Inhibition of paraoxonase activity in human liver microsomes by exposure to EDTA, metals and mercurials

Chemico-Biological Interactions

Volumn 105, Issue 3, 1997, Pages 169-179

  Gonzalvo, M Carmen ^a   Gil, Fernando ^a   Hernández, Antonio F ^a   Villanueva, Enrique ^a   Pla, Antonio ^a  

^a UNIVERSITY OF GRANADA   (Spain)

Author keywords

EDTA; Human liver; Mercurials; Metals; Organophosphates; Paraoxonase

Indexed keywords

ARYLESTERASE; BARIUM; COBALT; COPPER; DITHIOTHREITOL; EDETIC ACID; HYDROXYMERCURIBENZOIC ACID; LANTHANUM; MAGNESIUM; MERCURY; MERCURY DERIVATIVE; METAL; PHENYLMERCURIC ACETATE; ZINC;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME KINETICS; HUMAN; HUMAN TISSUE; LIVER MICROSOME; NONHUMAN; RAT;

ANIMALS; ARYLDIALKYLPHOSPHATASE; DITHIOTHREITOL; EDETIC ACID; ENZYME ACTIVATION; ENZYME INHIBITORS; ESTERASES; HUMANS; KINETICS; MERCURY COMPOUNDS; METALS; MICROSOMES, LIVER; RATS; SULFHYDRYL COMPOUNDS;

ANIMALIA;

EID: 0031214358     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-2797(97)00046-X     Document Type: Article

References (18)

1. [1] W.N. Aldridge, Serum esterases 1. Two types of esterase (A and B) hydrolysing p-nitrophenyl acetate, propionate and butyrate, and a method for their determination, Biochem. J. 53 (1953) 110-117.
2. [2] W.N. Aldridge, A-esterases and B-esterases in perspective, in: E. Reiner, W.N. Aldridge, F.C.G. Hoskin (Eds.), Enzymes Hydrolising Organophosphorus Compounds, Ellis Horwood, Chichester, New York, 1989, pp. 1-14.
3. [3] W.N. Aldridge, The esterases: perspectives and problems, Chem.-Biol. Interact. 87 (1993) 5-13.
4. [4] F. Gil, M.C. Gonzalvo, A.F. Hernandez, E. Villanueva, A. Pla, Differences in the kinetic properties effect of calcium and sensitivity to inhibitors of paraoxon hydrolase activity in rat plasma and microsomal fraction from rat liver, Biochem. Pharmacol. 48 (1994) 1559-1568.
5. [5] M. Dixon, E.C. Webb, Enzymes, 2nd edn., Longmans, Green and Co., London, 1964.
6. [6] T. Shishido, J-I Fukami, Enzymatic hydrolysis of diazoxon by rat tissue homogenates. Pest. Biochem. Physiol. 2 (1972) 39-50.
7. [7] W.N. Aldridge, The enzymic hydrolysis of diethyl p-nitrophenyl phosphate (E600), Biochem. J. 49 (1951) i.
8. [8] E.L. Becker, J.F. Barbaro, The enzymatic hydrolysis of p-nitrophenyl ethyl phosphonates by mammalian plasmas, Biochem. Pharmacol. 13 (1964) 1219-1227.
9. [9] R. Traverso, A. Moretto, M. Lotti, Human serum 'A'-esterases. Hydrolysis of O,O-Dimethyl-2.2-Dichlorovinyl phosphate, Biochem. Pharmacol. 38 (1989) 671-676.
10. [10] E.G. Erdös. L.E. Boggs, Hydrolysis of paraoxon in mammalian blood, Nature 19O (1961) 716-717.
11. [11] A.F. Hernández, A. Pla, A. Valenzuela, F. Gil, E. Villanueva, Characterisation of paraoxonase activity in pericardial fluid. Usefulness as a marker of coronary disease. Chem.-Biol. Interact. 87 (1993) 173-178.
12. [12] C.E. Furlong, R.J. Richter, C. Chapline, J.W. Crabb, Purification of rabbit and human serum paraoxonase, Biochemistry 30 (1991) 10133-10140.
13. [13] M. Skrinjaric-Spoljar, E. Reiner, Hydrolysis of diethyl-p-nitrophenylphosphate and ethyl-p-nitrophenyl-ethylphosphonate by human sera, Biochim. Biophys. Acta 165 (1968) 289-292.
14. [14] C.L. Kuo, B.N. La Du, Comparison of purified human and rabbit serum paraoxonases, Drug Metabol. Dispos. 23 (1993) 935-944.
15. [15] W.N. Aldridge, Serum esterases 2. An enzyme hydrolysing diethyl p-nitrophenyl phosphate (E600) and its identity with the A-esterase of mammalian sera. Biochem. J. 53 (1953) 117-124.
16. [16] L.A. Mounter, Enzymic hydrolysis of organophosphorus compounds, in: P.D. Boyer, H. Lardy, L. Myrbäck (Eds.), The Enzymes, vol. 4, Academic Press, New York, 1960, pp. 541-550.
17. [17] B.N. La Du, S. Adkins, C.L. Kuo, D. Lipsig. Studies on human serum paraoxonase arylesterase, Chem.-Biol. Interact. 87 (1993) 25-34.
18. [18] C.E. Furlong, L.G. Costa, C. Hassett, R.J. Richter, J.A. Sundstrom, D.A. Adler, C.M. Disteche, C.J. Omiecinski, C. Chapline, J.W. Crabb, R. Humbert, Human and rabbit paraoxonases: purification, cloning, sequencing, mapping and role of polymorphism in organophosphate detoxification, Chem.-Biol. Interact. 87 (1993) 35-48.