Effects of fractionated 5-aminolevulinic acid administration on tissue levels of protoporphyrin in vivo

Journal of Photochemistry and Photobiology B: Biology

Volumn 40, Issue 2, 1997, Pages 107-110

  Herman, Mark A ^a   Webber, John ^a   Luo, Yu ^a   Patacsil, Veronique ^a   Kessel, David ^a   Fromm, David ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

5 Aminolevulinic acid (ALA); Photodynamic therapy (PDT); Protoporphyrin IX (PP)

Indexed keywords

AMINOLEVULINIC ACID; PROTOPORPHYRIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLON; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG TISSUE LEVEL; FEMALE; INTRAVENOUS DRUG ADMINISTRATION; KIDNEY; LIVER; MOUSE; NONHUMAN; PHOTODYNAMIC THERAPY; PLASMA; PRIORITY JOURNAL; SKELETAL MUSCLE; SKIN; TISSUE LEVEL; TUMOR; TUMOR XENOGRAFT;

AMINOLEVULINIC ACID; ANIMALS; ANTINEOPLASTIC AGENTS; COLONIC NEOPLASMS; FEMALE; MICE; PHOTOSENSITIZING AGENTS; PRODRUGS; PROTOPORPHYRINS;

EID: 0031234427     PISSN: 10111344     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1011-1344(97)00033-X     Document Type: Article

References (24)

1. [1] J. Moan, K. Berg, Photochemotherapy of cancer: experimental research, Photochem. Photobiol. 55 (1992) 938-948.
2. [2] B.W. Henderson, T.J. Dougherty, How does photodynamic therapy work?, Photochem. Photobiol. 55 (1992) 145-157.
3. [3] J.C. Kennedy, R.H. Pottier, Endogenous protoporphyrin IX, a clinically useful photosensitizer for photodynamic therapy, J. Photochem. Photobiol. B: Biol. 14 (1992) 275-292.
4. [4] Z. Malik, H. Lugaci, Destruction of erythroleukaemic cells by photoactivation of endogenous porphyrins, Br. J. Cancer 56 (1987) 589-595.
5. [5] Z. Malik, B. Ehrenberg, A. Faraggi, Inactivation of erythrocytic, lymphocytic, and myelocytic leukemic cells by photoexcitation of endogenous porphyrins, J. Photochem. Photobiol. B: Biol. 4 (1989) 195-205.
6. [6] J.C. Kennedy, R.H. Pottier, Using d-aminolevulinic acid in cancer therapy, ACS Symp. Ser. 559 (1994) 291-302.
7. [7] H.A. Dailey, A. Smith, Differential interaction of porphyrins used in photoradiation therapy with ferrochelatase, Biochem. J. 223 (1984) 441-445.
8. [8] N. Schoenfeld, O. Epstein, M. Lahav, R. Mamet, M. Shaklai, A. Atsmon, The heme biosynthetic pathway in lymphocytes of patients with malignant lymphoproliferative disorders, Cancer Lett. 43 (1988) 43-48.
9. [9] M.M.H. El-Sharabasy, A.M. El-Waseef, M.M. Hafez, S.A. Salim, Porphyrin metabolism in some malignant diseases, Br. J. Cancer 65 (1992) 409-412.
10. [10] J.H.P. Wilson, R. van Hillegersberg, J.W.O. van der Berg, W.J. Kort, O.T. Terpstra, Photodynamic therapy for gastrointestinal tumors, Scand. J. Gastroenterol. 26 (Suppl. 188) (1991) 20-25.
11. [11] Q. Peng, J. Moan, T. Warloe, J.M. Nesland, C. Rimington, Distribution and photosensitizing effect of porphyrins induced by application of exogenous 5-aminolevulinic acid in mice bearing mammary carcinoma, Int. J. Cancer 52 (1992) 433-443.
12. [12] J. Regula, B. Ravi, J. Bedwell, A.J. MacRobert, S.G. Brown, Photodynamic therapy using 5-aminolevulinic acid for experimental pancreatic cancer - prolonged animal survival, Br. J. Cancer 70 (1994) 248-254.
13. [13] J. Webber, D. Kessel, D. Fromm, Side effects and photosensitization of human tissues after aminolevulinic acid, J. Surg. Res. 68 (1997) 31-37.
14. [14] D.X.G. Divaris, J.C. Kennedy, R.H. Pottier, Phototoxic damage to sebaceous glands and hair follicles of mice after systemic administration of 5-aminolevulinic acid correlates with localized protoporphyrin IX fluorescence, Am. J. Pathol. 136 (1990) 891-897.
15. [15] C.S. Loh, J. Bedwell, A.J. MacRobert, N. Krasner, D. Phillips, S.G. Brown, Photodynamic therapy of the normal rat stomach: a comparative study between disulfonated aluminum phthalocyanine and 5-aminolevulinic acid, Br. J. Cancer 66 (1992) 452-462.
16. [16] J. Bedwell, A.J. MacRobert, D. Phillips, S.G. Brown, Fluorescence distribution and photodynamic effect of ALA-induced PPIX in the DMH rat colonic tumour model, Br. J. Cancer 65 (1992) 818-824.
17. [17] R. van Hillegersberg, J.W.O. van den Berg, W.J. Kort, O.T. Terpstra, J.H.P. Wilson, Selective accumulation of endogenously produced porphyrins in a liver metastasis model in rats, Gastroenterology 103 (1992) 647-651.
18. [18] Z. Hua, S.L. Gibson, T.H. Foster, R. Hilf, Effectiveness of d-aminolevulinic acid-induced protoporphyrin as a photosensitizer for photodynamic therapy in vivo, Cancer Res. 55 (1995) 1723-1731.
19. [19] S. Iinuma, R. Bachor, T. Flotte, T. Hasan, Biodistribution and phototoxicity of 5-aminolevulinic acid-induced PpIX in an orthotopic rat bladder tumor model, J. Urol. 153 (1995) 802-806.
20. [20] P. Mlkvy, H. Messman, J. Regula, H. Conio, M. Pauer, C.E. Millson, A.J. MacRobert, S.G. Brown, Sensitization and photodynamic therapy (PDT) of gastrointestinal tumors with 5-aminolaevulinic acid (ALA) induced protoporphyrin IX (PPIX). A pilot study, Neoplasma 42 (1995) 109-113.
21. [21] P. Mustajoki, K. Timonen, A. Gorchein, A. Seppalainen, E. Matikainen, R. Tenhunen, Sustained high plasma 5-aminolevulinic acid concentration in a volunteer: no porphyric symptoms, Eur. J. Clin. Invest. 22 (1992) 407-411.
22. [22] J. Regula, A.J. MacRobert, A. Gorchein, G.A. Buonaccursi, S.M. Thorpe, G.M. Spencer, A.R. Hatfield, S.G. Brown, Photosensitisation and photodynamic therapy of oesophageal, duodenal, and colorectal tumours using 5-aminolaevulinic acid induced protoporphyrin IX - a pilot study, Gut 36 (1995) 67-75.
23. 15N, Biochem. J. 64 (1956) 80-90.
24. 14C, Biochem. J. 64 (1956) 90-100.