The immunomodulatory effects of the herbicide propanil on murine macrophage interleukin-6 and tumor necrosis factor-α production

Toxicology and Applied Pharmacology

Volumn 145, Issue 1, 1997, Pages 184-191

  Xie, Y C ^a   Schafer, R ^a   Barnett, J B ^a  

^a WEST VIRGINIA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; HERBICIDE; INTERLEUKIN 6; PROPANIL; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; IMMUNOMODULATION; IMMUNOTOXICITY; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; SPLENOMEGALY; THYMUS ATROPHY;

ANIMALIA; MURINAE;

EID: 0031193852     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1997.8179     Document Type: Article

References (20)

1. Abbas A., Lichtman A. H., Pober J. S. Cellular and Molecular Immunology. 1994;W. B. Saunders, Philadelphia. p. 225-244.
2. Barnett J. B., Gandy J. Effect of acute propanil exposure on the immune response of C57B1/6 mice. Fundam. Appl. Toxicol. 12:1989;757-764.
3. Barnett J. B., Gandy J., Wilbourn D., Theus S. A. Comparison of the immunotoxicity of propanil and its metabolites, 3,4-dichloroaniline, in C57B1/6 mice. Fundam. Appl. Toxicol. 18:1992;628-631.
4. Blyler G., Landreth K. S., Lillis T., Schafer R., Theus S. A., Gandy J., Barnett J. B. Selective myelotoxicity of propanil. Fundam. Appl. Toxicol. 22:1993;505-510.
5. Church G. M., Gilbert W. Genomic sequencing. Proc. Natl. Acad. Sci. USA. 81:1984;1991-1995.
6. Cuff C. F., Zhao W., Nukui T., Schafer R., Barnett J. B. 3,4-Dichloro-propionanilide-induced atrophy of the thymus: Mechanisms of toxicity and recovery. Fundam. Appl. Toxicol. 33:1996;83-90.
7. Dutton R. W., Falkoff R., Hirst J. A. Is there evidence for a non-antigen specific diffusible chemical mediator from the thymus derived cell in the initiation of the immune response? Prog. Immunol. 1:1971;355-367.
8. Feinberg A. P., Vogelstein B. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Addendum. Anal. Biochem. 137:1984;266-267.
9. 2. Proc. Natl. Acad. Sci. USA. 84:1987;7629-7634.
10. Hilbert D. M., Cancro M. P., Scherle P. A., Nordan R. P., Van-Snick J., Gerhard W., Rudikoff S. T cell derived IL-6 is differentially required for antigen-specific antibody secretion by primary and secondary B cells. J. Immunol. 143:1989;4019-4025.
11. d) macrophages requires the presence of lipid-A-associated proteins. J. Immunol. 141:1988;4196-4202.
12. Ikebuchi K., Wong G. G., Clark S. C., Ihle J. N., Hirai Y., Ogawa M. Interleukin 6 enhancement of interleukin 3-dependent proliferation of multipotential hematopoietic progenitors. Proc. Natl. Acad. Sci. USA. 84:1987;9035-9041.
13. Okano A., Suzuki C., Takatsuki R. Effects of interleukin-6 on hematopoiesis in bone marrow-transplanted mice. Transplantation. 47:1989;738-744.
14. Schimpl A., Wecker E. Replacement of a T-cell function by a T-cell product. Nature. 237:1972;15-17.
15. ++. Int. Immunol. 3:1992;327-332.
16. Theus S. A., Tabor D. R., Gandy J., Barnett J. B. Alteration of macrophage cytotoxicity through endogenous interferon and tumor necrosis factor-alpha induction by propanil. Toxicol. Appl. Pharmacol. 118:1993;46-52.
17. Thomas P. S. Hybridization of denatured RNA transferred or dotted to nitrocellulose paper. Methods. Enzymol. 100:1983;255-266.
18. Xie Y., Schafer R., Barnett J. B. The inhibitory effect of 3,4-dichloropropionaniline on cytokine production by macrophages is associated with LPS-mediated signal transduction. J. Leuk. Biol. 1997.
19. Zhao W., Schafer R., Barnett J. B. The immunotoxic effect ofin vitro. The Toxicologist. 15:1995a;138.
20. Zhao W., Schafer R., Cuff C. F., Gandy J., Barnett J. B. Changes in primary and secondary lymphoid organ T-cell subpopulations resulting from acutein vivo. J. Toxicol. Environ. Health. 46:1995b;171-181.