-
1
-
-
0028175091
-
Raf meets Ras : Completing the framework of a signal transduction pathway
-
Avruch J, Zhang XF, Kyriakis JM. Raf meets Ras : completing the framework of a signal transduction pathway. TIBS 1994 ; 19 : 279-83.
-
(1994)
TIBS
, vol.19
, pp. 279-283
-
-
Avruch, J.1
Zhang, X.F.2
Kyriakis, J.M.3
-
2
-
-
0028797652
-
Signal transduction by Ras-like GTPases : A potential target for anticancer drugs
-
Spaargaren M, Bischoff JR, McCormick F. Signal transduction by Ras-like GTPases : a potential target for anticancer drugs. Gene Expression 1995 ; 4 : 345-56.
-
(1995)
Gene Expression
, vol.4
, pp. 345-356
-
-
Spaargaren, M.1
Bischoff, J.R.2
McCormick, F.3
-
3
-
-
0023068346
-
Ras genes
-
Barbacid M. Ras genes. Ann Rev Biochem 1987 ; 56 : 779-827.
-
(1987)
Ann Rev Biochem
, vol.56
, pp. 779-827
-
-
Barbacid, M.1
-
4
-
-
0024376173
-
ras oncogenes in human cancer : A review
-
Bos JL. ras oncogenes in human cancer : a review. Cancer Res 1989 ; 49 : 4682-9.
-
(1989)
Cancer Res
, vol.49
, pp. 4682-4689
-
-
Bos, J.L.1
-
5
-
-
0027905014
-
Altered growth of human colon cancer cell lines disrupted at activated Ki-ras
-
Shirazawa S, Furuse M, Yokoyama N, Sasazuki T. Altered growth of human colon cancer cell lines disrupted at activated Ki-ras. Science 1993 ; 26 : 85-8.
-
(1993)
Science
, vol.26
, pp. 85-88
-
-
Shirazawa, S.1
Furuse, M.2
Yokoyama, N.3
Sasazuki, T.4
-
6
-
-
0029901805
-
Loss of oncogenic ras expression does not correlate with loss of tumorigenicity in human cells
-
Plattner R, Anderson MJ, Sato KY, Fasching CL, Der CJ, Stanbridge EJ. Loss of oncogenic ras expression does not correlate with loss of tumorigenicity in human cells. Proc Natl Acad Sci USA 1996 ; 93 : 6665-70.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 6665-6670
-
-
Plattner, R.1
Anderson, M.J.2
Sato, K.Y.3
Fasching, C.L.4
Der, C.J.5
Stanbridge, E.J.6
-
7
-
-
0023631608
-
Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice : Synergetic action of oncogenes in vivo
-
Sinn E, Muller W, Pattengale P, Tepler I, Wallace R, Leder P. Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice : synergetic action of oncogenes in vivo. Cell 1987 ; 49 : 465-75.
-
(1987)
Cell
, vol.49
, pp. 465-475
-
-
Sinn, E.1
Muller, W.2
Pattengale, P.3
Tepler, I.4
Wallace, R.5
Leder, P.6
-
8
-
-
0029787957
-
An effect of K-ras gene mutation on epidermal growth factor receptor signal transduction in Panc-1 pancreatic carcinoma cells
-
Watanabe M, Nobuta A, Tanaka J, Asaka M. An effect of K-ras gene mutation on epidermal growth factor receptor signal transduction in Panc-1 pancreatic carcinoma cells. Int J Cancer 1996 ; 67 : 264-8.
-
(1996)
Int J Cancer
, vol.67
, pp. 264-268
-
-
Watanabe, M.1
Nobuta, A.2
Tanaka, J.3
Asaka, M.4
-
9
-
-
0023635251
-
Rodent fibroblast tumors expressing myc and ras genes. Growth, metastasis and endogenous oncogene expression
-
Wyllie AH, Rose KA, Morris RG, Steel CM, Foster E, Spandidos DA. Rodent fibroblast tumors expressing myc and ras genes. Growth, metastasis and endogenous oncogene expression. Br J Cancer 1987 ; 56 : 251-9.
