Binding of Malaria T Cell Epitopes to DR and DQ Molecules in Vitro Correlates with Immunogenicity in Vivo: Identification of a Universal T Cell Epitope in the Plasmodium falciparum Circumsporozoite Protein

Journal of Immunology

Volumn 159, Issue 3, 1997, Pages 1362-1373

  Calvo Calle, J Mauricio ^a   Hammer, Juergen ^b   Sinigaglia, Francesco ^b   Clavijo, Pedro ^a   Moya Castro, Z Rosa ^a   Nardin, Elizabeth H ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ROCHE MILANO RICERCHE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CIRCUMSPOROZOITE PROTEIN, PROTOZOAN; EPITOPE; HLA ANTIGEN CLASS 2; HLA DQ ANTIGEN; HLA DR ANTIGEN; PARASITE ANTIGEN; PEPTIDE FRAGMENT; PROTOZOAL PROTEIN;

A J MOUSE; ANIMAL; ARTICLE; B LYMPHOCYTE; BAGG ALBINO MOUSE; C3H MOUSE; C57BL MOUSE; CD4+ T LYMPHOCYTE; CELL CLONE; CELL LINE; DBA MOUSE; EPSTEIN BARR VIRUS; GENETICS; HAPLOTYPE; IMMUNIZATION; IMMUNOLOGY; ISOLATION AND PURIFICATION; METABOLISM; MOUSE; PLASMODIUM FALCIPARUM;

ANIMALS; ANTIGENS, PROTOZOAN; B-LYMPHOCYTES; CD4-POSITIVE T-LYMPHOCYTES; CELL LINE, TRANSFORMED; CLONE CELLS; EPITOPES, T-LYMPHOCYTE; HAPLOTYPES; HERPESVIRUS 4, HUMAN; HISTOCOMPATIBILITY ANTIGENS CLASS II; HLA-DQ ANTIGENS; HLA-DR ANTIGENS; IMMUNIZATION; MICE; MICE, INBRED A; MICE, INBRED BALB C; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, INBRED DBA; PEPTIDE FRAGMENTS; PLASMODIUM FALCIPARUM; PROTOZOAN PROTEINS;

EID: 0031202831     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (54)

