The NNP-1 gene (D21S2056E), which encodes a novel nuclear protein, maps in close proximity to the cystatin B gene within the EPM1 and APECED critical region on 21q22.3

Genomics

Volumn 42, Issue 2, 1997, Pages 336-341

  Jansen, Erik ^a   Meulemans, Sandra M P ^a   Orlans, Isabelle C R ^a   Van De Ven, Wim J M ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CAENORHABDITIS ELEGANS; CHROMOSOME 21Q; GENE EXPRESSION; GENE MAPPING; GENE SEQUENCE; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN ANALYSIS; SACCHAROMYCES CEREVISIAE;

CAENORHABDITIS ELEGANS; SACCHAROMYCES CEREVISIAE;

EID: 0031172067     PISSN: 08887543     EISSN: None     Source Type: Journal    
DOI: 10.1006/geno.1997.4755     Document Type: Article

References (19)

1. 1. Aaltonen, J., Björses, P., Sandkuijl, L., Perheentupa, J., and Peltonen, L. (1994). An autosomal locus causing autoimmune disease: Autoimmune polyglandular disease type I assigned to chromosome 21. Nature Genet. 8: 83-87.
2. 2. Agarwal, N., Swaroop, A., Zheng, K., Liou, J.-d., O'Rourke, K., Graves, K. A., Gieser, L., Del Monte, M., and Yang-Feng, T. L. (1995). Expression and chromosomal localization of cDNA clones from an enriched human retinal pigment epithelial (RPE) cell line library: Identification of two RPE-specific genes. Cytogenet. Cell Genet. 69: 71-74.
3. 3. Altschul, S. F., Gish, W., Miller, W., Myers, E. W., and Lipman, D. J. (1990). Basic local alignment search tool. J. Mol. Biol. 215: 403-410.
4. 4. Cheng, J.-F., Boyartchuk, V., and Zhu, Y. (1994). Isolation and mapping of human chromosome 21 cDNA: Progress in constructing a chromosome 21 expression map. Genomics 23: 75-84.
5. 5. Chinery, R., Williamson, J., and Poulsom, R. (1996). The gene encoding human intestinal trefoil factor (TFF3) is located on chromosome 21q22.3 clustered with other members of the trefoil peptide family. Genomics 32: 281-284.
6. 6. Detera-Wadleigh, S. D., Badner, J. A., Goldin, L. R., Berrettini, W. H., Sanders, A. R., Rollins, D. Y., Turner, G., Moses, T., Haerian, H., Muniec, D., Nurnberger, J. I., Jr., and Gershon, E. S. (1996). Affected-sib-pair analyses reveal support of prior evidence for a susceptibility locus for bipolar disorder, on 21q. Am. J. Hum. Genet. 58: 1279-1285.
7. 7. Dingwall, C., and Laskey, R. A. (1991). Nuclear targeting sequences - A consensus? Trends Biochem. Sci. 16: 478-481.
8. 8. Green, P. G., Lipman, D., Hillier, L., Waterson, R., States, D., and Claverie, J.-M. (1993). Ancient conserved regions in new gene sequences and the protein databases. Science 259: 1711-1716.
9. 9. Hedley, M. L., Amrein, H., and Maniatis, T. (1995). An amino acid sequence motif sufficient for subnuclear localization of an arginine/serine-rich splicing factor. Proc. Natl. Acad. Sci. USA 92: 11524-11528.
10. 10. Jansen, E., Ayoubi, T. A. Y., Meulemans, S. M. P., and Van de Ven, W. J. M. (1997). Cell type-specific protein-DNA interactions at the cAMP response elements of the prohormone convertase 1 promoter. J. Biol. Chem. 272: 2500-2508.
11. 11. Muenke, M., Bone, L. J., Mitchell, H. F., Hart, I., Walton, K., Hall-Johnson, K., Ippel, E. F., Dietz-Band, J., Kvaløy, K., Fan, C.-M., Tessier-Lavigne, M., and Patterson, D. (1995). Physical mapping of the holoprosencephaly critical region in 21q22.3, exclusion of SIM2 as a candidate gene for holoprosencephaly, and mapping of SIM2 to a region of chromosome 21 important for Down syndrome. Am. J. Hum. Genet. 57: 1074-1079.
12. 12. Nakai, K., and Kaneshisa, M. (1992). A knowledge base for predicting protein localization sites in eukaryotic cells. Genomics 14: 897-911.
13. 13. Pabo, C. O., and Sauer, R. T. (1992). Transcription factors: Structural families and principles of DNA recognition. Annu. Rev. Biochem. 61: 1053-1095.
14. 14. Pennacchio, L. A., Lehesjoki, A.-E., Stone, N. E., Willour, V. L., Virtaneva, K., Miao, J., D'Amato, E., Ramirez, L., Faham, M., Koskiniemi, M., Warrington, J. A., Norio, R., de la Chapelle, A., Cox, D. R., and Myers, R. M. (1996). Mutations in the gene encoding cystatin B in progressive myoclonus epilepsy (EPM1). Science 271: 1731-1734.
15. 15. Rost, B., and Sander, C. (1994). Combining evolutionary information and neural networks to predict protein secondary structure. Proteins 19: 55-72.
16. 16. Sertié, A. L., Quimby, M., Moreira, E. S., Murray, J., Zatz, M., Antonarakis, S. E., and Passos-Bueno, M. R. (1996). A gene which causes severe ocular alterations and occipital encephalocele (Knobloch syndrome) is mapped to 21q22.3. Hum. Mol. Genet. 5: 843-847.
17. 17. Spector, D. L. (1993). Nuclear organization of pre-mRNA processing. Curr. Opin. Cell. Biol. 5: 442-447.
18. 18. Stone, N. E., Fan, J.-B., Willour, V., Pennacchio, L. A., Warrington, J. A., Hu, A., de la Chapelle, A., Lehesjoki, A.-E., Cox, D. R., and Myers, R. M. (1996). Construction of a 750-kb bacterial clone contig and restriction map in the region of human chromosome 21 containing the progressive myoclonus epilepsy gene. Genome Res. 6: 218-225.
19. 19. Straub, R. E., Lehner, T., Luo, Y., Loth, J. E., Shao, W., Sharpe, L., Alexander, J. R., Das, K., Simon, R., Fieve, R. R., Lerer, B., Endicott, J., Ott, J., Gilliam, T. C., and Baron, M. (1994). A possible vulnerability locus for bipolar affective disorder on chromosome 21q22.3. Nature Genet. 8: 291-296.