Vital Capillary Microscopy of Skin Areas at the Forefoot of Diabetic Patients using Intraarterial Injection of Na-Fluorescein

International Journal of Microcirculation-Clinical and Experimental

Volumn 17, Issue 4, 1997, Pages 190-197

  Meier, M ^a   Caspary, A ^a   Creutzig, L ^a   Alexander, K ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Diabetes mellitus; Fluorescence videomicroscopy; Intraarterial injection; Microcirculation; Na fluorescein; Reactive hyperemia; Skin microangiopathy; Vital capillary microscopy

Indexed keywords

CONTRAST MEDIUM; FLUORESCEIN;

ADULT; AGED; ARTICLE; CAPILLARY; CASE CONTROL STUDY; DIABETIC FOOT; DIABETIC NEUROPATHY; FEMALE; HUMAN; HYPEREMIA; INTRAARTERIAL DRUG ADMINISTRATION; MALE; MICROSCOPY; MIDDLE AGED; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SKIN TEMPERATURE; TEMPERATURE; ULTRASTRUCTURE;

ADULT; AGED; CAPILLARIES; CASE-CONTROL STUDIES; CONTRAST MEDIA; DIABETIC FOOT; DIABETIC NEUROPATHIES; FEMALE; FLUORESCEIN; HUMANS; HYPEREMIA; INJECTIONS, INTRA-ARTERIAL; MALE; MICROSCOPY, VIDEO; MIDDLE AGED; SKIN TEMPERATURE; TEMPERATURE;

EID: 0031179540     PISSN: 01676865     EISSN: None     Source Type: Journal    
DOI: 10.1159/000179228     Document Type: Article

References (40)

