Constant delivery of proinsulin by encapsulation of transfected cells

Journal of Surgical Research

Volumn 70, Issue 1, 1997, Pages 41-45

  Taniguchi, Hideki ^a   Fukao, Katashi ^a   Nakauchi, Hiromitsu ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; INSULIN; PROINSULIN; STREPTOZOCIN;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; FEMALE; FIBROBLAST CULTURE; GENE THERAPY; GLUCOSE BLOOD LEVEL; HISTOLOGY; HYPERGLYCEMIA; IMPLANTATION; INFLAMMATION; INSULIN SYNTHESIS; MOUSE; NONHUMAN; PANCREAS; PRIORITY JOURNAL; STREPTOZOCIN DIABETES;

EID: 0031171411     PISSN: 00224804     EISSN: None     Source Type: Journal    
DOI: 10.1006/jsre.1997.5085     Document Type: Article

References (14)

1. Selden R. F., Skoskiewicz M. J., Howie K. B., Russell P. S., Goodman H. M. Implantation of genetically engineered fibroblasts into mice: implications for gene therapy. Science. 236:1987;714.
2. Dhawan J., Pan L. C., Pavlath G. K., Travis M. A., Lanctot A. M., Blau H. M. systemic delivery of human growth hormone by injection of genetically engineered myoblasts. Science. 254:1991;1509.
3. Hughes S. D., Johnson J. H., Quaade C., Newgard C. B. Engineering of glucose-stimulated insulin secretion and biosynthesis in non-islet cells. Proc. Natl. Acad. Sci. USA. 89:1992;688.
4. Taniguchi H., Hirochika R., Fukao K., Nakauchi H. Control of proinsulin production by sense-anti-sense regulation in response to glucocorticoids. Cell Transplant. 5:1996;S55.
5. Kawakami Y., Yamaoka T., Hirichika R., Yamashita K., Itakura M., Nakauchi H. Somatic gene therapy for diabetes with an immunological safety system for complete removal of transplanted cells. Diabetes. 41:1992;956.
6. Bell G. I., Pictet R. L., Rutter W. J., Cordell B., Tischer E., Goodman H. M. Sequence of the human insulin gene. Nature. 284:1980;26.
7. Karasuyama H., Melchers F. Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors. Eur. J. Immunol. 18:1988;97.
8. Nakayama K., Sarai A., Nakauchi H. Single amino acid substitutions determine mouse CD8 allotypes: epitope mapping of mouse CD8. Immunogenetics. 33:1991;206.
9. Ema H., Suda T., Miura Y., Nakauchi H. Colony formation of clone-sorted human hematopoietic progenitors. Blood. 75:1990;1941.
10. Nilsson K. W., Scheirer W., Merten O. W., Ostberg L., Leihl E., Katinger H. W. D., Mosbach K. Entrapment of animal cells for production of monoclonal antibodies and other biomolecules. Nature. 302:1983;629.
11. Iwata H., Amemiya H., Matsuda T., Takano H., Akutsu T. Microencapsulation of Langerhans islets in agarose microbeads and their application for a bioartificial pancreas. J. Bioactive Compatible Polym. 3:1988;356.
12. Docherty K. Prospects for gene therapy and cellular engineering in diabetes. Biotechnology of Insulin Therapy. 1991;Blackwell Scientific, London. p. 154-182.
13. Bergenstal R. M., Cohen R. M., Lever E., Polonsky K., Jaspan J., Blix P. M., Revers R., Olefsky J. M., Kolterman O., Steiner K., Cherrington A., Frank B., Galloway J., Rubenstein A. H. The metabolic effects of biosynthetic human proinsulin in individuals with type-1 diabetes. J. Clin. Endocrinol. Metab. 58:1984;973.
14. Iwata H., Amemiya H., Matsuda T., Takano H., Hayashi R., Akutsu T. Evaluation of microencapsulated islets in agarose gel as bioartificial pancreas by studies of hormone secretion in culture and by xenotransplantation. Diabetes. 38:1989;224.