-
(1987)
Br J Cancer
, vol.56
, pp. 251-259
-
-
Wyllie, A.H.1
Rose, K.A.2
Morris, R.G.3
Steel, C.M.4
Foster, E.5
Spandidos, D.A.6
-
10
-
-
0029562231
-
Massive programmed cell death induced by three-dimensional growth conditions : Suppression by mutant c-H-ras oncogene expression
-
Rak J, Mitsuhashi Y, Erdos V, Huang S, Filmus J, Kerbel RS. Massive programmed cell death induced by three-dimensional growth conditions : suppression by mutant c-H-ras oncogene expression. J Cell Biol 1995 ; 131 : 1587-98.
-
(1995)
J Cell Biol
, vol.131
, pp. 1587-1598
-
-
Rak, J.1
Mitsuhashi, Y.2
Erdos, V.3
Huang, S.4
Filmus, J.5
Kerbel, R.S.6
-
11
-
-
0028927887
-
Constitutive expression of the c-H-ras oncogene inhibits doxorubicin-induced apoptosis and promotes cell survival in a rhabdomyosarcoma cell line
-
Nooter K, Boersma AWM, Oostrum RG, Burger H, Jochemsen AG, Stoter G. Constitutive expression of the c-H-ras oncogene inhibits doxorubicin-induced apoptosis and promotes cell survival in a rhabdomyosarcoma cell line. Br J Cancer 1995 ; 71 : 556-61.
-
(1995)
Br J Cancer
, vol.71
, pp. 556-561
-
-
Nooter, K.1
Boersma, A.W.M.2
Oostrum, R.G.3
Burger, H.4
Jochemsen, A.G.5
Stoter, G.6
-
12
-
-
0029738762
-
Mutant H-ras overexpression inhibits drug and UV induced apoptosis
-
Fernandes RS, McGowan AJ, Cotter TG. Mutant H-ras overexpression inhibits drug and UV induced apoptosis. Anticancer Res 1996 ; 16 : 1691-706.
-
(1996)
Anticancer Res
, vol.16
, pp. 1691-1706
-
-
Fernandes, R.S.1
McGowan, A.J.2
Cotter, T.G.3
-
13
-
-
0027451668
-
p53-dependent apoptosis modulates the cytotoxicity of anticancer agents
-
Lowe SW, Ruley HE, Jacks T, Housman DE. p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell 1993 ; 74 : 957-67.
-
(1993)
Cell
, vol.74
, pp. 957-967
-
-
Lowe, S.W.1
Ruley, H.E.2
Jacks, T.3
Housman, D.E.4
-
14
-
-
0028822834
-
Mutant ras oncogenes upregulate VEGF/VPF expression : Implications for induction and inhibition of tumor angiogenesis
-
Rak J, Mitsuhashi Y, Bayko L, Filmus J, Shirazawa S, Sasasuki T, Kerbel RS. Mutant ras oncogenes upregulate VEGF/VPF expression : implications for induction and inhibition of tumor angiogenesis. Cancer Res 1995 ; 55 : 4575-80.
-
(1995)
Cancer Res
, vol.55
, pp. 4575-4580
-
-
Rak, J.1
Mitsuhashi, Y.2
Bayko, L.3
Filmus, J.4
Shirazawa, S.5
Sasasuki, T.6
Kerbel, R.S.7
-
15
-
-
0026619185
-
The ras/cholesterol connection : Implications for ras oncogenicity
-
Cox AD, Der CJ. The ras/cholesterol connection : implications for ras oncogenicity. Crit Rev Oncogenesis 1992 ; 3 : 365-400.
