Lysosomes and teratogenesis: From hypothesis to dogma and back

Reproductive Toxicology

Volumn 11, Issue 4, 1997, Pages 589-594

  Lloyd, John B ^a,b,c  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b NEMOURS ALFRED I DUPONT HOSPITAL FOR CHILDREN   (United States)

^c NEMOURS CHILDREN S CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRYPAN BLUE;

ANIMAL; ARTICLE; CONGENITAL MALFORMATION; LYSOSOME; PHYSIOLOGY; RAT; YOLK SAC;

ABNORMALITIES, DRUG-INDUCED; ANIMALS; LYSOSOMES; RATS; TRYPAN BLUE; YOLK SAC;

EID: 0031183431     PISSN: 08906238     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0890-6238(97)89178-2     Document Type: Article

References (36)

1. Brent RL. Immunological aspects of developmental biology. In Woollam DHM, ed. Advances in teratology. London: Academic Press;1966:81-129.
2. Beck F, Lloyd JB. The teratogenic effects of azo dyes. In Woollam DHM, ed. Advances in teratology. London: Academic Press; 1966: 131-93.
3. Beck F, Spencer B, Baxter JS. Effect of trypan blue on rat embryos. Nature. 1960; 187:605-7.
4. Lloyd JB, Beck F. An evaluation of acid disazo dyes by chloride determination and paper chromatography. Stain Technol. 1963;38: 165-71.
5. Lloyd JB, Beck F. The identification of some acid disazo dyes by paper electrophoresis of their reduction products. Stain Technol. 1964;39:7-12.
6. Beck F, Lloyd JB. The preparation and teratogenic properties of pure trypan blue and its common contaminants. J Embryol Exp Morphol. 1963:11:175-84.
7. Lloyd JB, Beck F. The relationship of chemical structure to teratogenic activity among bisazo dyes: a re-evaluation. J Embryol Exp Morphol. 1966;16:29-39.
8. Beck F, Lloyd JB. The relationship between foetal death and foetal malformation. J Anat. 1963:97:555-64.
9. Beck F, Lloyd JB. Dosage-response curves for the teratogenic activity of trypan blue. Nature. 1964;201:1136-7.
10. Lloyd JB, Beck F. Evidence for a mechanism of teratogenesis involving inhibition of embryotrophic nutrition. Lab Anim. 1968; 2:171-80.
11. Lloyd JB, Field FE. The red impurity of trypan blue. Experientia. 1970;26:868.
12. Field FE, Roberts G, Hallowes RC, Palmer AK, Williams KE, Lloyd JB. Trypan blue: identification and teratogenic and oncogenic activities of its coloured constituents. Chem-Biol Interact. 1977;16:69-88.
13. Wilson JG, Beaudoin AR, Free HJ. Studies on the mechanism of teratogenic action of trypan blue. Anat Rec. 1959; 133:115-28.
14. Beck F. Quoted by JD Ebert in the report of the Department of Embryology, Carnegie Institution of Washington Yearbook. 1964; 63:561-4.
15. De Reuck AVS, Cameron MP, eds. Lysosomes, A Ciba Foundation symposium. London: Churchill; 1963.
16. Beck F, Lloyd JB, Griffiths A. A histochemical and biochemical study of some aspects of placental function in the rat using maternal injection of horseradish peroxidase. J Anat. 1967;101: 461-78.
17. Beck F, Lloyd JB, Griffiths A. Lysosomal enzyme inhibition by trypan blue: a theory of teratogenesis. Science. 1967;157:1180-2.
18. Lloyd JB, Beck F, Griffiths A, Parry LM. The mechanism of action of acid bisazo dyes. In Campbell PN, ed. The interaction of drugs and subcellular components in animal cells. London: Churchill; 1968:171-200.
19. 125I-labelled albumin within rat liver lysosomes. Biochem J. 1971:121:21-6.
20. Lloyd JB. Cell physiology of the rat visceral yolk sac: a study of pinocytosis and lysosome function. Teratology. 1990;41:383-93.
21. Lloyd JB. Histiotrophic nutrition-a target for "macromolecular" teratogens. In Bass R, Beck F, Merker H-J, Neubert D, Randhahn B, eds. Metabolie pathways in mammalian embryos during organogenesis and its modification by drugs. Berlin: Freie Universität Berlin; 1971:575-92.
22. Williams KE, Roberts G, Kidston ME. Beck F, Lloyd JB. Inhibition of pinocytosis in rat yolk sac by trypan blue. Teratology. 1976:14:343-54.
23. Freeman SJ, Beck F, Lloyd JB. The role of the visceral yolk sac in mediating protein utilization by rat embryos cultured in vitro. J Embryol Exp Morphol. 1981:66:223-34.
24. Freeman SJ, Lloyd JB. Evidence that protein ingested by the visceral yolk sac yields amino acids for synthesis of embryonic protein. J Embryol Exp Morphol. 1983:73:307-15.
25. Slotnick V, Brent RL. The production of congenital malformations using tissue antisera. V. Fluorescent localization of teratogenic antisera in the maternal and fetal tissue of the rat. J Irnmunol. 1966:96:606-10.
26. Brent RL, Johnson AJ, Jensen M. The production of congenital malformations using tissue antisera. VII. Yolk-sac antiserum. Teratology. 1971:4:255-75.
27. New DAT, Brent RL. Effect of yolk-sac antibody on rat embryos grown in culture. J Embryol Exp Morphol. 1972:27:543-53.
28. Freeman SJ, Brent RL, Lloyd JB. The effect of teratogenic antiserum on yolk-sac function in rat embryos cultured in vitro. J Embryol Exp Morphol. 1982:71:63-74.
29. Freeman SJ, Lloyd JB. Inhibition of proteolysis in rat yolk sac as a cause of teratogenesis. Effects of leupeptin in vitro and in vivo. J Embryol Exp Morphol. 1983:78:183-93.
30. Freeman SJ, Lloyd JB. Evidence that suramin and aurothiomalate are teratogenic in rat by disturbing yolk sac-mediated embryonic protein nutrition. Chem-Biol Interact. 1986;58:149-60.
31. Beckman DA. Mechanisms of amino acid supply to the rat conceptus in normal and abnormal development. Reprod Toxicol. 1997:11:595-99.
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33. Beckman DA, Brent RL, Lloyd JB. Leucine sources for the rat fetus. Placenta. 1997;18;79-82.
34. Hartfield PJ, Williams KE, Geddes R, Lloyd JB. Glycogen metabolism in the rat visceral yolk sac. 1. Glycogen content and gestational age. Placenta. 1989:10:45-54.
35. Williams KE, Hartfield PJ, Cable H, Lloyd JB. Glycogen metabolism in the rat visceral yolk sac. 2. Activity of glycogen-degrading enzymes. Placenta. 1995:16:719-26.
36. Brent RL. Antibodies and malformations. In Tuchmann-Duplessis H, ed. Malformations congénitales des mammifères. Paris: Masson; 1971:187-220.