Abnormal G1 Arrest in the Cell Lines from LEC Strain Rats after X-Irradiation

Journal of Veterinary Medical Science

Volumn 59, Issue 9, 1997, Pages 769-773

  Hayashi, Masanobu ^a   Uehara, Kazuhisa ^a   Kirisawa, Rikio ^a   Endoh, Daiji ^b   Arai, Soichiro ^a   Okui, Toyo ^c  

^a RAKUNO GAKUEN UNIVERSITY   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

^c HOKKAIDO INSTITUTE OF PUBLIC HEALTH   (Japan)

Author keywords

Cell cycle; G1 arrest; LEC strain rat; p53 protein; X irradiation

Indexed keywords

DNA;

ANIMAL; ANIMAL DISEASE; ARTICLE; BIOSYNTHESIS; CELL CYCLE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; CELL DIVISION; CELL LINE; CYTOLOGY; FIBROBLAST; FLOW CYTOMETRY; LUNG; METABOLISM; RADIATION DOSE; RADIATION EXPOSURE; RAT; TIME;

ANIMALS; CELL CYCLE; CELL DIVISION; CELL LINE; DNA; FIBROBLASTS; FLOW CYTOMETRY; G1 PHASE; G2 PHASE; LUNG; RADIATION DOSAGE; RATS; S PHASE; TIME FACTORS;

EID: 0031216721     PISSN: 09167250     EISSN: None     Source Type: Journal    
DOI: 10.1292/jvms.59.769     Document Type: Article

References (28)

