Effects of Somatotropin and Salbutamol in Three Genotypes of Finishing Barrows: Blood Hormones and Metabolites and Muscle Characteristics

Journal of Animal Science

Volumn 75, Issue 7, 1997, Pages 1810-1821

  Hansen, J A ^a,c   Yen, J T ^b   Klindt, J ^b   Nelssen, J L ^a   Goodband, R D ^a  

^a KANSAS STATE UNIVERSITY   (United States)

^b U S MEAT ANIMAL RESEARCH CENTER   (United States)

^c Murphy Family Farms   (United States)

Author keywords

Genotypes; Hormones; Muscles; Pigs; Somatotropin; Adrenergic Agonists

Indexed keywords

GLYCINE MAX; SUIDAE; SUS SCROFA; ZEA MAYS;

BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CHOLESTEROL; DNA; FATTY ACID; GROWTH HORMONE; INSULIN; MUSCLE PROTEIN; NITROGEN; RNA; SALBUTAMOL; SOMATOMEDIN C; TRIACYLGLYCEROL;

ANIMAL; ANIMAL DISEASE; ARTICLE; BLOOD; BLOOD ANALYSIS; BODY COMPOSITION; CHEMISTRY; DIET; DRUG EFFECT; GENETICS; GENOTYPE; GLUCOSE BLOOD LEVEL; MALE; METABOLISM; METHODOLOGY; PHYSIOLOGY; PROBABILITY; RADIOIMMUNOASSAY; SKELETAL MUSCLE; SWINE;

ADRENERGIC BETA-AGONISTS; ALBUTEROL; ANIMALS; BLOOD CHEMICAL ANALYSIS; BLOOD GLUCOSE; BODY COMPOSITION; CHOLESTEROL; DIET; DNA; FATTY ACIDS, NONESTERIFIED; GENOTYPE; GROWTH HORMONE; INSULIN; INSULIN-LIKE GROWTH FACTOR I; MALE; MUSCLE PROTEINS; MUSCLE, SKELETAL; NITROGEN; PROBABILITY; RADIOIMMUNOASSAY; RNA; SWINE; TRIGLYCERIDES;

EID: 0031179085     PISSN: 00218812     EISSN: None     Source Type: Journal    
DOI: 10.2527/1997.7571810x     Document Type: Article

References (52)

