The effect of pentoxifylline on ultrastructural picture of type II alveolar epithelial cells and generation of reactive oxygen species during cyclophosphamide-induced lung injury

Journal of Submicroscopic Cytology and Pathology

Volumn 29, Issue 4, 1997, Pages 487-496

  Sulkowska, M ^a   Sulkowski, S ^b  

^a MEDICAL UNIVERSITY OF BIALYSTOK   (Poland)

^b NONE

Author keywords

Cyclophosphamide; Lungs; Pentoxifylline; Reactive oxygen species; Ultrastructure

Indexed keywords

CARCINOGEN; CYCLOPHOSPHAMIDE; PENTOXIFYLLINE; REACTIVE OXYGEN METABOLITE;

ANIMAL; ARTICLE; ELECTRON MICROSCOPY; EPITHELIUM; LUNG; MALE; METABOLISM; PATHOLOGY; RAT; ULTRASTRUCTURE; WISTAR RAT;

ANIMALS; CARCINOGENS; CYCLOPHOSPHAMIDE; EPITHELIUM; LUNG; MALE; MICROSCOPY, ELECTRON; PENTOXIFYLLINE; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES;

EID: 0031240810     PISSN: 11229497     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. BALIBREA-CANTERO J.L., ARIAS-DIAZ J., GARCIA C., TORRES-MELERO J., SIMON C., RODRIGUEZ J.M. and VARA E., 1994. Effect of pentoxifylline on the inhibition of surfactant synthesis induced by TNF-α in human type II pneumocytes. Am. J. Respir. Crit. Care Med. 149, 699-706.
2. BEUTLER B. and CERAMI A., 1987. Cachetin: more than a tumor necrosis factor. N. Engl. J. Med., 316, 379-385.
3. BOYD M.R., 1980. Biochemical mechanisms in chemical induced lung injury: Roles of metabolic activation. CRC Crit. Rev. Toxicol., 4, 103-176.
4. BUEGE J.A. and AUST S.D., 1978. Microsomal lipid peroxidation. Methods Enzymol., 310, 302-310.
5. CURRIE M.S., RAO K.M.K., PADMANABHAN J., JONES A., CRAWFORD J. and COHEN H.J., 1990. Stimulus-specific effects of pentoxifylline on neutrophil CR3 expression, degranulation, and superoxide production. J. Leukocyte Biol., 47, 244-250.
6. DEZUBE B.J., FRIDOVICH-KEIL J.L. and BOUVARD I., 1990. Pentoxifylline and wellbeing in patients with cancer [Letter]. Lancet, 335, 662.
7. DEZUBE B.J., SHERMAN M.L., FRIDOVICH-KEIL J.L., ALLEN-RYAN J. and PARDEE A.B., 1993. Down-regulation of tumor necrosis factor expression by pentoxifylline in cancer patients: a pilot study. Cancer Immunol. Immunother., 36, 57-60.
8. FRIDOVICH I., 1978. The biology of oxygen radicals. Science, 201, 875-880.
9. HAKKINEN P.J., MORSE C.C., MARTIN F.M., DALBEY W.E., HASCHEK W.M. and WITSCHI H.R., 1983. Potentiating effects of oxygen in lungs damaged by methylcyclopentadienyl manganese tricarbonyl, cadmium chloride, oleic acid and antitumor drugs. Toxicol. Appl. Pharmacol., 67, 55-69.
10. ISHIZAKA A., WU Z., STEPHENS K.E., HARADA H., HOGUE R.S., O'HANLEY P.T. and RAFFIN T.A., 1988. Attenuation of acute lung injury in septic guinea pigs by pentoxifylline. Am. Rev. Respir. Dis., 138, 376-382.
11. LILLY C.M., SANDHU J.S., ISHIZAKA A., HARADA H., YONEMARU M., LARRICK J.W., T-X SHI, O'HANLEY P.T. and RAFFIN T.A., 1989. Pentoxifylline prevents tumor necrosis factor-induced lung injury. Am. Rev. Respir. Dis., 139, 1361-1368.
12. LINDSEY H.J., KISALA J.M., AYALA A., LEHMAN D., HERDON C.D. and CHAUDRY I.H., 1994. Pentoxifylline attenuates oxygen induced lung injury. J. Surg. Res., 56, 543-548.
13. MCDONALD R.J., 1991. Pentoxifylline reduces injury to isolated lungs perfused with human neutrophils. Am. Rev. Respir. Dis., 144, 1347-1350.
14. MISRA H.P. and FRIDOVICH I., 1972. The role of superoxide anion in the autooxidation of epinephrine and a simple assay for superoxide dismutation. J. Biol. Chem., 247, 3170-3174.
15. MIZE C.E. and LANGDON R.G., 1962. Hepatic glutathione reductase. I. Purification and general kinetic properties. J. Biol. Chem., 237, 1589-1595.
16. NAURECKAS E.T., FACTOR P., BENJAMINOV O., HOFFER E., SRIRAM V. and SZNAJDER J.I., 1994. Pentoxifylline does not protect against hyperoxic lung injury in rats. Eur. Respir. J., 7, 1397-1402.
17. PAGLIA D.E. and VALENTINE W.N., 1967. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J. Lab. Clin. Med., 70, 158-169.
18. PATEL J.M., 1987. Stimulation of cyclophosphamide-induced pulmonary microsomal lipid peroxidation by oxygen. Toxicology, 45, 79-91.
19. PATEL J.M. and BLOCK E.R., 1985. Cyclophosphamide-induced depression of the antioxidant defence mechanisms of the lung. Exp. Lung Res., 8, 153-165.
20. SAMLASKA C.P. and WINFIELD E.A., 1994. Pentoxifylline. J. Am. Acad. Dermatol., 30, 603-621.
21. SCHÖNHARTING M.M. and SCHADE U.F. 1989. The effect of pentoxifylline in septic shock: new pharmacologic aspects of an established drug. J. Med., 20, 97-105.
22. SYKES J.A., MCCORMAC F.X. and O'BRIEN T.J., 1978. Preliminary study of the superoxide dismutase content of some human tumours. Cancer Res., 38, 2759-2762.
23. TANAKA J., TEICHER B.A. and HERMAN T.S., 1991. Etoposide with lonidamine or pentoxifylline as modulators of alkylating agent activity in vitro. Int. J. Cancer, 48, 631-637.
24. TEICHER B.A., HOLDEN S.A. and HERMAN T.S., 1991. Efficacy of pentoxifylline as a modulator of alkylating agent activity in vitro and in vivo. Anticancer Res., 11, 1555-1560.
25. VENKATESAN N. and CHANDRAKASAN G., 1995. Modulation of cyclophosphamide-induced early lung injury by curcumin, an anti-inflammatory antioxidant. Mol. Cell. Biochem., 142, 79-87.
26. WILLIAMS J.H., HESHMATI S., TAMADON S. and GUERRA J., 1991. Inhibition of alveolar macrophages by pentoxifylline. Crit. Care Med., 19, 1073-1078.