Brain benzodiazepine binding in aged rats

Neurochemistry International

Volumn 32, Issue 2, 1997, Pages 213-217

  Dalezios, Yannis ^a,b   Matsokis, Nikolaos ^a  

^a UNIVERSITY OF PATRAS   (Greece)

^b UNIVERSITY OF CRETE   (Greece)

Author keywords

Ageing; Benzodiazepine binding; Central; Cerebellum midbrain; Cortex; Peripheral; Striatum

Indexed keywords

4 AMINOBUTYRIC ACID; BENZODIAZEPINE RECEPTOR; FLUNITRAZEPAM; MESSENGER RNA;

AGING; ANIMAL TISSUE; ARTICLE; BINDING SITE; BRAIN; BRAIN CORTEX; CELL LOSS; CEREBELLUM; CONTROLLED STUDY; CORPUS STRIATUM; MEMBRANE BINDING; MESENCEPHALON; MESSENGER RNA SYNTHESIS; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR DENSITY;

AGING; ANIMALS; BENZODIAZEPINES; BRAIN; CEREBELLUM; CEREBRAL CORTEX; CORPUS STRIATUM; FLUNITRAZEPAM; MESENCEPHALON; RATS; RATS, WISTAR; RECEPTORS, GABA-A; RNA, MESSENGER; TRITIUM;

ANIMALIA;

EID: 0031200921     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0197-0186(97)00089-2     Document Type: Article

References (34)

1. Bakalian, A., Corman, B., Delhaye-Bouchaud, N., & Mariani, J. (1991). Quantitative analysis of the Purkinje cell population during extreme ageing in the cerebellum of the Wistar/Louvain rat. Neurobiol. Ageing, 12, 425-430.
2. Biegen, A., Duvdevani, R., Greenberger, V., & Segal, M. (1988). Ageing and brain cholinergic muscarinic receptors: An autoradiographic study in the rat. J. Neurochem., 51, 1381-1385.
3. Brizzee, K. R., Sherwood, N., & Timiras, P. S. (1968). A comparison of cell populations at various depth levels in cerebral cortex of young-adult and aged Long-Evans rats. J. Gerontol., 23, 289-297.
4. Corradetti, R., Kiedrowski, L., Nordstrom, O., & Pepeu, G. (1982). Disappearance of low affinity adenosine binding sites in ageing rat cerebral cortex and hippocampus. Neurosci. Lett., 49, 143-146.
5. Daval, J.-L., Post, R. M., & Marangos, P. J. (1989). Pyruvate dehydrogenase interactions with peripheral-type benzodiazepine receptors. J. Neurochem., 52, 110-116.
6. De Blasi, A., Cotecchia, S., & Mennini, T. (1982). Selective changes of receptor binding in brain regions of aged rats. Life Sci., 31, 335-340.
7. 35S]-butyl-bicyclo-phosphorothionate binding to the γ-aminobutyric acidA receptor-coupled chloride ionophore in rat cerebral cortex. J. Neurochem., 55, 648-651.
8. 3H]Diazepam binding in mammalian central nervous system: A pharmacological characterization. J. Neurosci., 1, 218-225.
9. 2-receptor-containing neurons in the rat striatum. Brain Res., 498, 299-307.
10. 3H]-diazepam binding in aged mice. Life Sci., 29, 971-974.
11. Komiskey, H. L., & MacFarlan, M. F. (1983). Ageing: Effect on neuronal and non-neuronal benzodiazepine binding sites. Neurochem. Res., 8, 1135-1141.
12. Lowry, O. H., Rosebrough, N. J., Farr, A. L., & Randall, R. J. (1951). Protein measurement with the Folin phenol reagent. J. Biol. Chem., 193, 265-275.
13. Maggi, A., Schmidt, M. J., Ghetti, B., & Enna, S. J. (1979). Effect of ageing on neurotransmitter receptor binding in rat and human brain. Life Sci., 24, 367-374.
14. Matsokis, N., & Valcana, T. (1983). GABA binding in cerebellum of mice and rats with altered GABA levels. 1st Cyprus Conference on New Methods in Drug Research, Limassol, Cyprus.
15. A receptor subunit mRNA levels in Fischer rats. Mol. Brain Res., 14, 71-78.
16. A receptor alpha subunit mRNAs revealed by developmental and regional expression in rat, chicken and human brain. FEBS Lett., 258, 94-98.
17. 2 receptors. Neuroscience, 36, 403-410.
18. 2A receptor binding, but not in benzodiazepine receptor binding in the brains of aged rats. Life Sci., 55, 1585-1593.
19. Niles, L. P., Pulido, O. M., & Pickering, D. S. (1988). Age-related changes in GABA and benzodiazepine receptor binding in rat brain are influenced by sampling time. Prog. Neuro-Psychopharmacol. & Biol. Psychiat., 12, 337-344.
20. 3H]piflutixol. Eur. J. Pharmacol., 105, 171-174.
21. 1 adenosine receptors in cortex, hippocampus and cerebellum in ageing mouse brain. Neuroreport, 3, 735-737.
22. Pradhan, S. N. (1980) Central neurotransmitters and ageing. Life Sci., 26, 1643-1656.
23. A/benzodiazepine receptor in rat hippocampus during ageing. J. Pharmacol. Exp. Ther., 256, 902-908.
24. A receptor complex during ageing, as assessed in 3- and 24-month-old rat cerebral cortex. Eur. J. Pharmacol., Mol. Pharmacol. S., 246, 81-87.
25. Ruano, D., Benavides, J., Machado, A., & Vitorica, J. (1995). Ageing-associated changes in the pharmacological properties of the benzodiazepine (ω) receptor isotypes in the rat hippocampus. J. Neurochem., 64, 867-873.
26. Scatchard, G. (1949). The attraction of proteins for small molecules and ions. Ann. N. Y. Acad. Sci., 51, 660-672.
27. 2 dopamine receptors in ageing mouse striatum: Determination of high- and low-affinity agonist binding sites. J. Pharmacol. Exp. Ther., 233, 361-368.
28. Shih, J. C., & Young, H. (1978). The alteration of serotonin binding sites in aged human brain. Life Sci., 23, 1441-1448.
29. Snyder, S. H., Verma, A., & Trifiletti, R. (1987). The peripheral-type benzodiazepine receptor: A protein of mitochondrial outer membranes utilizing porphyrins as endogenous ligands. FASEB J., 1, 282-288.
30. Syapin, P. J., and Skolnick, P. (1979). Characterization of benzodiazepine binding sites in cultured cells of neural origin. J. Neurochem., 32, 1047-1051.
31. Timiras, P. S., Hudson, D. B., & Oklund, S. (1973). Changes in brain GABA in the developing and ageing rat. ISN Tokyo Meeting.
32. Vaccarino, F. M., Ghetti, B., & Nurnberger, Sr, J. I. (1985). Residual benzodiazepine binding in the cortex of pcd mutant cerebella and qualitative benzodiazepine binding in the deep cerebellar nuclei of control and mutant mice: An autoradiographic study. Brain Res., 343, 70-78.
33. A/ benzodiazepine receptor complex during development of the rat brain. J. Neurochem., 54, 187-194.
34. Waller, S. B., Ingram, D. K., Reynolds, M. A., & London, E. D. (1983). Age and strain comparisons of neurotransmitter synthetic enzyme activities in the mouse. J. Neurochem., 41, 1421-28.