1. LoGerfo FW, Coffman JD: Vascular and microvascular disease of the foot in diabetes, Implications for foot care, N Engl J Med 1984: 311:1615-1619.
2. Tooke JE: The microcircuiation in diabetes, Br Med Bull 1987;45:206-223.
3. Katz MA, McCuskey P, Beggs JE, Johnson PC, Gaines JA: Relationship between mierovascu-lar function and capillary structure in diabetic and nondiabctic human skin, Diabetes 1989: 38:1245-1250
4. Caspary L, Abicht J, Creutzig A, Mitzkat HJ, Alexander K: Influence of diabetic neuropathy on skin microcircuiation assessed by transcuta-ncous oxymetry, Vasa 1995:24:340-346.
5. Railton R, Newman P, Hislop J, Harrowcr ADB: Reduced transcutaneous oxygen tension and impaired vascular response in type 1 (insulin-dependent) diabetes, Diabetologia 1983:25: 340-342.
6. Creutzig A: Pathogenesis of pcripherial diabetic microangiopathy, Critical Ischacmia 1994:4: 3.
7. Rendell M, Bamisedun O: Diabetic cutaneous microangiopathy, Am J Med 1992:93:611.
8. Sandeman DD, Shore AC, Tooke JE: Relation of skin capillary pressure in patients with insulin-dependent diabetes mellitus to complications and metabolic control, New Engl J Med 1992:327:760-764.
9. Tooke JE, Lins PE, Ostergren J, Fagrell B: Skin microvascular autorcgulatory responses in type I diabetes: The influence of duration and control, Int J Microcirc Clin Exp 1985:4:249-256.
10. Siperstcin MD, Unger RH, Madison LI: Studies of muscle capillary basement membranes in normal subjects, diabetic, and prcdiabetic patients, J Clin Invest 1968:47:1973-1999.
11. Kasrup J, Norgaard T, Pars ing HU, Lassen NA: Decreased distensibility of resistance vessels of the skin type 1 (insulin-dependent) diabetic patients with microangiopathy, Clin Sci 1987;72:123-130.
12. Katz MA, McNeill G: Defective vasodilation response to exercise in cutaneous precapillary vessels in diabetic humans, Diabetes 1987:36: 1386-1396.
13. Parving HH, Vigerti GC, Keen H, Christiansen JS, Lassen NA: Hacmodynamic factors in the genesis of diabetic microangiopathy, Metabolism 1983;32:943-949.
14. Zatz R, Brenner BM: Pathogenesis of diabetic microangiopathy: The haemodynamic view, Am J Med 1986;80:443-453.
15. Bollinger A, Frey J, Jager K, Furrer J, Siegen-thaler W: Patterns of diffusion through skin capillaries in patients with long-term diabetes, New Engl, J Med 1982:307:1305-1310.
16. Frey J, Furrer J, Bollinger A: Transkapillare Diffusion von Na-Fluoreszein des Fussriickens bei juvcnilen Diabetikern, Schweiz Med Wo-chenschr 1983:113:1964-1969.
17. JUnger M, Frey-Schncwlin G, Bollinger A: Mi-crovascular flow distribution and transcapillary diffusion at the forefoot in patients with peripheral ischemia, Int J Microcirc Clin Exp 1988;8:3-24.
18. 2 and dynamic capillaroscopy using intra-arterial injection of Na-fluorcs-cein in severe arterial ischemia, Int J Microcirc 1994:14:362.
19. Dyek PJ: Detection, characterization, and staging of polyneuropathy: Assessed in diabetics, Muscle Nerve 1988:11:21-32.
20. Jung F, Wapplcr M, Niittgens HP, Kicsewctter H, Wolf S, Miiller G: Zur Methodik der Vi-deokapillarmikroskopie: Bestimmung geome-trischerand dvnamischcr Messparameter, Bio-medTech 1987;32:204-213.
21. Fagrell B: Vital capillary microscopy - A clinical method for studying changes of the nutritional skin capillaries in legs with arteriosclerosis obliterans, Scand J Clin Lab Invest 1973; 31 (suppl 133): 1-50
22. Bollinger A, Fagrell B: Clinical capillaroscopy, A guide to its use in clinical research and practice, Toronto, Hogrefe &Huber, 1990
23. Bear-Suryadinata Ch, Bollinger A: Transcapillary diffusion of Na-fluorescein in skin areas measured by a 'large window technique', Int J Microcirc 1985:4:217-228.
24. Bollinger A, Jager K, Roten A, Timcus Ch, Mahler F: Diffusion, pericapillary distribution and clearance of Na-fluorescein in the human nailfold, Pflugers Arch 1979:382:137-143.
25. Jager K, Geser A, Bollinger A: Videodensito-metric measurement of the transcapillary passage and tissue distribution of Na-fluorescein in human skin capillaries, Vasa 1980:9:132-136.
26. Kjacrgaard JJ, Dideriksen K, Mourits-Ander-sen T: Some aspects of the pharmacokinet ics of fluorescein in normal and diabetic subjects, Int J Microcirc Clin Exp 1983;2:191-197.
27. Jorneskog G, Brismar K, Fagrell B: Skin capillary microcirculation severly impaired in toes of patients with IDDM, with and without late diabetic complications, Diabetologia 1995:38: 474-480
28. Jorneskog G, Brismar K, Fagrell B: Skin capillary circulation is more impaired in the toes of diabetic than non-diabetic patients with peripheral vascular disease, Diabetic Med 1995: 12:36-41.
29. Flynn MD, Edmonds ME, Tookc JE, Watkins PJ: Direct measurement of capillary blood flow in the diabetic neuropathic foot, Diabetologia 1988:31:652-656.
30. Boulton AJM, Scarpcllo JHB, Ward JD: Venous oxygenation in the diabetic neuropathic foot: Evidence of arteriovenous shunting, Diabetologia 1982;22:6-8.
31. Watkins PJ, Edmonds ME: Sympathetic nerve failure in diabetes, Diabetologia 1983:25:73-77.
32. Tooke JE, Rayman G: The investigation of foot skin microcirculation in diabetes mellitus: in Spence VA, Sheldon CD (eds): Practical as-pectsofskin blood flow measurement, London, Biological Engineering Society, 1985. pp 73-77.
33. Tookc JE, Ostergren J, Fagrell B: Skin micro-vascular blood flow control in long duration diabetics with and without complications, Diabetes Res 1987:5:189-192.
34. Ostergren J, Fagrell B, Karlander SG: Skin capillary blood flow dynamics in patients with diabetes mellitus, Int J Microcire Clin Exp 1982;1: 300
35. Ewald V, Tuvemo T, Rooth G: Early reduction of vascular reactivity in diabetic children detected by transcutaneous oxygen electrode, Lancet 1981;ii:1287-1288.
36. Shore AC, Price KJ, Sandemann D, Green EM, Tripp JH, Tooke JE: Impaired microvascular response in children with diabetes mellitus, Diabetic Med 1991:8:619-623.
37. Tooke JE: A capillary pressure disturbance in young diabetics, Diabetes 1980;29:815-819.
38. Sandeman DD, Shore AC, Tooke JE: Pre-capillary vasodilatation underlies capillary hypertension in type I diabetes mellitus (abstract), Clin Sci 1990:80(suppl 24): 13.
39. Tcsfave S, Malik R, Ward JD: Vascular factors in diabetic neuropathv, Diabetologia 1994:37: 847-854.
40. Tesfaye S, Harris N, Jakubowski JJ, Mody J, Wilson RM, Rennie IG, Ward JD: Impaired blood flow and arterio-venous shunting in human diabetic neuropathy: A novel technique of nerve photography and fluorescein angiography, Diabetologia 1993;36:1266-1274