Long-term enhanced chromaffin cell survival and behavioral recovery in hemiparkinsonian rats with co-grafted polymer-encapsulated human NGF- secreting cells

Experimental Neurology

Volumn 147, Issue 1, 1997, Pages 10-17

  Date, Isao ^a   Shingo, Tetsuro ^a   Ohmoto, Takashi ^a   Emerich, Dwaine F ^b  

^a OKAYAMA UNIVERSITY MEDICAL SCHOOL   (Japan)

^b CytoTherapeutics Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NERVE GROWTH FACTOR; POLYMER;

ADRENAL MEDULLA; ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL SURVIVAL; CELL TRANSPLANTATION; CHROMAFFIN CELL; CIRCLING BEHAVIOR; CONTROLLED STUDY; ENCAPSULATION; FIBROBLAST; HUMAN; IMMUNOCYTOCHEMISTRY; MALE; NONHUMAN; PARKINSONISM; PRIORITY JOURNAL; RAT;

EID: 0031239671     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.1997.6579     Document Type: Article

References (41)

1. Aebischer P., Tresco P. A., Winn S. R., Greene L. A., Jaeger C. B. Long-term cross-species brain transplantation of a polymer encapsulated dopamine-secreting cell line. Exp. Neurol. 111:1991;269-275.
2. Baetge E. E., Suh Y. H., Joh T. H. Complete nucleotide and deduced amino acid sequence of bovine phenylethanolamine N-methyltransferase: Partial homology with rat tyrosine hydroxylase. Proc. Natl. Acad. Sci. USA. 83:1986;5454-5458.
3. Bing G., Notter M. F. D., Hansen J. T., Kellogg C., Kordower J. H., Gash D. M. Cografts of adrenal medulla with C6 glioma cells in rats with 6-OHDA-induced lesions. Neuroscience. 34:1990;687-697.
4. Cunningham L. A., Hansen J. T., Short M. P., Bohn M. C. The use of genetically altered astrocyte to provide nerve growth factor to adrenal chromaffin cells grafted into the striatum. Brain Res. 561:1991;192-202.
5. Cunningham L. A., Short M. P., Breakefield X. O., Bohn M. C. Nerve growth factor released by transgenic astrocytes enhances the function of adrenal chromaffin cell grafts in a rat model of Parkinson's disease. Brain Res. 658:1994;219-231.
6. Date I., Felten S. Y., Felten D. L. Exogenous GM1 gangliosides induce partial recovery of the nigrostriatal dopaminergic system in MPTP-treated young mice but not in aging mice. Neurosci. Lett. 106:1989;282-286.
7. Date I., Felten D. L., Felten S. Y. Long-term effect of MPTP in the mouse brain in relation to aging: Neurochemical and immunocytochemical analysis. Brain Res. 519:1990;266-276.
8. Date I., Felten S. Y., Felten D. L. Cografts of adrenal medulla with peripheral nerve enhance the survivability of transplanted adrenal chromaffin cells and recovery of the host nigrostriatal dopaminergic system in MPTP-treated young adult mice. Brain Res. 537:1990;33-39.
9. Date I., Felten S. Y., Olschowka J. A., Felten D. L. Limited recovery of striatal dopaminergic fibers by adrenal medullary grafts in MPTP-treated aging mice. Exp. Neurol. 107:1990;197-207.
10. Date I., Notter M. F. D., Felten S. Y., Felten D. L. MPTP-treated young mice but not aging mice show partial recovery of the nigrostriatal dopaminergic system by stereotaxic injection of acidic fibroblast growth factor (aFGF). Brain Res. 526:1990;156-160.
11. Date I., Felten S. Y., Felten D. L. The nigrostriatal dopaminergic system in MPTP-treated mice shows more prominent recovery by syngeneic adrenal medullary graft than by allogeneic or xenogeneic graft. Brain Res. 545:1991;191-198.
12. Date I., Notter M. F. D., Felten S. Y., Felten D. L. Stereotaxic injection of GD1a ganglioside induces limited recovery of striatal dopaminergic system in MPTP-treated aging mice. J. Neurosci. Res. 28:1991;525-530.