-
(1992)
Crit Rev Oncogenesis
, vol.3
, pp. 365-400
-
-
Cox, A.D.1
Der, C.J.2
-
16
-
-
0024465343
-
Post-translational processing of p21ras is two steps and involves carboxyl-methylation and carboxy-terminal proteolysis
-
Gutierrez L, Magee AI, Marshall CJ, Hancock JF. Post-translational processing of p21ras is two steps and involves carboxyl-methylation and carboxy-terminal proteolysis. EMBO J 1989 ; 8 : 1093-8.
-
(1989)
EMBO J
, vol.8
, pp. 1093-1098
-
-
Gutierrez, L.1
Magee, A.I.2
Marshall, C.J.3
Hancock, J.F.4
-
17
-
-
0025649688
-
Posttranslational modification of proteins by isoprenoids in mammalian cells
-
Maltese WA. Posttranslational modification of proteins by isoprenoids in mammalian cells. FASEB J 1990 ; 4 : 3319-28.
-
(1990)
FASEB J
, vol.4
, pp. 3319-3328
-
-
Maltese, W.A.1
-
18
-
-
0026806554
-
Mammalian protein geranylgeranyltransferase
-
Moomaw JF, Casey PJ. Mammalian protein geranylgeranyltransferase. J Biol Chem 1992 ; 267 : 17438-43.
-
(1992)
J Biol Chem
, vol.267
, pp. 17438-17443
-
-
Moomaw, J.F.1
Casey, P.J.2
-
19
-
-
0029860753
-
Inhibitors of the Ras signal transduction pathway as potential antitumour agents
-
Perrin D, Halazy S, Hill BT. Inhibitors of the Ras signal transduction pathway as potential antitumour agents. J Enzyme Inhibition 1996 ; 11 : 77-95.
-
(1996)
J Enzyme Inhibition
, vol.11
, pp. 77-95
-
-
Perrin, D.1
Halazy, S.2
Hill, B.T.3
-
20
-
-
0028784266
-
Inhibitors of protein farnesylation : A new approach to cancer chemotherapy
-
Graham SL. Inhibitors of protein farnesylation : a new approach to cancer chemotherapy. Exp Opin Ther Patents 1995 ; 5 : 1269-85.
-
(1995)
Exp Opin Ther Patents
, vol.5
, pp. 1269-1285
-
-
Graham, S.L.1
-
22
-
-
0027409561
-
Identification of Ras farnesyltransferase inhibitors by microbial screening
-
Kara M, Akasaka K, Akinaga S, Okabe M, Nakano H, Gomez R, et al. Identification of Ras farnesyltransferase inhibitors by microbial screening. Proc Natl Acad Sci USA 1993 ; 90 : 2281-5.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 2281-2285
-
-
Kara, M.1
Akasaka, K.2
Akinaga, S.3
Okabe, M.4
Nakano, H.5
Gomez, R.6
-
23
-
-
0029877708
-
Suppression of human pancreatic cancer growth in BALB/c nude mice by manumycin, a farnesyl-protein transferase inhibitor
-
Ito T, Kawata S, Tamura S, Igura T, Nagase T, Miyagawa JI, et al. Suppression of human pancreatic cancer growth in BALB/c nude mice by manumycin, a farnesyl-protein transferase inhibitor. Jpn J Cancer Res 1996 ; 87 : 113-6.
-
(1996)
Jpn J Cancer Res
, vol.87
, pp. 113-116
-
-
Ito, T.1
Kawata, S.2
Tamura, S.3
Igura, T.4
Nagase, T.5
Miyagawa, J.I.6
-
24
-
-
0029940817
-
Inhibition of cell growth by a farnesyl protein transferase inhibitor : A preferential suppression of Ras farnesylation
-
Nagase T, Kawata S, Tamura S, Matsuda Y, Inui Y, Yamasaki E, et al. Inhibition of cell growth by a farnesyl protein transferase inhibitor : a preferential suppression of Ras farnesylation. Int J Cancer 1996 ; 65 : 620-6.