1. Nussenzweig, R. S., J. Vanderberg, H. Most, and C. Orton. 1967. Protective immunity produced by the injection of x-irradiated sporozoites of Plasmodium berghei. Nature 216:160.
2. Clyde, D. F., H. Most, V. McCarthy, and J. P. Vanderberg. 1973. Immunization of man against sporozoite-induced falciparum malaria. Am. J. Med. Sci. 266:169.
3. Herrington, D., J. Davis, E. Nardin, M. Beler, J. Cortese, H. Eddy, G. Losonsky, M. Hollingdale, M. Sztein, M. Levine, R. Nussenzweig, D. Clyde, and R. Edelman. 1991. Successful immunization of humans with irradiated malaria sporozoites: humoral and cellular responses of the protected individuals. Am. J. Trop. Med. Hyg. 45:535.
4. Nussenzweig, V., and R. S. Nussenzweig. 1989. Rationale for the development of an engineered sporozoite malaria vaccine. Adv. Immunol. 45:283.
5. Nardin, E. H., and R. S. Nussenzweig. 1993. T cell responses to pre-erythrocytic stages of malaria: role in protection and vaccine development. Annu. Rev. Immunol. 11:687.
6. Nardin, E. H., V. Nussenzweig, R. S. Nussenzweig, W. E. Collins, K. T. Harinasuta, P. Tapchaisri, and Y. Chomcharn. 1982. Circumsporozoite proteins of human malaria parasites Plasmodium falciparum and Plasmodium vivax. J. Exp. Med. 156:20.
7. Zavala, F., A. H. Cochrane, E. H. Nardin, R. S. Nussenzweig, and V. Nussenzweig. 1983. Circumsporozoite proteins of malaria parasites contain a single immunodominant region with two or more identical epitopes. J. Exp. Med. 157:1947.
8. Zavala, F., J. P. Tam, M. R. Hollingdale, A. H. Cochrane, I. Quakyi, R. S. Nussenzweig, and V. Nussenzweig. 1985. Rationale for development of a synthetic vaccine against Plasmodium falciparum malaria. Science 228:1436.
9. Herrington, D. A., D. F. Clyde, G. Losonsky, M. Cortesia, J. R. Murphy, J. Davis, S. Baqar, A. M. Felix, E. P. Heimer, D. Gillessen, E. Nardin, R. S. Nussenzweig, V. Nussenzweig, M. Hollingdale, and M. Levine. 1987. Safety and immunogenicity in man of a synthetic peptide malaria vaccine against Plasmodium falciparum sporozoites. Nature 328:257.
10. Etlinger, H. M., A. M. Felix, D. Gillessen, E. P. Heimer, M. Just, J. R. L. Pink, F. Sinigaglia, D. Sturchler, B. Takacs, A. Trzeciak, and H. Matile. 1988. Assessment in humans of a synthetic peptide-based vaccine against the sporozoite stage of the human malaria parasite, P. falciparum. J. Immunol. 140:626.
11. Good, M. F., D. Pombo, I. A. Quakyi, E. M. Riley, R. A. Houghten, A. Menon, D. W. Ailing, J. A. Berzofsky, and L. H. Miller. 1988. Human T-cell recognition of the circumsporozoite protein of Plasmodium falciparum: immunodominant T-cell domains map to the polymorphic regions of the molecule. Proc. Natl. Acad. Sci. USA 85:1199.
12. + clones from a malaria-immunized volunteer. Science 246:1603.
13. + T cells from a sporozoite-immunized volunteer recognize the P. falciparum CS protein. Int. Immunol. 3:997.
14. + T cell clones obtained from Plasmodium falciparum sporozoite-immunized volunteers recognize polymorphic sequences of the circumsporozoite protein. J. Immunol. 151:489.
15. Good, M. F., W. L. Maloy, M. W. Lunde, H. Margalit, J. L. Cornette, G. Smith, B. Moss, L. H. Miller, and J. A. Berzofsky. 1987. Construction of synthetic immunogen: use of new T-helper epitope on malaria circumsporozoite protein. Science 235:1059.
16. Dame, J. B., J. L. Williams, T. F. McCutchen, J. L. Weber, R. A. Wirtz, W. T. Hockmeyer, W. L. Maloy, J. D. Haynes, I. Schneider, D. Roberts, G. S. Sanders, E. P. Reddy, C. L. Diggs, and L. H. Miller. 1984. Structure of the gene encoding the immunodominant surface antigen on the sporozoite of the human malaria parasite Plasmodium falciparum. Science 225:593.
17. Cerami, C., U. Frevert, P. Sinnis, B. Takacs, P. Clavijo, M. J. Santos, and V. Nussenzweig. 1992. The basolateral domain of the hepatocyte plasma membrane bears receptors for the circumsporozoite protein of Plasmodium falciparum sporozoites. Cell 70:1021.
