A Brucella melitensis high-temperature-requirement A (htrA) deletion mutant is attenuated in goats and protects against abortion

Research in Veterinary Science

Volumn 63, Issue 2, 1997, Pages 165-167

  Phillips, R W ^a   Elzer, P H ^b   Robertson, G T ^a   Hagius, S D ^b   Walker, J V ^b   Fatemi, M B ^b   Enright, F M ^b   Roop II, R M ^a  

^a LOUISIANA STATE UNIV MEDICAL CENTER   (United States)

^b LOUISIANA STATE UNIVERSITY AGRICULTURAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; BACTERIAL VACCINE; BACTERIUM ANTIBODY; DEGP PROTEASE; HEAT SHOCK PROTEIN; LIVE VACCINE; PERIPLASMIC PROTEIN; SERINE PROTEINASE;

ANIMAL; ANIMAL DISEASE; ARTICLE; BLOOD; BRUCELLA MELITENSIS; BRUCELLOSIS; FEMALE; FETUS; GENE DELETION; GENETICS; GOAT; GOAT DISEASE; IMMUNOLOGY; MICROBIOLOGY; MUTATION; PATHOGENICITY; PATHOPHYSIOLOGY; PREGNANCY; PREGNANCY COMPLICATION; VETERINARY ABORTION; VIRULENCE;

ABORTION, VETERINARY; ANIMALS; ANTIBODIES, BACTERIAL; BACTERIAL PROTEINS; BACTERIAL VACCINES; BRUCELLA MELITENSIS; BRUCELLOSIS; FEMALE; FETUS; GENE DELETION; GOAT DISEASES; GOATS; HEAT-SHOCK PROTEINS; MUTATION; PERIPLASMIC PROTEINS; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; SERINE ENDOPEPTIDASES; VACCINES, ATTENUATED; VIRULENCE;

EID: 0031217345     PISSN: 00345288     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0034-5288(97)90012-6     Document Type: Article

References (18)

1. ALTON, G. G., JONES, L. M, & PIETZ, D. E. (1975) Laboratory Techniques in Brucellosis, Geneva, Switzerland, World Health Organization pp 64-124
2. ALTON, G. G. (1990) Brucella melitensis In Animal Brucellosis. Eds K. Nielsen and J. R. Duncan Boca Raton. Florida, CRC Press pp 383-410
3. BALDWIN, C L & WINTER, A. J. (1994) Macrophages and Brucella In Macrophage-Pathogen Interactions Eds B S. Zwilling and T. K. Eisenstein. New York, Marcel Dekker pp 363-380
4. BAUMLER, N. A., KUSTERS, J. G., STOJILJKOVIC, I. & HEFFRON, F. (1994) Salmonella typhimurium loci involved in survival within macrophages Infection and Immunity 62, 1623-1630
5. CORBEL, M. J. & BRINLEY-MORGAN, W. J. (1984) Brucella In Bergey's manual of systematic bacteriology Eds N R. Kneg and J G. Holt. Baltimore, Maryland, Wiliams and Wilkins. pp 377-388
6. DAVIES, K J. A. & LIN, S. W. (1988) Oxidatively denatured proteins are degraded by an ATP-independent proteolytic pathway in Escherichia coli. Free Radical Biology and Medicine 5, 225-236.
7. ELZER, P. H., PHILLIPS, R. W. KOVACH, M, E., PETERSON, K. M., & ROOP, R. M II (1994) Characterization and genetic complementation of Brucella abortus high-temperature A (htrA) deletion mutant. Infection and Immunity 62, 4135-4139
8. ELZER, P. H., ROBERTSON, G. T., PHILLIPS, R. W. & ROOP, R M II (1995) Evaluation of a Brucella abortus high-temperature-requirement A (htrA) deletion mutant in cultured murine macrophages. Abstracts of the 95th Annual Meeting of the American Society for Microbiology, p 224. Abstract B-336
9. ELZER, P. H., PHILLIPS, R. W. ROBERTSON, G T. AND R M. ROOP II. (1996a) The HtrA stress response protease contributes to resistance of Bmcella abortus to killing by murine phagocytes Infection and Immunity 64, 4838-4841
10. ELZER, P. H., HAGIUS, S. D , ROBERTSON, G. T., PHILLIPS, R. W., WALKER, J. V., FATEMI, M. B., ENRIGHT, F. M. & ROOP, R M. II. (1996b) Behavior of a high-temperature-requirement A (htrA) deletion mutant of Brucella abortus in goats Research in Veterinary Science 60, 48-50
11. ENRIGHT, F. M (1990) The pathogenesis and pathobiology of Brucella infection in domestic animals In Animal Brucellosis: Clinical and Laboratory Aspects, Eds. K H. Nielsen and J R Duncan, Boca Raton, Florida, CRC Press, pp 301-320
12. FARREL, I. D (1974) The development of a new selective medium for the isolation of Brucella abortus from contaminated sources. Research in Veterinary Science 16, 280-286
13. GORHAM, S L., ENRIGHT, F. M., SNIDER, T. G. III & ROBERTS, E. D. (1986) Morphological lesions in Brucella abortus infected ovine fetuses. Veterinary-Pathology 23, 331-332
14. JIANG, X., LEONARD, B , BENSON, R. & BALDWIN, C L (1993) Macrophage control of Brucella abortus: role of reactive oxygen intermediates and nitric oxide Cellular Immunology 151, 309-319
15. JOHNSON, K., CHARLES, I, DOUGAN, G., PICKARD, D., O'GAORA, P., COSTA, G , ALI, T., MILLER, I. & HORMAECHE, C. (1991) The role of a stress-response protein in Salmonella typhimurium virulence. Molecular Microbiology 5, 401-407
16. NICOLLETI, P. L (1989) Relationship between animal and human disease In Brucellosis: Clinical and Laboratory Aspects, Eds. K. H. Nielson and J R Duncan, Boca Raton, Florida, CRC Press, pp 41-52
17. PHILLIPS, R. W , ELZER, P. H. & ROOP, R. M. II. (1995) A Brucella mehtensis high-temperature-requirement A (htrA) deletion mutant demonstrates a stress response defective phenotype in vitro and transient attenuation in the BALB/c mouse model. Microbial Pathogenesis 19, 277-284
18. ROBERTSON, G. T , ELZER, P H & ROOP, R M II. (1996) In vitro and in vivo phenotypes resulting from deletion of the high-temperature-requirement A (htrA) gene from the bovine vaccine strain Brucella abortus S19. Veterinary Microbiology 49, 197-207