Expression of a Biologically Active Recombinant Mouse IL-1 Receptor Antagonist and Its Use in Vivo to Modulate Aspects of the Acute Phase Response

Journal of Immunology

Volumn 159, Issue 1, 1997, Pages 369-378

  Grehan, Sharon ^a   Uhlar, Clarissa M ^a   Sim, Robert B ^b   Herbert, Jeff ^c   Whitehead, Alexander S ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c HAMMERSMITH HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID; IL1RN PROTEIN, MOUSE; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; MESSENGER RNA; RECOMBINANT PROTEIN; SIALOGLYCOPROTEIN;

ACUTE PHASE RESPONSE; ANIMAL; ARTICLE; BIOSYNTHESIS; CELL LINE; DRUG ANTAGONISM; DRUG EFFECT; ESCHERICHIA COLI; GENETICS; IMMUNOLOGY; LIVER; MOUSE;

ACUTE-PHASE REACTION; AMYLOID; ANIMALS; CELL LINE; ESCHERICHIA COLI; INTERLEUKIN 1 RECEPTOR ANTAGONIST PROTEIN; LIVER; MICE; RECEPTORS, INTERLEUKIN-1; RECOMBINANT PROTEINS; RNA, MESSENGER; SIALOGLYCOPROTEINS;