1. Bates, P. C., and J. M. Pell. 1991. Action and interaction of growth hormone and the β-agonist clenbuterol, on growth, body composition and protein turnover in dwarf mice. Br. J. Nutr. 65:115.
2. Beermann, D. H. 1989. Status of current strategies for growth regulation. In: D. R. Campion, G. J. Hausman, and R. J. Martin (Ed.) Animal Growth Regulation. p 377. Plenum Press, New York.
3. Beermann, D. H., W. R. Butler, D. E. Hogue, V. K. Fishell, R. H. Dalrymple, C. A. Ricks, and C. G. Scanes. 1987. Cimaterolinduced muscle hypertrophy and altered endocrine status in lambs. J. Anim. Sci. 65:1514.
4. Bergen, W. G., S. E. Johnson, D. M. Skjaerlund, A. S. Babiker, N. K. Ames, R. A. Merkel, and D. B. Anderson. 1989. Muscle protein metabolism in finishing pigs fed ractopamine. J. Anim. Sci. 67: 2255.
5. Boyd, R. D., and D. E. Bauman. 1989. Mechanisms of action for somatotropin in growth. In: D. R. Campion, G. J. Hausman, and R. J. Martin (Ed.) Animal Growth Regulation, p 257. Plenum Press, New York.
6. Brier, B. H., and P. D. Gluckman. 1991. The regulation of postnatal growth: Nutritional influences on endocrine pathways and function of the somatotrophic axis. Livest. Prod. Sci. 27:77.
7. Campbell, R. G., R. J. Johnson, R. H. King, M. R. Taverner, and D. J. Meisinger. 1990. Interaction of dietary protein content and exogenous porcine growth hormone administration on protein and lipid accretion rates in growing pigs. J. Anim. Sci. 68:3217.
8. Caperna, T. J., N. C. Steele, D. R. Komarek, J. P. McMurtry, R. W. Rosebrough, M. B. Solomon, and A. D. Mitchell. 1990. Influence of dietary protein and recombinant porcine somatotropin administration in young pigs: Growth, body composition and hormone status. J. Anim. Sci. 68:4243.
9. Claeys, M. C., D. R. Mulvaney, F. D. McCarthy, M. T. Gore, D. N. Marple, and J. L. Sartin. 1989. Skeletal muscle protein synthesis and growth hormone secretion in young lambs treated with clenbuterol. J. Anim. Sci. 67:2245.
10. Cole, D.J.A., J. D. Wood, and M. J. Kilpatrick. 1988. Effects of the beta agonist GAH/034 on growth, carcass quality and meat quality in pigs. In: J. P. Hanrahan (Ed.) Beta-agonists and Their Effects on Animal Growth and Carcass Quality, p 137. Elsevier Science, New York.
11. DeVol, D. L., F. K. McKeith, P. J. Bechtel, J. Novakofski, R. D. Shanks, and T. R. Carr. 1988. Variation in composition and palatability traits and relationships between muscle characteristics and palatability in a random sample of pork carcasses. J. Anim. Sci. 66:385.
12. Dunshea, F. R., F. Birrell, N. J. Gannon, D. J. Kerton, R. G. Nason, S. L. Shaw, and R. A. Parr. 1996. Increased glucose production is not the cause of hyperglycemia during pST treatment of pigs. J. Anim. Sci. 74(Suppl. 1):144 (Abstr.).
13. Dunshea, F. R., D. M. Harris, D. E. Bauman, R. D. Boyd, and A. W. Bell. 1992a. Effect of somatotropin on nonesterified fatty acid and glycerol metabolism in growing pigs. J. Anim. Sci. 70:132.
14. Dunshea, F. R., D. M. Harris, D. E. Bauman, R. D. Boyd, and A. W. Bell. 1992b. Effect of porcine somatotropin on in vivo glucose kinetics and lipogenesis in growing pigs. J. Anim. Sci. 70:141.
15. Etherton, T. D., J. P. Wiggins, C. M. Evock, C. S. Chung, J. F. Rebhun, P. E. Walton, and N. C. Steele. 1987. Stimulation of pig growth performance by porcine growth hormone: Determination of the dose-response relationship. J. Anim. Sci. 64:433.
16. Evock, C. M., T. D. Etherton, C. S. Chung, and R. E. Ivy. 1988. Pituitary porcine growth hormone (pGH) and a recombinant pGH analog stimulate pig growth performance in a similar manner. J. Anim. Sci. 66:1928.