-
(1996)
Int J Cancer
, vol.65
, pp. 620-626
-
-
Nagase, T.1
Kawata, S.2
Tamura, S.3
Matsuda, Y.4
Inui, Y.5
Yamasaki, E.6
-
25
-
-
0027413551
-
Selective inhibition of farnesyl protein transferase blocks Ras processing in vivo
-
Gibbs JB, Pompliano DL, Mosser SD, Rands E, Lingham RB, Singh SB, et al. Selective inhibition of farnesyl protein transferase blocks Ras processing in vivo. J Biol Chem 1993 ; 268 : 7617-20.
-
(1993)
J Biol Chem
, vol.268
, pp. 7617-7620
-
-
Gibbs, J.B.1
Pompliano, D.L.2
Mosser, S.D.3
Rands, E.4
Lingham, R.B.5
Singh, S.B.6
-
26
-
-
0030011713
-
Inhibition of farnesyl protein transferase by new farnesyl phosphonate derivatives of phenylalanine
-
Lamothe M, Perrin D, Blotieres D, Leborgne M, Gras S, Bonnet D, et al. Inhibition of farnesyl protein transferase by new farnesyl phosphonate derivatives of phenylalanine. Bioorg Med Chem Lett 1996 ; 6 : 1291-6.
-
(1996)
Bioorg Med Chem Lett
, vol.6
, pp. 1291-1296
-
-
Lamothe, M.1
Perrin, D.2
Blotieres, D.3
Leborgne, M.4
Gras, S.5
Bonnet, D.6
-
27
-
-
0028941868
-
Different analogs of farnesyl pyrophosphate inhibit squalene synthase and protein : Farnesyltransferase to different extents
-
Cohen LH, Valentijn ARPM, Roodenburg L, Van Leeuwen REW, Holger Huisman R, Lutz RJ, et al. Different analogs of farnesyl pyrophosphate inhibit squalene synthase and protein : farnesyltransferase to different extents. Biochem Pharmacol 1995 ; 49 : 839-45.
-
(1995)
Biochem Pharmacol
, vol.49
, pp. 839-845
-
-
Cohen, L.H.1
Valentijn, A.R.P.M.2
Roodenburg, L.3
Van Leeuwen, R.E.W.4
Holger Huisman, R.5
Lutz, R.J.6
-
28
-
-
0027362493
-
Farnesylamine : An inhibitor of farnesylation and growth of Ras-transformed cells
-
Kothapalli R, Guthrie N, Chambers AF, Carroll KK. Farnesylamine : an inhibitor of farnesylation and growth of Ras-transformed cells. Lipids 1993 ; 28 : 969-73.
-
(1993)
Lipids
, vol.28
, pp. 969-973
-
-
Kothapalli, R.1
Guthrie, N.2
Chambers, A.F.3
Carroll, K.K.4
-
29
-
-
0028967646
-
Ras farnesylation as a target for novel antitumor agents : Potent and selective farnesyl diphosphate analogs inhibitors of farnesyltransferase
-
Manne V, Ricca CS, Gullo Brown J, Tuomari AV, Yan N, Patel D, et al. Ras farnesylation as a target for novel antitumor agents : potent and selective farnesyl diphosphate analogs inhibitors of farnesyltransferase. Drug Dev Res 1995 ; 34 : 121-37.
-
(1995)
Drug Dev Res
, vol.34
, pp. 121-137
-
-
Manne, V.1
Ricca, C.S.2
Gullo Brown, J.3
Tuomari, A.V.4
Yan, N.5
Patel, D.6
-
30
-
-
0029025272
-
Phosphonyl acid-based bisubstrate analog inhibitors of Ras farnesyl protein transferase
-
Patel DV, Gordon EM, Schmidt RJ, Weller HN, Young MG, Zahler R, et al. Phosphonyl acid-based bisubstrate analog inhibitors of Ras farnesyl protein transferase. J Med Chem 1995 ; 38 : 43542.
