.]
7. This is the first comprehensive book volume to cover this area.
8. Moreau WM: Semiconductor Lithography. New York: Plenum Press; 1988.
9. Verpoorte E, Van der School B, Jeannet S, Manz A, Widmer HM, de Rooij NF: Three dimensional microflow manifolds for miniaturized chemical analysis sytems, J Micromech Microeng 1994, 4:246-256.
10. Kim E, Xia Y, Whitesides G: Polymer microstructures formed by moulding in capillaries. Nature 1995, 376:581-584.
11. Roberts MA, Rossier JS, Bercier P, Girault H: UV laser machined polymer substrates for the development of microdiagnostic systems. Anal Chem 1997, 69:2035-2042. A ground breaking paper in which polymer micromachining and lamination were shown to be very fast and easy, compared to glass or silicon micromachining.
12. McCormick RM, Nelson RJ, Alonso-Amigo MG, Benvegnu DJ, Hooper HH: Microchannel electrophoretic separations of DNA in injection-molded plastic substrates. Anal Chem 1997, 69:2626-2630. An injection moulding approach to polymer micromachining particularly suited to high-throughput fabrication.
13. Pretorius V, Hopkins BJ, Schieke JD: A new concept for high-speed liquid chromatography. J Chromatogr 1974, 99:23-30.
14. Effenhauser CS, Paulus A, Manz A, Widmer HM: High-speed separation of antisense oligonucleotides on a micromachined capillary electrophoresis device. Anal Chem 1994, 66:2949-2953.
15. Woolley AT, Mathies RA: Ultra-high-speed fragment separations using microfabricated capillary electrophoresis. Proc Natl Acad Sci USA 1994, 91:11348-11352.
16. Woolley AT, Mathies RA: Ultra-high-speed DNA sequencing using capillary electrophoresis chips. Anal Chem 1995, 67:3676-3680.
17. Caliper Technologies Corporation: Rapid molecular separations. On the World Wide Web URL http://www.calipertech.com/tech/ rms.htm
18. Manz A, Harrison JD, Verpoorte E, Fettinger JC, Paulus A, Luedi H, Widmer HM: Capillary electrophoresis on a chip. J Chromatogr 1992, 593:253-258.
19. 7. Effenhauser CS, Manz A, Widmer HM: Manipulation of sample fractions on a capillary electrophoresis chip. Anal Chem 1995, 67:2284-2287.
20. Von Heeren F, Verpoorte E, Manz A, Thormann W: Micellar electrokinetic chromatography separations and analyses of biological samples on a cyclic planar micro structure. Anal Chem 1996, 68:2044-2053.
21. Von Heeren F, Verpoorte E, Manz A, Thormann W: Characterization of electrophoretic sample injection and separation in a gel-filled cyclic planar microctructure. J Microcolumn Separations 1996, 8:373-381.
22. Jacobson SC, Ramsey JM: Integrated microdevice for DNA restriction fragment analysis. Anal Chem 1996, 68:720-723. The first example of microchip-based precolumn DNA digestion and subsequent capillary gel electrophoretic separation; digestion and analysis required about 5 minutes.
23. Sammarco TS, Fields YD, Johnson BN, Jones DK, Burke DT, Mastrangelo CH, Burns MA: Microfabrication of an integrated DNA analysis system. In Proceedings of the 2nd International Symposium on Miniaturised Total Analysis Systems - μTAS 96. 1996 November 19-22, Basel, Switzerland. Analytical Methods and Instumentation: page 55.
24. Cheng J, Shoffner MA, Mitchelson KR, Kricka LJ, Wilding P: Analysis of ligase chain reaction products amplified in a silicon glass chip using capillary electrophoresis. J Chromatogr A 1996, 732:151-158.
25. Burns MA, Mastrangelo CH, Sammarco TS, Man FP, Webster JR, Johnsons BN, Foerster B, Jones D, Fields Y, Kaiser AR, Burke DT: Microfabricated structures for integrated DNA analysis. Proc Natl Acad Sci USA 1996, 93:5556-5561.
26. Cheng J, Shoffner MA, Hvichia GE, Kricka LJ, Wilding P: Chip PCR, investigation of different PCR amplification systems in microfabricated silicon glass chips. Nucleic Acids Res 1996, 24:380-385.
27. Northrup MA, Beeman B, Hadley D, Landre P, Lehew S: Integrated miniature DNA-based analytical instrumentation. In Proceedings of the 2nd International Symposium on Miniaturised Total Analysis Systems - μTAS 96. 1996 November 19-22, Basel, Switzerland. Analytical Methods and Instumentation: page 55.
28. Woudenberg TM, Winn-Deen ES, Albin M: High-density PCR and beyond. In Proceedings of the 2nd International Symposium on Miniaturised Total Analysis Systems - μTAS 96. 1996 November 19-22, Basel, Switzerland. Analytical Methods and Instumentation: page 153.
