Multiple chromosomal mechanisms generate an EWS/FLI1 or an EWS/ERG fusion gene in ewing tumors

Cancer Genetics and Cytogenetics

Volumn 97, Issue 1, 1997, Pages 12-19

  Desmaze, Chantal ^a   Brizard, Françoise ^b   Turc Carel, Claude ^c   Melot, Thomas ^a   Delattre, Oliver ^a   Thomas, Gilles ^a   Aurias, Alain ^a  

^a INSTITUT CURIE   (France)

^b Centre Hospitalier Régional   (France)

^c CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CENTROMERE; CHROMOSOME ABERRATION; CHROMOSOME TRANSLOCATION 11; CYTOGENETICS; DNA FLANKING REGION; EWING SARCOMA; FLUORESCENCE IN SITU HYBRIDIZATION; GENE LOCATION; GENE REARRANGEMENT; HUMAN; HUMAN TISSUE; METAPHASE; MULTIGENE FAMILY; PRIORITY JOURNAL; PROTEIN DOMAIN;

CHROMOSOME ABERRATIONS; CHROMOSOMES, HUMAN, PAIR 11; CHROMOSOMES, HUMAN, PAIR 12; CHROMOSOMES, HUMAN, PAIR 2; CHROMOSOMES, HUMAN, PAIR 21; CHROMOSOMES, HUMAN, PAIR 22; COSMIDS; DNA-BINDING PROTEINS; HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEINS; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; KARYOTYPING; ONCOGENE PROTEINS, FUSION; PROTO-ONCOGENE PROTEIN C-FLI-1; PROTO-ONCOGENE PROTEINS; RIBONUCLEOPROTEINS; RNA-BINDING PROTEIN EWS; SARCOMA, EWING'S; TRANS-ACTIVATORS; TRANSLOCATION, GENETIC; TUMOR CELLS, CULTURED;

EID: 0031214255     PISSN: 01654608     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-4608(96)00326-3     Document Type: Article

References (36)

