Usefulness of Mycobacterium tuberculosis genomic mutations in the genes katG and inhA for the prediction of isoniazid resistance

International Journal of Tuberculosis and Lung Disease

Volumn 1, Issue 4, 1997, Pages 365-369

  Dobner, P ^a   Rusch Gerdes S ^b   Bretzel, G ^c   Feldmann, K ^d   Rifai, M ^d   Loscher T ^a   Rinder, H ^a,e  

^a UNIVERSITY OF MUNICH   (Germany)

^b National Reference Center for Mycobacteria   (Germany)

^c Armauer Hansen Institute   (Germany)

^d ASKLEPIOS FACHKLINIKEN MÜNCHEN GAUTING   (Germany)

^e Department of Infectious Diseases ^*  (Germany)

Author keywords

inhA; Isoniazid resistance; katG; Mycobacterium tuberculosis

Indexed keywords

BACTERIAL PROTEIN; CATALASE HPI; INHA PROTEIN, MYCOBACTERIUM; ISONIAZID; OXIDOREDUCTASE; PEROXIDASE; TUBERCULOSTATIC AGENT;

ARTICLE; CODON; CULTURAL FACTOR; DRUG EFFECT; GENETICS; GERMANY; HUMAN; MICROBIOLOGY; MYCOBACTERIUM TUBERCULOSIS; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SIERRA LEONE; SITE DIRECTED MUTAGENESIS; TUBERCULOSIS;

ANTITUBERCULAR AGENTS; BACTERIAL PROTEINS; CODON; CROSS-CULTURAL COMPARISON; DNA MUTATIONAL ANALYSIS; GERMANY; HUMANS; ISONIAZID; MUTAGENESIS, SITE-DIRECTED; MYCOBACTERIUM TUBERCULOSIS; OXIDOREDUCTASES; PEROXIDASES; POLYMERASE CHAIN REACTION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; SIERRA LEONE; TUBERCULOSIS, MULTIDRUG-RESISTANT;

EID: 0031196349     PISSN: 10273719     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Wilson T M, Collins D M. ahpC, a gene involved in isoniazid resistance of the Mycobacterium tuberculosis complex. Mol Microbiol 1996; 19: 1025-1034.
2. Kapur V, Li L L, Hamrick M R, et al. Rapid Mycobacterium species assignment and unambiguous identification of mutations associated with antimicrobial resistance in Mycobacterium tuberculosis by automated DNA sequencing. Arch Pathol Lab Med 1995; 119: 131-138.
3. Banerjee A, Dubnau E, Qućmard A, et al. inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis. Science 1994; 263: 227-230.
4. Zhang Y, Heym B, Allen B, Young D, Cole S. The catalase-peroxidase gene and isoniazid resistance of Mycobacterium tuberculosis. Nature 1992; 358: 591-593.
5. Ristow M, Mohlig M, Rifai M, Schatz H, Feldmann K, Pfeiffer A. New isoniazid/ethionamide resistance gene mutation and screening for multidrug-resistant Mycobacterium tuberculosis strains. Lancet 1995; 346: 502-503.
6. O'Brien K L, Dietz H C, Romagnoli M, Eiden J. Evaluation of inhA gene and catalase-peroxidase gene among isoniazid-sensitive and resistant Mycobacterium tuberculosis isolates. Mol Cell Probes 1996; 10: 1-6.
7. Heym B, Honoré N, Truffot-Pernot C, et al. Implications of multidrug resistance for the future of short-course chemotherapy of tuberculosis: a molecular study. Lancet 1994; 344: 293-298.
8. Morris S, Bai G H, Suffys P, Portillo-Gomez L, Fairchok M, Rouse D. Molecular mechanisms of multiple drug resistance in clinical isolates of Mycobacterium tuberculosis. J Infect Dis 1995; 171: 954-960.
9. Rouse D A, Li Z, Bai G H, Morris S L. Characterization of the katG and inbA genes of isoniazid-resistanr clinical isolates of Mycobacterium tuberculosis. Antimicrob Agents Chemother 1995; 39: 2472-2477.
10. Musser J M, Kapur V, Williams D L, Kreiswirth B N, van Soolingen D, van Embden J D A. Characterization of the catalase-peroxidase gene (katG) and inhA locus in isoniazid-resistant and -susceptible strains of Mycobacterium tuberculosis by automated DNA sequencing: restricted array of mutations associated with drug resistance. J Infect Dis 1996; 173: 196-202.
11. Middlebrook G. Isoniazid resistance and catalase activity of tubercle bacilli. Am Rev Tuberc 1954; 69: 471-472.
12. Ferrazoli L, Palaci M, da Silva Telles M A, et al. Catalase expression, katG, and MIC of isoniazid for Mycobacterium tuberculosis isolates from Sao Paulo, Brazil. J Infect Dis 1995; 171: 237-240.
13. Goto M, Oka S, Tachikawa N, et al. katG sequence deletion is not the major cause of isoniazid resistance in Japanese and Yemeni Mycobacterium tuberculosis isolates. Mol Cell Probes 1995; 9: 433-439.
14. Stoeckle M Y, Guan L, Riegler N, et al. Catalase-peroxidase gene sequences in isoniazid-sensitive and -resistant strains of Mycobacterium tuberculosis from New York City. J Infect Dis 1993; 168: 1063-1065.
15. Altamirano M, Marostenmaki J, Wong A, FitzGerald M, Black W A, Smith J A. Mutations in the catalase-peroxidase gene from isoniazid-resistant Mycobacterium tuberculosis isolates. J Infect Dis 1994; 169: 1162-1165.
16. Pretorius G S, van Helden P D, Sirgel F, Eisenach K D, Victor T C. Mutations in katG gene sequences in isoniazid-resistant clinical isolates of Mycobacterium tuberculosis are rare. Antimicrob Agents Chemother 1995; 39: 2276-2281.
17. Rouse D A, Morris S L. Molecular mechanisms of isoniazid resistance in Mycobacterium tuberculosis and Mycobacterium bovis. Infect Immun 1995; 63: 1427-1433.
18. Cockerill F R, Uhl J R, Temesgen Z, et al. Rapid identification of a point mutation of the Mycobacterium tuberculosis catalase-peroxidase (katG) gene associated with isoniazid resistance. J Infect Dis 1995; 171: 240-245.
19. Heym B, Alzari P M, Honoré N, Cole S T. Missense mutations in the catalase-peroxidase gene, katG, arc associated with isoniazid resistance in Mycobacterium tuberculosis. Mol Microbiol 1995; 15: 235-245.
20. Victor T C, Pretorius G S, Felix J V, Jordaan A M, van Helden P D, Eisenach K D. katG mutations in isoniazid-resistant strains of Mycobacterium tuberculosis are not infrequent (letter to the editor). Antimicrob Agents Chemother 1996; 40: 1572.
21. Sheffield V C, Beck J S, Kwitek A E, Sadstorm D W, Stone E M. The sensitivity of single-strand conformation analysis for the detection of single base substitutions. Genomics 1993; 16: 325-332.