Association between p53 Mutation and Clinicopathological Features of Non-small Cell Lung Cancer

Japanese Journal of Clinical Oncology

Volumn 27, Issue 4, 1997, Pages 211-215

  Guang, Shao Guo ^a,c   Ogura, Tsutomu ^a   Sekine, Ikuo ^b   Yokozaki, Michiya ^b   Esumi, Hiroyasu ^a   Kodama, Tetsuro ^b   Nagai, Kanji ^b  

^a NATIONAL CANCER CENTER   (Japan)

^b NATIONAL CANCER CENTER HOSPITAL EAST   (Japan)

^c JILIN UNIVERSITY   (China)

Author keywords

Mutation; Nuclear atypia; p53; PCR SSCP; Sequencing

Indexed keywords

CYTOSINE; DNA; GUANINE;

ADENOCARCINOMA; ADENOSQUAMOUS CARCINOMA; ADULT; AGED; ANALYSIS OF VARIANCE; ARTICLE; CANCER INVASION; CANCER STAGING; CELL NUCLEUS; COMPARATIVE STUDY; DISEASE FREE SURVIVAL; DNA SEQUENCE; EPITHELIUM; EXON; FEMALE; GENETICS; HUMAN; INCIDENCE; LARGE CELL CARCINOMA; LUNG NON SMALL CELL CANCER; LUNG TUMOR; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; MUTATION; NUCLEOTIDE SEQUENCE; PATHOLOGY; PHENOTYPE; POINT MUTATION; SINGLE STRAND CONFORMATION POLYMORPHISM; SQUAMOUS CELL CARCINOMA; TUMOR SUPPRESSOR GENE; ULTRASTRUCTURE;

ADENOCARCINOMA; ADENOCARCINOMA, PAPILLARY; ADULT; AGED; AGED, 80 AND OVER; ANALYSIS OF VARIANCE; BASE SEQUENCE; CARCINOMA, ADENOSQUAMOUS; CARCINOMA, LARGE CELL; CARCINOMA, NON-SMALL-CELL LUNG; CARCINOMA, SQUAMOUS CELL; CELL NUCLEUS; CYTOSINE; DISEASE-FREE SURVIVAL; DNA, NEOPLASM; EPITHELIUM; EXONS; FEMALE; GENES, P53; GUANINE; HUMANS; INCIDENCE; LUNG NEOPLASMS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; MUTATION; NEOPLASM INVASIVENESS; NEOPLASM STAGING; PHENOTYPE; POINT MUTATION; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; SEQUENCE ANALYSIS, DNA;

EID: 0031205544     PISSN: 03682811     EISSN: None     Source Type: Journal    
DOI: 10.1093/jjco/27.4.211     Document Type: Article

References (21)

1. Chiba I, Takahashi T, Nau MM, D'Amico D, Curiel DT, Mitsudomi T et al. Mutations in the p53 gene are frequent in primary, resected non-small cell lung cancer. Oncogene 1990;5:1603-10.
2. Hollstein M, Sidransky D, Vogelstein B, Harris CC. p53 mutations in human cancer Science 1991,253:49-53.
3. Harris CC, Hollstein M. Clinical implications of the p53 tumor-suppressor gene. New Engl J Med 1993;329:1318-27.
4. Quinlan DC, Davidson AG, Summers CL, Warden HE, Doshi HM. Accumulation of p53 protein correlates with a poor prognosis in human lung cancer. Cancer Res 1992;52:4828-31.
5. Lee JS,Yoon A, Kalapurakal SK, Ro JY, Lee JJ, Tu N et al Expression of p53 oncoprotein in non-small-cell lung cancer: A favorable prognostic factor. J Clin Oncol 1996;13:1893-903.
6. Mitsudomi T, Oyama T, Nishida K, Ogami A, Osaki T, Nakanishi R et al p53 nuclear immunostaining and gene mutations in non-small-cell lung cancer and their effects on patient survival. Ann Oncol 1995;6(Suppl 3):S9-S13.
7. Nishio M, Koshikawa T, Koroishi T, Suyama M, Uchida K, Takagi Y et al. Prognostic significance of abnormal p53 accumulation in primary, resected non-small-cell lung cancers J Clin Oncol 1996;14:497-502.
8. Takise A, Kodama T, Shimosato Y, Watanabe S, Suemasu K. Histopathologic prognostic factors in adenocarcinomas of the peripheral lung less than 2 cm in diameter. Cancer 1988;61:2083-8.
9. Strauss GM, Kwiatkowski DJ, Harpole DH, Lynch TJ, Skarin AT, Sugarbaker DJ. Molecular and pathologic markers in stage I non-small-cell lung carcinoma of the lung. J Clin Oncol 1995;13:1265-76.
10. Barton CM, Staddon SL, Hughes CM. Abnormalites of the p53 tumor suppressor gene in human pancreatic cancer. Br J Cancer 1991;64:1076-82.
11. Sambrook J, Fritsh EF, Maniatis T. Molecular cloning. A Laboratory Manual 2nd ed. New York: Cold Spring Harbor Laboratory Press, 1989, 9.16-9.19
12. Noguchi M, Maezawa N, Nakanishi Y, Matsuno Y, Shimosato Y, Hirohashi S. Application of p53 gene mutation pattern for differential diagnosis of primary versus metastatic lung carcinoma. Diag Mol Pathol 1993, 2:28-35.
13. Makino R, Yazyu H, Kishimoto Y, Sekiya T, Hayashi K. F-SSCP: Fluorescence-based polymerase chain reaction-single-strand conformation polymorphism (PCR-SSCP) analysis. PCR Methods and Applications 1992;2:10-13.
14. Suzuki Y, Sekiya T, Hayashi K. Allele-specific polymerase chain reaction: a method for amplification and sequence determination of a single component among a mixture of sequence variants. Anal Biochem 1991, 192:82-4.
15. The World Health Organization. The World Health Organization histological typing of lung tumors. Am J Clin Pathol 1982;77:123-36.
16. Shimosato Y, Kodama T, Kameya T. Morphogenesis of peripheral type adenocarcinoma of the lung. In: Morphogenesis of lung cancer, vol 1, Shimosato Y, Melamed MR, Nettesheim P, editors. Boca Raton, Florida: CRC Press, 1982;65-89
17. Kurokawa T, Matsuno Y, Noguchi M, Mizuno S, Shimosato Y. Surgically curable 'early' adenocarcinoma in the periphery of the lung. Am J Surg Pathol 1994;18:431-8.
18. Hosmer DW, Lemeshow S. Applied logistic regression. New York: John Wiley and Sons, 1989.
19. Greenblatt MS, Bennett WP, Hollstein M, Harris CC. Mutations in the p53 tumor suppressor gene: Clues to cancer etiology and molecular pathogenesis. Cancer Res 1994;54:4855-78.
20. Fujino M, Dosaka-Akita H, Harada M, Hiroumi H, Kinoshita I, Akie K et al. Prognostic significance of p53 and ras p21 expression in non small cell lung cancer. Cancer 1995;76:2457-63.
21. Shimosato Y. Pulmonary neoplasms. In: Sternberg SS, editor. Diagnostic Surgical Pathology, 2nd ed. New York: Raven Press, 1994;1045-93.