1. Arlett, C. F., Green, M. H. L., Priestley, A., Harcourt, S. A., and Mayne, L. V. 1988. Comparative human cellular radio sensitivity: I. The effect of SV40 transformation and immortalization on the gamma-irradiation survival of skin derived fibroblasts from normal individuals and from ataxia-telangiectasia patients and heterozygotes. Int. J. Radiat. Biol. 54: 911-928.
2. Blattner, C., Knebel, A., Radle-Pohl, A., Sachsenmaier, C., Herrlich, P., and Rahmsdorf, H. J. 1994. DNA damaging agents and growth factors induce changes in the program of expressed gene products through common routes. Environ. Mol. Mutagenesis 24: 3-10.
3. German, J. 1969. Chromosomal breakage syndromes. Birth Defects 5: 117-130.
4. Hayashi, M., Endoh, D., Kon, Y., Yamashita, T., Hashimoto, N., Sato, F., Kasai, N., and Namioka, S. 1992. Higher sensitivity of LEC strain rats in radiaiion-induced acute intestinal death. J. Vet. Med. Sci. 54: 269-273.
5. Hayashi, M., Endoh, D., Kon, Y., Yamashita, T., Sato, F., Kasai, N., and Namioka, S. 1993. Hypersensitivity of LEC strain rats in radiation-induced acute bone marrow death. J. Vet. Med. Sci 55: 13-18.
6. Hayashi, M., Okui, T., Endoh, D., Sato, F., Kasai, N., and Namioka, S. 1994. Radiation-hypersensitivity of LEC strain rats controlled by a single autosomal recessive gene. Mutat. Res. 314: 135-142.
7. Hayashi, M., Ishimori, K., Maeda, A., Watanabe, T., Arai, S., and Okui, T. 1996. Radioresistant DNA synthesis in fibroblast cell lines derived from LEC rats. Mutat. Res. 352: 117-121.
8. Hecht, F., Koeler, R. D., Rigas, D. A., Dahnke, G. S., Case, M. P., Eisdale, V., and Miller, R. W. 1966. Leukemia and lymphocytes in ataxia telangiectasia. Lancet 2: 1193.
9. Kastan, M. B., Onyekwere, O., Sidransky, D., Vogelstein, B., and Craig, R. W. 1991. Participation of p53 protein in the cellular response to DNA damage. Cancer Res. 51: 6304-6311.
10. Kastan, M. B., Zhan, Q., El-Deiry, W. S., Carrier, F., Jacks, T., Walsh, W. V., Plunkett, B. S., Vogelstein, B., and Fornace, J. Jr. 1992. A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell 71: 587-597.
11. Khanna, K. K. and Lavin, M. F. 1993. Ionizing radiation and UV induction of p53 protein by different pathways in ataxiatelangiectasia cells. Oncogene 8: 3307-3312.
12. Laderoute, M. L. 1996. Alterations in p53 do not correlate with radioresistant DNA synthesis. Anticancer Res. 16: 2825-2830.
13. Lane, D. P. and Crawford, L. V. 1979. T antigen is bound to a host protein in SV 40-transformed cells. Nature (Lond.) 278: 261-263.
14. Lu, X. and Lane, D. P. 1993. Differential induction of transcriptionally active p53 following UV or ionizing radiation: Defects in chromosome instability syndromes? Cell 75: 765-778.
15. Meyn, M. S. 1995. Ataxia-telangiectasia and cellular responses to DNA damage. Cancer Res. 55: 5991-6001.
16. Nelson, W. G. and Kastan, M. B. 1994. DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways. Mol. Cell. Biol. 14: 1815-1823.
17. Okui, T., Hayashi, M., Endoh, D., Sato, F., Kasai, N., Watanabe, T., and Namioka, S. 1994. A high frequency of induction of chromosome aberrations in the bone marrow cells of LEC strain rats by X-irradiation. Mutat. Res. Lett. 324: 165-169.
18. Painter, R. B. and Young, B. R. 1980. Radiosensitivity in ataxia-telangiectasia: a new explanation. Proc. Natl. Acad. Sci. U.S.A. 77: 7315-7317.
19. Paterson, M. C. and Smith, P. J. 1979. Ataxia-telangiectasia: an inherited human disorder involving hypersensitivity to ionizing radiation and related DNA-damaging chemicals. Annu. Rev. Genet. 13: 291-318.
20. Reed, E. B., Epstein, W. L., Border, W., and Sedgwick, R. 1966. Cutaneous manifestions of ataxia-telangiectasia. J. Am. Med. Assoc. 195: 746-753.
21. Rudolph, N. S. and Latt, S. A. 1989. Flow cytometric analysis of X-ray sensitivity in ataxia telangiectasia. Mutat. Res. 211: 31-41.
22. Sasaki, M., Yoshida, M. C., Kagamori, K., Takeichi, N., Kobayashi, H., Dempo, K., and Mori, M. 1985. Spontaneous hepatitis in an inbred strain of Long-Evans rats. Rat News Lett. 14: 4-6.
23. Savitsky, K., Bar-Shira, A., Gilad, S., Rotman, G., Ziv, Y., Vanagaite, L., Tagle, D. A., Smith, S., Uziel, T., Sfez, S., Ashkenazi, M., Pecker, I., Frydman, M., Harnik, R., Patanjali, S. R., Simmons, A., Clines, G. A., Satiel, A., Gatti, R. A., Cheesa, L., Sanal, O., Lavin, M. F., Jaspers, N. G. J., Malcolm, A., Taylor, R., Alertt, C. F., Miki, T., Weissman, S. M., Lovett, M., Collins, F. S., and Shiloh, Y. 1995. A single ataxia telangiectasia gene with a product similar to PI-3 kinase. Science 278: 1749-1753.
24. Swift, M. R., Reitnauer, P. J., Morrell, D., and Chase, C. L. 1987. Breast and other cancers in families with ataxia-telangiectasia. New. Engl. J. Med. 316: 1289-1294.
25. Taylor, A. R. M., Flude, E., Laher, B., Stancey, M., McKay, E., Watt, J., Green, S. H., and Harding, A. E. 1979. Variant forms of ataxia telangiectasia. J. Med. Genet. 24: 669-677.
26. Taylor, A. M. R., Metcalf, J. A., and McConville, C. 1989. Increased radiosensitivity and the basic defect in ataxia telangiectasia. Int. J. Radiat. Biol. 56: 677-684.
27. Uehara, K., Arai, S., Okui, T., and Hayashi, M. 1997. Resistance to UV-irradiation of DNA synthesis in fibroblast cell lines derived from LEC strain rats. J. Vet. Med. Sci. 59: 67-69.
28. Yoshida, M. C., Masuda, R., Sasaki, M., Takeichi, N., Kobayashi, H., Dempo, K., and Mort, M. 1987. New mutation causing hereditary hepatitis in the laboratory rat. J. Hered. 78: 361-365.