EID: 0031181335     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. Dinarello, C. A. 1988. Biology of interleukin 1. FASEB J. 2:108.
2. Oppenheim, J. J., E. J. Kovacs, K. Matsushima, and S. K. Durum. 1986. There is more than one interleukin 1. Immunol. Today 7:45.
3. Neta, R., and J. J. Oppenheim. 1988. Why should internists be interested in interleukin-1? Ann. Intern. Med. 109:1.
4. O' Garra, A. 1989. Interleukins and the immune system I. Lancet 1:943.
5. Curtis, B. M., B. Gallis, R. O. Overell, C. J. McMahan, P. DeRoos, R. Ireland, J. Eisenman, S. K. Dower, and J. Sims. 1989. T-cell interleukin 1 receptor cDNA expressed in Chinese hamster ovary cells regulates functional responses to interleukin 1. Proc. Natl. Acad. Sci. USA 86:3045.
6. Re, F., M. Mengozzi, M. Muzio, C. A. Dinarello, A. Mantovani, and F. Colotta. 1993. Expression of interleukin-1 receptor antagonist (IL-1ra) by human circulating polymorphonuclear cells. Eur. J. Immunol. 23:570.
7. Arend, W. P., F. G. Joslin, and R. J. Massoni. 1985. Effects of immune complexes on production by human monocytes of interleukin 1 or interleukin 1 inhibitor. J. Immunol. 134:3868.
8. Seckinger, P., J. Klein-Nulend, C. Alander, R. C. Thompson, J-M. Dayer, and L. G. Raisz. 1990. Natural and rccombinant human receptor antagonist blocks the effect of IL-1 on bone resorption and prostaglandin production. J. Immunol. 145:4181.
9. Carter, D. B., Deibel, M. R., Jr., C. J. Dunn, C. S. Tomich, A. L. Laborde, J. L. Slightom, A. H. Berger, M. J. Bienkowski, F. F. Sun, R. N. McEwan, P. K. W. Harris, A. W. Yem, G. A. Waszak, J. G. Chosay, L. C. Sieu, M. M. Hardee, H. A. Zurcher-Neely, I. M. Reardon, R. L. Heinrickson, S. H. Truesdell, J. A. Shelly, T. E. Eessalu, B. M. Taylor, and D. E. Tracey. 1990. Purification, cloning, expression and biological characterisation of an interleukin-1 receptor antagonist protein. Nature 344:633.
10. Conca, W., P. E. Auron, M. Aoun-Wathne, N. Bennet, P. Seckinger, H. G. Welgus, S. R. Goldring, S. P. Eisenberg, J-M. Dayer, S. M. Krane, and L. Gehrke. 1991. An interleukin 1β point mutant demonstrates jun/fos expression is not sufficient for fibroblast metalloproteinase expression. J. Biol. Chem. 266:16265.
11. Dripps, D. J., B. J. Brandhuber, R. C. Thompson, and S. P. Eisenberg. 1991. Interleukin-1 (IL-1) receptor antagonist binds to the 80-kDa IL-1 receptor but does not initiate IL-1 signal transduction. J. Biol. Chem. 266:10331.
12. Hannum, C. H., C. J. Wilcox, W. P. Arend, F. G. Joslin, D. J. Dripps, P. L. Heimdal, L. G. Armes, A. Sommer, S. P. Eisenberg, and R. C. Thompson. 1990. Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor. Nature 343:336.
13. Arend, W. P., M. F. Smith, R. W. Janson, and F. G. Joslin. 1991. IL-1 receptor antagonist and IL-1β production in human monocytes are regulated differently. J. Immunol. 147:1530.
14. Eisenberg, S. P., M. T. Brewer, E. Verderber, P. Heimdal, B. J. Brandhuber, and R. C. Thompson. 1991. Interleukin 1 receptor antagonist is a member of the interleukin 1 gene family: evolution of a cytokine control mechanism. Proc. Natl. Acad. Sci. USA 88:5232.
15. Zahedi, K., M. F. Seldin, M. Rits, R. A. B. Ezekowitz, and A. S. Whitehead. 1991. Mouse IL-1 receptor antagonist protein: molecular characterization, gene mapping, and expression of mRNA in vitro and in vivo. J. Immunol 146:4228.
16. D'Eustachio, P., S. Jadidi, R. C. Fuhlbrigge, P. W. Gray, and D. D. Chaplin. 1987. Interleukin-1α and β genes: linkage on chromosome 2 in the mouse. Immunogenetics 26:339.
17. Silver, A. J. R., W. K. Masson, A. M. George, J. Adam, and R. Cox. 1990. The IL-1α and β genes are closely linked ( <70kb) on mouse chromosome 2. Somat. Cell. Mol. Genet. 16:549.
18. Arend, W. P., F. G. Joslin, R. C. Thompson, and C. H. Hannum. 1989. An IL-1 inhibitor from human monocytes: production and characterization of biological properties. J. Immunol. 143:1851.
19. Dinarello, C. A., and R. C. Thompson. 1991. Blocking IL-1: interleukin 1 receptor antagonist in vivo and in vitro. Immunol. Today 12:404.
20. Steinkasserer, A., R. Solari, H. R. Mott, R. T. Aplin, C. C. Robinson, A. C. Willis, and R. B. Sim. 1992. Human interleukin-1 receptor antagonist: high yield expression in E. coli and examination of cysteine residues. FEBS Lett. 310:63.
21. Shuck, M. E., T. E. Eessalu, D. E. Tracey, and M. J. Bienkowski. 1991. Cloning, heterologous expression and characterisation of murine interleukin 1 receptor antagonist protein. Eur. J. Immunol. 21:2775.
