The use of a PID controller to model vecuronium pharmacokinetics and pharmacodynamics during liver transplantation

IEEE Transactions on Biomedical Engineering

Volumn 44, Issue 7, 1997, Pages 610-619

  O'Hara, Dorene A ^a  

^a ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

Computer control; Liver transplantation; Neuromuscular blockade; Pharmacodynamics; Pharmacokinetics; Proportional integral derivative; Vecuronium

Indexed keywords

COMPUTER CONTROL; DRUG PRODUCTS; DRUG THERAPY; ELECTROMYOGRAPHY; PHARMACODYNAMICS; PHARMACOKINETICS; PHYSIOLOGY; TRANSPLANTATION (SURGICAL);

LIVER TRANSPLANTATION; NEUROMUSCULAR BLOCKADE; VECURONIUM;

TWO TERM CONTROL SYSTEMS;

VECURONIUM;

ADULT; ANESTHESIA COMPLICATION; ARTICLE; BLEEDING; BODY TEMPERATURE; CLINICAL ARTICLE; DRUG METABOLISM; FEMALE; HUMAN; LIVER BLOOD FLOW; LIVER TRANSPLANTATION; MALE; NEUROMUSCULAR BLOCKING;

ADOLESCENT; ADULT; COMPUTER SIMULATION; DRUG THERAPY, COMPUTER-ASSISTED; ELECTROMYOGRAPHY; FEMALE; HUMANS; INFUSION PUMPS; INTRAOPERATIVE PERIOD; LIVER TRANSPLANTATION; MALE; MIDDLE AGED; MODELS, BIOLOGICAL; NEUROMUSCULAR DEPOLARIZING AGENTS; NEUROMUSCULAR NONDEPOLARIZING AGENTS; TIME FACTORS; VECURONIUM BROMIDE;

EID: 0031195193     PISSN: 00189294     EISSN: None     Source Type: Journal    
DOI: 10.1109/10.594902     Document Type: Article

References (22)

