Split-course Accelerated Hyperfractionation Radiotherapy for Advanced Head and Neck Cancer: Influence of Split Time and Overall Treatment Time on Local Control

Japanese Journal of Clinical Oncology

Volumn 27, Issue 4, 1997, Pages 240-243

  Akimoto, Tetsuo ^a,b   Mitsuhashi, Norio ^a   Hayakawa, Kazushige ^a   Sakurai, Hideyuki ^a   Murata, Osamu ^a   Ishizeki, Kei ^a   Ishikawa, Hitoshi ^a   Nasu, Sachiko ^a   Yamakawa, Michitaka ^a   Niibe, Hideo ^a  

^a GUNMA UNIVERSITY   (Japan)

^b GUNMA UNIVERSITY   (Japan)

Author keywords

Accelerated hyperfractionation; Head and neck cancer; Overall treatment time; Radiotherapy; Split time

Indexed keywords

ADULT; AGED; ANALYSIS OF VARIANCE; ARTICLE; CANCER STAGING; CAUSE OF DEATH; FEMALE; FOLLOW UP; HEAD AND NECK TUMOR; HUMAN; LYMPH NODE METASTASIS; MALE; MEGAVOLTAGE RADIOTHERAPY; MIDDLE AGED; MULTIVARIATE ANALYSIS; PATHOLOGY; PROPORTIONAL HAZARDS MODEL; RADIATION DOSE; RADIATION DOSE FRACTIONATION; REMISSION; RETROSPECTIVE STUDY; SALVAGE THERAPY; SEX DIFFERENCE; SQUAMOUS CELL CARCINOMA; SURVIVAL RATE; TIME; TREATMENT OUTCOME; TUMOR RECURRENCE;

ADULT; AGED; AGED, 80 AND OVER; ANALYSIS OF VARIANCE; CARCINOMA, SQUAMOUS CELL; CAUSE OF DEATH; DOSE FRACTIONATION; FEMALE; FOLLOW-UP STUDIES; HEAD AND NECK NEOPLASMS; HUMANS; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; PROPORTIONAL HAZARDS MODELS; RADIOTHERAPY DOSAGE; RADIOTHERAPY, HIGH-ENERGY; REMISSION INDUCTION; RETROSPECTIVE STUDIES; SALVAGE THERAPY; SEX FACTORS; SURVIVAL RATE; TIME FACTORS; TREATMENT OUTCOME;

EID: 0031205325     PISSN: 03682811     EISSN: None     Source Type: Journal    
DOI: 10.1093/jjco/27.4.240     Document Type: Article

References (21)

1. Marcial VA, Pajak TF. Radiation therapy alone or in combination with surgery in head and neck cancer. Cancer 1989;55:2259-65.
2. Dragovic J, Doyle TJ, Tilchen EJ, Nichols RD, Bennmger MS, Carlson ER, et al. Accelerated fractionation radiotherapy and concomitant chemotherapy in patients with stage IV inoperable head and neck cancer. Cancer 1995;76:1655-61.
3. Wang CC, Blitzer PH, Suit HD. Twice-a-day radiation therapy for cancer of the head and neck. Cancer 1985;55:2100-4.
4. Akimoto T, Mitsuhashi N, Sakurai H, Takahashi T, Hayakawa K, Niibe H, et al. Results of radiation therapy for hypopharyngeal carcinoma: impact of accelerated hyperfractionation on prognosis. Jpn J Clin Oncol 1996;26:169-74
5. Withers HR, Taylor MG, Maciejewski B The hazard of accelerated tumor clonogen repopulation during radiotherapy. Acta Oncol 1988;27:131-46.
6. Schmidt-Ullrich RK, Johnson CR, Wazer DE, Masko G, Chasin WD, Karmody CS. Accelerated superfractsonated irradiarion for advanced carcinoma of the head and neck: concomitant boost technique. Int J Radiat Oncol Biol Phys 1991;21:563-8.
7. Fu KK, Clery M, Ang KK, Byhardt RW, Maor MH, Beitler JJ. Randomized phase I/II trial of two variants of accelerated fractionated radiotherapy regimen for advanced head and neck cancer results of RTOG 88-09. Int J Radiat Oncol Biol Phys 1995;32:589-97.
8. Cox JD, Pajak TF, Hanks GE, Mohiuddin M, Fu KK, Byhardt RW, et al. Dose-response for local control with hyperfractionated radiation therapy in advanced carcinoma of the upper aerodigestive tracts: preliminary report of Radiation Therapy Oncology Group protocol 83-13. Int J Radiat Oncol Biol Phys 1990;18:515-21.
9. Saunders MI, Dische S, Barrett A, Parmar MKB, Harvey A, Gibson D. Randomized multicentric trials of CHART vs. conventional radiotherapy in head and neck and non-small-cell-lung cancer: an interim report. (On behalf of the CHART Steering Committee). Br J Cancer 1996;73:1455-62.
10. Bourhis J, Fortin A, Dupuis O, Domenge C, Lusinchi A, Marandas P, et al. Very accelerated radiation therapy: preliminary results in locally unresectable head and neck carcinomas. Int J Radiat Oncol Biol Phys 1995;32:747-52.
11. Hermaneck P, Sobin LH, editors. UICC: TNM Classification of malignant tumors. 7th edition. Berlin: Springer, 1987.
12. Kaplan EL, Meier P. Non-parametric estimation from incomplete observation. J Am Stat Assoc 1958;53:457-81.
13. Mantel N. Chi-square test with one-degree of freedom: experience of the Mantel-Haenszel procedure. J Am Stat Assoc 1963;58:690-700.
14. Mantel N. Evaluation of survival and two new rank order statistics arising in its consideration. Cancer Chemother Rep 1966;50:163-70.
15. Cox DR. Regression model and life table (with discussion). J R Stat Soc 1972;34:187-220.
16. Wang CC. Local control of oropharyngeal carcinoma after two accelerated hyperfractionation radiation therapy schemes. Int J Radiat Oncol Biol Phys 1988;14:1143-6.
17. Marks LB, Dewhirst M. Accelerated repopulation: friend or foe? Exploiting changes in tumor growth characteristics to improve the 'efficiency' of radiotherapy. Int J Radiat Oncol Biol Phys 1991;21:1377-83.
18. Delaney GP, Fischer RJ, Smee RI, Hook H, Barton MB. Split-course accelerated therapy in head and neck cancer: an analysis of toxicity. Int J Radiat Oncol Biol Phys 1995;32:763-76.
19. Fu KK, Pajak TF, Marcial V, Ortiz HG, Rotman M, Asbell S, et al. Late effects of hyperfractionated radiotherapy for advanced head and neck cancer: long-term follow-up results of RTOG 83-13. Int J Radiat Oncol Biol Phys 1995;32:577-88.
20. Cox JD, Pajak TF, Marcial V, Coia L, Mohiuddin M, Fu KK, et al ASTRO plenary: inter-fraction interval is a major determinant of late effects, with hyperfractionated radiation therapy of carcinoma of upper respiratory and digestive tracts: results from Radiation Therapy Oncology Group protocol 8313. Int J Radiat Oncol Biol Phys 1991;20:1191-5.
21. Wang CC, Efird MSJ, Nakfor B, Martins P. Local control of T3 carcinomas after accelerated fractionation: a look at the 'gap '. Int J Radiat Oncol Biol Phys 1996;35:439-41.