RU486 inhibits synthesis of an endogenous inhibitor of cell arachidonate release from choriodecidua tissue

Molecular Human Reproduction

Volumn 3, Issue 9, 1997, Pages 743-747

  Schuster Woldan, N ^a   Hilton, M ^a   Wilson, T ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

Gravidin; Mifepristone; Phospholipase; RU486; Secretory component

Indexed keywords

ARACHIDONIC ACID; CYCLOHEXIMIDE; DACTINOMYCIN; ENZYME INHIBITOR; GLUCOCORTICOID; GRAVIDIN; HORMONE ANTAGONIST; MIFEPRISTONE; PLACENTA PROTEIN; PROGESTERONE;

ADULT; ARTICLE; BIOSYNTHESIS; CHORION; DECIDUA; DRUG ANTAGONISM; DRUG EFFECT; FEMALE; HUMAN; METABOLISM; PLACENTA; PREGNANCY; SECRETION; WESTERN BLOTTING;

ADULT; ARACHIDONIC ACID; BLOTTING, WESTERN; CHORION; CYCLOHEXIMIDE; DACTINOMYCIN; DECIDUA; ENZYME INHIBITORS; FEMALE; GLUCOCORTICOIDS; HORMONE ANTAGONISTS; HUMANS; MIFEPRISTONE; PLACENTA; PREGNANCY; PREGNANCY PROTEINS; PROGESTERONE;

EID: 0031230419     PISSN: 13609947     EISSN: None     Source Type: Journal    
DOI: 10.1093/molehr/3.9.743     Document Type: Article

References (18)

1. Avrech, O.M., Golan A., Weinraub, Z. et al. (1991) Mifepristone (RU-486) alone or in combination with a prostaglandin analogue for termination of early pregnancy: a review. Fertil. Steril., 56, 385-393.
2. Bradford, M.M. (1976) A rapid method for the quantification of microgram quantities of protein utilising the principle of protein-dye binding. Anal.Biochem., 72, 248-254.
3. Casey, M.L and MacDonald, P.C. (1988) Biomolecular processes in theinitiation of parturition decidual activation. Clin. Obstet. Gynecol., 31,533-552.
4. Cheng, L., Kelly, R.W., Thong, K.J. et al. (1993) The effects of mifepristone (RU-486) on prostaglandin dehydrogenase in decidual and chorionic tissuein early pregnancy. Hum. Reprod., 8, 705-709.
5. Cleveland, M.G., Bakos, M.A., Pyron, D.L. et al. (1991) Characterisation of secretory component in amniotic fluid. J Immunol., 147, 181-188.
6. Haluska, G.J., Kaler, C.A., Cook, M.J. and Novy, M.J. (1994) Prostaglandin production during spontaneous labor and after treatment with RU486 in pregnant rhesus macaques. Biol. Reprod., 51, 760-765.
7. Heikinheimo, O., Ylikorkala, O., Turpeinen, U. and Lahteenmaki, P. (1990) Pharmakokinetics of the anti progesterone RU 486. no correlation to clinical performance of RU 486. Acta Endocrinol , 123, 298-304.
8. Kelly, R.W. (1992) Mechanism of action of antiprogestins. Rec. Adv. Endocrinol. Metab., 4, 67-81.
9. Kelly, R.W. and Bukman, A. (1990) Antiprogestagenic inhibition of uterine prostaglandin inactivation: a permissive mechanism for uterine stimulation. J. Steroid Biochem. Mol. Biol., 37, 97-101.
10. Laemmli, U.K (1970), Cleavage of structural proteins during the assembly of the head of bactenophage T4. Nature, 222, 680-685
11. 2. Gen. Pharmacol., 24, 1311-1318.
12. Wilson, T. (1993b) Raised serum gravidin levels are associated with pregnancy-induced hypertension. Am. J. Perinatol., 10, 168-171.
13. 2 activity, is a secretory component of IgA. Biochem. Biophys. Res. Commun., 176, 447-452.
14. Wilson, T. and Ganendren, R (1992) Serum concentrations of secretory IgA in pregnancies delivering at term or preterm. Prostaglandins, 44, 373-378.
15. Wilson, T., Liggins, G.C., Aimer, G.P. and Watkins, E.J. (1986) The effect of progesterone on the release of arachidonic acid from human endometnal cells stimulated by histamine. Prostaglandins, 31, 343-360.
16. Wilson, T., Liggins, G.C. and Joe, L. (1989) Purification and characterisation of a uterine phospholipase inhibitor that loses activity after labor onset in women. Am. J. Obstet. Gynecol., 160, 602-606.
17. Wilson, T., Ralph, R.K. and Ganendren, R. (1992) Decreased inhibition by gravidin of arachidonate release from transformed compared to nontransformed cells. Br. J. Pharmacol., 105, 311-314.
18. Wilson, T., Thong, K.J. and Howie, P.W. (1994) Decrease in human plasma gravidin levels after medical abortion. Prostaglandins, 48, 175-183.