18. Sinnis, P., P. Clavijo, D. Feyo, B. Chait, C. Cerami, and V. Nussenzweig. 1994. Structural and functional properties of region II-plus of the malaria circumsporozoite protein. J. Exp. Med. 180:297.
19. Panina-Bordignon, P., A. Tan, A. Termijtelen, S. Demotz, G. Corradin, and A. Lanzavecchia. 1989. Universally immunogenic T cell epitopes: promiscuous binding to human MHC class II and promiscuous recognition by T cells. Eur. J. Immunol. 19:2237.
20. Sinigaglia, F., M. Guttinger, J. Kilgus, D. Doran, H. Matile, H. Etlinger, A. Trzeciak, D. Gillessen, and J. R. L. Pink. 1988. A malaria T cell epitope recognized in association with most mouse and human MHC class II molecules. Nature 336:778.
21. Greenstein, J. L., V. C. Schad, W. H. Goodwin, A. B. Brauer, B. K. Bollinger. R. D. Chin, and M.-C. Kuo. 1992. A universal T cell epitope-containing peptide from hepatitis B surface antigen can enhance antibody specific for HIV gp120. J. Immunol. 148:3970.
22. Malcherek, G., V. Gnau, G. Jung, H-G. Rammensee, and A. Melms. 1995. Supermotifs enable natural invariant chain derived peptides to interact with many major histocompatibility complex-class II molecules. J. Exp. Med. 181:527.
23. Tam, J. P. 1988. Synthetic peptide vaccine design: synthesis and properties of a high density multiple antigenic peptide system. Proc. Natl. Acad. Sci. USA 85: 5409.
24. Nardin, E. H., G. Oliveira, J. M. Calvo-Calle, and R. S. Nussenzweig. 1995. The use of multiple antigen peptides in the analysis and induction of protective immune responses against infectious diseases. Adv. Immunol. 60:105.
25. Munesinghe, D. Y., P. Clavijo, M. Calvo-Calle, R. S. Nussenzweig, and E. Nardin. 1991. Immunogenicity of multiple antigen peptides (MAP) containing T and B cell epitopes of the repeat region of the P. falciparum circumsporozoite protein. Eur. J. Immunol. 21:3015.
26. Gillis, S., M. Ferm, and K. Smith. 1978. T cell growth factor: parameters of production and a quantitative microassay for activity. J. Immunol. 120:2027.
27. Trucco, M., G. Garotta, J. Stocker, and R. Ceppellini. 1979. Murine monoclonal antibodies against HLA structures. Immunol. Rev. 47:219.
28. Spits, H., J. Borst, M. Giphart, J. Coligan, C. Terhorst, and J. De Vries. 1984. HLA-DC antigens can serve as recognition elements for human cytotoxic T lymphocytes. Eur. J. Immunol. 14:299.
29. Busch, R., and J. B. Rothbard. 1990. Detection of peptide-MHC class II complexes on the surface of intact cells. J. Immunol. Methods 134:1.
30. Hammer, J., E. Bono, F. Gallazzi, C. Belunis, Z. Nagy, and F. Sinigaglia. 1994. Precise prediction of major histocompatibility complex class II-peptide interaction based on peptide side chain scanning. J. Exp. Med. 180:2353.
31. Hammer, J., F. Gallazzi, E. Bono, R. Karr, J. Guenot, P. Valsasnini, Z. Nagy, and F. Sinigaglia. 1995. Peptide binding specificity of HLA DR4 molecules: correlation with rheumatoid arthritis association. J. Exp. Med. 181:1847.
32. Valli, A., A. Sette, L. Kappos, C. Oseroff, J. Sidney, G. Miescher, M. Hochberger, E. D. Albert, and L. Adorini. 1993. Binding of myelin basic protein peptides to human histocompatibilily leukocyte antigen class II molecules and their recognition by T cells from multiple sclerosis patients. J. Clin. Invest. 91:616.
33. Geluk, A., W. Bloemhoff, R. R. P. De Vries, and T. H. M. Ottenhoff. 1992. Binding of a major T cell epitope of mycobacteria to a specific pocket within HLA-DRw17 (DR3) molecules. Eur. J. Immunol. 22:107.
34. Good, M. F., J. A. Berzofsky, W. L. Maloy, Y. Hayashi, N. Fujii, W. T. Hockmeyer, and L. H. Miller. 1986. Genetic control of the immune response in mice to a Plasmodium falciparum sporozoite vaccine: widespread nonresponsiveness to a single malaria T epitope in highly repetitive vaccine. J. Exp. Med. 164:655.
35. b restricted: possible implications for malaria vaccines. J. Immunol. 137:2952.
