A TCR Vα CDR3-specific motif associated with lewis rat autoimmune encephalomyelitis and basic protein-specific T cell clones

Journal of Immunology

Volumn 158, Issue 11, 1997, Pages 5472-5483

  Buenafe, Abigail C ^a,b   Tsu, Rachel C ^b   Bebo Jr , Bruce ^a,b   Bakke, Antony C ^a   Vandenbark, Arthur A ^a,b   Offner, Halina ^a,b  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b PORTLAND VA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; CD4 ANTIGEN; LYMPHOCYTE ANTIGEN RECEPTOR; MYELIN BASIC PROTEIN;

ALLERGIC ENCEPHALOMYELITIS; AMINO ACID SEQUENCE; ANIMAL; ARTICLE; CELL CLONE; FEMALE; GENETICS; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOLOGY; LEWIS RAT; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; RAT; SEQUENCE ANALYSIS; T LYMPHOCYTE;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, CD4; AUTOANTIGENS; BASE SEQUENCE; CLONE CELLS; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; IMMUNOGLOBULIN VARIABLE REGION; MOLECULAR SEQUENCE DATA; MYELIN BASIC PROTEINS; RATS; RATS, INBRED LEW; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; SEQUENCE ANALYSIS; T-LYMPHOCYTES;

EID: 0031155388     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Davis, M. M., and P. J. Bjorkman. 1988. T-cell antigen receptor genes and T-eell recognition. Nature 334:395,
2. Chothia, C., D. R. Boswell, and A. M. Lesk. 1988. The outline structure of the T-cell αβ receptor. EMBO J. 7:3745.
3. Lafaille, J. J., A. DeCloux, M. Bonneville, Y. Takagaki, and S. Tonegawa. 1989. Junctional sequences of T cell receptor 78 genes: implications for γδ T cell lineages and for a novel intermediate of V-(D)-J joining. Cell 59:859.
4. Alvord, E. C., Jr. 1984. Species-restricted encephalitogenic determinants. In Experimental Allergic Encephalomyelitis: A Useful Model for Multiple Sclerosis, Vol. 146. E. C. Alvord, Jr., M. W. Kies, and A. J. Suckling, eds. Alan R. Liss, New York, pp. 523-537.
5. Tuohy, V. K., Z. Lu, R. A. Sobel, R. A. Laursen, and M. B. Lees. 1989. Identification of an encephalitogenic determinant of myelin proteolipid protein for SJL mice. J. Immunol. 142:1523.
6. Offner, H., M. Vainiene, D. P. Gold, B. Celnik, R. Y. Wang, G. A. Hashim, and A. A. Vandenbark. 1992. Characterization of the immune response to a secondary encephalitogenic epitope of basic protein in Lewis rats. I. TCR peptide regulation of T cell clones expressing cross-reaciive Vβ genes. J. Immunol. 148:1706.
7. + T cells that induce EAE. J. Neuroimmunol. 40:57.
8. Weinberg, A. D., J. J. Wallin, R. E. Jones, T. J. Sullivan, D. N. Bourdette, A. A. Vandenbark, and H. Offner. 1994. Target organ specific upregulation of the MRC OX-40 marker and selective production of Th 1 lymphokine mRNA by encephalitogenic T helper cells isolated from the spinal cord of rats with experimental autoimmune encephalomyelitis. J. Immunol. 152:4712.
9. Ando, D. G., J. Clayton, D. Kono, J. L. Urban, and E. E. Sercarz. 1989. Encephalitogenic T cells in the B 10.PL model of experimental allergic encephalomyelitis (EAE) are of the Th-1 lymphokine subtype. Cell. Immunol. 124:132.
10. Bums, F. R., X. Li, N. Shen, H. Offner, Y. Chou, A. A. Vandenbark, and E. Heber-Katz. 1989. Both rat and mouse T cell receptors specific for the encephalitogenic determinant of myelin basic protein use similar Vα and Vβ chain genes even though the major histocompatibility complex and encephalitogenic determinants being recognized are different. J. Exp. Med. 169:27.
11. Chluba, J., C. Steeg, A. Becker, H. Wekerle, and J. T. Epplen. 1989. T cell receptor β chain usage in myelin basic protein-specific rat T lymphocytes. Eur. J. Immunol. 19:279.
12. Sun, D., and C. Coleclough. 1993. Diverse T cell receptor beta chain usage by rat encephalitogenic T cells reactive to residues 68-88 of myelin basic protein. Eur. J. Immunol. 23:494.
13. Sun, D., X. Z. Hu, J. Le, and R. H. Swanborg. 1994. Characterization of brain-isolated rat encephalitogenic T cell lines. Eur. J. Immunol. 24:1359.
14. Offner, H., A. Buenafe, M. Vainiene, B. Celnik, A. D. Weinberg, D. P. Gold, G. Hashim, and A. A. Vandenbark. 1993. Where, when, and how to detect biased expression of disease-relevant Vβ genes in rats with experimental autoimmune encephalomyelitis. J. Immunol. 151:506.
15. Weinberg, A. D., M. Lemon, A. J. Jones, M. Vainiene, B. Celnik, A. C. Buenafe, N. Culbertson, A. Bakke, A. A. Vandenbark, and H. Offner. 1996. OX-40 antibody enhances for autoantigen specific Vβ8.2"1" T cells within the spinal cord of Lewis rats with autoimmune encephalomyelitis. J. Neuroscience. Res. 43:42.
16. Fields, B. A., and R. A. Mariuzza. 1996. Structure and function of the T-cell receptor: insights from X-ray crystallography. Immunol. Today 17:330.
17. Jorgensen, J. L., P. A. Reay, E. W. Ehrich, and M. M. Davis. 1992. Molecular components of T-cell recognition. Annu. Rev. Immunol. 10:835.
18. Mantegaza, R., F. Andreetta, P. Bernasconi, F. Baggi, J. R. Oksenberg, O. Simoncini, M. Mora, F. Cornelio, and L. Steinman. 1993. Analysis of T cell receptor repertoire of muscle-infiltrating T lymphocytes in polymyositis: restricted V alpha/beta rearrangements may indicate antigen-driven selection. J. Clin. Invest. 91:2880.
19. Oksenberg, J. R., M. A. Panzara, A. B. Begovich, D. Mitchell. H. A. Erlich, R. S. Murray, R. Shimonkevita, M. Sherritt, J. Rothbard, C. C. A. Bernard, and L. Steinman. 1993. Selection for T-cell receptor Vβ-Dβ-Jβ gene rearrangements with specificity for a myelin basic protein peptide in brain lesions of multiple sclerosis. Nature 362:68.
20. + T lymphocytes on the basis of CDR3 diversity. Int. Immunol. 6:897.
21. Pierce, J. L., K. A. Zborowski, E. Kraig, and A. J. Infante. 1994. Highly conserved TCR β chain CDR3 sequences among immunodominant acetylcholine receptor-reactive T cells in murine myaslhenia gravis. Int.-Immunol. 6:775.
22. Jones, C. M., R. A. Lake, J. R. Lamb, and A. Faith. 1994. Degeneracy of T cell receptor recognition of an influenza virus hemagglutinin epitope restricted by HLA-DQ and -DR class II molecules. Eur. J. Immunol. 24:1137.
23. Wang, X., L. Golkar, K. Uyemura, J. D. Ohmen, L. G. Villahermosa,. T. T. Fajardo, Jr., R. V. Cellona, G. P. Walsh, and R. L. Modlin. 1993. T cells bearing V beta 6 T cell receptors in the cell-mediated immune response to Mycobacterium leprae. J. Immunol. 151:7105.