Effects of intracerebroventricular infusion of leptin in obese zucker rats

Obesity Research

Volumn 5, Issue 5, 1997, Pages 387-394

  Al Barazanji, Kamal A ^a   Buckingham, Robin E ^a   Arch, Jonathan R S ^a   Haynes, Andrea ^a   Mossakowska, Danuta E ^a   McBay, Diane L ^a   Holmes, Stephen D ^a   McHale, Mark T ^a   Wang, Xin Min ^a   Gloger, Israel S ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

BAT temperature; Blood glucose; Food intake; Plasma hormones; Plasma triglycerides

Indexed keywords

CORTICOSTERONE; INSULIN; LEPTIN; PROTEIN; RECOMBINANT PROTEIN; TRIACYLGLYCEROL;

ANIMAL; ARTICLE; BLOOD; BODY TEMPERATURE; BODY WEIGHT; BRAIN; BROWN ADIPOSE TISSUE; DRUG EFFECT; EATING; ENERGY METABOLISM; GLUCOSE BLOOD LEVEL; INFUSION PUMP; MALE; METABOLISM; MOUSE; OBESITY; PATHOPHYSIOLOGY; RAT; ZUCKER RAT;

ADIPOSE TISSUE, BROWN; ANIMALS; BLOOD GLUCOSE; BODY TEMPERATURE; BODY WEIGHT; BRAIN; CORTICOSTERONE; EATING; ENERGY METABOLISM; INFUSION PUMPS, IMPLANTABLE; INSULIN; LEPTIN; MALE; MICE; OBESITY; PROTEINS; RATS; RATS, ZUCKER; RECOMBINANT PROTEINS; TRIGLYCERIDES;

EID: 0031226662     PISSN: 10717323     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1550-8528.1997.tb00660.x     Document Type: Article

References (10)

1. Ahima RS, Prabakaran D, Mantzoros C, et al. Role of leptin in the neuroendocrine response to fasting. Nature. 1996;382:250-252.
2. Arch JRS, Ainsworth AT. Thermogenic and antiobesity activity of a novel β-adrenoceptor agonist (BRL 26830A) in mice and rats. Am J Clin Nutr. 1983;38:549-558.
3. Banks WA, Kastin AJ, Huang W, Jaspan JB, Maness LM. Leptin enters the brain by a saturable system independent of insulin. Peptides. 1996;17:305-311.
4. Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P. Recombinant mouse ob protein: Evidence for a peripheral signal linking adiposity and central neural networks. Science. 1995;269:546-549.
5. Chen H, Charlat O, Tartaglia LA, et al. Evidence that the diabetes gene encodes the leptin receptor: Identification of a mutation in the leptin receptor gene in db/db mice. Cell. 1996;84:491-495.
6. Chua SC, White DW, Wu-Peng XS, et al. Phenotype of fatty due to Gln269Pro mutation in the leptin receptor (Lepr). Diabetes. 1996;45:1141-1143.
7. Coleman DL. Effects of parabiosis of obese with diabetes and normal mice. Diabetologia. 1973;9:294-298.
8. Cusin I, Rohner-Jeanrenaud F, Stricker-Krongard A, Jeanrenaud B. The weight-reducing effect of an intracerebroventricular bolus injection of leptin in genetically obese fa/fa rats. Diabetes. 1996;45:1446-1450.
9. Cusin I, Sainsbury A, Doyle P, Rohner-Jeanrenaud F, Jeanrenaud B. A relationship leading to clues to the understanding of obesity. Diabetes. 1995;44:1467-1470.
10. De Vos P, Saladin R, Auwerx J, Staels B. Induction of ob gene expression by corticosteroids is accompanied by body weight loss and reduced food intake. J Biol Chem. 1995;270:15958-15961.