An ~1.2-Mb bacterial artificial chromosome contig refines the genetic and physical maps of the lurcher locus on mouse chromosome 6

Genome Research

Volumn 7, Issue 7, 1997, Pages 736-746

  De Jager, Philip L ^a   Zuo, Jian ^a   Heintz, Nathaniel ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONTIG;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; BACTERIAL GENETICS; CEREBELLAR ATAXIA; CHROMOSOME; CHROMOSOME 6; DEGENERATIVE DISEASE; GENE LOCUS; GENE MUTATION; MARKER GENE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PURKINJE CELL; ANIMAL; ATAXIA; CHROMOSOME MAP; GENETICS; LETTER; MOLECULAR GENETICS;

ANIMALIA; ATAXIA; BACTERIA (MICROORGANISMS);

ANIMALS; ATAXIA; CHROMOSOME MAPPING; CHROMOSOMES; MICE; MOLECULAR SEQUENCE DATA;

EID: 0031178341     PISSN: 10889051     EISSN: None     Source Type: Journal    
DOI: 10.1101/gr.7.7.736     Document Type: Article

References (17)

1. Akazawa, C., M. Ishibashi, C. Shimizu, S. Nakanishi, and R. Kageyama. 1995. A mammalian helix-loop-helix factor structurally related to the product of Drosophila proneural gene atonal is a positive transcriptional regulator expressed in the developing nervous system. J. Biol. Chem. 270: 8730-8738.
2. Bahary, N., J. E. Pachter, R. Felman, R. L. Leibel, K. Albright, S. Cram, and J. M. Friedman. 1992. Molecular mapping of mouse Chromosomes 4 and 6: Use of a flow-sorted Robertsonian chromosome. Genomics 13: 761-769.
3. Ben-Arie N., A.E. McCall, S. Berkman, G. Eichele, H.J. Bellen, and H.Y. Zoghbi. 1996. Evolutionary conservation of sequence and expression of the bHLH protein Atonal suggests a conserved role in neurogenesis. Hum. Mol. Genet. 5: 1207-1216.
4. Caddy, K.W. and T.J. Biscoe. 1979. Structural and quantitative studies on the normal C3H and lurcher mutant mouse. [Review]. Phil. Trans. Roy. Soc. Lond. Ser. B. Biol. Sci. 287: 167-201.
5. Cheng, S. and N. Heintz. 1997. Perinatal death of homozygous lurcher mice results from massive loss of hindbrain neurons during embryonic development of homozygous lurcher mice. J. Neurosci. 17: 2400-2407.
6. Dumesnil-Bousez, N. and C. Sotelo. 1992. Early development of the lurcher cerebellum: Purkinje cell alterations and impairment of synaptogenesis. J. Neurocytol. 21: 506-529.
7. Norman, D.J., C. Fletcher, and N. Heintz. 1991. Genetic mapping of the lurcher locus on mouse Chromosome 6 using an intersubspecific backcross. Genomics 9: 147-153.
8. Norman, D.J., L. Feng, S.S. Cheng, J. Gubbay, E. Chan, and N. Heintz. 1995. The lurcher gene induces apoptotic death in cerebellar Purkinje cells. Development 121: 1183-1193.
9. Phillips, R.J.S. 1960. "Lurcher", a new gene in linkage group XI of the house mouse. J. Genet. 57: 35-42.
10. Rabacchi, S.A., Y. Bailly, N. Delhaye-Bouchaud, K. Herrup, and J. Mariani. 1992. Role of target in synapse elimination: Studies in cerebellum of developing lurcher mutants and adult chimeric mice. J. Neurosci. 12: 4712-4720.
11. Shizuya, H., B. Birren, U.-J. Kim, V. Mancino, T. Slepak, Y. Tachiiri, and M. Simon. 1992. Cloning and stable maintenance of 300-kilobase-pair fragments of human DNA in Escherichia coli using an F-factor-based vector. Proc. Natl. Acad. Sci. 89: 8794-8797.
12. Vidal-Puig, A. and D.E. Moller. 1994. Comparative sensitivity of alternative single-strand conformation polymorphism (SSCP) methods. BioTechniques 17: 490-492.
13. Wetts, R. and K. Herrup. 1982a. Cerebellar Purkinje cells are descended from a small number of progenitors committed during early development: Quantitative analysis of lurcher chimeric mice. J. Neurosci. 2: 1494-1498.
14. _. 1982b. Interaction of granule, Purkinje and inferior olivary neurons in lurcher chimaeric mice. I. Qualitative studies. J. Embryol. Exp. Morphol. 68: 87-98.
15. _. 1982c. Interaction of granule, Purkinje and inferior olivary neurons in lurcher chimeric mice. II. Granule cell death. Brain Res. 250: 358-362.
16. _. 1983. Direct correlation between Purkinje and granule cell number in the cerebella of lurcher chimeras and wild-type mice. Brain Res. 312: 41-47.
17. Zuo, J., P.L. De Jager, D.N. Norman, and N. Heintz. 1995. Generation of a high-resolution genetic map and a YAC contig of the lurcher locus on mouse Chromosome 6. Genome Res. 5: 381-392.