Loss of heterozygosity at the α-inhibin locus on chromosome 2q is not a feature of human granulosa cell tumors

Gynecologic Oncology

Volumn 65, Issue 3, 1997, Pages 387-390

  Watson, Richard H ^a   Roy Jr , William J ^a   Davis, Michael ^a   Hitchcock, Andrew ^b   Campbell, Ian G ^a  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^b SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CARCINOGENESIS; CHROMOSOME 2Q; FEMALE; GENE LOCUS; GRANULOSA CELL TUMOR; HETEROZYGOSITY LOSS; HUMAN; HUMAN TISSUE; OVARY CANCER; POINT MUTATION; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

EID: 0031172131     PISSN: 00908258     EISSN: None     Source Type: Journal    
DOI: 10.1006/gyno.1997.4682     Document Type: Article

References (15)

1. 1. Willemsen W, Kruitwagen R, Bastiaans B, Hanselaar T, Rolland R: Ovarian stimulation and granulosa cell tumor. Lancet 341: 1993
2. 2. Young RE, Scully RE: Ovarian sex cord-stromal tumors: recent progress. Int J Gynaecol Pathol 1:153, 1980
3. 3. Bjorkholm E, Pettersson F: Granulosa-cell and thecal-cell tumors: the clinical picture and long-term outcome for Radiumhemet series. Acta Obstet Gynecol Scand 59:278, 1983
4. 4. Fox H, Agarical K, Langley FA: A clinicopathologic study of 92 cases of granulosa cell tumors of the ovary with special reference to the factors influencing the prognosis. Cancer 35:231, 1975
5. 5. Halvorson LM, Decherney AH: Inhibin, activin and follistatin in reproductive medicine. Fertil Steril 65:459-469, 1996
6. 6. Matzuk MM, Finegold MJ, Su J-GJ, Hsueh AJW, Bradley A: Alpha inhibin is a tumor suppressor gene with gonadal specificity in mice. Nature 360:313-319, 1992
7. 7. Müllenbach R, Lagoda PJL, Welter C: An efficient salt chloroform extraction of DNA from blood and tissues. Trends Genet 5:391, 1989
8. 8. Campbell IG, Nicolai HM, Foulkes WD, Senger G, Stamp GW, Allan G, Boyer C, Jones K, Bast RC Jr, Solomon E, Trowsdale J, Black DM: A novel gene encoding a B-box protein within the BRCA1 region at 17q21.1. Hum Mol Genet 3:589-594, 1994
9. 9. Spurr NK, Bashir R, Bushby K, Cox A, Cox S, Hildebrandt F, Hill N, Kao F-T, Krols L, Marzella R, Miller N, Nothwang HG, Rocchi M, Sarfarazi M, Stratakis CA, Wallgren-Pettersson C, Naylor S: Report of the fourth international workshop on human chromosome 2 mapping 1996. Cytogenet Cell Genet 73:255-273, 1996
10. 10. Liu FS, Ho ESC, Lai CR, Chen JT, Shih RTP, Yang CH, Tsao CM: Overexpression of p53 is not a feature of ovarian granulosa cell tumors. Gynecol Oncol 61:50-53, 1996
11. 11. Cooke I, O'Brien M, Charnock FM, Groome N, Ganesan TS: Inhibin as a marker for ovarian cancer. Br J Cancer 71:1046-1050, 1995
12. 12. Jobling T, Mamers P, Healy DL, Maclachlan V, Burger HG, Quinn M, Rome R, Day AJ: A prospective study of inhibin in granulosa cell tumors of the ovary. Gynecol Oncol 55:285-289, 1994
13. 13. Burger HG, Robertson DM, Cahir N, Mamers P, Healy DL, Jobling T, Groome N: Characterization of inhibin immunoreactivity in post-menopausal women with ovarian tumors. Clin Endocrinol 44:413-418, 1996
14. 14. Nicolaides NC, Papadopoulos N, Liu B, Wei YF, Carter KC, Ruben SM, Rosen CA, Haseltine WA, Fleischmann RD, Fraser CM, Adams MD, Venter JC, Dunlop MG, Hamilton SR, Petersen GM, Delachapelle A, Vogelstein B, Kinzler KW: Mutations of 2 pms homologs in hereditary nonpolyposis colon-cancer. Nature 371:75-80, 1994
15. 15. Risma KA, Clay CM, Nett TM, Wagner T, Yun J, Nilson JH: Targeted Overexpression of LH in transgenic mice leads to infertility, polycystic ovaries and ovarian tumors. Proc Natl Acad Sci USA 92:1322-1326, 1995