17. Goodband, R. D., J. L. Nelssen, R. H. Hines, D. H. Kropf, R. C. Thaler, B. R. Schricker, G. E. Fitzner, and A. J. Lewis. 1990. The effects of porcine somatotropin and dietary lysine on growth performance and carcass characteristics of finishing swine. J. Anim. Sci. 68:3261.
18. Gopinath, R., and T. D. Etherton. 1989a. Effects of porcine growth hormone on glucose metabolism of pigs: I. Acute and chronic effects on plasma glucose and insulin status. J. Anim. Sci. 67: 682.
19. Gopinath, R., and T. D. Etherton. 1989b. Effects of porcine growth hormone on glucose metabolism of pigs: II. Glucose tolerance, peripheral tissue insulin sensitivity and glucose kinetics. J. Anim. Sci. 67:689.
20. Hansen, J. A., J. L. Nelssen, R. D. Goodband, and J. L. Laurin. 1994. Interactive effects among porcine somatotropin, the beta-adrenergic agonist salbutamol, and dietary lysine on growth performance and nitrogen balance of finishing swine. J. Anim. Sci. 72:1540.
21. Hansen, J. A., J. T. Yen, J. L. Nelssen, J. A. Nienaber, R. D. Goodband, and T. L. Wheeler. 1997. Effects of somatotropin and salbutamol in three genotypes of finishing barrows: Growth, carcass, and calorimeter criteria. J. Anim. Sci. 75: 1798-1809.
22. Harris, K. B., H. R. Cross, W. G. Pond, and H. J. Mersmann. 1993. Effect of dietary fat and cholesterol level on tissue cholesterol concentrations of growing pigs selected for high or low serum cholesterol. J. Anim. Sci. 71:807.
23. Kim, Y. S., R. D. Sainz, R. J. Summers, and P. Molenaar. 1992. Cimaterol reduces β-adrenergic receptor density in rat skeletal muscles. J. Anim. Sci. 70:115.
24. Klindt, J., F. C. Buonomo, and J. T. Yen. 1992. Administration of porcine somatotropin by sustained-release implant: Growth and endocrine responses in genetically lean and obese barrows and gilts. J. Anim. Sci. 70:3721.
25. Klindt, J., J. J. Ford, J. G. Berardinelli, and L. L. Anderson. 1983. Growth hormone secretion after hypophysial stalk transection in pigs. Proc. Soc. Exp. Biol. Med. 172:508.
26. Knight, C. D., T. R. Kasser, G. H. Swenson, R. L. Hintz, M. J. Azain, R. O. Bates, T. R. Cline, J. D. Crenshaw, G. L. Cromwell, H. B. Hedrick, S. J. Jones, D. H. Kropf, A. J. Lewis, D. C. Mahan, F. M. McKeith, C. L. McLaughlin, J. L. Nelssen, J. W. Novakofski, M. W. Orcutt, and N. A. Parrett. 1991. The performance and carcass composition responses of finishing swine to a range of porcine somatotropin doses in a 1-week delivery system. J. Anim. Sci. 69:4678.
27. Krick, B. J., K. R. Roneker, R. D. Boyd, D. H. Beermann, P. J. David, and D. J. Meisinger. 1992. Influence of genotype and sex on the response of growing pigs to recombinant porcine somatotropin. J. Anim. Sci. 70:3024.
28. LeBarca, C., and K. Paigen. 1980. A simple, rapid, and sensitive DNA assay procedure. Anal. Biochem. 102:344.
29. Lefaucheur, L., A. Missohou, P. Ecolan, G. Monin, and M. Bonneau. 1992. Performance, plasma hormones, histochemical and biochemical muscle traits, and meat quality of pigs administered exogenous somatotropin between 30 or 60 kilograms and 100 kilograms body weight. J. Anim. Sci. 70:3401.
30. Lowry, O. H., N. J. Rosebrough, A. L. Farr, and R. J. Randall. 1951. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:265.
31. Maltin, C. A., M. I. Delday, S. M. Hay, G. M. Innes, and P.E.V. Williams. 1990. Effects of bovine pituitary growth hormone alone or in combination with the β-agonist clenbuterol on muscle growth and composition in veal calves. Br. J. Nutr. 63:535.
32. Mersmann, H. J. 1989a. Acute changes in blood flow in pigs infused with β-adrenergic agonists. J. Anim. Sci. 67:2913.
33. Mersmann, H. J. 1989b. Influence of infused β-adrenergic agonists on porcine blood metabolites and catecholamines. J. Anim. Sci. 67:2633.