1. D.A. O'Hara, G.J. Derbyshire, F.J. Overdyk, D.K. Bogen, and B.E. Marshall, "Closed-loop infusion of atracurium with four different anesthetic techniques," Anesth., vol. 74, pp. 258-263, 1991.
2. D.A. O'Hara, B. Chen, Y. Zhu, and J. K.-J. Li, "Closed-Loop Controllers for Automatic Drug Delivery," in P roc. 19th NE Bioeng. Conf., 1993, pp. 17-18.
3. J.D.F. White, J.C. Caldwell, M.C. Prager, M.L. Sharma, L.D. Gruenke, and R.D. Miller, "The pharmacokinetics of vecuronium during liver transplantation in humans," Anesth. Analg., vol. 70, p. S432, 1990.
4. B. O'Kelly, P. Jayais, P. Veroli, C. Lhuissier, and C. Ecoffey, "Dose requirements of vecuronium, pancuronium, and atracurium during orthotopic liver transplantation," Anesth. Analg., vol. 73, pp. 794-798, 1991.
5. R.R. Jaklitsch, D.R. Westenskow, N.L. Pace, J.B. Streisand, and K.A. East, "A comparison of computer-controlled versus manual administration of vecuronium in humans," J. Clin. Monit., vol. 3, pp. 269-276, 1987.
6. N.T. Smith, M.L. Quinn, Y. Fukui, R. Fleming, and J.R. Coles, "Automatic control in anesthesia: A comparison in performance between the anesthetist and the machine," Anesth. Analg., vol. 63, pp. 715-722, 1984.
7. M. Buhrer, P.O. Maitre, O.R. Hung, W.F. Ebling, S.L. Shafer, and D.R. Stanski, "Thiopental Pharmacodynamics: I - Defining the pseudosteady-state serum concentration-EEG effect relationship," Anesth., vol. 77, pp. 226-236, 1992.
8. O.R. Hung, J.R. Varvel, S.L. Shafer, and D.R. Stanski, "Thiopental Pharmacodynamics: II - Quantitation of clinical and electroencephalographic depth of anesthesia," Anesth., vol. 77, pp. 237-244, 1992.
9. G.N.C. Kenny, W. McFadzean, H. Mantzaridis, and A.C. Fisher, "Closed-loop control of anesthesia," Anesth., vol. 77, p. A38, 1992.
10. L.B. Sheiner, D.R. Stanski, S. Vozeh, R.D. Miller, and J. Ham, "Simultaneous modeling of pharmacokinetics and pharmacodynamics: Application to d-tubocurarine," Clin. Pharmacol. Ther., vol. 25, pp. 358-371, 1979.
11. R.R. Jaklitsch and D.R. Westenskow, "A model-based self-adjusting two-phase controller for vecuronium-induced muscle relaxation during anesthesia," IEEE Trans. Biomed. Eng., vol. BME-34, pp. 583-594, 1987.
12. J.R. Arden, D.P. Lynam, K.P. Castagnoli, P.C. Canfell, J.C. Cannon, and R.D. Miller, "Vecuronium in alcoholic liver disease: A pharmacokinetic and pharmacodynamic analysis," Anesth., vol. 68, pp. 771-776, 1988.
13. L. Lebrault, J.L. Berger, A.A. D'Hollander, R. Gomeni, D. Henzel, P. Duvaldestin, "Pharmacokinetics and pharmacodynamics of vecuronium (ORG NC45) in patients with cirrhosis," Anesth., vol. 62, pp. 601-605, 1985.
14. C. Lebrault, P. Duvaldestin, D. Henzel, M. Chauvin, and P. Guesnon, "Pharmacokinetics and pharmacodynamics of vecuronium in patients with cholestasis," Br.J. Anaesth., vol. 58, pp. 983-987, 1986.
15. J.E. Paanaker, J.M.S.L. Thio, H.M. Van den Wildenberg, and F.M. Kaspersen, "Assay of vecuronium in plasma using solid-phase extraction, high-performance liquid chromatography and post-column ion-pair extraction with fluorimetric detection," J. Chromatogr., vol. 421, pp. 327-335, 1987.
16. D. Verrota, S.L. Beal, and L.B. Sheiner, "Semiparametric approach to pharmacokinetic-pharmacodynamic data," Amer.J. Physiol., vol. 256, pp. R1005-1010, 1989.
17. J.P. Pittet, D.R. Morel, G. Mentha, C. Schopfer, J. Belenger, A. Benakis, and E. Tassonyi, "Vecuronium neuromuscular blockade reflects liver function during hepatic autotransplantation in pigs," Anesth., vol. 81, pp. 168-175, 1994.
18. P. Duvaldestin, S. Agoston, D. Henzel, U.W. Kersten, and J.M. Desmonts, "Pancuronium pharmacokinetics in patients with liver cirrhosis," Br.J. Anaesth., vol. 50, pp. 1131-1136, 1978.
19. C.A. Shanks, M.J. Avram, A.K. Ronai, and D.J. Bowsher, "The pharmacokinetics of d-tubocurarine with surgery involving salvaged autologous blood," Anesth., vol. 62, pp. 161-165, 1985.
20. J.E. Cannon, M.R. Fahey, K.P. Castagnoli, T. Furuta, P.C. Canfell, M. Sharma, and R.D. Miller, "Continuous infusion of vecuronium: The effect of anesthetic agents," Anesth., vol. 67, pp. 503-506, 1987.
21. D.A. O'Hara, D.K. Bogen, and A. Noordergraaf, "The use of computers for controlling the delivery of anesthesia," Anesth., vol. 77, pp. 563-581, 1992.
22. H. Schwilden and H. Stoeckel, "Effective therapeutic infusions produced by closed-loop feedback control of methohexital administration during total intravenous anesthesia with fentanyl," Anesth., vol. 73, pp. 225-229, 1990.