International Workshop Organised under the auspices of the BIOMED I Concerted Action 'Cytokines in the brain', Marseille, 7 December 1996: Neural pathways from the immune system to the brain

European Cytokine Network

Volumn 8, Issue 2, 1997, Pages 221-223

  Konsman, Jan Pieter ^a   Cartmell, Tammy ^b  

^a INSERM   (France)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Brain; Circumventricular organs; Cytokines; Vagus nerve

Indexed keywords

CYTOKINE;

BLOOD BRAIN BARRIER; BRAIN FUNCTION; CONFERENCE PAPER; CRANIAL NERVE; HUMAN; HUMAN CELL; IMMUNE SYSTEM; NERVE TRACT; ANIMAL; BRAIN; IMMUNOLOGY; IMMUNOMODULATION; PHYSIOLOGY; SENSORY NERVE; SIGNAL TRANSDUCTION;

AFFERENT PATHWAYS; ANIMALS; BRAIN; CYTOKINES; HUMANS; NEUROIMMUNOMODULATION; SIGNAL TRANSDUCTION;

EID: 0031158593     PISSN: 11485493     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (10)

1. Dantzer R. 1994. How do cytokines say hello to the brain? Neural versus humoral mediation. (Review) Eur: Cytokine Net. 5: 271.
2. Watkins L R, Maier S F, Goehler L E. 1995. Cytokine to brain communication: a review and analysis of alternative mechanisms. (Review) Life Sci. 57: 1011.
3. Watkins L R, Goehler L E, Relton J K, Tartaglia N, Silbert L, Martin D, Maier S F. 1995. Blockade of interleukin-1 induced hyperthermia by subdiaphragmatic vagotomy: evidence for vagal mediation of immune-brain communication. Neurosci. Lett. 183: 27.
4. Bluthé R M, Walter V, Parnet R, Laye S, Lestage J, Verrier D, Poole S, Stenning B E, Kelley K W, Dantzer R. 1994. Lipopolysaccharide induces sickness behaviour in rats by a vagal mediated mechanism. C. R. Acad. Sci. III 317: 499.
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7. Kapas L, Hansen M K, Chang H M, Kreuger. 1996. Sleep responses to systemic injections of lipopolysaccharide are attenuated in vagotomized animals. Abstract presented at the 3rd International Congress of the International Society for Neuroimmunomodulation, Bethesda, Maryland.
8. Fleshner M, Goehler L E, Hermann J, Relton J K, Maier S F, Watkins L R. 1995. Interleukin-1β induced corticosterone elevation and hypothalamic NE depletion is vagally mediated. Brain Res. Bull. 37: 605.
9. Layé S, Bluthé R M, Kent S, Combe C, Médina C, Parnet P, Kelley K W, Dantzer R. 1996. Subdiaphragmatic vagotomy blocks induction of IL-1β mRNA in mice brain in response to peripheral LPS. Am. J. Physiol. 268: R1327.
10. As pointed out by Stephen Poole (NIBSC, Potters Bar), given that various LPS preparations differ both qualitatively and quantitatively in their biopotency, preparations of LPS should be standardised (expressed in IU of endotoxin/ml), for allowing appropriate comparison between laboratories of the biological responses and mechanisms induced by LPS.