Different responses of non-ischemic and post-ischemic myocardium towards Ca2+ sensitization

Journal of Molecular and Cellular Cardiology

Volumn 29, Issue 8, 1997, Pages 2053-2066

  Korbmacher, Bernhard ^a   Sunderdiek, Ulrich ^b   Selcan, Gündez ^b   Arnold, Gunther ^b   Schipke, Jochen D ^b  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b NONE

Author keywords

Ca2+ sensitivity; Ca2+ sensitizer; Efficiency; Global ventricular function; Isolated heart; Myocardial stunning

Indexed keywords

5 [1 (ALPHA ETHYLIMINO 3,4 DIMETHOXYBENZYL) 1,2,3,4 TETRAHYDRO 6 QUINOLINYL] 3,6 DIHYDRO 6 METHYL 2H 1,3,4 THIADIAZIN 2 ONE; CALCIUM ION; THIADIAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HEART MUSCLE; HEART MUSCLE ISCHEMIA; HEART RATE; HEART VENTRICLE FUNCTION; INOTROPISM; ISOLATED HEART; MALE; NONHUMAN; PRIORITY JOURNAL; RABBIT; SENSITIZATION; STUNNED HEART MUSCLE;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 0031214710     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmcc.1997.0440     Document Type: Article

References (59)