13. Date I., Yoshimoto Y., Gohda Y., Furuta T., Asari S., Ohmoto T. Long-term effects of cografts of pretransected peripheral nerve with adrenal medulla in animal models of Parkinson's disease. Neurosurgery. 33:1993;685-690.
14. Date I., Yoshimoto Y., Imaoka T., Miyoshi Y., Gohda Y., Furuta T., Asari S., Ohmoto T. Enhanced recovery of the nigrostriatal dopaminergic system in MPTP-treated mice following intrastriatal injection of basic fibroblast growth factor in relation to aging. Brain Res. 621:1993;150-154.
15. Date I., Yoshimoto Y., Miyoshi Y., Imaoka T., Furuta T., Asari S., Ohmoto T. The influence of donor age on cografting of adrenal medulla with pretransected peripheral nerve. Brain Res. 624:1993;233-238.
16. Date I., Furukawa S., Ohmoto T. Increased nerve growth factor level in the distal stump of transected sciatic nerve in relation to aging and its application for neural grafting. Exp. Neurol. 130:1994;168-171.
17. Date I., Miyoshi Y., Imaoka T., Furuta T., Asari S., Ohmoto T. Efficacy of pretransection of peripheral nerve for promoting the survival of cografted chromaffin cells and recovery of host dopaminergic fibers in animal models of Parkinson's disease. Neurosci. Res. 20:1994;213-221.
18. Date I., Yoshimoto Y., Imaoka T., Miyoshi Y., Furuta T., Asari S., Ohmoto T. Effect of host age upon the degree of nigrostriatal dopaminergic system recovery following cografts of adrenal medulla and pretransected peripheral nerve. Brain Res. 637:1994;50-56.
19. Date I., Asari S., Ohmoto T. Two-year follow-up study of a parkinsonian patient and severe motor fluctuations treated by cografts of adrenal medulla and peripheral nerve into bilateral caudate nuclei. Neurosurgery. 37:1995;515-519.
20. Date I. Parkinson's disease, trophic factors, and adrenal medullary chromaffin cell grafting: Basic and clinical studies. Brain Res. Bull. 40:1996;1-19.
21. Date I., Imaoka T., Miyoshi Y., Ono T., Asari S., Ohmoto T. Chromaffin cell survival and host dopaminergic fiber recovery in a patient with Parkinson's disease treated by cografts of adrenal medulla and pretransected peripheral nerve: Case report. J. Neurosurg. 84:1996;685-689.
22. Date I., Miyoshi Y., Imaoka T., Ono T., Furuta T., Asari S., Ohmoto T., Iwata H. Preliminary report of polymer encapsulated dopamine-secreting cell grafting into the brain. Cell Transplant. 5:1996;S17-S19.
23. Date I., Ohmoto T. Neural transplantation and trophic factors in Parkinson's disease: Special reference to chromaffin cell grafting, NGF support from pretransected peripheral nerve and encapsulated dopamine-secreting cell grafting. Exp. Neurol. 137:1996;333-344.
24. Date I., Ohmoto T., Imaoka T., Ono T., Hammang J. P., Francis J., Greco C., Emerich D. F. Cografting with polymer-encapsulated human nerve growth factor-secreting cells and chromaffin cell survival and behavioral recovery in hemiparkinsonian rats. J. Neurosurg. 84:1996;1006-1012.
25. Date I., Ohmoto T., Imaoka T., Shingo T., Emerich D. F. Chromaffin cell survival from both young and old donors is enhanced by cografts of polymer-encapsulated human NGF-secreting cells. Neuroreport. 7:1996;1813-1818.
26. I. Date, T. Ohmoto, Neural transplantation for Parkinson's disease, Cell. Mol. Neurobiol.