-
(1995)
J Med Chem
, vol.38
, pp. 43542
-
-
Patel, D.V.1
Gordon, E.M.2
Schmidt, R.J.3
Weller, H.N.4
Young, M.G.5
Zahler, R.6
-
31
-
-
0029000897
-
Bisubstrate inhibitors of farnesyltransferase : A novel class of specific inhibitors of ras transformed cells
-
Manne V, Yan N, Carboni JM, Tuomari AV, Ricca CS, Gullo-Brown J, et al. Bisubstrate inhibitors of farnesyltransferase : a novel class of specific inhibitors of ras transformed cells. Oncogene 1995 ; 10 : 1763-79.
-
(1995)
Oncogene
, vol.10
, pp. 1763-1779
-
-
Manne, V.1
Yan, N.2
Carboni, J.M.3
Tuomari, A.V.4
Ricca, C.S.5
Gullo-Brown, J.6
-
32
-
-
0029154458
-
Farnesyltransferase inhibitors block the neurofibromatosis type I (NF1) malignant phenotype
-
Yan N, Ricca C, Fletcher J, Glover T, Seizinger BR, Manne V. Farnesyltransferase inhibitors block the neurofibromatosis type I (NF1) malignant phenotype. Cancer Res 1995 ; 55 : 3569-75.
-
(1995)
Cancer Res
, vol.55
, pp. 3569-3575
-
-
Yan, N.1
Ricca, C.2
Fletcher, J.3
Glover, T.4
Seizinger, B.R.5
Manne, V.6
-
33
-
-
0029586503
-
Novel tricyclic inhibitors of farnesyl protein transferase
-
Bishop WR, Bond R, Petrin J, Wang L, Patton R, Doll R, et al. Novel tricyclic inhibitors of farnesyl protein transferase. J Biol Chem 1995 ; 270 : 30611-8.
-
(1995)
J Biol Chem
, vol.270
, pp. 30611-30618
-
-
Bishop, W.R.1
Bond, R.2
Petrin, J.3
Wang, L.4
Patton, R.5
Doll, R.6
-
34
-
-
0029738813
-
Inhibitors of farnesyl protein transferase-a possible cancer chemotherapeutic
-
Scholten JD, Zimmerman K, Oxender M, Sebolt-Leopold J, Gowan R, Leonard D, Hupe DJ. Inhibitors of farnesyl protein transferase-a possible cancer chemotherapeutic. Bioorg Med Chem 1996 ; 4 : 1537-43.
-
(1996)
Bioorg Med Chem
, vol.4
, pp. 1537-1543
-
-
Scholten, J.D.1
Zimmerman, K.2
Oxender, M.3
Sebolt-Leopold, J.4
Gowan, R.5
Leonard, D.6
Hupe, D.J.7
-
35
-
-
0025194466
-
Inhibition of purified p21ras farnesyl protein transferase by Cys-AAX peptides
-
Reiss Y, Goldstein JL, Seabra MC, Casey PJ, Brown MS. Inhibition of purified p21ras farnesyl protein transferase by Cys-AAX peptides. Cell 1990 ; 62 : 81-8.
-
(1990)
Cell
, vol.62
, pp. 81-88
-
-
Reiss, Y.1
Goldstein, J.L.2
Seabra, M.C.3
Casey, P.J.4
Brown, M.S.5
-
36
-
-
0026040193
-
Non-farnesylated tetrapeptide inhibitors of protein farnesyl transferase
-
Goldstein JL, Brown MS, Stradley SJ, Reiss Y, Gierasch LM. Non-farnesylated tetrapeptide inhibitors of protein farnesyl transferase. J Biol Chem 1991 ; 266 : 15575-8.
