Osteochondrodysplasia Occurring in Transgenic Mice Expressing Interferon-γ

Veterinary Pathology

Volumn 34, Issue 5, 1997, Pages 431-441

  Nii, A ^a,b   Reynolds, D A ^a   Young, H A ^a   Ward, J M ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b ASTELLAS PHARMA INC   (Japan)

Author keywords

Bone resorption; Cartilage; Collagen; Cytokines; Interferon ; Osteochondrodysplasia; Osteoclast; Osteogenesis imperfecta; Transgenic mice

Indexed keywords

MURINAE; MUS MUSCULUS;

ACID PHOSPHATASE; ACID PHOSPHATASE TARTRATE RESISTANT ISOENZYME; COLLAGEN; DIFFERENTIATION ANTIGEN; GALECTIN 3; GAMMA INTERFERON; ISOENZYME; TARTRATE-RESISTANT ACID PHOSPHATASE;

ANIMAL; ANIMAL DISEASE; ARTICLE; BONE; BONE MARROW; CHEMISTRY; CHONDRODYSPLASIA; DISEASE MODEL; ELECTRON MICROSCOPY; FEMALE; GENE EXPRESSION REGULATION; GENETICS; GROWTH PLATE; IMMUNOHISTOCHEMISTRY; INCIDENCE; MALE; METABOLISM; METHODOLOGY; MOUSE; OSTEOCLAST; PATHOLOGY; RADIOGRAPHY; THYMUS; TRANSGENIC MOUSE; ULTRASTRUCTURE;

ACID PHOSPHATASE; ANIMALS; ANTIGENS, DIFFERENTIATION; BONE AND BONES; BONE MARROW; COLLAGEN; DISEASE MODELS, ANIMAL; FEMALE; GALECTIN 3; GENE EXPRESSION REGULATION; GROWTH PLATE; IMMUNOHISTOCHEMISTRY; INCIDENCE; INTERFERON TYPE II; ISOENZYMES; MALE; MICE; MICE, TRANSGENIC; MICROSCOPY, ELECTRON; OSTEOCHONDRODYSPLASIAS; OSTEOCLASTS; THYMUS GLAND;

EID: 0031230904     PISSN: 03009858     EISSN: None     Source Type: Journal    
DOI: 10.1177/030098589703400507     Document Type: Article

References (47)