1. 1. Aurias A, Rimbaud C, Buffe D, Dubousset J, Mazabraud A (1983): Chromosomal translocations in Ewing's sarcoma. N Eng J Med 309:496-497.
2. 2. Turc-Carel C, Philip I, Berger M-P, Philip T, Lenoir GM (1983): Chromosomal translocations in Ewing's sarcoma. N Eng J Med 309:497-498.
3. 3. Turc-Carel C, Aurias A, Mugneret F, Lizard S, Sidaner I, Volk C, Thiery J-P, Olschwang S, Philip I, Berger M-P, Philip T, Lenoir GM, Mazabraud A (1988): Chromosomes in Ewing's sarcoma. An evaluation of 85 cases and remarkable consistency of t(11;22)(q24;q12). Cancer Genet Cytogenet 32:229-238.
4. 4. Whang-Peng J, Triche TJ, Knutsen T, Miser J, Kao-Shan S, Tsai S, Israel MA (1986): Cytogenetic characterization of selected small round cell tumors of childhood. Cancer Genet Cytogenet 21:185-208.
5. 5. Speleman F, Van Roy N, Wiegant J, Dierick A-M, Uyttendaele D, Leroy JG (1992): Molecular cytogenetic analysis of a complex t(10;22;11) translocation in Ewing's sarcoma. Genes Chromosom Cancer 4:188-189.
6. 6. Giovannini M, Beigel JA, Serra M, Wang JY, Wei YH, Nycum L, Emanuel BS, Evans GA (1994): EWS-erg and EWS-Fli1 fusion transcripts in Ewing's sarcoma and primitive neuroectodermal tumors with variant translocations. J Clin Invest 94:489-496.
7. 7. Becher R, Wake N, Gibas Z, Ochi H, Sandberg AA (1984): Chromosomes changes in soft tissue sarcomas. J Natl Cancer Inst 72:823-831.
8. 8. Aurias A (1988): Données cytogénétiques dans les sarcomes des os et des tissus mous. Bull Cancer 75:423-429.
9. 9. Soukup S, Wang-Wuu S, Workman L, Lampkin B, Koufos A (1986): Special findings in chromosome analysis of Ewing's sarcoma. Am J Hum Genet 39:A43.
10. 10. Delattre O, Zucman J, Plougastel B, Desmaze C, Melot T, Peter M, Kovar H, Joubert I, De Jong P, Rouleau G, Aurias A, Thomas G (1992): Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours. Nature 359:162-165.
11. 11. Delattre O, Zucman J, Melot T, Sastre X, Zucker JM, Lenoir G, Ambros P, Sheer D, Turc-Carel C, Triche T, Aurias A, Thomas G (1994): The Ewing family of tumors: A subgroup of small round cell tumors defined by specific chimeric transcripts. N Engl J Med 331:294-299.
12. 12. Zucman J, Delattre O, Desmaze C, Plougastel B, Joubert I, Melot T, Peter M, De Jong P, Rouleau G, Aurias A, Thomas G (1992): Cloning and characterization of the Ewing's sarcoma and peripheral neuroepithelioma t(11;22) translocation breakpoint. Genes Chromosom Cancer 5:271-277.
13. 13. Douglass EC, Valentine M, Green AA, Ann Hayes F, Thompson EI (1986): t(11;22) and other chromosomal rearrangements in Ewing's sarcoma. J Natl Cancer Inst 77:1211-1215.
14. 14. May WA, Gishizky ML, Lessnick SL, Lunsford LB, Lewis BC, Delattre O, Zucman J, Thomas G, Denny CT (1993): Ewing's sarcoma t(11;22) translocation encodes a chimeric transcription factor that requires DNA-binding domain of FLI-1 for transformation. Proc Natl Acad Sci USA 90:5752-5756.
15. 15. Zucman J, Melot T, Desmaze C, Ghysdael J, Plougastel B, Peter M, Zucker JM, Triche T, Patel K, Turc-Carel C, Ambros P, Combaret V, Lenoir G, Aurias A, Thomas G, Delattre O (1993): Combinatorial generation of variable fusion proteins in peripheral primitive neuroectodermal tumours. EMBO J 12:4481-4487.
16. 16. Jeon IS, Davis JN, Braun BS, Sublett JE, Roussel MF, Denny CT, Shapiro DN (1995): A variant Ewing's sarcoma translocation (7;22) fuses the EWS gene to the ETS gene FTV1. Oncogene 10:1229-1234.
17. 17. Urano F, Umezawa A, Hong W, Kikuchi H, Hata J (1996): A novel chimera gene between EWS and E1AF, encoding the adenovirus E1A enhancer-binding protein, in extraosseus Ewing's sarcoma. Biochem Biophys Res Commun 219:608-612.
18. 18. Crété N, Gosset P, Theophile D, Duterque-Coquillaud M, Blouin JL, Vayssettes C, Sinet PM, Creau-Goldberg N (1993): Mapping the Down syndrome chromosome region. Eur J Hum Genet 1:51-63.