-
(1991)
J Biol Chem
, vol.266
, pp. 15575-15578
-
-
Goldstein, J.L.1
Brown, M.S.2
Stradley, S.J.3
Reiss, Y.4
Gierasch, L.M.5
-
37
-
-
0027323459
-
Benzodiazepine peptidomimetics : Potent inhibitors of Ras farnesylation in animal cells
-
James GL, Goldstein JL, Brown MS, Rawson TE, Somers TC, McDowell RS, et al. Benzodiazepine peptidomimetics : potent inhibitors of Ras farnesylation in animal cells. Science 1993 ; 260 : 1937-42.
-
(1993)
Science
, vol.260
, pp. 1937-1942
-
-
James, G.L.1
Goldstein, J.L.2
Brown, M.S.3
Rawson, T.E.4
Somers, T.C.5
McDowell, R.S.6
-
38
-
-
0027248872
-
Selective inhibition of ras-dependent transformation by a farnesyltransferase inhibitor
-
Kohl NE, Mosser SD, Jane deSolms S, Giuliani EA, Pompliano DL, Graham SL, et al. Selective inhibition of ras-dependent transformation by a farnesyltransferase inhibitor. Science 1993 ; 260 : 1934-7.
-
(1993)
Science
, vol.260
, pp. 1934-1937
-
-
Kohl, N.E.1
Mosser, S.D.2
Jane Desolms, S.3
Giuliani, E.A.4
Pompliano, D.L.5
Graham, S.L.6
-
39
-
-
0027320616
-
Peptidomimetic inhibitors of Ras farnesylation and function in whole cells
-
Garcia AM, Rowell C, Ackerman K, Kowalczyk JJ, Lewis MD. Peptidomimetic inhibitors of Ras farnesylation and function in whole cells. J Biol Chem 1993 ; 268 : 18415-8.
-
(1993)
J Biol Chem
, vol.268
, pp. 18415-18418
-
-
Garcia, A.M.1
Rowell, C.2
Ackerman, K.3
Kowalczyk, J.J.4
Lewis, M.D.5
-
40
-
-
0030034763
-
Potent, cell active, non-thiol tetrapeptide inhibitors of farnesyltransferase
-
Hunt JT, Lee VG, Leftheris K, Seizinger B, Carboni J, Mabus J, et al. Potent, cell active, non-thiol tetrapeptide inhibitors of farnesyltransferase. J Med Chem 1996 ; 39 : 353-8.
-
(1996)
J Med Chem
, vol.39
, pp. 353-358
-
-
Hunt, J.T.1
Lee, V.G.2
Leftheris, K.3
Seizinger, B.4
Carboni, J.5
Mabus, J.6
-
41
-
-
0028973293
-
Ras CAAX peptidomimetic FTI-277 selectively blocks Ras signaling by inducing cytoplasmic accumulation of inactive Ras-Raf complexes
-
Lerner EC, Qian Y, Blaskovich MA, Fossum RD, Vogt A, Sun J, et al. Ras CAAX peptidomimetic FTI-277 selectively blocks Ras signaling by inducing cytoplasmic accumulation of inactive Ras-Raf complexes. J Biol Chem 1995 ; 270 : 26802-6.
-
(1995)
J Biol Chem
, vol.270
, pp. 26802-26806
-
-
Lerner, E.C.1
Qian, Y.2
Blaskovich, M.A.3
Fossum, R.D.4
Vogt, A.5
Sun, J.6
-
42
-
-
0028603395
-
Protein farnesylfransferase inhibitors block the growth of ras-dependent tumors in nude mice
-
Kohl NE, Wilson FR, Mosser SD, Giuliani E, Jane deSolms S, Conner MW, et al. Protein farnesylfransferase inhibitors block the growth of ras-dependent tumors in nude mice. Proc Natl Acad Sci USA 1994 ; 91 : 9141-5.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 9141-9145
-
-
Kohl, N.E.1
Wilson, F.R.2
Mosser, S.D.3
Giuliani, E.4
Jane Desolms, S.5
Conner, M.W.6
-
43
-
-
0029150669
-
Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice
-
Kohl NE, Omer CA, Conner MW, Anthony NJ, Davide JS, Jane deSolms S, et al. Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice. Nature Med 1995 ; 1 : 792-6.