1. BAILEY C, VILLAR-PILASI C, 1971. Cyclic AMP dependent phosphorylation of troponin. Fed Proc 30: 1147-1151.
2. BARANY M, BARANY K, 1981. Protein phosphorylation in cardiac and vascular smooth muscle. Am J Physiol 241: 117-128.
3. 2+ as an inotropic mechanism. Circulation 72 (Suppl. III): III-85-III-98.
4. BRITZ M, SUNDERDIEK U, SCHIPKE JD, 1992. Easydat: a computer program for data acquisition and processing. [Abstract]. Pflügers Arch 420 (Suppl. 1): R140.
5. BRUNCKHORST D, VAN DER LEYEN H, MEYER W, NIGBUR R, SCHMIDT SCHUMACHER C, SCHOLZ H, 1989. Relation of positive inotropic and chronotropic effects of pimobendan, UD-CG 212 Cl, milrinone and other phosphodieesterase inhibitors to phosphodiesterase III inhibition in guinea-pig heart. Naunyn Schmiedebergs Arch Pharmacol 339: 575-583.
6. CARROZZA JP, BENTIVEGNA LA, WILLIAMS CP, KUNTZ RE, GROSSMAN W, MORGAN JP, 1992. Decreased myofilament responsiveness in myocardial stunning follows transient calcium overload during ischemia and reperfusion. Circ Res 71: 1334-1340.
7. DEAN EN, SHLAFER M, NIKLAS JM, 1990. The oxygen consumption paradox of "stunned myocardium" in dogs. Basic Res Cardiol 85: 120-131.
8. DIETRICH DLL, VAN LEEUWEN GR, STIENEN GJM, ELZINGA G, 1994. Stunning does not change the relation between calcium and force in skinned rat trabeculae. J Mol Cell Cardiol 25: 541-549.
9. GAMBASSI G, SOLARO RJ, SPURGEON HA et al., 1992. EMD 57033, a novel inotropic agent, reverses myofilament effects of butanedione monoxime (BDM). [Abstract]. Circulation 86: 1-623.
10. 2+ sensitivity in intact versus skinned rat ventricular muscle. Circ Res 74: 408-415.
11. GAO WD, ATAR D, BACKX PH, MARBAN E, 1995. Relationship between intracellular calcium and contractile force in stunned myocardium. Circ Res 76: 1036-1048.
12. GROSS T, LUES I, DAUT J, 1993. A new cardiotonic drug reduces the energy cost of active tension in cardiac muscle. J Mol Cardiol 25: 239-244.
13. 2+ during hypoxia and reoxygenation in myocardium. Am J Physiol 259: 784-795.
14. HERZIG JW, DEPERSIN H, HUBER P et al., 1991. Ca sensitivity of the myocardium as influenced by Ca sensitizing agents and in some models of heart failure. [Abstract]. J Mol Cell Cardiol 23: 30.
15. HEUSCH G, SCHÄFER S, KRÖGER K, 1988. Recruitment of inotropic reserve in "stunned" myocardium by the cardiotonic agent AR-L 57. Basic Res Cardiol 83: 602-610.
16. HIBBERD MG, JEWELL BR, 1982. Calcium-and length-dependent force production in rat ventricular muscle. J Physiol 329: 527-540.
17. HOFFMAN PA, MILLER WA, MOSS RL, 1993. Altered calcium sensitivity of isometric tension in myocyte-sized preparations of porcine postischemic stunned myocardium. Circ Res 72: 50-56.
18. KATZ AM, 1989. Energy requirements of contraction and relaxation: implications for inotropic stimulation of the failing heart. Basic Res Cardiol 84 (Suppl. 1): 47-53.
19. KENTISH JC, 1986. The effects of inorganic phosphate and creatine phosphate on force production in skinned muscles from rat ventricle. J Physiol Lond 370: 585-604.
20. KLOCKE FJ, 1987. Measurements of coronary flow reserve: defining pathophysiology versus marking decisions about patient care. Circulation 76: 1183-1189.
21. 2+ sensitivity in normal and stunned myocardium of isolated rabbit hearts. Basic Res Cardiol 89: 549-562.
22. 2+ sensitizer and a phosphodiesterase inhibitor on stunned myocardium. J Pharmacol Exp Ther 275: 1433-1441.
23. 2+-sensitivity of the myofibrillar ATPase. Circulation 78: 77.
24. 2+ transients underlie stunning? Circ Res 66: 1268-1276.
25. KUSUOKA H, MARBAN E, 1992. Cellular mechanisms of myocardial stunning. Ann Rev Physiol 54: 243-256.
26. LAMERS JMJ, DUNCKER DJ, BEZSTAROSTI K, MCFALLS EO, SASSEN LMA VERDOUW PD, 1993. Increased activity of the sarcoplasmic reticular calcium pump in porcine stunned myocardium. Cardiovasc Res 27: 520-524.
27. LAXSON DD, HOMANS DC, DAI X-Z, SUBLETT E, BACHE RJ, 1989. Oxygen consumption and coronary reactivity in postischemic myocardium. Circ Res 64: 9-20.
28. LEE JA, ALLEN DG, 1990. Calcium sensitizers. Br Med J 300: 551-552.
29. LEE JA, ALLEN DG, 1991. EMD 53998 sensitizes the contractile proteins to calcium in the ferret ventricle muscle. Circ Res 69: 927-936.
30. LEE JA, SHAH N, WHITE J, ORCHARD CH, 1993. A novel thiadiazinone derivative fully reverses acidosis-induced depression of force in cardiac muscle by a calcium effect. Clin Sci 84: 141-144.
31. LUES I, 1995. Calcium-Sensitisierung als neues Therapiekonzept: Tierexperimentelle Befunde. Z Kardiol 84: 1050.