34. Munro, H. N., and A. Fleck. 1969. Analysis of tissues and body fluids for nitrogenous constituents. In: H. N. Munro (Ed.) Mammalian Protein Metabolism. Vol. III. p 423. Academic Press, New York.
35. Oksbjerg, N, A. Blackshaw, P. Henckel, J. A. Fernández, and N. Agergaard. 1990. Alterations in protein accretion and histochemical characteristics of the M. longissimus dorsi in pigs caused by salbutamol (a β-adrenergic agonist). Acta Agric. Scand. 40:397.
36. Oscarsson, J., S. Olofsson, G. Bondjers, and S. Eden. 1989. Differential effects of continuous versus intermittent administration of growth hormone to hypophysectomized female rats on serum lipoproteins and their apoproteins. Endocrinology 125:1638.
37. Pell, J. M., and P. C. Bates. 1990. The nutritional regulation of growth hormone action. Nutr. Res. Rev. 3:163.
38. Perkins, S. N., W. S. Evans, M. O. Thorner, and M. J. Cronin. 1983. Beta-adrenergic stimulation of growth hormone release from perifused rat anterior pituitary cells. Neuroendocrinology 37: 473.
39. Perkins, S. N., W. S. Evans, M. O. Thorner, D. M. Gibbs, and M. J. Cronin. 1985. β-Adrenergic binding and secretory responses of the anterior pituitary. Endocrinology 117:1818.
40. Prusa, K. J., J. A. Love, and L. F. Miller. 1989. Composition and sensory analysis of rib chops from pigs supplemented with porcine somatotropin (pSt). J. Food Qual. 12:455.
41. SAS. 1988. SAS/STAT® User's Guide (Release 6.03). SAS Inst. Inc., Cary, NC.
42. Solomon, M. B., R. G. Campbell, N. C. Steele, and T. J. Caperna. 1991. Effects of exogenous porcine somatotropin administration between 30 and 60 kilograms on longissimus muscle fiber morphology and meat tenderness of pigs grown to 90 kilograms. J. Anim. Sci. 69:641.
43. Solomon, M. B., R. G. Campbell, N. C. Steele, T. J. Caperna, and J. P. McMurtry. 1988. Effect of feed intake and exogenous porcine somatotropin on longissimus muscle fiber characteristics of pigs weighing 55 kilograms live weight. J. Anim. Sci. 66:3279.
44. Trout, W. E., and B. D. Schanbacher. 1990. Growth hormone and insulin-like growth factor-I responses in steers actively immunized against somatostatin or growth hormone-releasing factor. J. Endocrinol. 125:123.
45. Walker, W. R., D. D. Johnson, J. H. Brendemuhl, R. H. Dalrymple, and G. E. Combs. 1989. Evaluation of cimaterol for finishing swine including a drug withdrawal period. J. Anim. Sci. 67:168.
46. Warriss, P. D., S. N. Brown, T. P. Rolph, and S. C. Kestin. 1990a. Interactions between the beta-adrenergic agonist salbutamol and genotype on meat quality in pigs. J. Anim. Sci. 68:3669.
47. Warriss, P. D., S. C. Kestin, T. P. Rolph, and S. N. Brown. 1990b. The effects of the beta-adrenergic agonist salbutamol on meat quality in pigs. J. Anim. Sci. 68:128.
48. Webster, B., S. R. Vigna, T. Paquette, and D. J. Koerker. 1986. β-Adrenergic modulation of insulin binding in skeletal muscle. Am. J. Physiol. 250:E198.
49. Whipple, G., M. C. Hunt, R. D. Klemm, D. H. Kropf, R. D. Goodband, and B. R. Schricker. 1992. Effects of porcine somatotropin and supplemental lysine on porcine muscle histochemistry. J. Muscle Foods 3:217.
50. Yen, J. T., H. J. Mersmann, D. A. Hill, and W. G. Pond. 1990a. Effects of ractopamine on genetically obese and lean pigs. J. Anim. Sci. 68:3705.
51. Yen, J. T., H. J. Mersmann, J. A. Nienaber, D. A. Hill, and W. G. Pond. 1990b. Responses to cimaterol in genetically obese and lean pigs. J. Anim. Sci. 68:2698.
52. Yen, J. T., J. A. Nienaber, J. Klindt, and J. D. Crouse. 1991. Effect of ractopamine on growth, carcass traits, and fasting heat production of U.S. contemporary crossbred and Chinese Meishan pure- and crossbred pigs. J. Anim. Sci. 69:4810.