1. Anderson GN, Marks SC Jr: Tartrate-resistant acid ATP-ase as a cytochemical marker for osteoclasts. J Histochem Cytochem 37:115-117, 1989
2. Barka T, Anderson PJ: Histochemical methods for acid phosphatase using hexazonium pararosanilin as coupler. J Histochem Cytochem 10:741-753, 1962
3. Bateman JF, Chan D, Mascara T, Rogers JG, Cole WG: Collagen defects in lethal perinatal osteogenesis imperfecta. Biochem J 240:699-708, 1986
4. Bonadio J, Saunders TL, Tsai E, Goldstein SA, Morris-Wiman J, Brinkley L, Dolan D, Altschuler RA, Hawkins JE Jr, Bateman JF, Mascara T, Jaenisch R: Transgenic mouse model of the mild dominant form of osteogenesis imperfecta. Proc Natl Acad Sci USA 87:7145-7149, 1990
5. Centrella M, McCarthy TL, Canalis E: Growth factors and cytokines. In: Bone, Volume 3, Bone Metabolism and Mineralization, ed. Hall BK, pp. 47-72. CRC Press, Boca Raton, FL, 1992
6. Cherayil BJ, Weiner SJ, Pillai S: The Mac-2 antigen is a galactose-specific lectin that binds IgE. J Exp Med 170:1959-1972, 1989
7. Chipman ST, Sweet HO, McBride DJ Jr, Davisson MT, Marks SC Jr, Shuldiner AR, Wenstrup RJ, Rowe DW. Shapiro JR: Defective proα2(I) collagen synthesis in a recessive mutation in mice: a model of human osteogenesis imperfecta. Proc Natl Acad Sci USA 90:1701-1705, 1993
8. Cole WG: Osteogenesis imperfecta as a consequence of naturally occurring and induced mutations of type I collagen. In: Bone and Mineral Research/8, ed. Heersche JNM and Kanis JA, pp. 167-204. Elsevier Science BV, Amsterdam, The Netherlands, 1994
9. Egwuagu CE, Sztein JS, Chan C-C, Reid W, Mahdi R, Nussenblatt RB, Chepelinsky AB: Ectopic expression of gamma interferon in the eyes of transgenic mice induces ocular pathology and MHC class II gene expression. Invest Ophthalmol Vis Sci 35:332-341, 1994
10. 3, and interleukin 1 in fetal mouse forearm bones. Calcif Tissue Int 47:178-182, 1990
11. 1-chain gene. Proc Natl Acad Sci USA 88:9648-9652, 1991
12. Gehron Robey P, Termine JD: Biochemical markers of metabolic bone disease. In: Metabolic Bone Disease and Clinically Related Disorders, ed. Avioli LV and Krane SM, 2nd ed., pp. 244-263. WB Saunders, Philadelphia, PA, 1990
13. Goldering MB, Goldering S: Skeletal tissue response to cytokines. Clin Orthop 258:245-278, 1990
14. Goldring MB, Sandell LJ, Stephenson ML, Krane SM: Immune interferon suppresses levels of procollagen mRNA and type II collagen synthesis in cultured human articular and costal chondrocytes. J Biol Chem 261:9049-9056, 1986
15. Gowen M, Nedwin GE, Mundy GR: Preferential inhibition of cytokine-stimulated bone resorption by recombinant interferon gamma. J Bone Min Res 1:469-474, 1986
16. Granstein RD, Murphy GF, Margolis RJ, Byrne MH, Amento EP: Gamma-interferon inhibits collagen synthesis in vivo in the mouse. J Clin Invest 79:1254-1258, 1987
17. Hoffmann O, Klaushofer K, Gleispach H, Leis HJ, Luger T, Koller K, Peterlik M: Gamma interferon inhibits basal and interleukin 1-induced prostaglandin production and bone resorption in neonatal mouse calvaria. Biochem Biophys Res Commun 143:38-43, 1987
18. Ijzermans JNM, Marquet RL: Interferon-gamma: a review. Immunobiol 179:456-473, 1989
19. Iwakura Y, Hayashi M, Asano M: Transgenic mice carrying interferon genes. Mol Reprod Develo 36:245-247, 1993
20. Jonsson R, Tarkowski A, Klareskog L: A demineralization procedure for immunohistopathological use: EDTA treatment preserves lymphoid cell surface antigens. J Immunol Meth 88:109-114, 1986
21. Kuivaniemi H, Tromp G, Prockop DJ: Mutations in collagen genes: causes of rare and some common diseases in humans. FASEB J 5:2052-2060, 1991
22. Lewis DB, Liggitt HD, Effmann EL, Motley TM, Teitelbaum SL, Jepsen KJ, Goldstein SA, Bonadio J, Carpenter J, Perlmutter RM: Osteoporosis induced in mice by overproduction of interleukin 4. Proc Natl Acad Sci USA 90:11618-11622, 1993
23. Marks SC Jr, Popoff S: Bone cell biology: the regulation of development, structure, and function in the skeleton. Am J Anat 183:1-44, 1988
24. Minkin C: Bone acid phosphatase: tartrate-resistant acid phosphatase as a marker of osteoclast function. Calcif Tiss Int 34:285-290, 1982
25. Mundy GR: Cytokines of bone. In: Physiology and Pharmacology of Bone. Handbook of Experimental Pharmacology, ed. Mundy GR and Martin TJ, pp. 185-214. Springer, New York, NY, 1993