-
(1995)
Nature Med
, vol.1
, pp. 792-796
-
-
Kohl, N.E.1
Omer, C.A.2
Conner, M.W.3
Anthony, N.J.4
Davide, J.S.5
Jane Desolms, S.6
-
44
-
-
0029023145
-
Ras CAAX peptidomimetic FTI 276 selectively blocks tumor growth in nude mice of a human lung carcinoma with K-ras mutation and p53 deletion
-
Sun J, Qian Y, Hamilton AD, Sebti SM. Ras CAAX peptidomimetic FTI 276 selectively blocks tumor growth in nude mice of a human lung carcinoma with K-ras mutation and p53 deletion. Cancer Res 1995 ; 55 : 4243-7.
-
(1995)
Cancer Res
, vol.55
, pp. 4243-4247
-
-
Sun, J.1
Qian, Y.2
Hamilton, A.D.3
Sebti, S.M.4
-
45
-
-
13344276587
-
Development of highly potent inhibitors of Ras farnesyltransferase possessing cellular and in vivo activity
-
Leftheris K, Kline T, Vite GD, Cho YH, Bhide RS, Patel DV, et al. Development of highly potent inhibitors of Ras farnesyltransferase possessing cellular and in vivo activity. J Med Chem 1996 ; 39 : 224-36.
-
(1996)
J Med Chem
, vol.39
, pp. 224-236
-
-
Leftheris, K.1
Kline, T.2
Vite, G.D.3
Cho, Y.H.4
Bhide, R.S.5
Patel, D.V.6
-
46
-
-
0028869067
-
Inhibition of human tumor xenograft growth by treatment with the farnesyltransferase inhibitor B956
-
Nagasu T, Yoshimatsu K, Rowell C, Lewis MD, Garcia AM. Inhibition of human tumor xenograft growth by treatment with the farnesyltransferase inhibitor B956. Cancer Res 1995 ; 55 : 5310-4.
-
(1995)
Cancer Res
, vol.55
, pp. 5310-5314
-
-
Nagasu, T.1
Yoshimatsu, K.2
Rowell, C.3
Lewis, M.D.4
Garcia, A.M.5
-
47
-
-
0028835253
-
A peptidomimetic inhibitor of farnesyl protein transferase blocks the anchorage-dependent and -independent growth of human tumor cell lines
-
Sepp-Lorenzino L, Ma Z, Rands E, Kohl NE, Gibbs JB, Oliff A, Rosen N. A peptidomimetic inhibitor of farnesyl protein transferase blocks the anchorage-dependent and -independent growth of human tumor cell lines. Cancer Res 1995 ; 55 : 5302-9.
-
(1995)
Cancer Res
, vol.55
, pp. 5302-5309
-
-
Sepp-Lorenzino, L.1
Ma, Z.2
Rands, E.3
Kohl, N.E.4
Gibbs, J.B.5
Oliff, A.6
Rosen, N.7
-
48
-
-
0028810275
-
Disruption of oncogenic K-Ras4B processing and signaling by a potent geranylgeranyltransferase I inhibitor
-
Lerner EC, Qian Y, Hamilton AD, Sebti SM. Disruption of oncogenic K-Ras4B processing and signaling by a potent geranylgeranyltransferase I inhibitor. J Biol Chem 1995 ; 270 : 26770-3.
-
(1995)
J Biol Chem
, vol.270
, pp. 26770-26773
-
-
Lerner, E.C.1
Qian, Y.2
Hamilton, A.D.3
Sebti, S.M.4
-
49
-
-
0028958919
-
Polylysine and CVIM sequences of K-RasB dictate specificity of prenylation and confer resistance to benzodiazepine peptidomimetic in vitro
-
James GL, Goldstein JL, Brown MS, Polylysine and CVIM sequences of K-RasB dictate specificity of prenylation and confer resistance to benzodiazepine peptidomimetic in vitro. J Biol Chem 1995 ; 270 : 6221-6.
