Transcription of the Leishmania major Hsp70-I gene locus does not proceed through the noncoding region

Experimental Parasitology

Volumn 86, Issue 3, 1997, Pages 206-212

  Dresel, Annette ^a   Clos, Joachim ^a  

^a BERNHARD NOCHT INSTITUTE FOR TROPICAL MEDICINE   (Germany)

Author keywords

Hsp70; Leishmania, heat shock; RNA polymerase II; Transcription termination

Indexed keywords

ARTICLE; ENZYME ACTIVITY; EUKARYOTE; EXON; GENE EXPRESSION; GENE LOCUS; GENETIC ANALYSIS; GENETIC TRANSCRIPTION; HEAT SHOCK; LEISHMANIA MAJOR; LEISHMANIASIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTOZOON; RNA SYNTHESIS; SPECIES DIFFERENCE;

EUKARYOTA; LEISHMANIA MAJOR; PROTOZOA;

EID: 0031194165     PISSN: 00144894     EISSN: None     Source Type: Journal    
DOI: 10.1006/expr.1997.4161     Document Type: Article

References (25)

1. Agami, R., Aly, R., Halman, S., and Shapira, M. 1994. Functional analysis of cis-acting DNA elements required for expression of the SL RNA gene in the parasitic protozoan Leishmania amazonensis. Nucleic Acids Research 22, 1959-1965.
2. Brandau, S., Dresel, A., and Clos, J. 1995. High constitutive levels of heat-shock proteins in human-pathogenic parasites of the genus Leishmania. Biochemical Journal 310, 225-232.
3. Coulson, R. M. R., and Smith, D. F. 1990. Isolation of genes showing increased or unique expression in the infective promastigotes of Leishmania major. Molecular and Biochemical Parasitology 40, 63-76.
4. Fernandes, M., O'Brien, T., and Lis, J. T. 1994. Structure and regulation of heat shock gene promoters. In "The Biology of Heat Shock Proteins and Molecular Chaperones" (R. I. Morimoto, A. Tissières, and C. Georgopoulos, Eds.), pp. 375-393. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
5. Glass, D. J., Polvere, R. I., and van der Ploeg, L. H. T. 1986. Conserved sequences and transcription of the hsp70 gene family in Trypanosoma brucei. Molecular and Cellular Biology 6, 4657-4666.
6. Graham, S. V. 1995. Mechanisms of stage-regulated gene expression in kinetoplastida. Parasitology Today 11, 217-223.
7. Huang, J., and van der Ploeg, L. H. T. 1991. Maturation of polycistronic pre-mRNA in Trypanosoma brucei: Analysis of trans splicing and poly(A) addition at nascent RNA transcripts from the hsp70 locus. Molecular and Cellular Biology 11, 3180-3190.
8. Hübel, A., and Clos, J. 1996. The genomic organisation of the HSP83 gene locus is conserved in three Leishmania species. Experimental Parasitology 82, 225-228.
9. Imboden, M. A., Laird, P. W., Affolter, M., and Seebeck, T. 1987. Transcription of the intergenic regions of the tubulin gene cluster of Trypanosoma brucei: Evidence for a polycistronic transcription unit in a eukaryote. Nuclei Acids Research 15, 7357-7368.
10. Johnson, P. J., Kooter, J. M., and Borst, P. 1987. Inactivation of transcription by UV irradiation of T. brucei provides evidence for a multicistronic transcription unit including a VSG gene. Cell 51, 273-281.
11. Lee, M. G.-S. 1996. An RNA polymerase II promoter in the hsp70 locus of Trypanosoma brucei. Molecular and Cellular Biology 16, 1220-1230.
12. Lee, M. G.-S., Atkinson, B. L., Giannini, S. H., and van der Ploeg, L. H. T. 1988. Structure and expression of the HSP 70 gene family of Leishmania major. Nucleic Acids Research 16, 9567-9585.
13. Lee, M. G.-S., and van der Ploeg, L. H. T. 1990. Transcription of the heat shock 70 locus in Trypanosoma brucei. Molecular and Biochemical Parasitology 41, 221-232.
14. Lodes, M. J., Merlin, G., deVos, T., Ghosh, A., Madhubala, R., Myler, P. J., and Stuart, K. 1995. Increased expression of LD1 genes transcribed by RNA polymerase I in Leishmania donovani as a result of duplication into the rRNA locus. Molecular and Cellular Biology 15, 6845-6853.
15. Muhich, M. L., and Boothroyd, J. C. 1988. Polycistronic transcripts in trypanosomes and their accumulation during heat shock: Evidence for a precursor role in mRNA synthesis. Molecular and Cellular Biology 8, 3837-3846.
16. Platt, T. 1986. Transcription termination and the regulation of gene expression. Annual Reviews in Biochemistry 55, 339-372.
17. Rudenko, G., Chung, H.-M. M., Pham, V. P., and van der Ploeg, L. H. T. 1991. RNA polymerase I can mediate expression of CAT and neo protein-coding genes in Trypanosoma brucei. EMBO Journal 10, 3387-3397.
18. Saito, R. M., Elgort, M. G., and Campbell, D. A. 1994. A conserved upstream element is essential for transcription of the Leishmania tarentolae mini-exon gene. EMBO Journal 13, 5460-5469.
19. Sherman, D. R., Janz, L., Hug, M., and Clayton, C. 1991. Anatomy of the PARP gene promoter of Trypanosoma brucei. EMBO Journal 10, 3379-3386.
20. Tschudi, C., and Ullu, E. 1987. Polygene transcripts are precursors to calmodulin mRNAs in trypanosomes. EMBO Journal 6, 455-463.
21. Walder, J. A., Eder, P. S., Engman, D. S., Brentano, S. T., Walder, R. Y., Knutzon, D. S., Dorfman, D. M., and Donelson, J. E. 1986. The 35-nucleotide splice leader sequence is common to all trypanosome messenger RNA. Science 233, 569-571.
22. Wong, A. K. C., Curotto de Lafaille, M. A., and Wirth, D. F. 1994. Identification of a cis-acting gene regulatory element from the lemdr1 locus of Leishmania enriettii. The Journal of Biological Chemistry 269, 26497-26502.
23. World Health Organization (WHO) 1990. "Control of the Leishmaniases. Report of a WHO Expert Committee." World Health Organization Technical Report Series 793.
24. Wu, C., Clos, J., Giorgi, S., Haroun, R. I., Kim, S-J., Rabindran, S. K., Westwood, J. T., Wisniewski, J., and Yim, G. 1994. Structure and regulation of heat shock transcription factor. In "The Biology of Heat Shock Proteins and Molecular Chaperones" (R. I. Morimoto, A. Tissières, and C. Georgopoulos, Eds.), pp. 395-416. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
25. Zomerdijk, J., Kieft, R., and Borst, P. 1991. Efficient production of functional mRNA mediated by RNA polymerase I in Trypanosoma brucei. Nature 353, 772-775.