19. 19. Desmaze C, Zucman J, Delattre O, Melot T, Thomas G, Aurias A (1994): Interphase molecular cytogenetics of Ewing's sarcoma and peripheral neuroepithelioma t(11;22) translocation with flanking and overlapping cosmid probes. Cancer Genet Cytogenet 74:13-18.
20. 20. Turc-Carel C, Philip I, Berger MP, Philip T and Lenoir GM (1984): Chromosome study of Ewing's sarcoma (ES) cell lines. Consistency of a reciprocal translocation t(11;22)(q24;q12). Cancer Genet Cytogenet 12:1-19.
21. 21. Delattre O, Azambuja CJ, Aurias A, Zucman J, Peter M, Zhang FR, Flors-Cayla MC, Rouleau G, Thomas G (1991): Mapping of human chromosome 22 with a panel of somatic cell hybrids. Genomics 9:732-727.
22. 22. Desmaze G, Zucman J, Delattre O, Thomas G, Aurias A (1992): Unicolor and bicolor in situ hybridization in the diagnosis of peripheral neuroepithelioma and related tumors. Genes Chromosom Cancer 5:30-34.
23. 23. Aubry M, Marineau C, Zhang FR, Zahed L, Figlewicz D, Delattre O, Thomas G, De Jong P, Julien JP (1992): Cloning of six new genes with zinc finger motifs mapping to short and long arms of human acrocentric chromosome 22 (p and q11.2). Genomics 13:641-648.
24. 24. Desmaze C, Prieur M, Amblard F, Aïkem M, LeDeist F, Demczuk S, Zucman J, Plougastel B, Delattre O, Croquetle M-F, Brevière G-M, Huon C, Le Merrer M, Mathieu M, Sidi D, Stephan J-L, Aurias A (1993): Physical mapping by FISH of the DiGeorge critical region. Involvement of the region in familial cases. Am J Hum Genet 53:1239-1249.
25. 25. Zucman J, Delattre O, Desmaze C, Azambuja GJ, Rouleau G, De Jong P, Aurias A, Thomas G (1992): Rapid isolation of cosmids from defined subregions by differential Alu-PCR hybridization on chromosome 22 specific library. Genomics 13:395-401.
26. 26. Hagemeijer A, de Klein A, Gödde-Salz E, Turc-Carel C, Smit EME, van Agthoven AJ, Grosveld GC (1985): Translocation of c-abl to "masked" Ph in chronic myeloid leukemia. Cancer Genet Cytogenet 18:95-104.
27. 1 translocation? Cancer Genet Cytogenet 13:1-16.
28. 28. Morris CM, Fitzgerald PH (1987): Complexity of an apparently simple variant Ph translocation in chronic myeloid leukemia. Leukemia Res 11:163-169.
29. 29. Ganesan TS, Rassool F, Guo A-P, Th'ng KH, Dowding C, Hibbin JA, Young BD, White H, Kumaran TO, Galton DAG, Goldman JM (1986): Rearrangement of the bcr gene in Philadelphia chromosome-negative chronic myeloid leukemia. Blood 68: 957-960.
30. 1-negative chronic myeloid leukemia. Nature 320:281-283.
31. 31. Morris C, Heisterkamp N, Kennedy M, Fitzgerald P, Groffen J (1990): Ph-negative chronic myeloid leukemia: Molecular analysis of ABL insertion in to M-BCR on chromosome 22. Blood 76:1812-1818.
32. 1-negative chronic myelocytic leukemia. Hum Genet 83:115-118.
33. 33. van der Plas DC, Hermans ABC, Soekarman D, Smith EME, de Klein A, Smadja N, Alimena G, Goudsmit R, Grosveld GC, Hagemeijer A (1989): Cytogenetic and molecular analysis in Philadelphia negative CML. Blood 73:1038-1044.
34. 34. Morris C, Kennedy M, Heisterkamp N, Columbano-Green L, Romeril K, Groffen J, Fitzgerald P (1991): A complex chromosome rearrangement forms the BCR-ABL fusion gene in leukemic cells with a normal karyotype. Genes Chromosom Cancer 3:268-271.
35. 35. Sorensen PHB, Lessnick SL, Terrada DL, Lieu XF, Triche TJ, Denny CT (1994): A second Ewing's sarcoma translocation, t(21;22), fuses the EWS gene to another ETS-family transcription factor, ERG. Nature Genet 6:146-151.
36. 36. Beverloo HB, Le Coniat M, Wijsman J, Lillington DM, Bernard O, de Klein A, van Wering E, Welborn J, Young BD, Hagemeijer A, Berger R (1995) Breakpoint heterogeneity in t(10;11) translocation in AML-M4/M5 resulting in fusion of AF 10 and MLL is resolved by fluorescent in situ hybridization analysis. Cancer Res 55:4220-4224.