Role of 3,4-dichlorophenyl methyl sulfone, a metabolite of o-dichlorobenzene, in the changes in hepatic microsomal drug-metabolizing enzymes caused by o-dichlorobenzene administration in rats

Toxicology and Applied Pharmacology

Volumn 145, Issue 2, 1997, Pages 277-284

  Kato, Yoshihisa ^a   Kimura, Ryohei ^a  

^a UNIVERSITY OF SHIZUOKA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1,2 DICHLOROBENZENE; AMINOPYRINE N DEMETHYLASE; ANTIBIOTIC AGENT; CYTOCHROME P450; CYTOCHROME P450 ISOENZYME; UNSPECIFIC MONOOXYGENASE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; LIVER MICROSOME METABOLISM; MALE; METABOLITE; NONHUMAN; RAT; TISSUE DISTRIBUTION; TOXICOKINETICS; XENOBIOTIC METABOLISM;

ANIMALIA; APUS APUS;

EID: 0031214054     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1997.8191     Document Type: Article

References (28)

1. Aimoto T., Ito O., Nozaki K., Harakawa E., Murata T. Metabolism and disposition of bitolterol, a new bronchodilator, in mice. Yakuzaigaku. 37:1977;128-134.
2. Allis J. W., Simmons J. E., House D. E., Robinson B. L., Berman E. The differential hepatotoxicity and cytochrome P450 responses of Fischer-344 rats to the three isomers of dichlorobenzene. J. Biochem. Toxicol. 7:1992;257-264.
3. Bakke J. E. Biochemical and physiological dispositions of glutathione conjugates. Drug Metab. Rev. 22:1990;637-647.
4. Bakke J. E., Huwe J. K., Mulford D. J., Bergman Å. Metabolism of 1,2,4-trichlorobenzene in rats: Examination of thiol formation. Xenobiotica. 22:1992;199-210.
5. ®. Fresenius' Z. Anal. Chem. 279:1976;113-114.
6. Haraguchi H., Kuroki H., Masuda Y., Shigematsu N. Determination of methylthio and methylsulphone polychlorinated biphenyls in tissues of patients with 'Yusho'. Food Chem. Toxicol. 22:1984;283-288.
7. Haraguchi K., Athanasiadou M., Bergman Å., Hovander L., Jensen S. PCB and PCB methyl sulfones in selected groups of seals from Swedish waters. Ambio. 21:1992;546-549.
8. Jansson B., Bergman Å. Sulfur-containing derivatives of hexachlorobenzene (HCB)-metabolites in the rat. Chemosphere. 3:1978;257-268.
9. Kato Y., Kogure T., Sato M., Murata T., Kimura R. Evidence that methylsulfonyl metabolites ofm. Toxicol. Appl. Pharmacol. 82:1986;505-511.
10. Kato Y., Kogure T., Sato M., Kimura R. Contribution of methylsulfonyl metabolites ofm. Toxicol. Appl. Pharmacol. 96:1988a;550-559.
11. Kato Y., Kogure T., Sato M., Kimura R. Effects of chlorobenzenes and their methyl sulfone metabolites on microsomal enzymes associated with drug metabolism in rat liver. J. Pharmacobio-Dyn. 11:1988b;758-762.
12. Kato Y., Yamada S., Sato M., Kimura R. Role of 2,3,5-trichlorophenyl methyl sulfone, a metabolite of 1,2,4-trichlorobenzene, in the induction of hepatic microsomal drug-metabolizing enzymes by 1,2,4-trichlorobenzene in rats. Toxicol. Appl. Pharmacol. 122:1993;214-221.
13. Kimura R., Hayashi T., Sato M., Aimoto T., Murata T. Identification of sulfur-containing metabolites ofp. J. Pharmacobio-Dyn. 2:1979;237-244.
14. Kimura R., Kawai M., Sato M., Aimoto T., Murata T. Induction of hepatic microsomal drug-metabolizing enzymes by sulfur-containing metabolites of chlorinated benzenes in rats. Toxicol. Appl. Pharmacol. 67:1983;338-345.
15. Kimura R., Sano H., Itagaki K., Kogure T., Sato M., Murata T. Identification of sulfur-containing metabolites ofm. J. Pharmacobio-Dyn. 7:1984;234-245.
16. Kimura R., Kawai M., Kato Y., Sato M., Aimoto T., Murata T. Role of 3,5-dichlorophenyl methyl sulfone, a metabolite ofmm. Toxicol. Appl. Pharmacol. 78:1985;300-309.
17. Klutch A., Levin W., Chang R. L., Vane F., Conney A. H. Formation of a thiomethyl metabolite of phenacetin and acetaminophen in dogs and man. Clin. Pharmacol. Ther. 24:1978;287-293.
18. Lingg R. D., Kaylor W. H., Pyle S. M., Kopfler F. C., Smith C. C., Wolfe G. F., Cragg S. Comparative metabolism of 1,2,4-trichlorobenzene in the rat and rhesus monkey. Drug Metab. Dispos. 10:1982;134-141.
19. Lowry O. H., Rosebrough N. J., Farr A. L., Randall R. J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:1951;265-275.
20. Mio T., Sumino K., Mizutani T. Sulfur-containing metabolites of 2,5,2′,5′-tetrachlorobiphenyl, a major component of commercial PCB's. Chem. Pharm. Bull. 24:1976;1958-1960.
21. Norén K., Lundén Å., Pettersson E., Bergman Å. Methylsulfonyl metabolites of PCBs and DDE in human milk in Sweden, 1972-1992. Environ. Health Perspect. 104:1996;766-772.
22. Omura T., Sato R. The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature. J. Biol. Chem. 239:1964a;2370-2378.
23. Omura T., Sato R. The carbon monoxide-binding pigment of liver microsomes. II. Solubilization, purification, and properties. J. Biol. Chem. 239:1964b;2379-2385.
24. Renner G. Biotransformation of the fungicides hexachlorobenzene and pentachloronitrobenzene. Xenobiotica. 11:1981;435-446.
25. Tanaka A., Sato M., Tsuchiya T., Adachi T., Niimura T., Yamaha T. Excretion, distribution and metabolism of 1,2,4-trichlorobenzene in rats. Arch. Toxicol. 59:1986;82-88.
26. Tateishi M. Methylthiolated metabolites. Drug Metab. Rev. 14:1983;1207-1234.
27. Walle T., Walle U. K., Knapp D. R., Conradi E. C., Bargar E. M. Identification of major sulfate conjugates in the metabolism of propranolol in dog and man. Drug Metab. Dispos. 11:1983;344-349.
28. Yamaoka K., Nakagawa T. A nonlinear least squares program based on differential equations, MULTI (RUNGE), for microcomputers. J. Pharmacobio-Dyn. 6:1983;595-606.