29. Woolley AT, Hadley D, Landre P, deMello AJ, Mathies RA, Northrup MA: Functional integration of PCR amplification and capillary electrophoresis in a microfabricated DNA analysis device. Anal Chem 1996, 68:4081-4086. This article demonstrates the integration of a polymerase chain reaction (PCR) heating chamber coupled to a capillary electrophoresis separation channel to amplify and analyse PCR products on a single device.
30. Li PCH, Harrison DJ: Transport manipulation, and reaction of biological cells on-chip using electrokinetic effects. Anal Chem 1997, 69:1564-1568.
31. Andersson PE, Li PCH, Smith R, Szarka RJ, Harrison DJ: Biological cell assays on an electrokinetic microchip [abstract #4C1.03]. 1997 International Conference on Solid-State Sensors and Actuators - Transducers '97. 1997 June 16-19, Chicago; 2:1311.
32. Fuhr G: Examples of three-dimensional micro-structures for handling and investigation of adherently growing cells and sub-micron particles. In Proceedings of the 2nd Intermational Symposium on Miniaturised Total Analysis Systems - μTAS 96. 1996 November 19-22, Basel, Switzerland. Analytical Methods and Instumentation: page 39.
33. Becker FF, Wang X-B, Huang Y, Pethig R, Vykoukal J, Gascoyne PRC: Separation of human breast cancer cells from blood by differential dielectric affinity. Proc Natl Acad Sci USA 1995, 92:860-864.
34. Koutny LB, Schmaling D, Taylor TA, Fuchs M: Microchip electrophoretic immunoassay for serum cortisol. Anal Chem 1996, 68:18-22.
35. Chiem N, Harrison DJ: Microchip-based capillary electrophoresis for immunoassays: analysis of monoclonal antibodies and theophylline. Anal Chem 1997, 69:373-378.
36. Chiem N, Colyer C, Harrison DJ: Microfluidic systems for clinical diagnostics [abstract #1C4.02]. 1997 International Conference on Solid-State Sensors and Actuators - Transducers '97. 1997 June 16-19, Chicago; 1:187. A remarkable microchip which is capable of performing competitive theophylline immunoassays, electrophoretic separation and fluorescence detection of the products within -2 min is described.
37. Harvey EC, Rumsby PT, Gower MC, Remnant JL: Microstructuring by excimer laser. Process Technol - Proc SPIE 1995, 2639:266-277.
38. Droit J, Lindström K, Rosengren L, Laurell T: Porous silicon as the carrier matrix in microstructured enzyme reactors yielding high enzyme activities. J Micromech Microeng 1997, 7:14-23.
39. Regnier FE, He B, Afeyan N: Liquid chromatography in microfabricated systems [abstract L-114], Oral presentation at the 21st Symposium on High Performance Liquid Phase Separations and Related Techniques - HPLC '97. 1997 June 23-27, Birmingham, UK, Volume B:73.
40. Jacobson SC, Hergenröder R, Moore AW Jr, Ramsey JM: Precolumn reactions with electrophoretic analysis integrated on a microchip. Anal Chem 1994, 66:4127-4132.
41. Jacobson SC, Koutny LB, Hergenröder R, Moore AW Jr, Ramsey JM: Microchip capillary electrophoresis with an integrated postcolumn reactor. Anal Chem 1994, 66:3472-3476.
42. Fluri K, Fitzpatrick G, Chiem N, Harrison DJ: Integrated capillary electrophoresis devices with an efficient postcolumn reactor in planar quartz and glass chips. Anal Chem 1996, 68:4285-4290.
43. Liang Z, Chiem N, Ocvirk G, Tang T, Fluri K, Harrison DJ: Microfabrication of a planar absorbance and fluorescence cell for integrated capillary electrophoresis devices. Anal Chem 1996, 68:1040-1046. This impressive article shows the integration of longitudinal detection op-tics right into the plane of the microchip, with enhanced sensitivity for both absorbance and fluorescence detection.
44. Kirby DP, Thorne JM, Götxinger WK, Karger BL: A CE/ESI-MS interface for stable, low-flow operation. Anal Chem 1996, 68:4451-4457.
45. Xue Q, Foret F, Dunayevskiy YM, Zavracky PM, McGruer NE, Karger BL: Multichannel microchip electrospray mass spectrometry. Anal Chem 1997, 69:426-430.
46. Figeys D, Ning Y, Aebersold R: A microfabricated device for rapid protein identification by microelectrospray ion trap mass spectrometry. Anal Chem 1997, 69:3153-3160. This paper describes a microfabricated, multisample electrospray device coupled to a mass spectrometer; different samples were switched through the electrospray device with no cross contamination.
47. Ramsey RS, Ramsey JM: Generating electrospray from microchip devices using electroosmotic pumping. Anal Chem 1997, 69:1174-1178. A paper in which electrospray for the mass spectrometer was generated directly from an electroosmotically pumped chip; no additional capillaries or coatings were required at the channel outlet.