32. LUES I, BEIER N, JONAS R, KLOCKOW M, HAEUSLER G, 1993. The two mechanisms of action of racemic cardiotonic EMD 53 998, calcium sensitization and phosphodiesterase inhibition, reside in different enantiomers. J Cardiovasc Pharmacol 21: 883-892.
33. 2+ sensitive microelectrodes. Nature 286: 845-850.
34. MARBAN E, KORETSUNE Y, CORRETTI M, CHACKO VP, KUSUOKA H, 1989. Calcium and its role in myocardial cell injury during ischemia and reperfusion. Circulation 80 (Suppl. IV): IV-17-IV-22.
35. MASON DT, BRAUNWALD E, COVELL JW, SONNENBLICK EH, ROSS J JR, 1971. Assessment of cardiac contractility. The relation between the rate of pressure rise and ventricular pressure during isovolumic systole. Circulation 44: 47-58.
36. MORGAN JP, 1991. Abnormal intracellular modulation of calcium as a major cause of cardiac contractile dysfunction. New Engl J Med 325: 625-632.
37. MORGAN JP, PERREAULT CL, MORGAN KG, 1991. The cellular basis of contraction and relaxation in cardiac and vascular smooth muscle. Am Heart J 121: 961-968.
38. NOLAND TA, RAYNOR RL, KUO JF, 1989. Identification of sites phosphorylated in bovine cardiac troponin I and troponin T by protein kinase C and comparative substrate activity of synthesis peptides containing the phosphorylationsites. J Biol Chem 264: 20778-20785.
39. OHGOSHI Y, GOTO Y, FUTAKI S, YAKU H, KAWAGUCHI O, SUGA H, 1991. Increased oxygen cost of contractility in stunned myocardium of dog. Circ Res 69: 975-988.
40. 2+ sensitizing agent EMD 60 263 and its enantiomer EMD 60 264: inotropic and electrophysiologic actions [Abstract]. Naunyn Schmiedebergs Arch Pharmacol 348: R166.
41. 2+ sensitization. Mol Cell Biochem 157: 245-249.
42. RÜEGG JC, 1992. In: Rüegg JC (ed.). Calcium in muscle contraction. 2nd ed. Berlin, The vertebrate heart: Modulation of calcium control. Heidelberg, New York: Springer-Verlag. 165-200.
43. RÜEGG JC, MORANO I, 1989. Calcium-sensitivity modulation of cardiac myofibrillar proteins. J Cardiovasc Pharmacol 14 (Suppl. 3): S20-S23.
44. SCHÄDLER M, 1967. Proportionale Aktivierung von ATPase-Aktivität und Kontraktions-spanning durch Calciumionen in isolierten contraktilen Strukturen verschiedener Muskelarten. Pflügers Arch Eur J Physiol 296: 70-90.
45. SCHIPKE JD, SUNDERDIEK U, KORBMACHER B, SCHWANKE U, ARNOLD G, 1995. Utilization of oxygen by the contractile apparatus is disturbed during reperfusion of post-ischemic myocardium. Eur Heart J 16: 1476-1481.
46. 2+ sensitization predominantly enhances function and mechanical efficiency of stunned myocardium. Circulation 90: 959-969.
47. SOEI LK, BEZSTAROSTI K, LAMERS JMJ et al., 1995. Desensitization mechanism at the contractile L49 proteins in the stunned myocardium. [Abstract]J Mol Cell Cardiol 27: A278.
48. SOLARO RJ, MOIR AGJ, PERRY SV, 1976. Phosphorylation of troponin I and the inotropic effect of adrenalin in perfused rabbit heart. Nature 262: 615-616.
49. SOLARO RJ, RÜEGG JC, 1982. Stimulation of calcium binding and ATPase activity of dog cardiac myofibrils by AR-L 115 BS, a novel cardiotonic agent. Circ Res 51: 290-294.
50. SOLARO RJ, GAMBASSI G, WARSHAW DM, KELLER MR, SPURGEON HA, BEIER N, LAKATTA EG, 1993. Stereoselective actions of thiadiazinones on canine myocytes and myofilaments. Circ Res 73: 981-990.
51. STAHL LD, WEISS HR, BECKER LC, 1988. Myocardial oxygen consumption, oxygen supply/demand heterogeneity, and microvascular patency in regionally stunned myocardium. Circulation 77: 865-872.
52. STRAUSS JD, RÜEGG JC, LUES I, 1993. In: In search of calcium sensitizer compounds: from subcellular models of muscle to in vivo positive inotropic action. Lee JA, Allen DG, (eds). Modulation of cardiac calcium sensitivity: A new approach to increasing the strength of the heart. Oxford, Oxford University Press. 37-66.
53. SUGA H, HISANO R, HIRATA S, HAYASHI T, YAMADA O, NINOMIYA I, 1983. Heart rate-independent energetics and systolic pressure-volume area in dog heart. Am J Physiol 244: H206-H214.
54. WALLACE AG, SKINNER NS JR., MITCHELL JH, 1963. Hemodynamic determinants of the maximal rate of rise of left ventricular pressure. Am J Physiol 205: 30-36.
55. WEISBERG A, MCCLELLAN G, TUCKER M, LIN LE, WINEGRAD S, 1983. Regulation of calcium sensitivity in perforated mammalian cardiac cells. J Gen Physiol 81: 195-211.
56. 2+ in isolated ferret cardiac. Circ Res 73: 61-70.
57. WILKINSON L, 1980. REGM: a multivariate general linear hypothesis program. Am Statistician 34: 182.
58. WU C, BOHR DF, 1991. Mechanisms of calcium relaxation of vascular smooth muscle. Am J Physiol 261: 1411-1416.
59. ZHAO M, SONNENBLICK EH, ZHANG H, ENG C, 1992. Increased in myofilament separation in the "stunned" myocardium. J Mol Cell Cardiol 24: 269-276.