26. Niida S, Amizuka N, Hara F, Ozawa H, Kodama H: Expression of Mac-2 antigen in the preosteoclast and osteoclast identified in the op/op mouse injected with macrophage colony-stimulating factor. J Bone Min Res 9:873-881, 1994
27. Pereira R, Khillan JS, Helminen HJ, Hume EL, Prockop DJ: Transgenic mice expressing a partially deleted gene for type I procollagen (COL1A1): a breeding line with a phenotype of spontaneous fractures and decreased bone collagen and mineral. J Clin Invest 91:709-716, 1993
28. Peterlik M, Hoffmann O, Swetly P, Klaushofer K, Koller K: Recombinant γ-interferon inhibits prostaglandin-mediated and parathyroid hormone-induced bone resorption in cultured neonatal mouse calvaria. FEBS Lett 185:287-290, 1985
29. Rimoin DL, Lachman RS: The chondrodysplasias. In: Principles and Practice of Medical Genetics, vol. 2, ed. Emery AEH and Rimoin DL, pp. 703-735. Churchill Livingstone, London, UK, 1983
30. Rowe DW: Osteogenesis imperfecta. In: Bone and Mineral Research/7, ed. Heersche JNM and Kanis JA, pp. 209-241. Elsevier Science Publishers BV, Amsterdam, The Netherlands, 1990
31. Rowe DW, Shapiro JR: Osteogenesis imperfecta. In: Metabolic Bone Disease and Clinically Related Disorders, ed. Avioli LV and Krane SM, 2nd ed., pp. 659-701. WB Saunders, Philadelphia, PA, 1990
32. Sarvetnick N, Liggitt D, Pitts SL, Hansen SE, Stewart TA: Insulin-dependent diabetes mellitus induced in transgenic mice by ectopic expression of class II MHC and interferon-gamma. Cell 52:773-782, 1988
33. Sato K, Satoh T, Shizume K, Yamakawa Y, Ono Y, Demura H, Akatsu T, Takahashi N, Suda T: Prolonged decrease of serum calcium concentration by murine γ-interferon in hypercalcemic, human tumor (EC-GI)-bearing nude mice. Cancer Res 52:444-449, 1992
34. Shioi A, Teitelbaum SL, Ross FP, Welgus HG, Suzuki H, Ohara J, Lacey DL: Interleukin 4 inhibits murine osteoclast formation in vitro. J Cell Biochem 47:272-277, 1991
35. Smith DD, Gowen M, Mundy GR: Effect of interferon-γ and other cytokines on collagen synthesis in fetal rat bone cultures. Endocrinology 120:2494-2499, 1987
36. Stacy A, Bateman J, Choi T, Mascara T, Cole W, Jaenisch R: Perinatal lethal osteogenesis imperfecta in transgenic mice bearing an engineered mutant pro-α1(I) collagen gene. Nature 332:131-136, 1988
37. Stephenson ML, Krane SM, Amento EP, McMroskery PA, Byrne M: Immune interferon inhibits collagen synthesis by rheumatoid synovial cells and associated with decreased levels of the procollagen mRNAs. FEBS Lett 180:43-50, 1985
38. Takahashi N, Mundy G, Roodman GD: Recombinant human interferon-γ inhibits formation of human osteoclast-like cells. J Immunol 137:3544-3549, 1986
39. Thomas JT, Ayad S, Grant ME: Cartilage collagens: strategies for the study of their organization and expression in the extracellular matrix. Ann Rheumat Dis 53:488-496, 1994
40. Tilstra DJ, Byers PH: Molecular basis of hereditary disorders of connective tissue. Annu Rev Med 45:149-163, 1994
41. Toyonaga T, Hino O, Sugai S, Wakasugi S, Abe K, Shichiri M, Yamamura K: Chronic active hepatitis in transgenic mice expressing interferon-γ in the liver. Proc Natl Acad Sci USA 91:614-618, 1994
42. Trinchieri G, Perussia B: Immune interferon: a pleiotropic lymphokine with multiple effects. Immunol Today 6:131-136, 1985
43. Vandenberg P, Khillan JS, Prockop DJ, Helminen H, Kontusaari S, Ala-Kokko L: Expression of a partially deleted gene of human type II procollagen (COL2A1) in transgenic mice produces a chondrodysplasia. Proc Natl Acad Sci USA 88:7640-7644, 1991
44. van der Rest M: The collagens of bone. In: Bone, Volume 3, Bone Matrix and Bone Specific Products, ed. Hall BK pp. 187-237. CRC Press, Boca Raton, FL, 1991
45. Vikkula M, Metsäranta M, Ala-Kokko L: Type II collagen mutations in rare and common cartilage diseases. Ann Med 26:107-114, 1994
46. Watanabe K, Tanaka Y, Morimoto I, Yahata K, Zeki K, Fujihira T, Yamashita U, Eto S: Interleukin-4 as a potent inhibitor of bone resorption. Biochem Biophys Res Commun 172:1035-1041, 1990
47. Young HA, Klinman DM, Reynolds DA, Grzegorzewski KJ, Nii A, Ward JM, Winkler-Pickett RT, Ortaldo JR, Kenny JJ, Komschlies KL: Bone marrow and thymus expression of interferon-γ results in severe B-cell lineage reduction, T-cell lineage alterations and hematopoietic progenitor deficiencies. Blood 89:583-595, 1997