CD28-induced cytokine production and proliferation by thymocytes are differentially regulated by the p59fyn tyrosine kinase

Journal of Immunology

Volumn 159, Issue 5, 1997, Pages 2169-2176

  Ong, Christopher J ^a   Lim, Andrew S P ^a   Teh, Hung Sia ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN; FYN PROTEIN, MOUSE; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; LYMPHOCYTE ANTIGEN RECEPTOR; MONOCLONAL ANTIBODY; ONCOPROTEIN; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE FYN;

ANIMAL; ANTIBODY SPECIFICITY; ARTICLE; BIOSYNTHESIS; CELL CULTURE; CELL DIVISION; COMPARATIVE STUDY; CYTOLOGY; DRUG EFFECT; FEMALE; GENETICS; IMMUNOLOGY; LYMPH NODE; LYMPHOCYTE ACTIVATION; MALE; MOUSE; MOUSE MUTANT; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN PROCESSING; SIGNAL TRANSDUCTION; T LYMPHOCYTE; THYMUS; TRANSGENIC MOUSE;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD28; CELL DIVISION; CELLS, CULTURED; FEMALE; INTERLEUKIN-2; LYMPH NODES; LYMPHOCYTE ACTIVATION; MALE; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; ORGAN SPECIFICITY; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-FYN; RECEPTORS, ANTIGEN, T-CELL; RECEPTORS, INTERLEUKIN-2; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TETRADECANOYLPHORBOL ACETATE; THYMUS GLAND;

EID: 0031225512     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Bretscher, P., and M. Cohn. 1970. A theory of self-nonself discrimination. Science 169:1042.
2. Linsley, P. S., and J. A. Ledbetter. 1993. The role of the CD28 receptor during T cell responses to antigen. Annu. Rev. Immunol. 11:191.
3. Schwartz, R. H. 1992. Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy. Cell 71:1065.
4. Jenkins, M. K., and R. H. Schwartz. 1987. Antigen presentation by chemically modified splenocytes induces antigen specific T cell unresponsiveness in vitro and in vivo. J. Exp. Med. 165:302.
5. Jenkins, M. H., J. D. Ashwell, and R. H. Schwartz. 1988. Allogeneic non-T spleen cells restore the responsiveness of normal T cell clones stimulated with antigen and chemically modified antigen-presenting cells. J. Immunol. 140:3324.
6. Mueller, D. L., M. K. Jenkins, and R. H. Schwartz. 1989. Clonal expansion versus functional clonal inactivation: a costimulatory signalling pathway determines the outcome of T cell antigen receptor occupancy. Annu. Rev. Immunol. 7:445.
7. Lafferty, K. J., and R. G. Gill. 1993. The maintenance of self tolerance. Immunol. Cell Biol. 71:209.
8. Harding, F. A., J. G. McArthur, J. A. Gross, D. H. Raulet, and J. P. Allison. 1992. CD28-mediated signaling co-stimulates murine T cells and prevents induction of anergy in T cell clones. Nature 356:607.
9. Jenkins, M. H., P. S. Taylor, S. D. Norton, and K. B. Urdahl. 1991. CD28 delivers a costimulatory signal involved in antigen-specific IL-2 production by human T cells. J. Immunol. 147:2461.
10. Linsley, P. S., E. A. Clark, and J. A. Ledbetter. 1990. T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB1. Proc. Natl. Acad. Sci. USA 87:5031.
11. Freeman, G. J., F. Borriello, R. J. Hodes, H. Reiser, K. S. Hathcock, G. Laszlo, A. J. McKnight, J. Kim, L. Du, L. A. Lombard, G. S. Gray, L. M. Nadler, and A. H. Sharpe. 1993. Uncovering the functional alternative CTLA-4 counter-receptor in B7-deficient mice. Science 262:907.
12. Freeman, G. J., F. Borriello, R. J. Hodes, H. Reiser, J. G. Gribben, J. W. Ng, J. Kim, J. M. Goldberg, K. S. Hathcock, G. Laszlo, L. A. Lombard, S. Wang, G. S. Gray, L. M. Nadler, and A. H. Sharpe. 1993. Murine B7-2, an alternative CTLA-4 counter-receptor that costimulates T cell proliferation and Interleukin-2 production. J. Exp. Med. 178:2185.