-
(1995)
J Biol Chem
, vol.270
, pp. 6221-6226
-
-
James, G.L.1
Goldstein, J.L.2
Brown, M.S.3
-
50
-
-
0028920240
-
CAAX geranylgeranyl transferase transfers farnesyl as efficiently as geranylgeranyl to RhoB
-
Armstrong SA, Hannah VC, Goldstein JL, Brown MS. CAAX geranylgeranyl transferase transfers farnesyl as efficiently as geranylgeranyl to RhoB. J Biol Chem 1995 ; 270 : 7864-8.
-
(1995)
J Biol Chem
, vol.270
, pp. 7864-7868
-
-
Armstrong, S.A.1
Hannah, V.C.2
Goldstein, J.L.3
Brown, M.S.4
-
51
-
-
0027052132
-
Ras-related GTPases and the cytoskeleton
-
Hall A. Ras-related GTPases and the cytoskeleton. Mol Biol Cell 1992 ; 3 : 475-9.
-
(1992)
Mol Biol Cell
, vol.3
, pp. 475-479
-
-
Hall, A.1
-
52
-
-
0029057465
-
Critical role of Rho in cell transformation by oncogenic Ras
-
Prendergast GC, Khosravi-Far R, Solski PA, Kurzawa H, Lebowitz PF, Der CJ. Critical role of Rho in cell transformation by oncogenic Ras. Oncogene 1995 ; 10 : 2289-96.
-
(1995)
Oncogene
, vol.10
, pp. 2289-2296
-
-
Prendergast, G.C.1
Khosravi-Far, R.2
Solski, P.A.3
Kurzawa, H.4
Lebowitz, P.F.5
Der, C.J.6
-
54
-
-
0028892646
-
Evidence that farnesyltransferase inhibitors suppress Ras transformation by interfering with Rho activity
-
Lebowitz PF, Davide JP, Prendergast GC. Evidence that farnesyltransferase inhibitors suppress Ras transformation by interfering with Rho activity. Mol Cell Biol 1995 ; 15 : 6613-22.
-
(1995)
Mol Cell Biol
, vol.15
, pp. 6613-6622
-
-
Lebowitz, P.F.1
Davide, J.P.2
Prendergast, G.C.3
-
55
-
-
0028318136
-
Farnesyltransferase inhibition causes morphological reversion of ras-transformed cells by a complex mechanism that involves regulation of the actin cytoskeleton
-
Prendergast GC, Davide JP, Jane deSolms S, Giuliani EA, Graham SL, Gibbs JB, et al. Farnesyltransferase inhibition causes morphological reversion of ras-transformed cells by a complex mechanism that involves regulation of the actin cytoskeleton. Mol Cell Biol 1994 ; 14 : 4193-202.
-
(1994)
Mol Cell Biol
, vol.14
, pp. 4193-4202
-
-
Prendergast, G.C.1
Davide, J.P.2
Jane Desolms, S.3
Giuliani, E.A.4
Graham, S.L.5
Gibbs, J.B.6
-
56
-
-
0029921232
-
The farnesyltransferase inhibitor FTI-277 radiosensitizes H-ras-transformed rat embryo fibroblasts
-
Bernhard EJ, Kao G, Cox AD, Sebti SM, Hamilton AD, Muschel RJ, McKenna WG. The farnesyltransferase inhibitor FTI-277 radiosensitizes H-ras-transformed rat embryo fibroblasts. Cancer Res 1996 ; 56 : 1727-30.
-
(1996)
Cancer Res
, vol.56
, pp. 1727-1730
-
-
Bernhard, E.J.1
Kao, G.2
Cox, A.D.3
Sebti, S.M.4
Hamilton, A.D.5
Muschel, R.J.6
McKenna, W.G.7
|