36. Calvo-Calle, J. M., G. A. de Oliveira, P. Clavijo, M. Maracic, J. P. Tam, Y.-A. Lu, E. Nardin, R. S. Nussenzweig, and A. H. Cochrane. 1993. Immunogenicity of multiple antigen peptides containing B and non-repeat T cell epitopes of the circumsporozoite protein of Plasmodium falciparum. J. Immunol. 150:1403.
37. Hammer, J., B. Takacs, and F. Sinigaglia. 1992. Identification of a motif for HLA-DR1 binding peptides using M13 display libraries. J. Exp. Med. 176:1007.
38. Hammer, J., P. Valsasnini, K. Tolba, D. Bolin, J. Higelin, B. Takacs, and F. Sinigaglia. 1993. Promiscuous and allele-specific anchors in HLA-DR binding peptides. Cell 74:197.
39. Hammer, J., C. Belunis, D. Bolin, J. Papadopoulos, R. Walsky, J. Higelin, W. Danho, F. Sinigaglia, and Z. Nagy. 1994. High affinity binding of short peptides to MHC class II molecules by anchor combinations. Proc. Natl. Acad. Sci. USA 91:4456.
40. Davenport, M. P., C. L. Quinn, P. Valsasnini, F. Sinigaglia, and A. V. S. Hill. 1996. Analysis of peptide-binding motifs for two disease associated HLA-DR13 alleles using an M13 phage display library. Immunology 88:482.
41. Alexander, J., J. Sidney, S. Southwood, J. Ruppert, C. Oseroff, A. Maewal, K. Snoke, H. Serra, R. Kubo, A. Sette, and H. Grey. 1994. Development of high potency universal DR restricted helper epitopes by modification of high affinity DR-blocking peptides. Immunity 1:751.
42. Sloan-Lancaster, J., and P. M. Allen. 1996. Altered peptide ligand-induced partial T cell activation: molecular mechanisms and role in T cell biology. Annu. Rev. Immunol. 14:1.
43. Zavala, F., and S. Chai. 1990. Protective anti-sporozoite antibodies induced by a chemically defined synthetic vaccine. Immunol. Lett. 25:271.
44. Wang, R., Y. Charoenvit, G. Corradin, R. Porrozzi, R. L. Hunter, G. Glenn, C. R. Alving, P. Church, and S. L. Hoffman. 1995. Induction of protective polyclonal antibodies by immunization with a Plasmodium yoelii circumsporozoite protein multiple antigen peptide vaccine. J. Immunol. 154:2784.
45. Chai, S. K., P. Clavijo, J. P. Tam, and F. Zavala. 1992. Immunogenic properties of multiple antigen peptide systems containing defined T and B epitopes. J. Immunol. 149:2385.
46. Fern, J., and M. F. Good. 1992. Promiscuous malaria peptide epitope stimulates CD45Ra T cells from peripheral blood of non-exposed donors. J. Immunol. 148: 907.
47. Ahmed, R., and D. Gray. 1996. Immunological memory and protective immunity: understanding their relation. Science 272:54.
48. Stoute, J. A., M. Slaoui, G. Heppner, P. Momin, K. E. Kester, P. Desmons, B. T. Wellde, N. Garcon, U. Krzych, M. Marchand, W. R. Ballou, and J. D. Cohen. 1997. A preliminary evaluation of a recombinant circumsporozoite protein vaccine against Plasmodium falciparum malaria. N. Engl. J. Med. 336:86.
49. Blum-Tirouvanziam, U., C. Servis, A. Habluetzel, D. Valmori, Y. Men, F. Esposito, L. Del Nero, N. Holmes, N. Fasel, and G. Corradin. 1995. Localization of HLA-A2.1 restricted T cell epitopes in the circumsporozoite protein of Plasmodium falciparum. J. Immunol. 154:3922.
50. Romero, P., J. L. Maryanski, G. Coradin, R. S. Nussenzweig, V. Nussenzweig, and F. Zavala. 1989. Cloned cytotoxic T cells recognize an epitope in the circumsporozoite protein and protect against malaria. Nature 341:323.
51. + cytolytic T cell clone confers protection against murine malaria. J. Exp. Med. 172:1353.
52. + T cell clones against Plasmodium yoelii liver stages. J. Immunol. 150:1471.
53. Ferreira, A., L. Schofield, V. Enea, H. Schellekens, P. Van Der Meide, W. E. Collins, R. S. Nussenzweig, and V. Nussenzweig. 1986. Inhibition of development of exoerythrocytic forms of malaria parasites by γ-interferon. Science 232: 881.
54. Valmori, D., A. Pessi, E. Bianchi, and G. Corradin. 1992. Use of human universally antigenic tetanus toxin T cell epitopes as carriers for human vaccination. J. Immunol. 149:717.