22. Smith, D. B., and K. S. Johnson. 1988. Single step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. Gene 67:31.
23. Uhlar, C. M., S. Grehan, D. M. Steel, A. Steinkasserer, and A. S. Whitehead. 1997. Use of the acute phase serum amyloid A2 (SAA2) gene promoter in the analysis of pro- and anti-inflammatory mediators: differential kinetics of SAA2 promoter induction by IL-1β and TNFα compared to IL-6. J. Immunol Methods. 203:123.
24. Auffray, C., and F. Rougeon. 1980. Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumour RNA. Eur. J. Bio-chem. 107:303.
25. Pepys, M. B. 1979. Isolation of serum amyloid P component (protein SAP) in the mouse. Immunology 37:637.
26. Pepys, M. B., A. C. Dash, A. H. L. Fielder, and D. D. Mirjah. 1977. Isolation and study of murine C3. Immunology 33:491.
27. Betts, J. C., J. K. Cheshire, S. Akira, T. Kishimoto, and P. Woo. 1993. The role of NF-κB and NF-IL6 transactivating factors in the synergistic activation of human serum amyloid A gene expression by interleukin-1 and interleukin-6. J. Biol. Chem. 268:25624.
28. Edbrooke, M. R., D. W. Bun, J. K. Cheshire, and P. Woo. 1989. Identification of cis-acting sequences responsible for phorbol ester induction of human serum amyloid A gene expression via a nuclear factor κB like transcription factor. Mol. Cell Biol. 9:1908.
29. Numerof, R. P., J. D. Sipe, E. G. Trehu, C. A. Dinarello, and J. W. Mier. 1992. Suppression of IL-2-induced SAA gene expression in mice by the administration of an IL-1 receptor antagonist. Cytokine 4:555.
30. Alexander, H. R., G. M. Doherty, C. M. Buresh, D. J. Venzon, and J. A. Norton. 1991. A recombinant human receptor antagonist to interleukin 1 improves survival after endotoxemia in mice. J. Exp. Med. 173:1029.
31. Lerderer, J. A., and C. J. Czuprynski. 1994. Species-specific binding of IL-1, but not the IL-1 receptor antagonist, by fibroblasts. Cytokine 6:154.
32. Meek. R. L., and E. P. Benditt. 1986. Amyloid A gene family expression in different mouse tissues. J. Exp. Med. 164:2006.
33. Benson, M. D., and E. Kleiner. 1980. Synthesis and secretion of serum amyloid protein A (SAA) by hepatocytes in mice treated with casein. J. Immunol. 124:495.
34. deBeer, M. C., M. S. Kindy, W. S. Lane, and P. C. deBeer. 1994. Mouse Serum amyloid A protein (SAA5) structure and expression. J. Biol. Chem. 269:4661.
35. Zahedi, K., and A. S. Whitehead. 1989. Acute phase induction of mouse serum amyloid P component: correlation with other parameters of inflammation. J. Immunol. 143:2880.
36. Rygg, M., G. Husby, and G. Marhaug. 1993. Differential expression of rabbit serum amyloid A genes in response to various inflammatory agents. Scand. J. Immunol. 38:417.
37. Lowell, C. A., R. S. Stearman, and J. F. Morrow. 1986. Transcriptional regulation of serum amyloid A gene expression. J. Biol. Chem. 261:8453.
38. Ramadori, G., J. D. Sipe, and H. R. Colten. 1985. Expression and regulation of the murine serum amyloid A (SAA) gene in extrahepatic sites. J. Immunol. 135:3645.
39. Le, P. T., and R. F. Mortensen. 1986. Induction and regulation by monokines of hepatic synthesis of the mouse serum amyloid P component (SAP). J. Immunol. 136:2526.
40. Lin, B. F., N. O. Ku, K. Zahedi, A. S. Whitehead, and R. F. Mortensen. 1990. IL-1 and IL-6 mediate increased production and synthesis by hepatocytes of acute-phase reactant mouse serum amyloid P component (SAP), inflammation 14:297.
41. Zahedi, K., and A. S. Whitehead. 1993. Regulation of mouse serum amyloid P gene expression by cytokines in vitro. Biochim. Biophys. Acta 1176:162.
42. Baltz, M. L. R. F. Dyck, and M. B. Pepys. 1985. Studies of the in vivo synthesis and catabolism of serum amyloid P component (SAP) in the mouse. Clin. Exp. Immunol. 59:235.
43. Pepys, M. B., M. Baltz, K. Corner, A. J. S. Davies, and M. Doenhoff. 1979. Serum amyloid P-component is an acute-phase reactant in the mouse. Nature 278:259.
44. Mortensen, R. F., K. Beisel, N. J. Zelznik, and P. T. Le. 1983. Acute-phase reactants of mice. II. Strain dependence of serum amyloid P component (SAP) levels and response to inflammation. J. Immunol. 130:885.
45. Itoh, Y., S. Takeuchi, K. Shigemoto, S. Kubo, S. Handa, N. Ishikawa, and N. Maruyama. 1992. The strain-dependent constitutive expression of murine serum amyloid P component is regulated at the transcriptional level. Biochim. Biophys. Acta 1131:261.
46. Baumann, H., and J. Gauldie. 1994. The acute phase response. Immunol. Today 15:74.