27. Doering L. C. Peripheral nerve segments promote consistent long term survival of adrenal medulla transplants in the brain. Exp. Neurol. 118:1992;253-260.
28. Emerich D. F., Winn S. R., Christenson L., Palmatier M., Gentile F. T., Sanberg P. R. A novel approach to neural transplantation in Parkinson's disease: Use of polymer-encapsulated cell therapy. Neurosci. Biobehav. Rev. 16:1992;437-447.
29. Emerich D. F., Frydel B. R., Flanagan T. R., Palmitier M., Winn S. R., Christenson L. Transplantation of polymer encapsulated PC12 cells: use of chitosan as an immobilization matrix. Cell Transplant. 2:1993;241-249.
30. Emerich D. F., Winn S. R., Harper J., Hammang J. P., Baetge E. E., Kordower J. H. Implants of polymer-encapsulated human NGF-secreting cells in the nonhuman primate: Rescue and sprouting of degenerating cholinergic basal forebrain neurons. J. Comp. Neurol. 349:1994;148-164.
31. Kordower J. H., Fiandaca M. S., Notter M. F. D., Hansen J. T., Gash D. M. NGF-like trophic support from peripheral nerve for grafted rhesus adrenal chromaffin cells. J. Neurosurg. 73:1990;418-428.
32. Kordower J. H., Winn S. R., Liu Y. T., Mufson E. J., Sladek J. R. J., Hammang J. P., Baetge E. E., Emerich D. F. The aged monkey basal forebrain: Rescue and sprouting of axotomized basal forebrain neurons following grafts of encapsulated human NGF-secreting cells. Proc. Natl. Acad. Sci. USA. 91:1994;10898-10902.
33. Lindner M. D., Winn S. R., Baetge E. E., Hammang J. P., Gentile F. T., Doherty E., McDermott P. E., Frydel B., Ullman M. D., Schallert T. Implantation of encapsulated catecholamine and GDNF-producing cells in rats with unilateral dopamine depletions and parkinsonian symptoms. Exp. Neurol. 132:1995;62-76.
34. Miyoshi Y., Date I., Ohmoto T., Iwata H. Histological analysis of microencapsulated dopamine-secreting cells in agarose/poly(styrene sulfonic acid) mixed gel xenotransplanted into the brain. Exp. Neurol. 138:1996;169-175.
35. Olson L., Backlund E.-O., Ebendal T., Freedman R., Hamberger B., Hansson P., Hoffer B., Lindblom U., Meyerson B., Stromberg I., Sydou O., Seiger A. Intraputaminal infusion of nerve growth factor to support adrenal medullary autografts in Parkinson's disease. Arch. Neurol. 48:1991;373-381.
36. Springer J. Nerve growth factor receptors in the central nervous system. Exp. Neurol. 102:1988;354-365.
37. Stromberg I., Herrera-Marschitz M., Ungerstedt U., Ebendal T., Olson L. Chronic implants of chromaffin tissue into the dopamine-denervated striatum. Effects of NGF on graft survival, fiber growth and rotational behavior. Exp. Brain Res. 60:1985;335-349.
38. Unsicker K., Krisch B., Otten U., Thoenen H. Nerve growth factor-induced fiber outgrowth from isolated rat adrenal chromaffin cells: Impairment by glucocorticoids. Proc. Natl. Acad. Sci. USA. 75:1978;3498-3502.
39. Unsicker K. The trophic cocktail made by adrenal chromaffin cells. Exp. Neurol. 123:1993;167-173.
40. Winn S. R., Hammang J. P., Emerich D. F., Lee A., Palmiter R. D., Baetge E. E. Polymer-encapsulated cells genetically modified to secrete human nerve growth factor promote the survival of axotomized septal cholinergic neurons. Proc. Natl. Acad. Sci. USA. 91:1994;2324-2328.
41. Winn S. R., Lindner M. D., Lee A., Haggett G., Francis J. M., Emerich D. F. Polymer-encapsulated genetically modified cells continue to secrete human nerve growth factor for over one year in rat ventricles: Behavioral and anatomical consequences. Exp. Neurol. 140:1996;126-138.